DE2112553C3 - 1 -alpha-Aminolsobuttersäurecorticotropinpeptide, deren Derivate, Säureadditionssalze und Komplexe sowie Arzneipräparate - Google Patents
1 -alpha-Aminolsobuttersäurecorticotropinpeptide, deren Derivate, Säureadditionssalze und Komplexe sowie ArzneipräparateInfo
- Publication number
- DE2112553C3 DE2112553C3 DE2112553A DE2112553A DE2112553C3 DE 2112553 C3 DE2112553 C3 DE 2112553C3 DE 2112553 A DE2112553 A DE 2112553A DE 2112553 A DE2112553 A DE 2112553A DE 2112553 C3 DE2112553 C3 DE 2112553C3
- Authority
- DE
- Germany
- Prior art keywords
- acid
- valyl
- prolyl
- arginyl
- lysyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 239000002253 acid Substances 0.000 title claims description 41
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 58
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- 229940024606 amino acid Drugs 0.000 claims description 40
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- -1 L-lysine ester Chemical class 0.000 claims description 30
- 239000004472 Lysine Substances 0.000 claims description 27
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 21
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 18
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- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims description 15
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- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims description 7
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- 125000000539 amino acid group Chemical group 0.000 claims description 7
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims description 6
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- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 claims description 5
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- OGDDUPYYEQZVHV-KDDYFZQKSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N OGDDUPYYEQZVHV-KDDYFZQKSA-N 0.000 claims 1
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- ASQFIHTXXMFENG-XPUUQOCRSA-N Val-Ala-Gly Chemical group CC(C)[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O ASQFIHTXXMFENG-XPUUQOCRSA-N 0.000 claims 1
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- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2219070 | 1970-03-16 | ||
| JP3887870 | 1970-05-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2112553A1 DE2112553A1 (de) | 1971-09-30 |
| DE2112553B2 DE2112553B2 (de) | 1974-09-26 |
| DE2112553C3 true DE2112553C3 (de) | 1975-05-28 |
Family
ID=26359367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2112553A Expired DE2112553C3 (de) | 1970-03-16 | 1971-03-16 | 1 -alpha-Aminolsobuttersäurecorticotropinpeptide, deren Derivate, Säureadditionssalze und Komplexe sowie Arzneipräparate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3873511A (enExample) |
| BE (1) | BE764351A (enExample) |
| CA (1) | CA965777A (enExample) |
| CH (1) | CH566297A5 (enExample) |
| DE (1) | DE2112553C3 (enExample) |
| FR (1) | FR2085715B1 (enExample) |
| GB (1) | GB1316545A (enExample) |
| NL (1) | NL7103476A (enExample) |
| NO (1) | NO137151C (enExample) |
| SE (2) | SE395885B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888836A (en) * | 1972-05-30 | 1975-06-10 | Merck & Co Inc | Pentapeptide intermediate of lhrh and derivatives thereof |
| JPS5116667A (enExample) * | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk | |
| JPS5116666A (enExample) * | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk | |
| US4071510A (en) * | 1974-12-16 | 1978-01-31 | Lars Ake Ingemar Carlsson | Peptides having a high adrenocorticotropic effect and a method of producing the same |
| US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
| US4752601A (en) * | 1983-08-12 | 1988-06-21 | Immunetech Pharmaceuticals | Method of blocking immune complex binding to immunoglobulin FC receptors |
| JPS62500025A (ja) * | 1984-08-10 | 1987-01-08 | イミユーンテツク・フアーマシユーテイカルズ | 免疫療法用ポリペプチド剤 |
| US5157023A (en) * | 1984-08-21 | 1992-10-20 | Lipton James M | Antipyretic and anti-inflammatory lys pro val compositions and method of use |
| US5028592A (en) * | 1986-08-08 | 1991-07-02 | Lipton James M | Antipyretic and anti-inflammatory peptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1493649A1 (de) * | 1963-08-16 | 1969-11-13 | Hoechst Ag | Verfahren zur Herstellung adrenocorticotrop wirksamer Peptide |
| US3503951A (en) * | 1965-06-15 | 1970-03-31 | Ciba Geigy Corp | Complexes of a.c.t.h. peptides with polyglutamic and polyaspartic acid |
| DE1817285A1 (de) * | 1968-12-28 | 1969-08-28 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung von adrenocorticotropem Hormon und dessen Derivaten sowie neue Derivate des adrenocorticotropen Hormons |
| US3651039A (en) * | 1968-12-30 | 1972-03-21 | Takeda Chemical Industries Ltd | Beta-alanine**1 and gamma-aminobutyric acid**1-a.c.t.h. peptides |
-
1971
- 1971-03-02 CA CA106,594A patent/CA965777A/en not_active Expired
- 1971-03-12 SE SE7103201A patent/SE395885B/xx unknown
- 1971-03-15 FR FR7108969A patent/FR2085715B1/fr not_active Expired
- 1971-03-15 US US124549A patent/US3873511A/en not_active Expired - Lifetime
- 1971-03-15 CH CH371971A patent/CH566297A5/xx not_active IP Right Cessation
- 1971-03-15 NO NO969/71A patent/NO137151C/no unknown
- 1971-03-16 BE BE764351A patent/BE764351A/xx unknown
- 1971-03-16 NL NL7103476A patent/NL7103476A/xx unknown
- 1971-03-16 DE DE2112553A patent/DE2112553C3/de not_active Expired
- 1971-04-19 GB GB2406371*A patent/GB1316545A/en not_active Expired
-
1974
- 1974-06-10 SE SE7407603A patent/SE395886B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3873511A (en) | 1975-03-25 |
| SE395886B (sv) | 1977-08-29 |
| CA965777A (en) | 1975-04-08 |
| GB1316545A (en) | 1973-05-09 |
| SE395885B (sv) | 1977-08-29 |
| DE2112553B2 (de) | 1974-09-26 |
| DE2112553A1 (de) | 1971-09-30 |
| CH566297A5 (enExample) | 1975-09-15 |
| NL7103476A (enExample) | 1971-09-20 |
| FR2085715B1 (enExample) | 1975-01-17 |
| BE764351A (fr) | 1971-08-16 |
| NO137151C (no) | 1978-01-11 |
| SE7407603L (enExample) | 1974-06-10 |
| FR2085715A1 (enExample) | 1971-12-31 |
| NO137151B (no) | 1977-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |