AT344890B - Verfahren zur herstellung von neuen 6-thiatetracyclinen - Google Patents
Verfahren zur herstellung von neuen 6-thiatetracyclinenInfo
- Publication number
- AT344890B AT344890B AT689275A AT689275A AT344890B AT 344890 B AT344890 B AT 344890B AT 689275 A AT689275 A AT 689275A AT 689275 A AT689275 A AT 689275A AT 344890 B AT344890 B AT 344890B
- Authority
- AT
- Austria
- Prior art keywords
- thiatetracyclines
- producing new
- producing
- new
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2442829A DE2442829A1 (de) | 1974-09-06 | 1974-09-06 | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA689275A ATA689275A (de) | 1977-12-15 |
| AT344890B true AT344890B (de) | 1978-08-10 |
Family
ID=5925100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT689275A AT344890B (de) | 1974-09-06 | 1975-09-05 | Verfahren zur herstellung von neuen 6-thiatetracyclinen |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4024272A (de) |
| JP (1) | JPS5154564A (de) |
| AT (1) | AT344890B (de) |
| BE (1) | BE833048A (de) |
| CA (1) | CA1068285A (de) |
| CS (1) | CS191275B2 (de) |
| DD (1) | DD121637A5 (de) |
| DE (1) | DE2442829A1 (de) |
| DK (1) | DK397875A (de) |
| ES (1) | ES440765A1 (de) |
| FR (1) | FR2283690A1 (de) |
| GB (1) | GB1467206A (de) |
| HU (2) | HU173491B (de) |
| IE (1) | IE41675B1 (de) |
| IL (1) | IL48044A (de) |
| IT (1) | IT7948216A0 (de) |
| LU (1) | LU73332A1 (de) |
| NL (1) | NL7510505A (de) |
| PL (1) | PL96677B1 (de) |
| SE (1) | SE7509880L (de) |
| ZA (1) | ZA755699B (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2746044C2 (de) * | 1977-10-13 | 1979-09-06 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur Herstellung von e-Thiatetracyclinracematen mit natürlicher Konfiguration und ihren optischen Antipoden |
| US4436748A (en) * | 1980-10-20 | 1984-03-13 | Hoechst-Roussel Pharmaceuticals Inc. | Benzo[b]thiophenes |
| US4672138A (en) * | 1980-10-20 | 1987-06-09 | Hoechst Roussel Pharmaceuticals Inc. | Phenyl substituted carbamothioic acid esters |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| EP0416564A3 (en) * | 1989-09-05 | 1992-03-11 | Kao Corporation | Novel aroyl ketone derivative, uv ray absorber comprising the same, and cosmetic composition containing the same |
| US6756365B2 (en) * | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| FR2795722A1 (fr) * | 1999-07-02 | 2001-01-05 | Rhodia Chimie Sa | Procede de preparation d'une arylhydrazine hydroxylee, produits intermediaires et leur procede d'obtention |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| HRP20020322B1 (en) | 1999-09-14 | 2009-04-30 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| WO2001052858A1 (en) * | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| EP1272459B1 (de) | 2000-03-31 | 2007-06-27 | Trustees Of Tufts College | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
| EP2308863A1 (de) * | 2000-05-15 | 2011-04-13 | Paratek Pharmaceuticals, Inc. | 7-Substituierte kondensierte Zyklus Tetrazyclin Verbindungen |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20050143353A1 (en) * | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| EP1303479B1 (de) | 2000-07-07 | 2011-04-06 | Trustees Of Tufts College | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| KR101083571B1 (ko) | 2000-07-07 | 2011-11-14 | 파라테크 파마슈티컬스, 인크. | 7-치환 테트라사이클린 화합물 |
| IL153674A0 (en) | 2000-07-07 | 2003-07-06 | Tufts College | 13-substituted methacycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| ATE544745T1 (de) | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
| EP1241160A1 (de) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracyclinderivate und ihre Verwendung als Antibiotica |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| ATE404528T1 (de) | 2001-03-13 | 2008-08-15 | Paratek Pharm Innc | 7,9 substituierte tetracyclinverbindungen |
| CA2457234A1 (en) * | 2001-03-14 | 2002-09-19 | Mark L. Nelson | Substituted tetracycline compounds as antifungal agents |
| JP2005504722A (ja) | 2001-03-14 | 2005-02-17 | パラテック ファーマシューティカルズ インコーポレイテッド | 相乗的抗真菌薬剤としての置換テトラサイクリン化合物 |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| ATE455092T1 (de) | 2001-04-24 | 2010-01-15 | Paratek Pharm Innc | Substituierte tetracyclin-verbindungen zur behandlung von malaria |
| ES2551708T3 (es) | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| US6730697B2 (en) * | 2002-02-07 | 2004-05-04 | Aventis Pharma Deutschland Gmbh | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid |
| EP2301534A1 (de) * | 2002-03-08 | 2011-03-30 | Paratek Pharmaceuticals, Inc. | Aminomethyl-substituierte Tetracyclin-Verbindungen |
| CN1653037A (zh) | 2002-03-21 | 2005-08-10 | 帕拉特克药品公司 | 取代的四环素化合物 |
| AU2003261161B2 (en) | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| AU2003287218C1 (en) | 2002-10-24 | 2010-07-15 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP1648859B1 (de) | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituierte tetracyclinverbindungen |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| US20050137174A1 (en) | 2003-07-09 | 2005-06-23 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CA2553510C (en) * | 2004-01-15 | 2012-09-25 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| US7858601B2 (en) * | 2004-10-25 | 2010-12-28 | Paratek Pharmaceuticals, Inc. | 4-substituted tetracyclines and methods of use thereof |
| US8466132B2 (en) | 2004-10-25 | 2013-06-18 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| JP2008530023A (ja) | 2005-02-04 | 2008-08-07 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物の１１ａ，１２−誘導体 |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| EP2298324A1 (de) | 2006-01-24 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | Verfahren zur Verbesserung der oralen Bioverfügbarkeit von Tetracyclinen |
| EP2007713A2 (de) * | 2006-04-17 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Isolierung von tetracyclinderivaten |
| PL2016045T3 (pl) * | 2006-04-24 | 2015-04-30 | Teva Pharma | Krystaliczna postać tygecykliny i sposoby jej otrzymywania |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| EP2537934A3 (de) * | 2006-05-15 | 2013-04-10 | Paratek Pharmaceuticals, Inc. | Verfahren zur Regelung der Genexpression oder von Genprodukten mit substituierten Tetracyclinverbindungen |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| EP2251320A1 (de) * | 2006-11-29 | 2010-11-17 | Teva Pharmaceutical Industries Ltd. | Kristallformen von Tigecyclin und Verfahren zu deren Herstellung |
| US20080234504A1 (en) * | 2006-11-30 | 2008-09-25 | Evgeny Tsiperman | Processes for preparation of 9-haloacetamidominocyclines |
| SI2120963T1 (sl) | 2006-12-21 | 2019-02-28 | Paratek Pharmaceuticals, Inc. | Substituirane spojine tetraciklina za zdravljenje vnetnih kožnih motenj |
