DE202014011399U1 - Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation - Google Patents

Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation Download PDF

Info

Publication number
DE202014011399U1
DE202014011399U1 DE202014011399.8U DE202014011399U DE202014011399U1 DE 202014011399 U1 DE202014011399 U1 DE 202014011399U1 DE 202014011399 U DE202014011399 U DE 202014011399U DE 202014011399 U1 DE202014011399 U1 DE 202014011399U1
Authority
DE
Germany
Prior art keywords
lacto
hmo
concentrate
fucosyllactose
neutral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE202014011399.8U
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chr Hansen HMO GmbH
Original Assignee
Jennewein Biotechnologie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49949589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE202014011399(U1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie GmbH filed Critical Jennewein Biotechnologie GmbH
Publication of DE202014011399U1 publication Critical patent/DE202014011399U1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • C07H1/08Separation; Purification from natural products
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/163Sugars; Polysaccharides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L5/00Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/14Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pediatric Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • Saccharide Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Feed For Specific Animals (AREA)
DE202014011399.8U 2014-01-20 2014-12-23 Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation Expired - Lifetime DE202014011399U1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14151737.5 2014-01-20
EP14151737.5A EP2896628B1 (en) 2014-01-20 2014-01-20 Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation

Publications (1)

Publication Number Publication Date
DE202014011399U1 true DE202014011399U1 (de) 2020-02-12

Family

ID=49949589

Family Applications (2)

Application Number Title Priority Date Filing Date
DE202014011399.8U Expired - Lifetime DE202014011399U1 (de) 2014-01-20 2014-12-23 Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation
DE202014011358.0U Expired - Lifetime DE202014011358U1 (de) 2014-01-20 2014-12-23 Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE202014011358.0U Expired - Lifetime DE202014011358U1 (de) 2014-01-20 2014-12-23 Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation

Country Status (18)

