DE19954245A1 - Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen - Google Patents
Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von WirkstoffenInfo
- Publication number
- DE19954245A1 DE19954245A1 DE19954245A DE19954245A DE19954245A1 DE 19954245 A1 DE19954245 A1 DE 19954245A1 DE 19954245 A DE19954245 A DE 19954245A DE 19954245 A DE19954245 A DE 19954245A DE 19954245 A1 DE19954245 A1 DE 19954245A1
- Authority
- DE
- Germany
- Prior art keywords
- layer
- layers
- preparation according
- film
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 58
- 229920001477 hydrophilic polymer Polymers 0.000 title claims abstract description 5
- 239000004480 active ingredient Substances 0.000 title claims description 30
- 239000000126 substance Substances 0.000 claims abstract description 31
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 239000003125 aqueous solvent Substances 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 31
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 14
- 241001465754 Metazoa Species 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 13
- 238000001035 drying Methods 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 10
- 241000282414 Homo sapiens Species 0.000 claims description 8
- 229920003086 cellulose ether Polymers 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 7
- 239000002131 composite material Substances 0.000 claims description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 6
- 210000001124 body fluid Anatomy 0.000 claims description 6
- 239000010839 body fluid Substances 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 230000000144 pharmacologic effect Effects 0.000 claims description 6
- 238000005507 spraying Methods 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 241000282412 Homo Species 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000011877 solvent mixture Substances 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 210000003800 pharynx Anatomy 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 239000003765 sweetening agent Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000080 wetting agent Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 82
- 239000010408 film Substances 0.000 description 48
- 239000000243 solution Substances 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000002356 single layer Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920002959 polymer blend Polymers 0.000 description 3
- 229940068984 polyvinyl alcohol Drugs 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 229920006254 polymer film Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000271915 Hydrophis Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000011102 Thera Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- -1 hydroxymethyl propyl Chemical group 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y10T428/31913—Monoolefin polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y10T428/31928—Ester, halide or nitrile of addition polymer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954245A DE19954245A1 (de) | 1999-11-11 | 1999-11-11 | Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen |
| IL14957300A IL149573A0 (en) | 1999-11-11 | 2000-11-03 | Multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients |
| ES00983105T ES2272344T3 (es) | 1999-11-11 | 2000-11-03 | Preparacion laminar multicapas a base de polimeros hidrofilos para la liberacion rapida de principios activos. |
| CN00816734A CN1407886A (zh) | 1999-11-11 | 2000-11-03 | 用于迅速释放活性物质呈亲水性聚合物薄膜形式的多层制剂 |
| EP00983105A EP1227801B1 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
| DE50013472T DE50013472D1 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
| JP2001536121A JP4213383B2 (ja) | 1999-11-11 | 2000-11-03 | 活性成分を急速放出するための親水性ポリマーの薄膜状多層薬剤 |
| KR1020027006077A KR100731263B1 (ko) | 1999-11-11 | 2000-11-03 | 필름층 내에 존재하는 활성 성분을 물 또는 수성 시스템으로 방출하기 위한 필름 형태의 적층 제제의 제조 방법 |
| AT00983105T ATE339193T1 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
| US10/129,835 US7332230B1 (en) | 1999-11-11 | 2000-11-03 | Multilayer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients |
| AU19981/01A AU778619B2 (en) | 1999-11-11 | 2000-11-03 | Multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients |
| PCT/EP2000/010856 WO2001034121A2 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
| CA002391406A CA2391406C (en) | 1999-11-11 | 2000-11-03 | Multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients |
| ARP000105935A AR026427A1 (es) | 1999-11-11 | 2000-11-10 | Compuesto multicapa en forma de pelicula a base de polimeros hidrofilos para la liberacion rapida de principios activos y proceso para la fabricacion |
| IL149573A IL149573A (en) | 1999-11-11 | 2002-05-09 | Process for the production of a multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients and a use thereof |
| US11/932,345 US7803430B2 (en) | 1999-11-11 | 2007-10-31 | Multi-layer preparation in film form, consisting of hydrophilic polymers, for the rapid release of active ingredients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954245A DE19954245A1 (de) | 1999-11-11 | 1999-11-11 | Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19954245A1 true DE19954245A1 (de) | 2001-07-19 |
Family
ID=7928670
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19954245A Withdrawn DE19954245A1 (de) | 1999-11-11 | 1999-11-11 | Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen |
| DE50013472T Expired - Lifetime DE50013472D1 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE50013472T Expired - Lifetime DE50013472D1 (de) | 1999-11-11 | 2000-11-03 | Mehrschichtige filmförmige zubereitung aus hydrophilen polymeren zur schnellen freisetzung von wirkstoffen |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7332230B1 (enExample) |
| EP (1) | EP1227801B1 (enExample) |
| JP (1) | JP4213383B2 (enExample) |
| KR (1) | KR100731263B1 (enExample) |
| CN (1) | CN1407886A (enExample) |
| AR (1) | AR026427A1 (enExample) |
| AT (1) | ATE339193T1 (enExample) |
| AU (1) | AU778619B2 (enExample) |
| CA (1) | CA2391406C (enExample) |
| DE (2) | DE19954245A1 (enExample) |
| ES (1) | ES2272344T3 (enExample) |
| IL (2) | IL149573A0 (enExample) |
| WO (1) | WO2001034121A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20307771U1 (de) * | 2003-05-19 | 2004-09-23 | Cofresco Frischhalteprodukte Gmbh & Co. Kg | Beschichtung und Beutel |
| EP1522225A1 (en) * | 2003-10-10 | 2005-04-13 | ORB Co., Ltd. | Bilayer edible sheet |
| DE102021100783A1 (de) | 2021-01-15 | 2022-07-21 | Lts Lohmann Therapie-Systeme Ag. | Mehrschichtiger oraler dünnfilm |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10107659B4 (de) | 2001-02-19 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
| JP5089840B2 (ja) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8603514B2 (en) * | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| KR20050000424A (ko) * | 2002-05-16 | 2005-01-03 | 규큐 야쿠힝 고교 가부시키가이샤 | 속용성 필름형상 제제 |
| US20040202698A1 (en) * | 2003-04-02 | 2004-10-14 | The Procter & Gamble Company | Drug delivery systems comprising an encapsulated active ingredient |
| CA2535846A1 (en) * | 2003-08-15 | 2005-02-24 | Qlt Usa, Inc. | Adhesive bioerodible transmucosal drug delivery system |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| US8469036B2 (en) | 2003-11-07 | 2013-06-25 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| US7727576B2 (en) * | 2004-04-16 | 2010-06-01 | Hewlett-Packard Development Company, L.P. | System and a method for producing layered oral dosage forms |
| ES2452733T3 (es) | 2004-05-28 | 2014-04-02 | Abbvie Deutschland Gmbh & Co Kg | Forma de dosificación obtenible a partir de una mezcla pulverulenta que comprende un pigmento inorgánico |
| US20050281757A1 (en) * | 2004-06-17 | 2005-12-22 | Sayed Ibrahim | Oral care film |
| BRPI0611035A2 (pt) * | 2005-05-25 | 2010-08-10 | Us Smokeless Tobacco Co | composições de tabaco |
| FR2912915B1 (fr) * | 2007-02-28 | 2012-11-16 | Pf Medicament | Film a desintegration rapide pour l'administration buccale de substances actives. |
| US20080260836A1 (en) * | 2007-04-18 | 2008-10-23 | Thomas James Boyd | Films Comprising a Plurality of Polymers |
| DK2952191T3 (en) | 2009-06-12 | 2018-12-10 | Sunovion Pharmaceuticals Inc | Sublingual apomorphine |
| US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
| US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
| PL2415382T3 (pl) | 2010-08-06 | 2013-02-28 | Electrolux Home Products Corp Nv | Zmywarka nablatowa |
| EP2415383B1 (en) | 2010-08-06 | 2013-06-05 | Electrolux Home Products Corporation N.V. | Table top dishwasher |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| CA3115378A1 (en) | 2010-12-16 | 2012-06-21 | Sunovion Pharmaceuticals Inc. | Sublingual films comprising apomorphine and an organic base |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
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| US2700035A (en) * | 1950-08-26 | 1955-01-18 | Du Pont | Production of polyvinyl alcohol |
| US3511728A (en) * | 1964-03-16 | 1970-05-12 | Westinghouse Electric Corp | Methods for making flat electrical cables |
| JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
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| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| JPS63171565A (ja) * | 1987-01-07 | 1988-07-15 | 積水化学工業株式会社 | 口腔粘膜貼付用構成体およびその製造方法 |
| WO1995005416A2 (en) * | 1993-08-19 | 1995-02-23 | Cygnus Therapeutic Systems | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
| JPH07196992A (ja) * | 1993-12-28 | 1995-08-01 | Nippon Autom Kk | 制振シート |
| JP2791317B2 (ja) * | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | 多層フィルム製剤 |
| US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| US5760484A (en) * | 1997-02-11 | 1998-06-02 | Mosel Vitelic Inc. | Alignment mark pattern for semiconductor process |
-
1999
- 1999-11-11 DE DE19954245A patent/DE19954245A1/de not_active Withdrawn
-
2000
- 2000-11-03 CN CN00816734A patent/CN1407886A/zh active Pending
- 2000-11-03 IL IL14957300A patent/IL149573A0/xx active IP Right Grant
- 2000-11-03 DE DE50013472T patent/DE50013472D1/de not_active Expired - Lifetime
- 2000-11-03 CA CA002391406A patent/CA2391406C/en not_active Expired - Lifetime
- 2000-11-03 US US10/129,835 patent/US7332230B1/en not_active Expired - Lifetime
- 2000-11-03 EP EP00983105A patent/EP1227801B1/de not_active Expired - Lifetime
- 2000-11-03 WO PCT/EP2000/010856 patent/WO2001034121A2/de not_active Ceased
- 2000-11-03 AU AU19981/01A patent/AU778619B2/en not_active Expired
- 2000-11-03 KR KR1020027006077A patent/KR100731263B1/ko not_active Expired - Fee Related
- 2000-11-03 JP JP2001536121A patent/JP4213383B2/ja not_active Expired - Lifetime
- 2000-11-03 ES ES00983105T patent/ES2272344T3/es not_active Expired - Lifetime
- 2000-11-03 AT AT00983105T patent/ATE339193T1/de not_active IP Right Cessation
- 2000-11-10 AR ARP000105935A patent/AR026427A1/es unknown
-
2002
- 2002-05-09 IL IL149573A patent/IL149573A/en unknown
-
2007
- 2007-10-31 US US11/932,345 patent/US7803430B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20307771U1 (de) * | 2003-05-19 | 2004-09-23 | Cofresco Frischhalteprodukte Gmbh & Co. Kg | Beschichtung und Beutel |
| EP1522225A1 (en) * | 2003-10-10 | 2005-04-13 | ORB Co., Ltd. | Bilayer edible sheet |
| DE102021100783A1 (de) | 2021-01-15 | 2022-07-21 | Lts Lohmann Therapie-Systeme Ag. | Mehrschichtiger oraler dünnfilm |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1407886A (zh) | 2003-04-02 |
| AR026427A1 (es) | 2003-02-12 |
| EP1227801B1 (de) | 2006-09-13 |
| US7803430B2 (en) | 2010-09-28 |
| EP1227801A2 (de) | 2002-08-07 |
| JP2003513906A (ja) | 2003-04-15 |
| AU1998101A (en) | 2001-06-06 |
| CA2391406C (en) | 2008-07-29 |
| ATE339193T1 (de) | 2006-10-15 |
| AU778619B2 (en) | 2004-12-16 |
| US7332230B1 (en) | 2008-02-19 |
| US20080057087A1 (en) | 2008-03-06 |
| KR100731263B1 (ko) | 2007-06-21 |
| ES2272344T3 (es) | 2007-05-01 |
| IL149573A (en) | 2007-09-20 |
| WO2001034121A2 (de) | 2001-05-17 |
| CA2391406A1 (en) | 2001-05-17 |
| KR20020058006A (ko) | 2002-07-12 |
| IL149573A0 (en) | 2002-11-10 |
| DE50013472D1 (de) | 2006-10-26 |
| WO2001034121A3 (de) | 2002-04-11 |
| JP4213383B2 (ja) | 2009-01-21 |
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