| JP5583411B2 (ja) | 2006-12-21 | 2014-09-03 | パラテック ファーマシューティカルズ インコーポレイテッド | 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体 |
| US20080214869A1 (en) * | 2007-03-01 | 2008-09-04 | Sergei Fine | Processes for purification of tigecycline |
| EP2144614A1 (de) | 2007-04-12 | 2010-01-20 | Paratek Pharmaceuticals, Inc. | Verfahren zur behandlung von spinaler muskelatrophie mittels tetracyclinverbindungen |
| EP2213655A1 (de) * | 2007-04-27 | 2010-08-04 | Paratek Pharmaceuticals, Inc. | Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen |
| EA201070233A1 (ru) | 2007-07-06 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
| MX2010009693A (es) | 2008-03-05 | 2010-12-20 | Paratek Pharm Innc | Compuestos de monociclina y metodos de uso de la misma. |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| EP2276342A4 (de) * | 2008-04-14 | 2012-02-22 | Paratek Pharm Innc | Substituierte tetracyclinverbindungen |
| TW202436282A (zh) | 2008-05-19 | 2024-09-16 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| JP2012503017A (ja) * | 2008-09-19 | 2012-02-02 | パラテック ファーマシューティカルズ インコーポレイテッド | 関節リウマチの治療用のテトラサイクリン化合物および関連する治療方法 |
| DE202010018378U1 (de) | 2009-04-10 | 2016-04-07 | Tufts Medical Center, Inc. | PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1) |
| CN107021887A (zh) | 2009-05-08 | 2017-08-08 | 四相制药公司 | 四环素类化合物 |
| PL2707003T3 (pl) | 2011-05-12 | 2019-11-29 | Paratek Pharm Innc | Krystaliczne sole amidu kwasu (4s,4as,5ar,12as)-4-dimetyloamino-3,10,12,12a-tetrahydroksy-7-[(metoksy(metylo)amino)metylo]-1,11-diokso- 1,4,4a,5,5a,6,11,12a-oktahydronaftaceno- 2-karboksylowego i sposoby ich stosowania |
| PL2890673T3 (pl) * | 2012-08-31 | 2019-06-28 | Tetraphase Pharmaceuticals, Inc. | Związki tetracyklinowe |
| JP6269300B2 (ja) * | 2014-05-01 | 2018-01-31 | 国立大学法人大阪大学 | スルホキシドの脱酸素用触媒、及び該脱酸素用触媒を用いたスルフィドの製造方法 |
| KR102660864B1 (ko) | 2016-10-19 | 2024-04-25 | 테트라페이즈 파마슈티컬스, 인코포레이티드 | 에라바사이클린의 결정질 형태 |
| US10383884B2 (en) | 2016-11-01 | 2019-08-20 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP) |
| EP3654988B1 (de) | 2017-07-21 | 2023-09-06 | Almirall, LLC | Sarecyclin zur behandlung von nicht-entzündlichen akneläsionen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2437487A1 (de) * | 1974-08-03 | 1976-02-19 | Merck Patent Gmbh | 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung |
-
1974
- 1974-09-06 DE DE2442829A patent/DE2442829A1/de not_active Withdrawn
-
1975
- 1975-08-26 US US05/607,803 patent/US4024272A/en not_active Expired - Lifetime
- 1975-08-29 CS CS755903A patent/CS191275B2/cs unknown
- 1975-09-03 BE BE7000704A patent/BE833048A/xx unknown
- 1975-09-03 IL IL48044A patent/IL48044A/xx unknown
- 1975-09-04 CA CA234,780A patent/CA1068285A/en not_active Expired
- 1975-09-04 GB GB3652475A patent/GB1467206A/en not_active Expired
- 1975-09-04 DK DK397875A patent/DK397875A/da unknown
- 1975-09-04 DD DD188192A patent/DD121637A5/xx unknown
- 1975-09-04 FR FR7527132A patent/FR2283690A1/fr active Granted
- 1975-09-04 LU LU73332A patent/LU73332A1/xx unknown
- 1975-09-05 SE SE7509880A patent/SE7509880L/xx unknown
- 1975-09-05 ES ES440765A patent/ES440765A1/es not_active Expired
- 1975-09-05 NL NL7510505A patent/NL7510505A/xx not_active Application Discontinuation
- 1975-09-05 ZA ZA00755699A patent/ZA755699B/xx unknown
- 1975-09-05 IE IE1947/75A patent/IE41675B1/en unknown
- 1975-09-05 JP JP50108472A patent/JPS5154564A/ja active Pending
- 1975-09-05 HU HU75ME1895A patent/HU173491B/hu unknown