Country Link
US (4) US10377787B2 (enExample)
EP (5) EP2896628B1 (enExample)
JP (2) JP6901857B2 (enExample)
KR (1) KR102137027B1 (enExample)
CN (1) CN106132977B (enExample)
AT (2) AT17418U1 (enExample)
AU (1) AU2014377374B2 (enExample)
BR (1) BR112016016705A8 (enExample)
CZ (2) CZ35289U1 (enExample)
DE (2) DE202014011399U1 (enExample)
DK (6) DK2896628T3 (enExample)
ES (4) ES2701163T3 (enExample)
FI (2) FI3686211T3 (enExample)
MX (2) MX394692B (enExample)
PH (2) PH12016501421A1 (enExample)
PL (4) PL2896628T3 (enExample)
RU (1) RU2682445C2 (enExample)
WO (1) WO2015106943A1 (enExample)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2701163T3 (es) 2014-01-20 2019-02-21 Jennewein Biotechnologie Gmbh Procedimiento para la purificación eficiente de oligosacáridos de la leche humana (HMO) neutros a partir de la fermentación microbiana
EP3227309B1 (en) * 2014-12-05 2025-09-24 Glycom A/S Crystalline difucosyllactose
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
WO2017101958A1 (en) 2015-12-18 2017-06-22 Glycom A/S Fermentative production of oligosaccharides
ES2991621T3 (es) * 2016-03-07 2024-12-04 Glycom As Separación de oligosacáridos de caldo de fermentación
EP3445770B1 (en) * 2016-04-19 2025-11-26 Glycom A/S Separation of oligosaccharides from fermentation broth
US11214588B2 (en) 2017-06-30 2022-01-04 Glycom A/S Synthesis of oligosaccharides
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
CA3073332A1 (en) * 2017-09-29 2019-04-04 Frieslandcampina Nederland B.V. Process for the purification of a neutral human milk oligosaccharide (hmo) from microbial fermentation
EP3486326A1 (en) * 2017-11-21 2019-05-22 Jennewein Biotechnologie GmbH Method for the purification of n-acetylneuraminic acid from a fermentation broth
KR20200096779A (ko) * 2017-12-08 2020-08-13 젠와인 바이오테크놀로지 게엠바하 분무건조된 인간 모유 올리고당 혼합물
ES3039685T3 (en) 2017-12-08 2025-10-23 Chr Hansen Hmo Gmbh Spray-dried tetrasaccharides
EP3494807A1 (en) 2017-12-11 2019-06-12 Jennewein Biotechnologie GmbH Spray-dried sialyllactose
ES3040419T3 (en) 2017-12-08 2025-10-30 Chr Hansen Hmo Gmbh Spray-dried lacto-n-fucopentaose
EP3494804B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried 3-fucosyllactose
PL3524067T3 (pl) * 2018-02-08 2025-06-09 Chr. Hansen HMO GmbH Suszona rozpyłowo mieszanina oligosacharydów mleka ludzkiego
EP3546060A1 (en) * 2018-03-27 2019-10-02 DuPont Nutrition Biosciences ApS Process for spray drying fucosyllactose solutions and related product compositions
SG11202010729XA (en) 2018-05-07 2020-11-27 Jennewein Biotechnologie Gmbh A SIMPLE METHOD FOR THE PURIFICATION OF LACTO-N-NEOTETRAOSE (LNnT) FROM CARBOHYDRATES OBTAINED BY MICROBIAL FERMENTATION
US20210230656A1 (en) * 2018-05-23 2021-07-29 Dsm Ip Assets B.V. Production of oligosaccharides
SG11202011734QA (en) * 2018-06-01 2020-12-30 Jennewein Biotechnologie Gmbh A simple method for the purification of a sialyllactose
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
CA3122178A1 (en) 2018-12-19 2020-06-25 Basf Se Method for separating biomass from a solution comprising biomass and at least one oligosaccaride
US20220081732A1 (en) * 2019-01-21 2022-03-17 Dupont Nutrition Biosciences Aps Process for making l-fucose
EP3686210A1 (en) * 2019-01-24 2020-07-29 DuPont Nutrition Biosciences ApS Process for purifying a human milk oligosaccharide and related compositions
WO2020174386A1 (en) 2019-02-25 2020-09-03 Nutribam Bvba Composition, food supplement and method for supporting and/or improving intestinal health
BE1027078A9 (nl) * 2019-02-25 2020-09-28 Nutribam Bvba Samenstelling, voedingssupplement en werkwijze voor het ondersteunen en/of verbeteren van de darmgezondheid
EP3741770A1 (en) 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
FI3979827T3 (fi) * 2019-06-04 2023-09-22 Nutricia Nv 2’-fukosyllaktoosia ja 3'-galaktosyllaktoosia käsittävä ravintokoostumus
EP3822282A1 (en) * 2019-11-18 2021-05-19 DuPont Nutrition Biosciences ApS Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
ES3041027T3 (en) 2019-09-04 2025-11-06 Inbiose Nv Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
AU2020354581A1 (en) 2019-09-24 2022-03-03 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
EP4097118A4 (en) * 2020-01-29 2024-02-28 DSM IP Assets B.V. METHOD FOR OBTAINING AND PURIFYING OLIGOSACCHARIDES FROM HUMAN MILK
CN111540125B (zh) * 2020-04-20 2021-01-05 中国人民解放军火箭军工程设计研究院 一种充电桩的充电管理方法、设备及计算机可读存储介质
EP4165057A1 (en) * 2020-06-12 2023-04-19 Basf Se Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides
MX2023001743A (es) 2020-08-14 2023-04-21 Prolacta Bioscience Inc Composiciones de oligosacáridos de la leche humana para usarse con bacterioterapias.
CN112568439A (zh) * 2020-12-21 2021-03-30 湖北福星生物科技有限公司 一种从微生物发酵液中分离纯化母乳低聚糖的方法及其应用
KR20230131228A (ko) 2021-01-12 2023-09-12 프롤랙타 바이오사이언스, 인코포레이티드 신바이오틱 치료 요법
CN112920234B (zh) * 2021-01-27 2022-03-29 南开大学 一种2′-岩藻糖基乳糖的富集纯化方法
US20240349770A1 (en) * 2021-04-30 2024-10-24 Dsm Ip Assets B.V. Infant formula with low level of arsenic
DK181242B1 (en) 2021-05-17 2023-05-30 Dsm Ip Assets Bv GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME
WO2022263425A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029435B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
US20240287116A1 (en) 2021-06-15 2024-08-29 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029434B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
WO2023066907A1 (en) 2021-10-18 2023-04-27 Dsm Ip Assets B.V. A method for providing an amorphous hmo product by drying
CN114539433B (zh) * 2021-12-29 2022-11-01 北京三元食品股份有限公司 一种乳低聚糖的制备方法及制备的低聚糖粉、食品
US20250305016A1 (en) * 2022-03-25 2025-10-02 Kirin Holdings Kabushiki Kaisha Production method for lactodifucotetraose (ldft)
CN117003803A (zh) * 2022-05-07 2023-11-07 山东恒鲁生物科技有限公司 一种三糖的新晶型
CN115873051B (zh) 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
CN119403613A (zh) 2022-06-14 2025-02-07 帝斯曼知识产权资产管理有限公司 从发酵液中分离人乳寡糖
WO2024047096A1 (en) 2022-08-30 2024-03-07 Inbiose N.V. Process for purification of an oligosaccharide
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production
CN115651039A (zh) * 2022-12-27 2023-01-31 保龄宝生物股份有限公司 一种高密度2’-岩藻糖基乳糖的生产方法
CN116425810B (zh) * 2023-06-14 2023-08-11 山东合成远景生物科技有限公司 一种混合液中3-岩藻糖基乳糖的纯化方法
CN117089503B (zh) * 2023-10-17 2024-01-02 保龄宝生物股份有限公司 一种大肠杆菌k-12 mg1655 blbyzt6及其应用
WO2025114343A2 (en) * 2023-11-29 2025-06-05 Frieslandcampina Nederland B.V. Process for the production of human milk oligosaccharides

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61271296A (ja) 1985-05-28 1986-12-01 Kyogyo Kumiai N F I N−アセチルキトオリゴ糖の製造方法
JPH0614870B2 (ja) * 1986-12-15 1994-03-02 株式会社ヤクルト本社 ガラクトオリゴ糖の製造法
ATE304546T1 (de) 1996-10-10 2005-09-15 Neose Technologies Inc Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration
US5945314A (en) 1997-03-31 1999-08-31 Abbott Laboratories Process for synthesizing oligosaccharides
US6323008B1 (en) * 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
US6017433A (en) 1997-11-12 2000-01-25 Archer Daniels Midland Company Desalting aqueous streams via filled cell electrodialysis
WO2000024918A1 (en) 1998-10-27 2000-05-04 Cargill, Incorporated Method for purifying a polyol product stream
DE19906865C2 (de) 1999-02-18 2003-03-13 Infineon Technologies Ag Verfahren und Einrichtung zur Entzerrung und Decodierung eines Datensignals
FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
FR2799754A1 (fr) 1999-10-18 2001-04-20 Roquette Freres Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
US6288222B1 (en) 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream
US6618584B1 (en) 2000-08-30 2003-09-09 Telefonaktiebolaget Lm Ericsson (Publ) Terminal authentication procedure timing for data calls
JP2003047402A (ja) * 2001-08-06 2003-02-18 Meiji Milk Prod Co Ltd 中性オリゴ糖含有育児用調製乳
JP2003048901A (ja) 2001-08-09 2003-02-21 Oji Paper Co Ltd 長鎖キシロオリゴ糖組成物およびその製造方法
FR2844209B1 (fr) 2002-09-06 2007-10-19 Applexion Ste Nouvelle De Rech Procede de purification par nanofiltration d'une solution aqueuse sucree contenant des anions et cations monovalents et polyvalents
EP1625224B1 (en) 2003-05-06 2010-07-28 E.I. Du Pont De Nemours And Company Purification of biologically-produced 1,3-propanediol
MXPA05010349A (es) * 2003-06-30 2006-03-08 Clasado Inc Composicion novedosa de galactooligosacaridos y preparacion de la misma.
EP1789570A2 (en) 2004-09-17 2007-05-30 Neose Technologies, Inc. Production of oligosaccharides by microorganisms
KR20070057901A (ko) * 2004-10-01 2007-06-07 에자이 알앤드디 매니지먼트 가부시키가이샤 미립자 함유 조성물 및 그의 제조 방법
EP1846554A1 (en) 2005-02-11 2007-10-24 DSMIP Assets B.V. Fermentive vitamin c production
US20070256936A1 (en) 2006-05-04 2007-11-08 Robert Jansen Method for Deashing Syrup by Electrodialysis
WO2009008362A1 (ja) * 2007-07-12 2009-01-15 Yotsuba Milk Products Co., Ltd. シアル酸化合物含有組成物の製造方法
AU2009329543B2 (en) 2008-12-19 2015-04-16 Chr. Hansen HMO GmbH Synthesis of fucosylated compounds
GB0904562D0 (en) 2009-03-17 2009-04-29 Separation Technologies Invest Isolation and purification of components of whey
WO2010115935A1 (en) 2009-04-07 2010-10-14 Glycom A/S Synthesis of 2 ' -o-fucosyllactose
ES2660698T3 (es) 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
JP2012532195A (ja) * 2009-07-06 2012-12-13 チルドレンズ ホスピタル メディカル センター 乳オリゴ糖による炎症の阻害
IT1395068B1 (it) 2009-08-07 2012-09-05 Inalco Spa Processo per la produzione di galatto-oligosaccaridi ultrapuri
CN101691538B (zh) 2009-09-29 2012-05-09 保龄宝生物股份有限公司 一种米曲霉菌种及其制备高纯度低聚半乳糖的方法
BR112012017978A2 (pt) * 2010-01-19 2016-05-03 Abbott Lab fórmulas nutricionais contendo simbióticos
EP2576578B1 (en) 2010-06-01 2018-09-19 Glycom A/S Polymorphs of 2'-o-fucosyllactose and producing thereof
PL2944690T3 (pl) 2010-10-11 2018-05-30 Jennewein Biotechnologie Gmbh Nowe fukozylotransferazy i ich zastosowanie
EP2455387A1 (en) 2010-11-23 2012-05-23 Nestec S.A. Oligosaccharide mixture and food product comprising this mixture, especially infant formula
TW201233340A (en) * 2010-12-31 2012-08-16 Abbott Lab Human milk oligosaccharides for modulating inflammation
BR112013016903A2 (pt) 2010-12-31 2019-09-24 Abbott Lab oligossacarídeos de leite humano para modular inflamação
CN102154163A (zh) 2010-12-31 2011-08-17 朱莉 一种3′-唾液酸乳糖的制备方法
NZ612455A (en) * 2010-12-31 2015-02-27 Abbott Lab Human milk oligosaccharides to promote growth of beneficial bacteria
ES2439507T3 (es) 2011-01-20 2014-01-23 Jennewein Biotechnologie Gmbh Fucosiltransferasas novedosas y sus aplicaciones
AU2012217650B9 (en) * 2011-02-16 2017-09-14 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
CN102095181A (zh) 2011-03-16 2011-06-15 黎昌兴 Led强光源流体巡回散热装置
US9567361B2 (en) * 2011-05-13 2017-02-14 Glycosyn LLC Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics
EP2526784A1 (en) 2011-05-24 2012-11-28 Nestec S.A. Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition
PL2722394T3 (pl) * 2011-06-07 2018-09-28 Hero Ag Otrzymywanie oligosacharydów za pomocą procesu biotechnologicznego
NL2007268C2 (en) * 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
JP6017133B2 (ja) * 2011-12-12 2016-10-26 Mcフードスペシャリティーズ株式会社 風味改良剤
EP3009010B1 (en) 2011-12-19 2020-02-05 PureCircle SDN BHD Methods for purifying steviol glycosides
WO2013139344A1 (en) 2012-03-20 2013-09-26 Glycom A/S Synthesis of the trisaccharide 3-o-fucosyllactose and intermediates thereof
WO2013182206A1 (en) 2012-06-08 2013-12-12 Glycom A/S Method for producing oligosaccharides and oligosaccharide glycosides by fermentation
EP2861609A4 (en) 2012-06-14 2015-11-04 Glycom As IMPROVING STABILITY AND PURITY AND INCREASING THE BIOAVAILABILITY OF HUMAN MILK OLIGOSACCHARIDES OR PRECURSORS OR MIXTURES THEREOF
ITFI20120143A1 (it) * 2012-07-12 2014-01-13 Inalco S A S Di Giovanni Cipollett I & C Polimorfi idrati e anidri del 2'-o-fucosillattosio e loro metodi di produzione.
US9029136B2 (en) 2012-07-25 2015-05-12 Glycosyn LLC Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
WO2014086373A1 (en) 2012-12-07 2014-06-12 Glycom A/S Crystallisation of human milk oligosaccharides (hmo)
PL2845905T3 (pl) 2013-09-10 2021-09-27 Chr. Hansen HMO GmbH Wytwarzanie oligosacharydów
CN103468766B (zh) 2013-09-18 2015-07-01 恩施天天佳生物科技有限公司 一种高纯度甘露低聚糖的制备方法
EP2857410A1 (en) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
ES2701163T3 (es) 2014-01-20 2019-02-21 Jennewein Biotechnologie Gmbh Procedimiento para la purificación eficiente de oligosacáridos de la leche humana (HMO) neutros a partir de la fermentación microbiana
EP3461890B1 (en) 2014-03-31 2025-09-24 Chr. Hansen HMO GmbH Total fermentation of oligosaccharides
US20170044538A1 (en) 2014-04-17 2017-02-16 Biogen Ma Inc. Compositions and Methods for Modulation of SMN2 Splicing in a Subject
WO2015188834A1 (en) 2014-06-11 2015-12-17 Glycom A/S Separation of 2'-o-fucosyllactose from fermentation broth
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export

