DE2233555C3 - Verfahren zur Herstellung von Spectinomycin - Google Patents
Verfahren zur Herstellung von SpectinomycinInfo
- Publication number
- DE2233555C3 DE2233555C3 DE2233555A DE2233555A DE2233555C3 DE 2233555 C3 DE2233555 C3 DE 2233555C3 DE 2233555 A DE2233555 A DE 2233555A DE 2233555 A DE2233555 A DE 2233555A DE 2233555 C3 DE2233555 C3 DE 2233555C3
- Authority
- DE
- Germany
- Prior art keywords
- spectinomycin
- atcc
- medium
- streptomyces
- agar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 238000000034 method Methods 0.000 title claims description 8
- 241000187391 Streptomyces hygroscopicus Species 0.000 claims description 10
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
- 239000002609 medium Substances 0.000 description 14
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 12
- 239000003242 anti bacterial agent Substances 0.000 description 10
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- 230000001580 bacterial effect Effects 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 229920002678 cellulose Polymers 0.000 description 1
- AKFVOKPQHFBYCA-ASKSIGGCSA-N chembl1967607 Chemical compound N=1C2C(N=3)=CSC=3C(C(C)OC(=O)C=3N=C4C(O)C(NC(C(C)C)C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C)C(=O)N5)C=CC4=C(C(C)O)C=3)NC(=O)C(N=3)=CSC=3C(C(C)(O)C(C)O)NC(=O)C(N=3)CSC=3C(=C/C)/NC(=O)C(C(C)O)NC(=O)C(N=3)=CSC=3C25CCC=1C1=NC(C(=O)NC(=C)C(=O)NC(=C)C(N)=O)=CS1 AKFVOKPQHFBYCA-ASKSIGGCSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- VZRAWAPJMFPCNZ-CXCOFNEZSA-N copiamycin Chemical compound C1C(OC(=O)CC(O)=O)CC(O)CC(O)C(C)C(O)\C=C/C(C)C(C(C)CC(/C)=C/CC/C=C/CCCNC(=N)NC)OC(=O)\C=C\C(C)C(O)CC(O)C(C)C(O)CCC(C)C(O)CC2(O)C(O)C(O)CC1O2 VZRAWAPJMFPCNZ-CXCOFNEZSA-N 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- OSERMIPXNLXAPD-MJMYBOKFSA-N elaiophylin Chemical compound O([C@@H]1C[C@@](O)(O[C@H](C)[C@H]1CC)[C@@H](C)[C@H](O)[C@H](C)[C@@H]1[C@H](/C=C/C=C/C(=O)O[C@@H]([C@@H](C)/C=C/C=C/C(=O)O1)[C@@H](C)[C@@H](O)[C@H](C)[C@]1(O)O[C@H](C)[C@@H](CC)[C@H](O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)C1)C)[C@H]1C[C@H](O)[C@H](O)[C@H](C)O1 OSERMIPXNLXAPD-MJMYBOKFSA-N 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- IUQPDUPFFGXZFJ-UHFFFAOYSA-N glebomycin Chemical compound NC(=N)NC1C(O)C(O)C(O)C(OC(N)=O)C1O.O1C(CO)C(O)C(O)C(NC)C1OC1C(CO)(O)C(C)OC1O IUQPDUPFFGXZFJ-UHFFFAOYSA-N 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
- 229940097277 hygromycin b Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 239000006877 oatmeal agar Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- XGECDDPXIKFBTE-AUFVQPSPSA-N ossamycin Chemical compound O1[C@@H](C[C@H](O)CC)CCC[C@]11O[C@H]([C@H]2C)C[C@]3(O)OC(C)(C)C[C@H]3/C=C/CCCCC[C@@](C)(O)[C@H](O)[C@@H](O[C@@H]3O[C@@H](C)[C@H](CC3)N(C)C)[C@H](O)[C@@H](C)[C@H](O)[C@](C)(O)/C=C/C(=O)O[C@H]2C1 XGECDDPXIKFBTE-AUFVQPSPSA-N 0.000 description 1
- 230000000793 phophlogistic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- BNZYRKVSCLSXSJ-IOSLPCCCSA-N psicofuranin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@]1(CO)O[C@H](CO)[C@@H](O)[C@H]1O BNZYRKVSCLSXSJ-IOSLPCCCSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229950010526 relomycin Drugs 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 108010088584 siomycin Proteins 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- NRAUADCLPJTGSF-VLSXYIQESA-N streptothricin F Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-VLSXYIQESA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007196 tryptone yeast extract agar Substances 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
- A01N63/28—Streptomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pest Control & Pesticides (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5030371 | 1971-07-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2233555A1 DE2233555A1 (de) | 1973-02-01 |
| DE2233555B2 DE2233555B2 (de) | 1973-06-28 |
| DE2233555C3 true DE2233555C3 (de) | 1974-01-24 |
Family
ID=12855114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2233555A Expired DE2233555C3 (de) | 1971-07-09 | 1972-07-07 | Verfahren zur Herstellung von Spectinomycin |
Country Status (8)
| Country | Link |
|---|---|
| AR (1) | AR193110A1 (OSRAM) |
| BE (1) | BE786019A (OSRAM) |
| CA (1) | CA983872A (OSRAM) |
| CH (1) | CH549639A (OSRAM) |
| DE (1) | DE2233555C3 (OSRAM) |
| ES (1) | ES404603A1 (OSRAM) |
| FR (1) | FR2145504B1 (OSRAM) |
| GB (1) | GB1346278A (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007001198B4 (de) * | 2007-01-05 | 2021-02-11 | Bela-Pharm Gmbh & Co Kg | Verfahren zur Verminderung von Anomeren des Spectinomycin |
| CN113861212A (zh) * | 2021-10-11 | 2021-12-31 | 河北圣雪大成唐山制药有限责任公司 | 一种改善盐酸大观霉素产品浊度的方法 |
-
0
- BE BE786019D patent/BE786019A/xx unknown
-
1972
- 1972-07-03 AR AR242873A patent/AR193110A1/es active
- 1972-07-04 CA CA146,313A patent/CA983872A/en not_active Expired
- 1972-07-06 FR FR7224536A patent/FR2145504B1/fr not_active Expired
- 1972-07-06 ES ES404603A patent/ES404603A1/es not_active Expired
- 1972-07-06 GB GB3183572A patent/GB1346278A/en not_active Expired
- 1972-07-07 DE DE2233555A patent/DE2233555C3/de not_active Expired
- 1972-07-07 CH CH1025272A patent/CH549639A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE786019A (fr) | 1973-01-08 |
| GB1346278A (en) | 1974-02-06 |
| FR2145504B1 (OSRAM) | 1975-06-20 |
| CH549639A (fr) | 1974-05-31 |
| FR2145504A1 (OSRAM) | 1973-02-23 |
| DE2233555B2 (de) | 1973-06-28 |
| ES404603A1 (es) | 1975-06-16 |
| AR193110A1 (es) | 1973-03-30 |
| CA983872A (en) | 1976-02-17 |
| DE2233555A1 (de) | 1973-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |