DE2112716A1 - Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester - Google Patents
Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre EsterInfo
- Publication number
- DE2112716A1 DE2112716A1 DE19712112716 DE2112716A DE2112716A1 DE 2112716 A1 DE2112716 A1 DE 2112716A1 DE 19712112716 DE19712112716 DE 19712112716 DE 2112716 A DE2112716 A DE 2112716A DE 2112716 A1 DE2112716 A1 DE 2112716A1
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- acid
- biphenylyl
- oxo
- butyric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (48)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712112716 DE2112716A1 (de) | 1971-03-17 | 1971-03-17 | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
CH371672A CH573387A5 (da) | 1971-03-17 | 1972-03-14 | |
CH1317075A CH572015A5 (da) | 1971-03-17 | 1972-03-14 | |
ES400791A ES400791A1 (es) | 1971-03-17 | 1972-03-15 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
NL7203400A NL7203400A (da) | 1971-03-17 | 1972-03-15 | |
AT00684/73A AT318587B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
IL38999A IL38999A (en) | 1971-03-17 | 1972-03-16 | 4-(4-biphenyl)-butyric acids and derivatives thereof and the preparation of such compounds |
AT00691/73A AT318591B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
BE780821A BE780821A (fr) | 1971-03-17 | 1972-03-16 | Nouveaux derives de l'acide 4-(4-biphenylyl) butyrique |
DK124072A DK132944C (da) | 1971-03-17 | 1972-03-16 | Analogifremgangsmade til fremstilling af 4-(4-biphenylyl)-4-oxo-smorsyrer eller estere eller salte heraf |
SE7203420A SE393102B (sv) | 1971-03-17 | 1972-03-16 | Forfarande for framstellning av nya 4-(4-bifenylyl)-4-oxo-smorsyror med farmakologiska egenskaper |
AT00687/73A AT318590B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00692/73A AT317880B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
ZA721798A ZA721798B (en) | 1971-03-17 | 1972-03-16 | Improvements relating to 4-(4-biphenylyl)-butyric acid derivatives |
AT00694/73A AT318592B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00680/73A AT319922B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxo-buttersaeuren,ihren salzen und ihren estern |
AT00695/73A AT318593B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00689/73A AT317879B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00682/73A AT319923B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxo-buttersaeuren,ihren salzen und ihren estern |
AT00686/73A AT318589B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
IE338/72A IE36174B1 (en) | 1971-03-17 | 1972-03-16 | 4-(4-biphenylyl)-butyric acid derivatives |
AT00683/73A AT320624B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00690/73A AT320625B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00681/73A AT320623B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00685/73A AT318588B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00697/73A AT318595B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00688/73A AT319924B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxo-buttersaeuren,ihren salzen und ihren estern |
GB1241672A GB1390091A (en) | 1971-03-17 | 1972-03-16 | 4-4-biphenylyl-butyric acid derivatives |
AT222272A AT311949B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur Herstellung von neuen 4-(4-Biphenylyl)-4-oxo-buttersäuren, ihren Salzen und ihren Estern |
AT00696/73A AT318594B (de) | 1971-03-17 | 1972-03-16 | Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-oxobuttersaeuren,ihren salzen und ihren estern |
AT00693/73A AT319925B (de) | 1971-03-17 | 1972-03-16 | Vzh von neuen 4-(4-biphenylyl)-4-oxo-buttersaeuren,ihren salzen und ihren estern |
FR7209420A FR2130390A1 (da) | 1971-03-17 | 1972-03-17 | |
ES406528A ES406528A1 (es) | 1971-03-17 | 1972-09-05 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
ES406536A ES406536A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406531A ES406531A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406539A ES406539A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406530A ES406530A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406527A ES406527A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406532A ES406532A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406529A ES406529A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
