DE2363351C2 - Substituierte 5(6)-Hydroxy-benzimidazol-2-carbaminsäuremethylester und diese enthaltende Heilmittel - Google Patents

Substituierte 5(6)-Hydroxy-benzimidazol-2-carbaminsäuremethylester und diese enthaltende Heilmittel

Info

Publication number
DE2363351C2
DE2363351C2 DE2363351A DE2363351A DE2363351C2 DE 2363351 C2 DE2363351 C2 DE 2363351C2 DE 2363351 A DE2363351 A DE 2363351A DE 2363351 A DE2363351 A DE 2363351A DE 2363351 C2 DE2363351 C2 DE 2363351C2
Authority
DE
Germany
Prior art keywords
udf54
benzimidazole
udf53
hydroxy
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2363351A
Other languages
German (de)
English (en)
Other versions
DE2363351A1 (de
Inventor
Colin C. Beard
John A. Edwards
John H. Palo Alto Calif. Fried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26981949&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2363351(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of DE2363351A1 publication Critical patent/DE2363351A1/de
Application granted granted Critical
Publication of DE2363351C2 publication Critical patent/DE2363351C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2363351A 1972-12-29 1973-12-20 Substituierte 5(6)-Hydroxy-benzimidazol-2-carbaminsäuremethylester und diese enthaltende Heilmittel Expired DE2363351C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31929972A 1972-12-29 1972-12-29
US417963A US3929821A (en) 1972-12-29 1973-11-21 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives

Publications (2)

Publication Number Publication Date
DE2363351A1 DE2363351A1 (de) 1974-07-11
DE2363351C2 true DE2363351C2 (de) 1987-03-12

Family

ID=26981949

Family Applications (3)

Application Number Title Priority Date Filing Date
DE2363351A Expired DE2363351C2 (de) 1972-12-29 1973-12-20 Substituierte 5(6)-Hydroxy-benzimidazol-2-carbaminsäuremethylester und diese enthaltende Heilmittel
DE2366070A Expired DE2366070C2 (https=) 1972-12-29 1973-12-20
DE19732366069 Granted DE2366069A1 (de) 1972-12-29 1973-12-20 Substituierte 5(6)-mercaptobenzimidazol-2- carbaminsaeuremethylester, ihre herstellung und diese enthaltende mittel

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE2366070A Expired DE2366070C2 (https=) 1972-12-29 1973-12-20
DE19732366069 Granted DE2366069A1 (de) 1972-12-29 1973-12-20 Substituierte 5(6)-mercaptobenzimidazol-2- carbaminsaeuremethylester, ihre herstellung und diese enthaltende mittel

Country Status (25)