- 1975-09-05 HU HU75ME2256A patent/HU176136B/hu unknown
- 1975-09-05 AT AT689275A patent/AT344890B/de not_active IP Right Cessation
- 1975-09-05 PL PL1975183138A patent/PL96677B1/pl unknown
-
1979
- 1979-03-05 IT IT7948216A patent/IT7948216A0/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8459975A (en) | 1977-03-10 |
| FR2283690A1 (fr) | 1976-04-02 |
| IT7948216A0 (it) | 1979-03-05 |
| IL48044A0 (en) | 1975-11-25 |
| CA1068285A (en) | 1979-12-18 |
| IE41675B1 (en) | 1980-02-27 |
| ZA755699B (en) | 1976-08-25 |
| BE833048A (nl) | 1976-03-03 |
| NL7510505A (nl) | 1976-03-09 |
| IL48044A (en) | 1978-12-17 |
| GB1467206A (en) | 1977-03-16 |
| US4024272A (en) | 1977-05-17 |
| ATA689275A (de) | 1977-12-15 |
| DK397875A (da) | 1976-03-07 |
| CS191275B2 (en) | 1979-06-29 |
| IE41675L (en) | 1976-03-06 |
| DD121637A5 (de) | 1976-08-12 |
| PL96677B1 (pl) | 1978-01-31 |
| ES440765A1 (es) | 1977-06-16 |
| SE7509880L (sv) | 1976-03-08 |
| DE2442829A1 (de) | 1976-03-18 |
| HU176136B (en) | 1980-12-28 |
| LU73332A1 (de) | 1976-04-13 |
| FR2283690B1 (de) | 1980-03-28 |
| JPS5154564A (de) | 1976-05-13 |
| HU173491B (hu) | 1979-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AT344890B (de) | Verfahren zur herstellung von neuen 6-thiatetracyclinen | |
| AT348693B (de) | Verfahren zur herstellung von neuen decapeptidamidderivaten | |
| AT337363B (de) | Verfahren zur herstellung von neuen daunomycinanaloga | |
| AT342769B (de) | Verfahren zur herstellung von neuen 1-oxacephemen | |
| AT344333B (de) | Verfahren zur herstellung von neuen 8-thiomethylergolinen | |
| AT342026B (de) | Verfahren zur herstellung von neuen d,l-n-acyltyrosinamiden | |
| AT348540B (de) | Verfahren zur herstellung von neuen substituierten phenylguanidinen | |
| AT345998B (de) | Verfahren zur herstellung von neuen 18-methyl- 19-nor-20-keto-pregnanen | |
| AT350529B (de) | Verfahren zur herstellung von neuen acylaminophenylalkylaminen | |
| AT345815B (de) | Verfahren zur herstellung von neuen thiadiazolylimidazolidinonderivaten | |
| ATA247775A (de) | Verfahren zur herstellung von neuen acylureidocephalosporinen | |
| AT343675B (de) | Verfahren zur herstellung von neuen biguaniden | |
| ATA428075A (de) | Verfahren zur herstellung von neuen 1-aethyl-3a-metasubstituiertes-phenyl-decahydroisochinolinen | |
| AT346311B (de) | Verfahren zur herstellung von neuen polyenverbindungen | |
| AT347935B (de) | Verfahren zur herstellung von neuen 2-carbalk- oxyamino-5(6)-phenylsulfonyloxy-benzimidazolen | |
| AT342590B (de) | Verfahren zur herstellung von neuen 2-amino-6-dialkylaminodihydropyridinen | |
| AT349140B (de) | Verfahren zur herstellung von neuen cephalosporinen | |
| AT341539B (de) | Verfahren zur herstellung von neuen 3-amino-2beta-thiohydrazoazetidinonen | |
| AT342046B (de) | Verfahren zur herstellung von neuen n-benzylaminooxazolinen | |
| AT349160B (de) | Verfahren zur herstellung von neuen bufatrienolidrhamnosidaethern | |
| AT348697B (de) | Verfahren zur herstellung von neuen d- homosteroiden | |
| AT343108B (de) | Verfahren zur herstellung von neuen nitrofurylverbindungen | |
| AT345485B (de) | Verfahren zur herstellung von neuen kortikoiden | |
| AT349161B (de) | Verfahren zur herstellung von neuen quaternaeren salzen | |
| ATA548975A (de) | Verfahren zur herstellung von neuen beta-acyloxycrotonsaureamid-n-sulfohalogeniden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |