DE2108404C3 - Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen - Google Patents
Verfahren zur Erzeugung von L-Arginin durch MikroorganismenInfo
- Publication number
- DE2108404C3 DE2108404C3 DE2108404A DE2108404A DE2108404C3 DE 2108404 C3 DE2108404 C3 DE 2108404C3 DE 2108404 A DE2108404 A DE 2108404A DE 2108404 A DE2108404 A DE 2108404A DE 2108404 C3 DE2108404 C3 DE 2108404C3
- Authority
- DE
- Germany
- Prior art keywords
- arginine
- assimilable
- medium
- microorganisms
- fermentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 title claims description 15
- 229930064664 L-arginine Natural products 0.000 title claims description 15
- 235000014852 L-arginine Nutrition 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 8
- 244000005700 microbiome Species 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 239000001963 growth medium Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- 150000007524 organic acids Chemical class 0.000 claims description 5
- 241000319304 [Brevibacterium] flavum Species 0.000 claims description 4
- 241001517047 Corynebacterium acetoacidophilum Species 0.000 claims description 2
- 238000009395 breeding Methods 0.000 claims description 2
- 230000001488 breeding effect Effects 0.000 claims description 2
- 241000186146 Brevibacterium Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 239000004475 Arginine Substances 0.000 description 12
- 239000002609 medium Substances 0.000 description 12
- 238000000855 fermentation Methods 0.000 description 11
- 230000004151 fermentation Effects 0.000 description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
- 235000009697 arginine Nutrition 0.000 description 6
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000003531 protein hydrolysate Substances 0.000 description 4
- 108010073771 Soybean Proteins Proteins 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000011218 seed culture Methods 0.000 description 3
- 235000019710 soybean protein Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/84—Brevibacterium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/843—Corynebacterium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1510870 | 1970-02-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2108404A1 DE2108404A1 (de) | 1971-09-09 |
| DE2108404B2 DE2108404B2 (de) | 1980-07-03 |
| DE2108404C3 true DE2108404C3 (de) | 1981-03-19 |
Family
ID=11879627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2108404A Expired DE2108404C3 (de) | 1970-02-21 | 1971-02-22 | Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3723249A (Sortimente) |
| DE (1) | DE2108404C3 (Sortimente) |
| FR (1) | FR2078850A5 (Sortimente) |
| GB (1) | GB1278917A (Sortimente) |
| IT (1) | IT1006517B (Sortimente) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5331236B1 (Sortimente) * | 1971-06-21 | 1978-09-01 | ||
| EP0251037B1 (en) * | 1986-06-20 | 1994-06-15 | Dainippon Pharmaceutical Co., Ltd. | Novel human TNF polypeptide mutants and DNAs encoding said mutants |
| DE3634541A1 (de) * | 1986-10-10 | 1988-04-14 | Degussa | Verfahren zur fermentativen herstellung von l-arginin |
| JP2578468B2 (ja) * | 1988-04-07 | 1997-02-05 | 協和醗酵工業株式会社 | 発酵法によるｌ−アルギニンの製造法 |
| WO2011106002A1 (en) | 2010-02-25 | 2011-09-01 | Colgate-Palmolive Company | Process of producing arginine employing corynebacteruim glutamicum atcc 21831 or corynebacterium glutamicum atcc 21493 in a afermantation medium comprising cassava bagasse or jackfruit seed as a carbon source |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL148936B (nl) * | 1962-07-14 | 1976-03-15 | Ajinomoto Kk | Werkwijze voor het bereiden van een of meer aminozuren door een microoerganisme te kweken en een of meer aminozuren uit de kweekbouillon te winnen. |
-
1971
- 1971-02-12 US US00115116A patent/US3723249A/en not_active Expired - Lifetime
- 1971-02-19 FR FR7105791A patent/FR2078850A5/fr not_active Expired
- 1971-02-20 IT IT20836/71A patent/IT1006517B/it active
- 1971-02-22 DE DE2108404A patent/DE2108404C3/de not_active Expired
- 1971-04-19 GB GB22079/71A patent/GB1278917A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US3723249A (en) | 1973-03-27 |
| FR2078850A5 (Sortimente) | 1971-11-05 |
| GB1278917A (en) | 1972-06-21 |
| DE2108404A1 (de) | 1971-09-09 |
| IT1006517B (it) | 1976-10-20 |
| DE2108404B2 (de) | 1980-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2730964C3 (de) | Verfahren zur Herstellung von L-Lysin auf mikrobiologischem Wege | |
| DE2105189C3 (de) | · Verfahren zur Herstellung von L-Methionin auf mikrobiologischem Wege | |
| DE2108404C3 (de) | Verfahren zur Erzeugung von L-Arginin durch Mikroorganismen | |
| DE2707105A1 (de) | Verfahren zur herstellung von l-arginin auf mikrobiologischem wege | |
| DE2411209C2 (de) | Verfahren zur fermentativen Herstellung von L-Valin | |
| DE2350647A1 (de) | Verfahren zur herstellung von l-lysin | |
| DE3121926C2 (de) | Verfahren zur Herstellung von L-Prolin durch Züchten eines Mikroorganismus | |
| DE2209078C3 (de) | Verfahren zur biotechnisehen Herstellung von Ribosiden heterocyclischer organischer Basen | |
| DE1967074C3 (de) | Verfahren zur Herstellung von a-Aminobenzylpenicillin | |
| DE2531999B2 (de) | Verfahren zur biotechnischen Herstellung von L-Lysin | |
| DE2101903B2 (de) | Mikrobiologisches verfahren zur erzeugung von l-histidin | |
| DE2358496C2 (de) | Herstellung von L-Serin | |
| DE2350210A1 (de) | Verfahren zur herstellung von larginin durch fermentierung | |
| DE1275980B (de) | Verfahren zur biotechnischen Herstellung von Inosinsaeure | |
| DE1911470A1 (de) | Verfahren zur Herstellung von L-Lysin | |
| DE2220508B2 (de) | Verfahren zur biotechnischen Herstellung cyclischer Adenosin-3',5'-monophosphorsäure | |
| DE1493442A1 (de) | Verfahren zur Herstellung von Alanin auf enzymatischem Wege | |
| DE2016496C (de) | Verfahren zur biotechnischen Herstel lung von L Histidin | |
| DE2050982C3 (Sortimente) | ||
| DE1767940A1 (de) | Verfahren zur Herstellung von Threonin durch Gaerung | |
| DE2321461C3 (de) | Verfahren zur fermentativen Herstellung von L-Lysin | |
| DE2357100C3 (de) | Verfahren zur biotechnischen Herstellung von L-Tryptophan | |
| DE1792403C (de) | Verfahren zur biotechnischen Herstellung von L Lysin | |
| DE1543719C (de) | Verfahren zur mikrowellen Herstellung von 1 Threonin | |
| DE1442258C (de) | Verfahren zur Herstellung von L-Glutaminsaure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: KOHLER, M., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: SOLF, A., DR.-ING., 8000 MUENCHEN ZAPF, C., DIPL.-ING., PAT.-ANW., 5600 WUPPERTAL |