Country Link
US (1) US3929821A (https=)
JP (1) JPS5939428B2 (https=)
AR (2) AR216037A1 (https=)
AT (1) AT332883B (https=)
BR (1) BR7310296D0 (https=)
CH (2) CH608006A5 (https=)
CS (1) CS187390B2 (https=)
DE (3) DE2363351C2 (https=)
DK (1) DK137329B (https=)
ES (2) ES421927A1 (https=)
FR (1) FR2212150B1 (https=)
GB (2) GB1456497A (https=)
HK (1) HK8280A (https=)
HU (1) HU169272B (https=)
IE (1) IE40046B1 (https=)
IL (1) IL43860A (https=)
IN (1) IN138644B (https=)
IT (1) IT1046097B (https=)
MY (1) MY8000273A (https=)
NL (1) NL169738C (https=)
PL (1) PL95987B1 (https=)
RO (1) RO67150A (https=)
SE (1) SE414402B (https=)
SU (1) SU727143A3 (https=)
YU (2) YU36706B (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002640A (en) * 1972-12-29 1977-01-11 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US4258198A (en) * 1973-05-29 1981-03-24 Smithkline Corporation 5-Cycloalkyl thio- and oxy-2-carbalkoxyaminobenzimidazoles
DE2441201C2 (de) * 1974-08-28 1986-08-07 Hoechst Ag, 6230 Frankfurt Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung
DE2441202C2 (de) * 1974-08-28 1986-05-28 Hoechst Ag, 6230 Frankfurt 2-Carbalkoxyamino-benzimidazolyl-5(6)-sulfonsäure-phenylester, Verfahren zu ihrer Herstellung und diese enthaltende anthelmintische Mittel
US4086235A (en) * 1976-04-12 1978-04-25 Syntex (U.S.A.) Inc. 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US4046908A (en) * 1976-07-16 1977-09-06 E. R. Squibb & Sons, Inc. Benzimidazole derivatives, compositions thereof and method of use as anthelmintics
USRE30990E (en) * 1976-07-16 1982-07-06 E. R. Squibb & Sons, Inc. Benzimidazole derivatives, compositions thereof and method of use as anthelmintics
US4166858A (en) * 1976-08-13 1979-09-04 Burroughs Wellcome Co. Method and composition for treating fluke infections
NZ184907A (en) * 1976-08-13 1981-01-23 Wellcome Found Synergistic flukicidal combination of diamphenethide and oxfendazole or an acid addition salt thereof
FR2362116A1 (fr) * 1976-08-20 1978-03-17 Oreal Metaphenylenediamines et compositions tinctoriales les contenant
US4093732A (en) * 1977-02-17 1978-06-06 E. R. Squibb & Sons, Inc. Sulfoxide derivatives of benzimidazoles
IT1076022B (it) * 1977-04-20 1985-04-22 Montedison Spa Benzimidazolcarbammati antielmintici
IT1107749B (it) * 1977-10-06 1985-11-25 Montedison Spa Benzimidazolcarbammato particolarmente attivo contro i parassiti gastroenterici e polmonari
US4152522A (en) * 1978-01-03 1979-05-01 Ethyl Corporation Process for the preparation of 2-benzimidazole carbamates
US4136174A (en) * 1978-01-18 1979-01-23 E. R. Squibb & Sons, Inc. Benzimidazolecarbamates and method
US4156006A (en) * 1978-01-09 1979-05-22 E. R. Squibb & Sons, Inc. Vinyl sulfide derivatives of benzimidazoles
JPS54104837A (en) * 1978-02-03 1979-08-17 Nippon Denso Co Ltd Controller of copying machines
US4145431A (en) * 1978-02-16 1979-03-20 E. R. Squibb & Sons, Inc. Method of treating helminthiasis by parenteral administration of sulfide- and sulfoxide-derivatives of benzimidazoles
US4154846A (en) * 1978-06-16 1979-05-15 E. R. Squibb & Sons, Inc. Substituted thio-, sulfinyl-, and sulfonyl-alkyl benzimidazole carbamates
US4174400A (en) * 1978-09-13 1979-11-13 Merck & Co., Inc. Anthelmintic benzimidazoles
DE2845537A1 (de) * 1978-10-19 1980-04-30 Bayer Ag Benzimidazolylcarbamidsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DD147539A5 (de) * 1978-12-06 1981-04-08 Montedison Spa Herstellung von in 5(6)-stellung substituierten benzimidazol-carbamaten
IT1100788B (it) * 1978-12-06 1985-09-28 Montedison Spa Benzimidazol-carbammati
US4198422A (en) * 1979-05-17 1980-04-15 E. R. Squibb & Sons, Inc. Substituted 2,3-naphthimidazole carbamates and method
EP0028455A1 (en) * 1979-10-12 1981-05-13 Imperial Chemical Industries Plc 5-Phenylselenobenzimidazole derivatives, their preparation and anthelmintic or fasciolicidal compositions containing them
US4599428A (en) * 1979-10-19 1986-07-08 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt Process for the preparation of 5(6)-thio substituted benzimidazoles
HU182763B (hu) * 1979-10-19 1984-03-28 Chinoin Gyogyszer Es Vegyeszet Eljárás 5(6)-alkiltio-benzimidazolil-alkil-karbamátok előállítására
IL61232A (en) * 1979-10-19 1985-09-29 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of 2-amino(or alkoxycarbonylamino)-5(6)-thiocyanato(or thiol)benzimidazole derivatives
US4299837A (en) 1979-12-05 1981-11-10 Montedison S.P.A. Anthelmintic benzimidazole-carbamates
DE3719783A1 (de) * 1987-06-13 1988-12-22 Hoechst Ag Verfahren zur herstellung von 5-phenylsulfinyl-1h-2-(methoxycarbonylamino)- benzimidazol
GB9205368D0 (en) * 1992-03-12 1992-04-22 Pfizer Ltd Benzimidozole anthelmintic agents
US6593466B1 (en) * 1999-07-07 2003-07-15 Isis Pharmaceuticals, Inc. Guanidinium functionalized nucleotides and precursors thereof
ES2344275T3 (es) * 2005-07-28 2010-08-23 Intervet International Bv Nuevos (tio) carbamatos de benzimidazol con actividad antiparasitaria y sintesis de ellos.
CN101466317B (zh) * 2006-06-12 2011-08-31 史密夫和内修有限公司 用于进行胫骨切除的系统、方法和装置
PL2037914T3 (pl) 2006-06-14 2014-04-30 Intervet Int Bv Zawiesina zawierająca karbaminian benzoimidazolu i polisorbat
CN102241635A (zh) * 2011-04-28 2011-11-16 江苏宝众宝达药业有限公司 一种苯并咪唑类驱虫药苯硫咪唑的制备方法
CN102863392A (zh) * 2012-10-18 2013-01-09 江苏宝众宝达药业有限公司 一种奥芬达唑生产过程中大幅减少溶剂使用量的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2933502A (en) * 1958-02-12 1960-04-19 Du Pont Benzimidazolone derivatives
US2933504A (en) * 1959-08-10 1960-04-19 Du Pont Derivatives of polyalkoxycarbonyl imine
US3010968A (en) * 1959-11-25 1961-11-28 Du Pont Process for manufacture of certain alkyl esters of benzimidazole carbamic acids
BE666795A (https=) * 1964-08-04 1966-01-13
US3506767A (en) * 1965-08-06 1970-04-14 Geigy Chem Corp Benzimidazole compositions and methods of use
US3401171A (en) * 1966-03-11 1968-09-10 Smithkline Corp 2-amidobenzimidazoles
CH456236A (de) * 1966-05-06 1968-07-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasermaterialien vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3480642A (en) * 1967-03-22 1969-11-25 Smithkline Corp Process for producing 2-carbalkoxyaminobenzimidazoles
CH490010A (de) * 1967-10-26 1970-05-15 Ciba Geigy Schädlingsbekämpfungsmittel
US3562290A (en) * 1967-11-07 1971-02-09 Du Pont Process for making 2-benzimidazolecarbamic acid alkyl esters
FR2059938A1 (en) * 1969-03-14 1971-06-11 Aries Robert 1-haloalk(en)yl sulphenyl-2-aryloxycarbon-yl -
US3657267A (en) * 1969-06-20 1972-04-18 Janssen Pharmaceutica Nv Benzimidazole carbamates
US3714180A (en) * 1970-08-12 1973-01-30 Squibb & Sons Inc Sulfonyl benzimidazoles
US3694455A (en) * 1970-11-19 1972-09-26 Smith Kline French Lab Acyloxyalkyl amidobenzimidazoles
US3720686A (en) * 1971-04-01 1973-03-13 Squibb & Sons Inc Mercaptobenzimidazole derivatives

