SU493972A3 - Способ получени сложных эфиров розамицина - Google Patents
Способ получени сложных эфиров розамицинаInfo
- Publication number
- SU493972A3 SU493972A3 SU1816333A SU1816333A SU493972A3 SU 493972 A3 SU493972 A3 SU 493972A3 SU 1816333 A SU1816333 A SU 1816333A SU 1816333 A SU1816333 A SU 1816333A SU 493972 A3 SU493972 A3 SU 493972A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- rosamycin
- acid
- esters
- added
- antibiotic
- Prior art date
Links
- IUPCWCLVECYZRV-ZRDIBKRKSA-N rosamicin Chemical compound O=CCC1CC(C)C(=O)\C=C\C2(C)OC2C(C)C(CC)OC(=O)CC(O)C(C)C1OC1OC(C)CC(N(C)C)C1O IUPCWCLVECYZRV-ZRDIBKRKSA-N 0.000 title description 10
- 238000000034 method Methods 0.000 title description 7
- 150000002148 esters Chemical class 0.000 title description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- 239000002253 acid Substances 0.000 description 12
- 150000008064 anhydrides Chemical class 0.000 description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 4
- 239000000908 ammonium hydroxide Substances 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 150000005690 diesters Chemical class 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- -1 hydrocarbon carboxylic acids Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 2
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- PYHXGXCGESYPCW-UHFFFAOYSA-M 2,2-diphenylacetate Chemical compound C=1C=CC=CC=1C(C(=O)[O-])C1=CC=CC=C1 PYHXGXCGESYPCW-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 235000013832 Valeriana officinalis Nutrition 0.000 description 1
- 244000126014 Valeriana officinalis Species 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US491670A | 1970-01-22 | 1970-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU493972A3 true SU493972A3 (ru) | 1975-11-28 |
Family
ID=21713168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1816333A SU493972A3 (ru) | 1970-01-22 | 1971-01-21 | Способ получени сложных эфиров розамицина |
Country Status (30)
-
1971
- 1971-01-19 NL NL7100704.A patent/NL158223B/xx not_active IP Right Cessation
- 1971-01-20 CH CH77171A patent/CH552583A/xx not_active IP Right Cessation
- 1971-01-20 PH PH12121*UA patent/PH9705A/en unknown
- 1971-01-20 CH CH1529473A patent/CH575420A5/xx not_active IP Right Cessation
- 1971-01-21 DE DE19712167020 patent/DE2167020A1/de active Pending
- 1971-01-21 LU LU62469D patent/LU62469A1/xx unknown
- 1971-01-21 BG BG016629A patent/BG22408A3/xx unknown
- 1971-01-21 PL PL1971145760A patent/PL87225B1/pl unknown
- 1971-01-21 CA CA103,488A patent/CA985193A/en not_active Expired
- 1971-01-21 NO NO218/71A patent/NO134061C/no unknown
- 1971-01-21 AT AT49071A patent/AT309677B/de active
- 1971-01-21 FR FR7101947A patent/FR2081448B1/fr not_active Expired
- 1971-01-21 DE DE19712102718 patent/DE2102718A1/de not_active Withdrawn
- 1971-01-21 CS CS442A patent/CS162739B2/cs unknown
- 1971-01-21 SE SE7100706A patent/SE370248B/xx unknown
- 1971-01-21 DK DK25671AA patent/DK127008B/da not_active Application Discontinuation
- 1971-01-21 BG BG022168A patent/BG21241A3/xx unknown
- 1971-01-21 IE IE76/71A patent/IE35230B1/xx unknown
- 1971-01-21 SU SU1816333A patent/SU493972A3/ru active
- 1971-01-21 ZA ZA710402A patent/ZA71402B/xx unknown
- 1971-01-21 ES ES387479A patent/ES387479A1/es not_active Expired
- 1971-01-22 IL IL36043A patent/IL36043A/xx unknown
- 1971-01-22 YU YU149/71A patent/YU35162B/xx unknown
- 1971-01-22 RO RO65688A patent/RO61396A/ro unknown
- 1971-01-22 FI FI710173A patent/FI48286C/fi active
- 1971-01-22 JP JP46001638A patent/JPS5020157B1/ja active Pending
- 1971-01-22 BE BE761922A patent/BE761922A/xx not_active IP Right Cessation
- 1971-01-22 OA OA54146A patent/OA03679A/xx unknown
- 1971-04-19 CY CY851A patent/CY851A/xx unknown
- 1971-04-19 GB GB2014771A patent/GB1302142A/en not_active Expired
-
1973
- 1973-06-01 ES ES415478A patent/ES415478A1/es not_active Expired
-
1976
- 1976-04-02 KE KE2615*UA patent/KE2615A/xx unknown
- 1976-06-03 HK HK311/76*UA patent/HK31176A/xx unknown
- 1976-12-30 MY MY142/76A patent/MY7600142A/xx unknown
Also Published As
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