DE2167020A1 - Verfahren zur herstellung von rosamicin (antibiotikum 67-694) - Google Patents
Verfahren zur herstellung von rosamicin (antibiotikum 67-694)Info
- Publication number
- DE2167020A1 DE2167020A1 DE19712167020 DE2167020A DE2167020A1 DE 2167020 A1 DE2167020 A1 DE 2167020A1 DE 19712167020 DE19712167020 DE 19712167020 DE 2167020 A DE2167020 A DE 2167020A DE 2167020 A1 DE2167020 A1 DE 2167020A1
- Authority
- DE
- Germany
- Prior art keywords
- antibiotic
- acid
- growth
- medium
- ftg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000000034 method Methods 0.000 title claims description 15
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- 238000004519 manufacturing process Methods 0.000 title description 12
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- 238000002360 preparation method Methods 0.000 claims description 5
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- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
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- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
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- 229920002521 macromolecule Polymers 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 125000005474 octanoate group Chemical class 0.000 description 1
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- 230000003287 optical effect Effects 0.000 description 1
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- 235000005985 organic acids Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
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- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 125000001302 tertiary amino group Chemical group 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US491670A | 1970-01-22 | 1970-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2167020A1 true DE2167020A1 (de) | 1977-06-30 |
Family
ID=21713168
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712102718 Withdrawn DE2102718A1 (de) | 1970-01-22 | 1971-01-21 | Neues Antibiotikum und Verfahren zu dessen Herstellung |
| DE19712167020 Pending DE2167020A1 (de) | 1970-01-22 | 1971-01-21 | Verfahren zur herstellung von rosamicin (antibiotikum 67-694) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712102718 Withdrawn DE2102718A1 (de) | 1970-01-22 | 1971-01-21 | Neues Antibiotikum und Verfahren zu dessen Herstellung |
Country Status (30)
-
1971
- 1971-01-19 NL NL7100704.A patent/NL158223B/xx not_active IP Right Cessation
- 1971-01-20 PH PH12121*UA patent/PH9705A/en unknown
- 1971-01-20 CH CH77171A patent/CH552583A/xx not_active IP Right Cessation
- 1971-01-20 CH CH1529473A patent/CH575420A5/xx not_active IP Right Cessation
- 1971-01-21 SE SE7100706A patent/SE370248B/xx unknown
- 1971-01-21 DK DK25671AA patent/DK127008B/da not_active Application Discontinuation
- 1971-01-21 DE DE19712102718 patent/DE2102718A1/de not_active Withdrawn
- 1971-01-21 IE IE76/71A patent/IE35230B1/xx unknown
- 1971-01-21 LU LU62469D patent/LU62469A1/xx unknown
- 1971-01-21 PL PL1971145760A patent/PL87225B1/pl unknown
- 1971-01-21 ZA ZA710402A patent/ZA71402B/xx unknown
- 1971-01-21 BG BG022168A patent/BG21241A3/xx unknown
- 1971-01-21 DE DE19712167020 patent/DE2167020A1/de active Pending
- 1971-01-21 AT AT49071A patent/AT309677B/de active
- 1971-01-21 CS CS442A patent/CS162739B2/cs unknown
- 1971-01-21 BG BG016629A patent/BG22408A3/xx unknown
- 1971-01-21 NO NO218/71A patent/NO134061C/no unknown
- 1971-01-21 FR FR7101947A patent/FR2081448B1/fr not_active Expired
- 1971-01-21 CA CA103,488A patent/CA985193A/en not_active Expired
- 1971-01-21 ES ES387479A patent/ES387479A1/es not_active Expired
- 1971-01-21 SU SU1816333A patent/SU493972A3/ru active
- 1971-01-22 OA OA54146A patent/OA03679A/xx unknown
- 1971-01-22 IL IL36043A patent/IL36043A/xx unknown
- 1971-01-22 YU YU149/71A patent/YU35162B/xx unknown
- 1971-01-22 BE BE761922A patent/BE761922A/xx not_active IP Right Cessation
- 1971-01-22 JP JP46001638A patent/JPS5020157B1/ja active Pending
- 1971-01-22 FI FI710173A patent/FI48286C/fi active
- 1971-01-22 RO RO65688A patent/RO61396A/ro unknown
- 1971-04-19 CY CY851A patent/CY851A/xx unknown
- 1971-04-19 GB GB2014771A patent/GB1302142A/en not_active Expired
-
1973
- 1973-06-01 ES ES415478A patent/ES415478A1/es not_active Expired
-
1976
- 1976-04-02 KE KE2615*UA patent/KE2615A/xx unknown
- 1976-06-03 HK HK311/76*UA patent/HK31176A/xx unknown
- 1976-12-30 MY MY142/76A patent/MY7600142A/xx unknown
Also Published As
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