ES406533A ES406533A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406538A ES406538A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
ES406526A ES406526A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
ES406535A ES406535A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406537A ES406537A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4-oxobutiricos y sus esteres. |
ES406534A ES406534A1 (es) | 1971-03-17 | 1972-09-09 | Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil)-4-oxobutiricos y sus esteres. |
US05/406,196 US4021479A (en) | 1971-03-17 | 1973-10-15 | Derivatives of 4-(4-biphenylyl)-butyric acid |
US05/543,266 US3997589A (en) | 1971-03-17 | 1975-01-23 | 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712112716 DE2112716A1 (de) | 1971-03-17 | 1971-03-17 | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2112716A1 true DE2112716A1 (de) | 1972-10-05 |
Family
ID=5801760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19712112716 Pending DE2112716A1 (de) | 1971-03-17 | 1971-03-17 | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
Country Status (7)
Country | Link |
---|---|
AT (19) | AT319924B (da) |
CH (2) | CH572015A5 (da) |
DE (1) | DE2112716A1 (da) |
DK (1) | DK132944C (da) |
ES (15) | ES400791A1 (da) |
SE (1) | SE393102B (da) |
ZA (1) | ZA721798B (da) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534909A1 (fr) * | 1981-10-22 | 1984-04-27 | Roussel Uclaf | Nouveaux derives amines de l'acide 4-phenyl 4-oxo 2-butenoiques, leur preparation, leur application comme medicaments et les compositions les renfermant |
EP0180290A1 (en) * | 1984-08-31 | 1986-05-07 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Omega-(2',4'-dihalobiphenylyl)oxo alkanoic acids and process for their preparation |
WO1997043245A1 (en) * | 1996-05-15 | 1997-11-20 | Bayer Corporation | Inhibition of matrix metalloproteases by acetylene containing compounds |
WO1997043247A1 (en) * | 1996-05-15 | 1997-11-20 | Bayer Corporation | Inhibition of matrix metalloproteases by substituted phenethyl compounds |
US5968795A (en) * | 1996-05-15 | 1999-10-19 | Bayer Corporation | Biaryl acetylenes as inhibitors of matrix metalloproteases |
WO2002042250A1 (fr) | 2000-11-27 | 2002-05-30 | Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) | DERIVES DE L'ACIDE 4-HYDROXYBUTANOÏQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU η-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES |
US7091228B2 (en) | 2003-05-09 | 2006-08-15 | Bayer Pharmaceuticals Corporation | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity |
WO2008003299A1 (de) * | 2006-07-07 | 2008-01-10 | Christian-Albrechts-Universitaet Zu Kiel | Basische acetophenone als hemmstoffe von no-synthasen |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003519206A (ja) * | 2000-01-04 | 2003-06-17 | コリア リサーチ インスティチュート オブ ケミカル テクノロジー | 2−フェニルアルカン酸誘導体の製造方法 |
WO2021262040A1 (ru) * | 2020-06-26 | 2021-12-30 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение производного глутаримида для терапии заболеваний, ассоциированных с аберрантной активностью интерлейкина-6 |
-
1971
- 1971-03-17 DE DE19712112716 patent/DE2112716A1/de active Pending
-
1972
- 1972-03-14 CH CH1317075A patent/CH572015A5/xx not_active IP Right Cessation
- 1972-03-14 CH CH371672A patent/CH573387A5/xx not_active IP Right Cessation
- 1972-03-15 ES ES400791A patent/ES400791A1/es not_active Expired
- 1972-03-16 AT AT00688/73A patent/AT319924B/de not_active IP Right Cessation
- 1972-03-16 AT AT00696/73A patent/AT318594B/de not_active IP Right Cessation
- 1972-03-16 AT AT00684/73A patent/AT318587B/de not_active IP Right Cessation
- 1972-03-16 AT AT00694/73A patent/AT318592B/de not_active IP Right Cessation
- 1972-03-16 SE SE7203420A patent/SE393102B/xx unknown
- 1972-03-16 DK DK124072A patent/DK132944C/da active
- 1972-03-16 AT AT00689/73A patent/AT317879B/de active
- 1972-03-16 AT AT00685/73A patent/AT318588B/de active
- 1972-03-16 AT AT00692/73A patent/AT317880B/de active
- 1972-03-16 AT AT00680/73A patent/AT319922B/de not_active IP Right Cessation
