DE2235152C2 - Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten - Google Patents
Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in KörperflüssigkeitenInfo
- Publication number
- DE2235152C2 DE2235152C2 DE2235152A DE2235152A DE2235152C2 DE 2235152 C2 DE2235152 C2 DE 2235152C2 DE 2235152 A DE2235152 A DE 2235152A DE 2235152 A DE2235152 A DE 2235152A DE 2235152 C2 DE2235152 C2 DE 2235152C2
- Authority
- DE
- Germany
- Prior art keywords
- quinoline
- blood
- detection
- peroxidatically
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001514 detection method Methods 0.000 title claims description 13
- 239000013543 active substance Substances 0.000 title claims description 7
- 210000001124 body fluid Anatomy 0.000 title claims description 4
- 239000010839 body fluid Substances 0.000 title claims description 4
- 210000004369 blood Anatomy 0.000 title description 13
- 239000008280 blood Substances 0.000 title description 13
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 238000012360 testing method Methods 0.000 claims description 30
- 239000012190 activator Substances 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 6
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 3
- 239000000123 paper Substances 0.000 description 17
- RDOWQLZANAYVLL-UHFFFAOYSA-N phenanthridine Chemical compound C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 14
- 230000035945 sensitivity Effects 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 9
- 210000000265 leukocyte Anatomy 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- HCAUQPZEWLULFJ-UHFFFAOYSA-N benzo[f]quinoline Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=N1 HCAUQPZEWLULFJ-UHFFFAOYSA-N 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 102000001554 Hemoglobins Human genes 0.000 description 6
- 108010054147 Hemoglobins Proteins 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- -1 2-methylphenanthridine 6-methylphenanthridine Chemical compound 0.000 description 4
- SUHRSZJZYUCLOD-UHFFFAOYSA-N 3-methylbenzo[f]quinoline Chemical compound C1=CC=C2C3=CC=C(C)N=C3C=CC2=C1 SUHRSZJZYUCLOD-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 4
- YEELFSTYCPPLQY-UHFFFAOYSA-N benzo[lmn]phenanthridine Chemical compound C1=CC=C2N=CC3=CC=CC4=CC=C1C2=C43 YEELFSTYCPPLQY-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OZKOMUDCMCEDTM-UHFFFAOYSA-N 1,7-phenanthroline Chemical class C1=CC=C2C3=NC=CC=C3C=CC2=N1 OZKOMUDCMCEDTM-UHFFFAOYSA-N 0.000 description 3
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 description 3
- DATYUTWESAKQQM-UHFFFAOYSA-N 4,7-phenanthroline Chemical compound C1=CC=C2C3=CC=CN=C3C=CC2=N1 DATYUTWESAKQQM-UHFFFAOYSA-N 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 102000036675 Myoglobin Human genes 0.000 description 3
- 108010062374 Myoglobin Proteins 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- WZJYKHNJTSNBHV-UHFFFAOYSA-N benzo[h]quinoline Chemical class C1=CN=C2C3=CC=CC=C3C=CC2=C1 WZJYKHNJTSNBHV-UHFFFAOYSA-N 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 3
- 150000002432 hydroperoxides Chemical class 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- TXCVRHZUZDGWBJ-UHFFFAOYSA-N 1,3-dimethylbenzo[f]quinoline Chemical compound C1=CC=C2C3=C(C)C=C(C)N=C3C=CC2=C1 TXCVRHZUZDGWBJ-UHFFFAOYSA-N 0.000 description 2
- JGBAASVQPMTVHO-UHFFFAOYSA-N 2,5-dihydroperoxy-2,5-dimethylhexane Chemical compound OOC(C)(C)CCC(C)(C)OO JGBAASVQPMTVHO-UHFFFAOYSA-N 0.000 description 2
