DE2442829A1 - Tetracyclische verbindungen und verfahren zu ihrer herstellung - Google Patents
Tetracyclische verbindungen und verfahren zu ihrer herstellungInfo
- Publication number
- DE2442829A1 DE2442829A1 DE2442829A DE2442829A DE2442829A1 DE 2442829 A1 DE2442829 A1 DE 2442829A1 DE 2442829 A DE2442829 A DE 2442829A DE 2442829 A DE2442829 A DE 2442829A DE 2442829 A1 DE2442829 A1 DE 2442829A1
- Authority
- DE
- Germany
- Prior art keywords
- dimethylamino
- amino
- des
- thiatetracycline
- azatetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2442829A DE2442829A1 (de) | 1974-09-06 | 1974-09-06 | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
US05/607,803 US4024272A (en) | 1974-09-06 | 1975-08-26 | Tetracyclic compounds |
CS755903A CS191275B2 (en) | 1974-09-06 | 1975-08-29 | Process for preparing new 6-thiatetracyclines |
IL48044A IL48044A (en) | 1974-09-06 | 1975-09-03 | Tetracyclic compounds and processes for their preparation |
BE7000704A BE833048A (nl) | 1974-09-06 | 1975-09-03 | Tetracyclische verbindingen |
DD188192A DD121637A5 (US07709020-20100504-C00041.png) | 1974-09-06 | 1975-09-04 | |
FR7527132A FR2283690A1 (fr) | 1974-09-06 | 1975-09-04 | Nouveaux composes tetracycliques utiles comme medicaments et leur procede de preparation |
CA234,780A CA1068285A (en) | 1974-09-06 | 1975-09-04 | 6-oxatetracycline and 6-thiatetracycline compounds and process for their preparation |
GB3652475A GB1467206A (en) | 1974-09-06 | 1975-09-04 | Oxa-, thia- and aza-tetracycline derivatives and their preparation |
LU73332A LU73332A1 (US07709020-20100504-C00041.png) | 1974-09-06 | 1975-09-04 | |
DK397875A DK397875A (da) | 1974-09-06 | 1975-09-04 | Fremgangsmade til fremstilling af tetracycliske forbindelser |
ES440765A ES440765A1 (es) | 1974-09-06 | 1975-09-05 | Procedimiento para la obtencion de compuestos tetraciclicos. |
IE1947/75A IE41675B1 (en) | 1974-09-06 | 1975-09-05 | Oxa-,thia-,and aza-tetracycline derivatives and their preparation |
HU75ME1895A HU173491B (hu) | 1974-09-06 | 1975-09-05 | Sposob poluchenija tetraciklicheskikh soedinenijj |
PL1975183138A PL96677B1 (pl) | 1974-09-06 | 1975-09-05 | Sposob wytwarzania nowych zwiazkow tetracyklinowych |
SE7509880A SE7509880L (sv) | 1974-09-06 | 1975-09-05 | Tetracykliska foreningar och forfarande for framstellning derav |
AT689275A AT344890B (de) | 1974-09-06 | 1975-09-05 | Verfahren zur herstellung von neuen 6-thiatetracyclinen |
JP50108472A JPS5154564A (US07709020-20100504-C00041.png) | 1974-09-06 | 1975-09-05 | |
ZA00755699A ZA755699B (en) | 1974-09-06 | 1975-09-05 | Tetracyclic compounds and processes for their preparation |
AU84599/75A AU495455B2 (en) | 1974-09-06 | 1975-09-05 | Tetracyclic compounds and processes for their preparation |
HU75ME2256A HU176136B (en) | 1974-09-06 | 1975-09-05 | Process for preparing tetracyclic compounds |
NL7510505A NL7510505A (nl) | 1974-09-06 | 1975-09-05 | Tetracyclische verbindingen. |
IT7948216A IT7948216A0 (it) | 1974-09-06 | 1979-03-05 | Composti tetracilici e procedimento per la loro produzione |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2442829A DE2442829A1 (de) | 1974-09-06 | 1974-09-06 | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2442829A1 true DE2442829A1 (de) | 1976-03-18 |
Family
ID=5925100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2442829A Withdrawn DE2442829A1 (de) | 1974-09-06 | 1974-09-06 | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
Country Status (21)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0001558A1 (de) * | 1977-10-13 | 1979-05-02 | MERCK PATENT GmbH | Verfahren zur Herstellung von 6-Thiatetracyclinracematen mit "natürlicher Konfiguration" und ihren optischen Antipoden |
EP2301912A3 (en) * | 2004-10-25 | 2012-07-11 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4672138A (en) * | 1980-10-20 | 1987-06-09 | Hoechst Roussel Pharmaceuticals Inc. | Phenyl substituted carbamothioic acid esters |
US4436748A (en) * | 1980-10-20 | 1984-03-13 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo[b]thiophenes |
US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
