CH609669A5 - Process for the preparation of metformin clofibrate - Google Patents

Process for the preparation of metformin clofibrate

Info

Publication number
CH609669A5
CH609669A5 CH362775A CH362775A CH609669A5 CH 609669 A5 CH609669 A5 CH 609669A5 CH 362775 A CH362775 A CH 362775A CH 362775 A CH362775 A CH 362775A CH 609669 A5 CH609669 A5 CH 609669A5
Authority
CH
Switzerland
Prior art keywords
metformin
preparation
clofibrate
salt
metformin clofibrate
Prior art date
Application number
CH362775A
Inventor
Claude Bohuon
Original Assignee
Marques Brev Soc Et Exploit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marques Brev Soc Et Exploit filed Critical Marques Brev Soc Et Exploit
Publication of CH609669A5 publication Critical patent/CH609669A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Metformin clofibrate (the salt of 2-(p-chlorophenoxy)-2-methylpropionic acid with N<1>,N<1>-dimethylbiguanide) is obtained by reacting clofibric acid with metformin. The latter is obtained by conversion of its hydrochloride to the free base using ion exchange. The new salt is useful as a medicament. It makes possible, for example, the control of glycaemia and the treatment of vascular complications of diabetes.
CH362775A 1974-03-22 1975-03-21 Process for the preparation of metformin clofibrate CH609669A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7409963A FR2264525B1 (en) 1974-03-22 1974-03-22

Publications (1)

Publication Number Publication Date
CH609669A5 true CH609669A5 (en) 1979-03-15

Family

ID=9136732

Family Applications (1)

Application Number Title Priority Date Filing Date
CH362775A CH609669A5 (en) 1974-03-22 1975-03-21 Process for the preparation of metformin clofibrate

Country Status (11)

Country Link
JP (1) JPS5526134B2 (en)
AT (1) AT346856B (en)
BE (1) BE826999A (en)
CA (1) CA1062280A (en)
CH (1) CH609669A5 (en)
DE (1) DE2511576C2 (en)
ES (1) ES435898A1 (en)
FR (1) FR2264525B1 (en)
GB (1) GB1462316A (en)
LU (1) LU72102A1 (en)
NL (1) NL169461C (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60196425A (en) * 1984-03-16 1985-10-04 Daido Metal Kogyo Kk Pad-type journal bearing unit kept its bearing clearance in constant
FR2774591B1 (en) * 1998-02-12 2000-05-05 Lipha PHARMACEUTICAL COMPOSITION COMPRISING THE ASSOCIATION OF METFORMIN AND FIBRATE AND THE USE THEREOF FOR THE PREPARATION OF MEDICINES FOR REDUCING HYPERGLYCEMIA
FR2796551B1 (en) * 1999-07-23 2003-07-25 Lipha NOVEL METFORMIN SALTS, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
FR2796940B1 (en) * 1999-07-26 2005-04-08 Lipha NOVEL METFORMIN SALTS, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7116M (en) * 1968-01-08 1969-07-15
AT317235B (en) * 1972-08-22 1974-08-26 Hurka Wilhelm Process for the preparation of the new 2- (p-chlorophenoxy) -2-methylpropionic acid salt of 1-phenethylbiguanide

Also Published As

Publication number Publication date
NL7503515A (en) 1975-09-24
GB1462316A (en) 1977-01-26
FR2264525A1 (en) 1975-10-17
DE2511576A1 (en) 1975-09-25
NL169461B (en) 1982-02-16
ES435898A1 (en) 1976-12-16
CA1062280A (en) 1979-09-11
DE2511576C2 (en) 1983-07-07
FR2264525B1 (en) 1977-11-04
NL169461C (en) 1982-07-16
LU72102A1 (en) 1975-08-20
ATA217875A (en) 1978-04-15
JPS5526134B2 (en) 1980-07-11
BE826999A (en) 1975-07-16
JPS50135043A (en) 1975-10-25
AT346856B (en) 1978-11-27

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Legal Events

Date Code Title Description
PL Patent ceased