- LDTDVEFHWTXWKN-UHFFFAOYSA-N 2,8-dimethyl-1,7-phenanthroline Chemical compound C1=C(C)N=C2C3=CC=C(C)N=C3C=CC2=C1 LDTDVEFHWTXWKN-UHFFFAOYSA-N 0.000 description 2
- WXMQHPKQCPCDQO-UHFFFAOYSA-N 4-dimorpholin-4-ylphosphorylmorpholine Chemical compound C1COCCN1P(N1CCOCC1)(=O)N1CCOCC1 WXMQHPKQCPCDQO-UHFFFAOYSA-N 0.000 description 2
- 235000001258 Cinchona calisaya Nutrition 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 229960000948 quinine Drugs 0.000 description 2
- 150000003248 quinolines Chemical class 0.000 description 2
- 210000004916 vomit Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XJFXRVMHROUWCL-UHFFFAOYSA-N 1,7-phenanthroline Chemical compound C1=CC=C2C3=NC=CC=C3C=CC2=N1.C1=CC=C2C3=NC=CC=C3C=CC2=N1 XJFXRVMHROUWCL-UHFFFAOYSA-N 0.000 description 1
- QRGXLGFKLPGONP-UHFFFAOYSA-N 2,4-dimethylbenzo[g]quinoline Chemical compound C1=CC=CC2=CC3=NC(C)=CC(C)=C3C=C21 QRGXLGFKLPGONP-UHFFFAOYSA-N 0.000 description 1
- ZRHBCLQODIIWNI-UHFFFAOYSA-N 2-ethylphenanthridine Chemical compound C1=CC=C2C3=CC(CC)=CC=C3N=CC2=C1 ZRHBCLQODIIWNI-UHFFFAOYSA-N 0.000 description 1
- XJEDMWZLWOWOSZ-UHFFFAOYSA-N 2-methylphenanthridine Chemical group C1=CC=C2C3=CC(C)=CC=C3N=CC2=C1 XJEDMWZLWOWOSZ-UHFFFAOYSA-N 0.000 description 1
- CODTWXNXJPQQOB-UHFFFAOYSA-N 3,8-dimethyl-4,7-phenanthroline Chemical compound CC1=CC=C2C3=CC=C(C)N=C3C=CC2=N1 CODTWXNXJPQQOB-UHFFFAOYSA-N 0.000 description 1
- FRIBMENBGGCKPD-UHFFFAOYSA-N 3-(2,3-dimethoxyphenyl)prop-2-enal Chemical compound COC1=CC=CC(C=CC=O)=C1OC FRIBMENBGGCKPD-UHFFFAOYSA-N 0.000 description 1
- XSRCFFDUTPZZHD-UHFFFAOYSA-N 3-methyl-2h-1,3-benzothiazole 1-oxide Chemical compound C1=CC=C2N(C)CS(=O)C2=C1 XSRCFFDUTPZZHD-UHFFFAOYSA-N 0.000 description 1
- SBPULJLRZWGMEL-UHFFFAOYSA-N 3-methyl-4,7-phenanthroline Chemical compound C1=CC=C2C3=CC=C(C)N=C3C=CC2=N1 SBPULJLRZWGMEL-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- IMEXZJCXIUEUSZ-UHFFFAOYSA-N 4-methylbenzo[g]quinoline Chemical compound C1=CC=C2C=C3C(C)=CC=NC3=CC2=C1 IMEXZJCXIUEUSZ-UHFFFAOYSA-N 0.000 description 1
- IFMDPNYROKZRER-UHFFFAOYSA-N 6-methylphenanthridine Chemical compound C1=CC=C2C(C)=NC3=CC=CC=C3C2=C1 IFMDPNYROKZRER-UHFFFAOYSA-N 0.000 description 1
- LUASDVPNVSXXPH-UHFFFAOYSA-N CCN(C(C)C1=O)NN1C1=CC=CC=C1 Chemical compound CCN(C(C)C1=O)NN1C1=CC=CC=C1 LUASDVPNVSXXPH-UHFFFAOYSA-N 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000000913 Kidney Calculi Diseases 0.000 description 1
- WZKXBGJNNCGHIC-UHFFFAOYSA-N Leucomalachite green Chemical compound C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)N(C)C)C1=CC=CC=C1 WZKXBGJNNCGHIC-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010029148 Nephrolithiasis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 1
- 238000001792 White test Methods 0.000 description 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 description 1
- 239000000370 acceptor Substances 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- SPTHWAJJMLCAQF-UHFFFAOYSA-M ctk4f8481 Chemical compound [O-]O.CC(C)C1=CC=CC=C1C(C)C SPTHWAJJMLCAQF-UHFFFAOYSA-M 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000004028 organic sulfates Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000008039 phosphoramides Chemical class 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 150000005839 radical cations Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000011896 sensitive detection Methods 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/904—Oxidation - reduction indicators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2235152A DE2235152C2 (de) | 1972-07-18 | 1972-07-18 | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten |
| US00376248A US3853472A (en) | 1972-07-18 | 1973-07-03 | Diagnostic test strip for the detection of components of body fluids |
| CA176,154A CA988011A (en) | 1972-07-18 | 1973-07-11 | Test strip |
| SE7309791A SE388693B (sv) | 1972-07-18 | 1973-07-12 | Testrmesor for pavisande av peroxidasaktivitet |
| AR294043A AR195135A1 (es) | 1972-07-18 | 1973-07-12 | Cinta reactiva para la identificacion de sustancias con actividad peroxidasica en liquidos corporales |
| FI2240/73A FI53511C (fi) | 1972-07-18 | 1973-07-13 | Diagnostiskt medel foer paovisning av blod och andra peroxidatiskt verkande substanser i kroppsvaetskor |
| NL737309779A NL152085B (nl) | 1972-07-18 | 1973-07-13 | Proefstroken voor het aantonen van stoffen met peroxydatische werking in lichaamsvloeistoffen. |
| IT26612/73A IT994949B (it) | 1972-07-18 | 1973-07-13 | Mezzo diagnostico per l identifica zione di sangue ed altre sostanze ad azione perossidasica in liquidi corporei |
| CH1034773A CH579275A5 (enrdf_load_stackoverflow) | 1972-07-18 | 1973-07-16 | |
| ZA734810A ZA734810B (en) | 1972-07-18 | 1973-07-16 | Test strip |
| GB3373173A GB1390900A (en) | 1972-07-18 | 1973-07-16 | Test strips |
| DD172306A DD105065A5 (enrdf_load_stackoverflow) | 1972-07-18 | 1973-07-16 | |
| FR7325947A FR2198643A5 (enrdf_load_stackoverflow) | 1972-07-18 | 1973-07-16 | |
| AT628773A AT326276B (de) | 1972-07-18 | 1973-07-17 | Teststreifen zum nachweis von blut und anderen peroxidatisch wirksamen substanzen in korperflüssigkeiten |
| HUBO1451A HU166368B (enrdf_load_stackoverflow) | 1972-07-18 | 1973-07-17 | |
| AU58263/73A AU468582B2 (en) | 1972-07-15 | 1973-07-18 | Test strip |
| JP48082405A JPS583680B2 (ja) | 1972-07-18 | 1973-07-18 | タイエキチユウノ カサンカセイサヨウブツシツオ ケンシユツスルタメノ シケンヘン |
| BE185336A BE864154Q (fr) | 1972-07-18 | 1978-02-21 | Agent de diagnostic pour la recherche du sang et autres substances a action de peroxydase dans les liquides physiologiques |
| HK205/78A HK20578A (en) | 1972-07-18 | 1978-04-13 | Test strips |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2235152A DE2235152C2 (de) | 1972-07-18 | 1972-07-18 | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2235152A1 DE2235152A1 (enrdf_load_stackoverflow) | 1974-01-10 |
| DE2235152B1 DE2235152B1 (de) | 1974-01-10 |
| DE2235152C2 true DE2235152C2 (de) | 1975-07-10 |
Family
ID=5850916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2235152A Expired DE2235152C2 (de) | 1972-07-15 | 1972-07-18 | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten |
Country Status (19)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19500768C2 (de) * | 1994-01-17 | 2003-11-20 | Aventis Res & Tech Gmbh & Co | Phenanthren-Derivate und ihre Verwendung in flüssigkristallinen Mischungen |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966414A (en) * | 1974-01-16 | 1976-06-29 | Bio-Medical Sciences, Inc. | Time temperature indicators |
| DE2436598C2 (de) * | 1974-07-30 | 1983-04-07 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabiler Teststreifen zum Nachweis von Inhaltsstoffen in Flüssigkeiten |
| CS176664B1 (enrdf_load_stackoverflow) * | 1975-02-14 | 1977-06-30 | ||
| US3986833A (en) * | 1975-09-08 | 1976-10-19 | Miles Laboratories, Inc. | Test composition, device, and method for the detection of peroxidatively active substances |
| DE2716060C3 (de) * | 1977-04-09 | 1980-06-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Stabilisierte Schnelldiagnostica mit Oxydationsindikatoren |
| US4175923A (en) * | 1978-06-26 | 1979-11-27 | Friend William G | Method and apparatus for occult blood testing in the home |
| US4148611A (en) * | 1978-06-28 | 1979-04-10 | Miles Laboratories, Inc. | Test composition, device and method for the detection of peroxidatively active substances |
| DE2905531A1 (de) * | 1979-02-14 | 1981-01-08 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten |
| DE2926271A1 (de) * | 1979-06-29 | 1981-01-08 | Behringwerke Ag | Mittel zum nachweis peroxidatisch wirksamer substanzen |
| US4339242A (en) * | 1979-11-13 | 1982-07-13 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4340394A (en) * | 1979-11-13 | 1982-07-20 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4339243A (en) * | 1979-11-13 | 1982-07-13 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4340392A (en) * | 1979-11-13 | 1982-07-20 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4340393A (en) * | 1979-11-13 | 1982-07-20 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4380585A (en) * | 1979-11-13 | 1983-04-19 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4340395A (en) * | 1979-11-13 | 1982-07-20 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4251223A (en) * | 1979-12-17 | 1981-02-17 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
| US4278439A (en) * | 1979-12-17 | 1981-07-14 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
| US4251222A (en) * | 1979-12-17 | 1981-02-17 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
| US4388271A (en) * | 1980-01-10 | 1983-06-14 | Rohm Gmbh | Rapid diagnostic agents |
| CA1143634A (en) * | 1980-06-02 | 1983-03-29 | Alan E. Burkhardt | Interference-resistant test device for determining a peroxidately active substance in a test sample and method for preparing it |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| US4676950A (en) * | 1984-02-03 | 1987-06-30 | Foster Research Corporation | Indicator and test device for detecting occult blood |
| US4672029A (en) * | 1984-12-06 | 1987-06-09 | Eastman Kodak Company | Color-forming couplers and their use in the analytical determination of hydrogen peroxide or other analytes |
| EP0196743A3 (en) * | 1985-01-31 | 1988-10-19 | Savyon Diagnostics Ltd. | Stable chemical compositions containing chromogenic materials and peroxides, and method for obtaining them |
| IL74205A (en) * | 1985-01-31 | 1990-01-18 | Savyon Diagnostics Ltd | Method for carrying out enzyme assays utilizing stable chemical compositions containing hydrogen peroxide and a chromogen |
| US4673654A (en) * | 1985-10-31 | 1987-06-16 | Warner-Lambert Company | Composition for determining peroxidase-like activity of hemoglobin |
| US4755472A (en) * | 1986-01-16 | 1988-07-05 | Miles Inc. | Stable composition for the determination of peroxidatively active substances |
| US4935346A (en) * | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US5369013A (en) * | 1987-06-22 | 1994-11-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method, reagent mixture and kit for determining the presence of bacterial or somatic cells in urine |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5827677A (en) * | 1996-02-01 | 1998-10-27 | Universal Lavel | Method and device for specifically detecting myoglobin using a non-discriminating peroxidase sensitive assay |