EP0416564A3 (en) * | 1989-09-05 | 1992-03-11 | Kao Corporation | Novel aroyl ketone derivative, uv ray absorber comprising the same, and cosmetic composition containing the same |
US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
FR2795722A1 (fr) * | 1999-07-02 | 2001-01-05 | Rhodia Chimie Sa | Procede de preparation d'une arylhydrazine hydroxylee, produits intermediaires et leur procede d'obtention |
US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
EP1666453A1 (en) | 1999-09-14 | 2006-06-07 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
CA2397863A1 (en) | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
ES2288945T3 (es) * | 2000-03-31 | 2008-02-01 | Trustees Of Tufts College | Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos. |
US6642270B2 (en) * | 2000-05-15 | 2003-11-04 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
DK1679305T3 (da) | 2000-07-07 | 2012-05-29 | Tufts College | 9-substituerede minocyclinforbindelser |
EP1303479B1 (en) | 2000-07-07 | 2011-04-06 | Trustees Of Tufts College | 7-, 8- and 9-substituted tetracycline compounds |
MXPA03000036A (es) | 2000-07-07 | 2003-07-14 | Tufts College | Compuestos de metaciclina sustituidos en posicion 13. |
US6818635B2 (en) | 2000-07-07 | 2004-11-16 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
JP2005506291A (ja) | 2001-03-13 | 2005-03-03 | パラテック ファーマシューティカルズ, インク. | 7,9−置換テトラサイクリン化合物 |
JP2005504722A (ja) | 2001-03-14 | 2005-02-17 | パラテック ファーマシューティカルズ インコーポレイテッド | 相乗的抗真菌薬剤としての置換テトラサイクリン化合物 |
US6841546B2 (en) | 2001-03-14 | 2005-01-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
AU2002254714C1 (en) | 2001-04-24 | 2010-01-07 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
EP2311796A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
US6730697B2 (en) * | 2002-02-07 | 2004-05-04 | Aventis Pharma Deutschland Gmbh | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid |
CA2478335C (en) * | 2002-03-08 | 2011-05-10 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
EP1503981A4 (en) * | 2002-03-21 | 2007-08-15 | Paratek Pharm Innc | SUBSTITUTED TETRACYCLINE COMPOUNDS |
WO2004006850A2 (en) | 2002-07-12 | 2004-01-22 | Paratek Pharmaceuticals, Inc | 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS |
CA2502464A1 (en) | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
EP2298322A3 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
CA2531732C (en) | 2003-07-09 | 2012-04-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
JP5010284B2 (ja) * | 2004-01-15 | 2012-08-29 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の芳香族a環誘導体 |
TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
EP2284155A3 (en) | 2004-10-25 | 2011-10-12 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
CA2597212A1 (en) * | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
EP1910273A2 (en) * | 2005-07-21 | 2008-04-16 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
CA2639406A1 (en) * | 2006-01-24 | 2007-08-02 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
EP2007713A2 (en) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolation of tetracycline derivatives |
US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
PT2016045E (pt) * | 2006-04-24 | 2015-02-05 | Teva Pharma | Forma cristalina de tigeciclina e processos para a sua preparação |
AU2007249695A1 (en) * | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
EP2086926A2 (en) * | 2006-11-29 | 2009-08-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
EP2084126A1 (en) * | 2006-11-30 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
US8318706B2 (en) | 2006-12-21 | 2012-11-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
AU2007338681B2 (en) | 2006-12-21 | 2013-09-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
EP2114865A1 (en) * | 2007-03-01 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
CA2688725A1 (en) * | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
EP2213655A1 (en) | 2007-04-27 | 2010-08-04 | Paratek Pharmaceuticals, Inc. | Methods For Purifying Aminoalkyl Tetracycline Compounds |
KR20100042276A (ko) | 2007-07-06 | 2010-04-23 | 파라테크 파마슈티컬스, 인크. | 치환 테트라사이클린 화합물의 합성방법 |
EP2262754A4 (en) | 2008-03-05 | 2012-03-14 | Paratek Pharm Innc | MINOCYCLINE COMPOUNDS AND METHODS OF USE THEREOF |
PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
JP2011517697A (ja) * | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
TW202021946A (zh) * | 2008-05-23 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
AU2009292986A1 (en) * | 2008-09-19 | 2010-03-25 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment |
US20120121706A1 (en) | 2009-04-10 | 2012-05-17 | Tufts Medical Center, Inc. | PAR-1 Activation by Metalloproteinase-1 (MMP-1) |
CN107021887A (zh) | 2009-05-08 | 2017-08-08 | 四相制药公司 | 四环素类化合物 |
SI2707003T1 (sl) | 2011-05-12 | 2019-10-30 | Paratek Pharm Innc | Kristalinične soli amida (4S,4AS,5AR,12AS)-4-dimetilamino-3,10,12,12A-tetrahidroksi-7-((metoksi (metil)amino)-metil)-1,11-diokso-1,4,4A,5,5A,6,11,12A-oktahidro-naftacen -2-karboksilne kisline in postopki za uporabo le-teh |
NZ740051A (en) * | 2012-08-31 | 2019-09-27 | Tetraphase Pharmaceuticals Inc | Tetracycline compounds |
JP6269300B2 (ja) * | 2014-05-01 | 2018-01-31 | 国立大学法人大阪大学 | スルホキシドの脱酸素用触媒、及び該脱酸素用触媒を用いたスルフィドの製造方法 |
MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
EP3534908A4 (en) | 2016-11-01 | 2020-05-27 | Paratek Pharmaceuticals, Inc. | 9-AMINOMETHYL-MINOCYCLINE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF AMBULANTLY ACQUIRED BACTERIAL PNEUMONIA (CABP) |
KR102662461B1 (ko) | 2017-07-21 | 2024-04-30 | 알미랄 엘엘씨 | 비염증성 병변의 치료 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2437487A1 (de) * | 1974-08-03 | 1976-02-19 | Merck Patent Gmbh | 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung |
-
1974
- 1974-09-06 DE DE2442829A patent/DE2442829A1/de not_active Withdrawn
-
1975
- 1975-08-26 US US05/607,803 patent/US4024272A/en not_active Expired - Lifetime
- 1975-08-29 CS CS755903A patent/CS191275B2/cs unknown
- 1975-09-03 IL IL48044A patent/IL48044A/xx unknown
- 1975-09-03 BE BE7000704A patent/BE833048A/xx unknown
- 1975-09-04 DK DK397875A patent/DK397875A/da unknown
- 1975-09-04 CA CA234,780A patent/CA1068285A/en not_active Expired
- 1975-09-04 DD DD188192A patent/DD121637A5/xx unknown
- 1975-09-04 GB GB3652475A patent/GB1467206A/en not_active Expired
- 1975-09-04 LU LU73332A patent/LU73332A1/xx unknown
- 1975-09-04 FR FR7527132A patent/FR2283690A1/fr active Granted
- 1975-09-05 PL PL1975183138A patent/PL96677B1/pl unknown
- 1975-09-05 SE SE7509880A patent/SE7509880L/xx unknown
- 1975-09-05 JP JP50108472A patent/JPS5154564A/ja active Pending
- 1975-09-05 IE IE1947/75A patent/IE41675B1/en unknown
- 1975-09-05 ZA ZA00755699A patent/ZA755699B/xx unknown
- 1975-09-05 NL NL7510505A patent/NL7510505A/xx not_active Application Discontinuation
- 1975-09-05 HU HU75ME1895A patent/HU173491B/hu unknown
- 1975-09-05 ES ES440765A patent/ES440765A1/es not_active Expired
- 1975-09-05 AT AT689275A patent/AT344890B/de not_active IP Right Cessation
- 1975-09-05 HU HU75ME2256A patent/HU176136B/hu unknown
-
1979
- 1979-03-05 IT IT7948216A patent/IT7948216A0/it unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0001558A1 (de) * | 1977-10-13 | 1979-05-02 | MERCK PATENT GmbH | Verfahren zur Herstellung von 6-Thiatetracyclinracematen mit "natürlicher Konfiguration" und ihren optischen Antipoden |
EP2301912A3 (en) * | 2004-10-25 | 2012-07-11 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
HU176136B (en) | 1980-12-28 |
FR2283690B1 (US07709020-20100504-C00041.png) | 1980-03-28 |
CA1068285A (en) | 1979-12-18 |
IL48044A (en) | 1978-12-17 |
DK397875A (da) | 1976-03-07 |
IE41675B1 (en) | 1980-02-27 |
ATA689275A (de) | 1977-12-15 |
ZA755699B (en) | 1976-08-25 |
DD121637A5 (US07709020-20100504-C00041.png) | 1976-08-12 |
PL96677B1 (pl) | 1978-01-31 |
FR2283690A1 (fr) | 1976-04-02 |
IE41675L (en) | 1976-03-06 |
US4024272A (en) | 1977-05-17 |
AT344890B (de) | 1978-08-10 |
BE833048A (nl) | 1976-03-03 |
AU8459975A (en) | 1977-03-10 |
HU173491B (hu) | 1979-05-28 |
SE7509880L (sv) | 1976-03-08 |
NL7510505A (nl) | 1976-03-09 |
CS191275B2 (en) | 1979-06-29 |
IT7948216A0 (it) | 1979-03-05 |
ES440765A1 (es) | 1977-06-16 |
GB1467206A (en) | 1977-03-16 |
IL48044A0 (en) | 1975-11-25 |
JPS5154564A (US07709020-20100504-C00041.png) | 1976-05-13 |
LU73332A1 (US07709020-20100504-C00041.png) | 1976-04-13 |
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