- 1972-03-16 AT AT00690/73A patent/AT320625B/de not_active IP Right Cessation
- 1972-03-16 AT AT00697/73A patent/AT318595B/de not_active IP Right Cessation
- 1972-03-16 AT AT00687/73A patent/AT318590B/de not_active IP Right Cessation
- 1972-03-16 AT AT00695/73A patent/AT318593B/de not_active IP Right Cessation
- 1972-03-16 AT AT00682/73A patent/AT319923B/de not_active IP Right Cessation
- 1972-03-16 ZA ZA721798A patent/ZA721798B/xx unknown
- 1972-03-16 AT AT222272A patent/AT311949B/de not_active IP Right Cessation
- 1972-03-16 AT AT00691/73A patent/AT318591B/de not_active IP Right Cessation
- 1972-03-16 AT AT00681/73A patent/AT320623B/de not_active IP Right Cessation
- 1972-03-16 AT AT00693/73A patent/AT319925B/de not_active IP Right Cessation
- 1972-03-16 AT AT00683/73A patent/AT320624B/de not_active IP Right Cessation
- 1972-03-16 AT AT00686/73A patent/AT318589B/de not_active IP Right Cessation
- 1972-09-05 ES ES406528A patent/ES406528A1/es not_active Expired
- 1972-09-09 ES ES406531A patent/ES406531A1/es not_active Expired
- 1972-09-09 ES ES406530A patent/ES406530A1/es not_active Expired
- 1972-09-09 ES ES406539A patent/ES406539A1/es not_active Expired
- 1972-09-09 ES ES406535A patent/ES406535A1/es not_active Expired
- 1972-09-09 ES ES406526A patent/ES406526A1/es not_active Expired
- 1972-09-09 ES ES406529A patent/ES406529A1/es not_active Expired
- 1972-09-09 ES ES406532A patent/ES406532A1/es not_active Expired
- 1972-09-09 ES ES406538A patent/ES406538A1/es not_active Expired
- 1972-09-09 ES ES406534A patent/ES406534A1/es not_active Expired
- 1972-09-09 ES ES406533A patent/ES406533A1/es not_active Expired
- 1972-09-09 ES ES406537A patent/ES406537A1/es not_active Expired
- 1972-09-09 ES ES406536A patent/ES406536A1/es not_active Expired
- 1972-09-09 ES ES406527A patent/ES406527A1/es not_active Expired
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534909A1 (fr) * | 1981-10-22 | 1984-04-27 | Roussel Uclaf | Nouveaux derives amines de l'acide 4-phenyl 4-oxo 2-butenoiques, leur preparation, leur application comme medicaments et les compositions les renfermant |
AT390254B (de) * | 1981-10-22 | 1990-04-10 | Roussel Uclaf | Verfahren zur herstellung von neuen aminderivaten der 4-phenyl-4-oxo-2-butensaeure und von deren salzen |
EP0180290A1 (en) * | 1984-08-31 | 1986-05-07 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | Omega-(2',4'-dihalobiphenylyl)oxo alkanoic acids and process for their preparation |
WO1997043245A1 (en) * | 1996-05-15 | 1997-11-20 | Bayer Corporation | Inhibition of matrix metalloproteases by acetylene containing compounds |
WO1997043247A1 (en) * | 1996-05-15 | 1997-11-20 | Bayer Corporation | Inhibition of matrix metalloproteases by substituted phenethyl compounds |
US5968795A (en) * | 1996-05-15 | 1999-10-19 | Bayer Corporation | Biaryl acetylenes as inhibitors of matrix metalloproteases |
WO2002042250A1 (fr) | 2000-11-27 | 2002-05-30 | Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) | DERIVES DE L'ACIDE 4-HYDROXYBUTANOÏQUE ET DE SON HOMOLOGUE SUPERIEUR COMME LIGANDS DES RECEPTEURS DU η-HYDROXYBUTYRATE (GHB) COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATIONS PHARMACEUTIQUES |
FR2817256A1 (fr) * | 2000-11-27 | 2002-05-31 | Univ Pasteur | Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques |
US7091228B2 (en) | 2003-05-09 | 2006-08-15 | Bayer Pharmaceuticals Corporation | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity |
US7423156B2 (en) | 2003-05-09 | 2008-09-09 | Bayer Pharmaceuticals Corporation | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity |
US7968576B2 (en) | 2003-05-09 | 2011-06-28 | Smith Roger A | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity |
US8013166B2 (en) | 2003-05-09 | 2011-09-06 | Bayer Healthcare Llc | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity |
WO2008003299A1 (de) * | 2006-07-07 | 2008-01-10 | Christian-Albrechts-Universitaet Zu Kiel | Basische acetophenone als hemmstoffe von no-synthasen |
US7994365B2 (en) | 2006-07-07 | 2011-08-09 | Christian-Albrechts-Universitaet Zu Kiel | Basic acetophenones as inhibitors of NO-synthases |
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