| WO1997035030A1 (en) * | 1996-03-22 | 1997-09-25 | Stc Technologies, Inc. | A solution-based assay for peroxidatively-active substances in bodily fluids |
| US5885789A (en) * | 1997-03-20 | 1999-03-23 | Stc Technologies Incorporated | Solution-based assay for peroxidatively-active substances in bodily fluids |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US8012761B2 (en) | 2006-12-14 | 2011-09-06 | Kimberly-Clark Worldwide, Inc. | Detection of formaldehyde in urine samples |
| US7846383B2 (en) | 2006-12-15 | 2010-12-07 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay device and absorbent article containing same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL126365C (enrdf_load_stackoverflow) * | 1963-06-24 | |||
| DE1941370C3 (de) * | 1969-08-14 | 1974-01-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nachweis von Nitrit und nitritbildenden Bakterien in Körperflüssigkeiten |
-
1972
- 1972-07-18 DE DE2235152A patent/DE2235152C2/de not_active Expired
-
1973
- 1973-07-03 US US00376248A patent/US3853472A/en not_active Expired - Lifetime
- 1973-07-11 CA CA176,154A patent/CA988011A/en not_active Expired
- 1973-07-12 AR AR294043A patent/AR195135A1/es active
- 1973-07-12 SE SE7309791A patent/SE388693B/xx unknown
- 1973-07-13 IT IT26612/73A patent/IT994949B/it active
- 1973-07-13 NL NL737309779A patent/NL152085B/xx not_active IP Right Cessation
- 1973-07-13 FI FI2240/73A patent/FI53511C/fi active
- 1973-07-16 DD DD172306A patent/DD105065A5/xx unknown
- 1973-07-16 ZA ZA734810A patent/ZA734810B/xx unknown
- 1973-07-16 FR FR7325947A patent/FR2198643A5/fr not_active Expired
- 1973-07-16 CH CH1034773A patent/CH579275A5/xx not_active IP Right Cessation
- 1973-07-16 GB GB3373173A patent/GB1390900A/en not_active Expired
- 1973-07-17 AT AT628773A patent/AT326276B/de active
- 1973-07-17 HU HUBO1451A patent/HU166368B/hu unknown
- 1973-07-18 JP JP48082405A patent/JPS583680B2/ja not_active Expired
- 1973-07-18 AU AU58263/73A patent/AU468582B2/en not_active Expired
-
1978
- 1978-02-21 BE BE185336A patent/BE864154Q/xx not_active IP Right Cessation
- 1978-04-13 HK HK205/78A patent/HK20578A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19500768C2 (de) * | 1994-01-17 | 2003-11-20 | Aventis Res & Tech Gmbh & Co | Phenanthren-Derivate und ihre Verwendung in flüssigkristallinen Mischungen |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA628773A (de) | 1975-02-15 |
| JPS4954094A (enrdf_load_stackoverflow) | 1974-05-25 |
| US3853472A (en) | 1974-12-10 |
| SE388693B (sv) | 1976-10-11 |
| GB1390900A (en) | 1975-04-16 |
| IT994949B (it) | 1975-10-20 |
| FI53511B (enrdf_load_stackoverflow) | 1978-01-31 |
| HU166368B (enrdf_load_stackoverflow) | 1975-03-28 |
| CH579275A5 (enrdf_load_stackoverflow) | 1976-08-31 |
| DD105065A5 (enrdf_load_stackoverflow) | 1974-04-05 |
| AT326276B (de) | 1975-12-10 |
| DE2235152A1 (enrdf_load_stackoverflow) | 1974-01-10 |
| AR195135A1 (es) | 1973-09-10 |
| ZA734810B (en) | 1974-07-31 |
| NL7309779A (enrdf_load_stackoverflow) | 1974-01-22 |
| AU468582B2 (en) | 1976-01-15 |
| HK20578A (en) | 1978-04-20 |
| FI53511C (fi) | 1978-05-10 |
| CA988011A (en) | 1976-04-27 |
| BE864154Q (fr) | 1978-08-21 |
| JPS583680B2 (ja) | 1983-01-22 |
| DE2235152B1 (de) | 1974-01-10 |
| AU5826373A (en) | 1975-01-23 |
| FR2198643A5 (enrdf_load_stackoverflow) | 1974-03-29 |
| NL152085B (nl) | 1977-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E77 | Valid patent as to the heymanns-index 1977 |