Also Published As

Publication number Publication date
MX394692B (es) 2025-03-24
RU2682445C2 (ru) 2019-03-19
EP3686211A3 (en) 2021-01-20
US11661435B2 (en) 2023-05-30
AT17271U1 (de) 2021-10-15
US11597740B2 (en) 2023-03-07
JP7000396B2 (ja) 2022-02-10
DK3131912T3 (da) 2020-02-10
PL3680249T3 (pl) 2023-05-15
EP2896628B1 (en) 2018-09-19
RU2016128955A3 (enExample) 2018-05-21
EP3686211B1 (en) 2023-03-01
EP3680249A3 (en) 2021-01-20
ES2701163T3 (es) 2019-02-21
US10377787B2 (en) 2019-08-13
DK201900054U1 (en) 2019-07-02
ES2779414T3 (es) 2020-08-17
DK3680249T3 (da) 2023-04-24
PH12016501421B1 (en) 2016-08-22
EP3375786A1 (en) 2018-09-19
US10882880B2 (en) 2021-01-05
EP3131912A1 (en) 2017-02-22
DK3686211T3 (da) 2023-04-24
KR102137027B1 (ko) 2020-07-23
ES2942586T3 (es) 2023-06-02
US20200231618A1 (en) 2020-07-23
DK2896628T3 (en) 2019-01-14
EP2896628A1 (en) 2015-07-22
EP3131912B1 (en) 2020-01-22
JP2017506065A (ja) 2017-03-02
CN106132977B (zh) 2020-05-12
US20190177352A1 (en) 2019-06-13
JP2020014482A (ja) 2020-01-30
DK201900072U1 (en) 2019-09-27
BR112016016705A8 (pt) 2022-10-11
DE202014011358U1 (de) 2019-09-26
RU2016128955A (ru) 2018-02-26
EP3680249B1 (en) 2023-03-01
KR20160132009A (ko) 2016-11-16
DK201900054Y4 (da) 2019-09-26
MX369375B (es) 2019-11-07
AU2014377374A1 (en) 2016-08-04
AU2014377374B2 (en) 2019-07-04
PL3686211T3 (pl) 2023-06-05
MX2016009394A (es) 2017-02-08
BR112016016705A2 (enExample) 2017-08-08
FI3680249T3 (fi) 2023-04-25
CZ35289U1 (cs) 2021-08-03
WO2015106943A1 (en) 2015-07-23
AT17418U1 (de) 2022-03-15
PH12020500199A1 (en) 2021-03-15
FI3686211T3 (fi) 2023-04-26
ES2942630T3 (es) 2023-06-05
PL2896628T3 (pl) 2019-03-29
JP6901857B2 (ja) 2021-07-14
US20210061836A1 (en) 2021-03-04
US20160333042A1 (en) 2016-11-17
MX2019013267A (es) 2020-01-13
EP3680249A2 (en) 2020-07-15
PL3131912T3 (pl) 2020-06-15
PH12016501421A1 (en) 2016-08-22
CN106132977A (zh) 2016-11-16
CZ35288U1 (cs) 2021-08-03
EP3686211A2 (en) 2020-07-29

Similar Documents

Publication Publication Date Title
DE202014011399U1 (de) Neutrale humane Milch-Oligosaccharide (HMOs) aus mikrobieller Fermentation
DE202017007249U1 (de) Abtrennung von Oligosacchariden aus der Fermentationsbrühe
DE202015009775U1 (de) Abscheidung von 2'-FL aus einer Fermentationsbrühe
EP0550509B1 (de) Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
EP3741770A1 (en) Purification of oligosaccharides from a fermentation broth by using filtration
EP0778256A1 (de) Verfahren zur Herstellung einer organischen Säure
HK40059566A (en) Purification of oligosaccharides from a fermentation broth by using filtration
EP3794949A1 (de) Verfahren zur gekoppelten herstellung von süssmolke und milchsäure aus sauermolke

Legal Events

Date Code Title Description
R207 Utility model specification
R150 Utility model maintained after payment of first maintenance fee after three years
R151 Utility model maintained after payment of second maintenance fee after six years
R152 Utility model maintained after payment of third maintenance fee after eight years
R071 Expiry of right