Also Published As

Publication number Publication date
JPS505518A (https=) 1975-01-21
CH613955A5 (https=) 1979-10-31
SE414402B (sv) 1980-07-28
GB1456497A (en) 1976-11-24
RO67150A (ro) 1980-12-30
DK137329B (da) 1978-02-20
NL169738B (nl) 1982-03-16
IL43860A (en) 1977-05-31
YU40868B (en) 1986-06-30
AT332883B (de) 1976-10-25
DE2366069C2 (https=) 1987-06-11
BR7310296D0 (pt) 1974-09-24
IL43860A0 (en) 1974-03-14
JPS5939428B2 (ja) 1984-09-22
MY8000273A (en) 1980-12-31
PL95987B1 (pl) 1977-11-30
GB1455728A (en) 1976-11-17
FR2212150A1 (https=) 1974-07-26
IE40046B1 (en) 1979-02-28
AR221816A1 (es) 1981-03-31
ES421927A1 (es) 1977-01-01
DE2366069A1 (de) 1977-11-10
IT1046097B (it) 1980-06-30
DK137329C (https=) 1978-07-24
SU727143A3 (ru) 1980-04-05
HU169272B (https=) 1976-10-28
AU6367473A (en) 1975-06-19
IN138644B (https=) 1976-03-06
DE2366070C2 (https=) 1987-06-11
YU337173A (en) 1981-11-13
FR2212150B1 (https=) 1977-01-28
IE40046L (en) 1974-06-29
US3929821A (en) 1975-12-30
NL169738C (nl) 1982-08-16
CS187390B2 (en) 1979-01-31
DE2363351A1 (de) 1974-07-11
HK8280A (en) 1980-03-14
NL7317797A (https=) 1974-07-02
YU36706B (en) 1984-08-31
ATA1075173A (de) 1976-02-15
AR216037A1 (es) 1979-11-30
ES445257A1 (es) 1977-10-01
CH608006A5 (https=) 1978-12-15
YU64180A (en) 1983-04-30

Similar Documents

Publication Publication Date Title
DE2363351C2 (de) Substituierte 5(6)-Hydroxy-benzimidazol-2-carbaminsäuremethylester und diese enthaltende Heilmittel
DD203052A5 (de) Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben
US3929823A (en) 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
DE2363348C3 (de) Substituierte 5 (6)-Phenoxy-benzimidazol-2-carbaminsäuremethylester, deren Herstellung und diese enthaltende Anthelminthika
DE2411295A1 (de) Substituierte benzimidazol-2-carbamatderivate, verfahren zu deren herstellung und diese enthaltende zusammensetzung
CH629203A5 (de) Verfahren zur herstellung von thiazolinylbenzimidazolen.
DE1914571C3 (de) L-SHydroxy-e-oxomorphinan-Verbindungen
DE2923817C2 (de) (3-Alkylamino-2-hydroxyproposy)-furan-2-carbonsäureanilide und deren physiologisch verträgliche Säureadditionssalze und Verfahren zu deren Herstellung sowie Arzneimittel mit einem Gehalt dieser Verbindungen
DE1695560C3 (de) Pyrid-2-thione und diese enthaltende pharmazeutische Zusammensetzungen
DE2332398A1 (de) 2-carbalkoxy-amino-benzimidazol-5(6)phenylaether, ihre herstellung und verwendung in mitteln gegen helminthen
EP0177054B1 (de) Neue Pyridinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
EP0000574B1 (de) Benzimidazol-2-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneimitteln
DE2259471C2 (de) 2-Halogen-9-phenyl-5,6-dihydro-7H-pyrido [2,3-f] [1,4] diazepinderivate
DE2450161C3 (de) N-ß-(3',4'-Dihydroxyphenäthyl)- glutamin und dessen Alkylester sowie deren pharmakologisch verträgliche Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2711945A1 (de) Neue benzimidazol-2-carbamat-derivate, verfahren zu deren herstellung und diese enthaltende zusammensetzungen
EP0138034A1 (de) Substituierte Pyrido(1,2-c)imidazo((1,2-a)benzimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung sowie pharmazeutische Präparate auf Basis dieser Verbindungen
EP0111205B1 (de) Acridanon-Derivate
DE2428640A1 (de) Anthelmintische verbindungen und verfahren zu ihrer herstellung
DE2406584C3 (de) Phenylthioharnstoffderivate
DE2727207C2 (de) Substituierte 2H-Pyran-2,6(3H)-dion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DD235870A5 (de) Verfahren zur herstellung von 3-substituierten thiopyronen
DE1695757C3 (de) Pyridinmethanolcarbamate und Verfahren zu deren Herstellung
CH592634A5 (en) Anthelmintic and fungicidal benzimidazoles - 5(6)-substd.-benzimidazole-2-carbamates
DE2406584B2 (de) Phenylthioharnstoffderivate
EP0346760A2 (de) Nigericinderivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und Verwendung derselben

Legal Events

Date Code Title Description
D2 Grant after examination
AH Division in

Ref country code: DE

Ref document number: 2366070

Format of ref document f/p: P

Ref country code: DE

Ref document number: 2366069

Format of ref document f/p: P

8364 No opposition during term of opposition