DE2108404C3 - Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen - Google Patents
Verfahren zur Erzeugung von L-Arginin durch MikroorganismenInfo
- Publication number
- DE2108404C3 DE2108404C3 DE2108404A DE2108404A DE2108404C3 DE 2108404 C3 DE2108404 C3 DE 2108404C3 DE 2108404 A DE2108404 A DE 2108404A DE 2108404 A DE2108404 A DE 2108404A DE 2108404 C3 DE2108404 C3 DE 2108404C3
- Authority
- DE
- Germany
- Prior art keywords
- arginine
- assimilable
- medium
- microorganisms
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 title claims description 15
- 229930064664 L-arginine Natural products 0.000 title claims description 15
- 235000014852 L-arginine Nutrition 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 8
- 244000005700 microbiome Species 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 239000001963 growth medium Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 150000007524 organic acids Chemical class 0.000 claims description 5
- 241000319304 [Brevibacterium] flavum Species 0.000 claims description 4
- 241001517047 Corynebacterium acetoacidophilum Species 0.000 claims description 2
- 238000009395 breeding Methods 0.000 claims description 2
- 230000001488 breeding effect Effects 0.000 claims description 2
- 241000186146 Brevibacterium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000004475 Arginine Substances 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- 238000000855 fermentation Methods 0.000 description 11
- 230000004151 fermentation Effects 0.000 description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
- 235000009697 arginine Nutrition 0.000 description 6
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000003531 protein hydrolysate Substances 0.000 description 4
- 108010073771 Soybean Proteins Proteins 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000011218 seed culture Methods 0.000 description 3
- 235000019710 soybean protein Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/84—Brevibacterium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/843—Corynebacterium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1510870 | 1970-02-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2108404A1 DE2108404A1 (de) | 1971-09-09 |
| DE2108404B2 DE2108404B2 (de) | 1980-07-03 |
| DE2108404C3 true DE2108404C3 (de) | 1981-03-19 |
Family
ID=11879627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2108404A Expired DE2108404C3 (de) | 1970-02-21 | 1971-02-22 | Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3723249A (https=) |
| DE (1) | DE2108404C3 (https=) |
| FR (1) | FR2078850A5 (https=) |
| GB (1) | GB1278917A (https=) |
| IT (1) | IT1006517B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5331236B1 (https=) * | 1971-06-21 | 1978-09-01 | ||
| DE3750056T2 (de) * | 1986-06-20 | 1995-04-06 | Dainippon Pharmaceutical Co | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. |
| DE3634541A1 (de) * | 1986-10-10 | 1988-04-14 | Degussa | Verfahren zur fermentativen herstellung von l-arginin |
| JP2578468B2 (ja) * | 1988-04-07 | 1997-02-05 | 協和醗酵工業株式会社 | 発酵法によるｌ−アルギニンの製造法 |
| BR112012021285B1 (pt) | 2010-02-25 | 2019-03-06 | Colgate-Palmolive Company | Processo para a produção de arginina empregando Corynebacterium glutamicum ATCC 21831 ou Corynebacterium glutamicum ATCC 21493 em um meio de fermentação que compreende bagaço de mandioca ou semente de jaca como uma fonte de carbono |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL148936B (nl) * | 1962-07-14 | 1976-03-15 | Ajinomoto Kk | Werkwijze voor het bereiden van een of meer aminozuren door een microoerganisme te kweken en een of meer aminozuren uit de kweekbouillon te winnen. |
-
1971
- 1971-02-12 US US00115116A patent/US3723249A/en not_active Expired - Lifetime
- 1971-02-19 FR FR7105791A patent/FR2078850A5/fr not_active Expired
- 1971-02-20 IT IT20836/71A patent/IT1006517B/it active
- 1971-02-22 DE DE2108404A patent/DE2108404C3/de not_active Expired
- 1971-04-19 GB GB22079/71A patent/GB1278917A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2108404B2 (de) | 1980-07-03 |
| IT1006517B (it) | 1976-10-20 |
| GB1278917A (en) | 1972-06-21 |
| US3723249A (en) | 1973-03-27 |
| DE2108404A1 (de) | 1971-09-09 |
| FR2078850A5 (https=) | 1971-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2730964C3 (de) | Verfahren zur Herstellung von L-Lysin auf mikrobiologischem Wege | |
| DE69007800T2 (de) | Verfahren zur fermentativen Herstellung von L-Arginin. | |
| DE2105189C3 (de) | · Verfahren zur Herstellung von L-Methionin auf mikrobiologischem Wege | |
| DE2108404C3 (de) | Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen | |
| DE2707105A1 (de) | Verfahren zur herstellung von l-arginin auf mikrobiologischem wege | |
| DE3121926C2 (de) | Verfahren zur Herstellung von L-Prolin durch Züchten eines Mikroorganismus | |
| DE2350647A1 (de) | Verfahren zur herstellung von l-lysin | |
| DE2209078C3 (de) | Verfahren zur biotechnisehen Herstellung von Ribosiden heterocyclischer organischer Basen | |
| DE1967074C3 (de) | Verfahren zur Herstellung von a-Aminobenzylpenicillin | |
| DE2531999B2 (de) | Verfahren zur biotechnischen Herstellung von L-Lysin | |
| DE2101903B2 (de) | Mikrobiologisches verfahren zur erzeugung von l-histidin | |
| DE2358496C2 (de) | Herstellung von L-Serin | |
| DE2350210A1 (de) | Verfahren zur herstellung von larginin durch fermentierung | |
| DE1275980B (de) | Verfahren zur biotechnischen Herstellung von Inosinsaeure | |
| DE1911470A1 (de) | Verfahren zur Herstellung von L-Lysin | |
| DE2220508B2 (de) | Verfahren zur biotechnischen Herstellung cyclischer Adenosin-3',5'-monophosphorsäure | |
| DE1493442A1 (de) | Verfahren zur Herstellung von Alanin auf enzymatischem Wege | |
| DE2016496C (de) | Verfahren zur biotechnischen Herstel lung von L Histidin | |
| DE2135246A1 (de) | Verfahren zur Herstellung von L Tyrosin auf mikrobiologischem Wege | |
| DE2050982C3 (https=) | ||
| DE1767940A1 (de) | Verfahren zur Herstellung von Threonin durch Gaerung | |
| DE2321461C3 (de) | Verfahren zur fermentativen Herstellung von L-Lysin | |
| DE2357100C3 (de) | Verfahren zur biotechnischen Herstellung von L-Tryptophan | |
| DE1792403C (de) | Verfahren zur biotechnischen Herstellung von L Lysin | |
| DE1543719C (de) | Verfahren zur mikrowellen Herstellung von 1 Threonin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: KOHLER, M., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: SOLF, A., DR.-ING., 8000 MUENCHEN ZAPF, C., DIPL.-ING., PAT.-ANW., 5600 WUPPERTAL |