CN1407886A - 用于迅速释放活性物质呈亲水性聚合物薄膜形式的多层制剂 - Google Patents

用于迅速释放活性物质呈亲水性聚合物薄膜形式的多层制剂 Download PDF

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Publication number
CN1407886A
CN1407886A CN00816734A CN00816734A CN1407886A CN 1407886 A CN1407886 A CN 1407886A CN 00816734 A CN00816734 A CN 00816734A CN 00816734 A CN00816734 A CN 00816734A CN 1407886 A CN1407886 A CN 1407886A
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CN
China
Prior art keywords
preparation
layer
multinomial
mixture
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00816734A
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English (en)
Chinese (zh)
Inventor
马库斯·克鲁姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of CN1407886A publication Critical patent/CN1407886A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31909—Next to second addition polymer from unsaturated monomers
    • Y10T428/31913—Monoolefin polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31909—Next to second addition polymer from unsaturated monomers
    • Y10T428/31928—Ester, halide or nitrile of addition polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Laminated Bodies (AREA)
CN00816734A 1999-11-11 2000-11-03 用于迅速释放活性物质呈亲水性聚合物薄膜形式的多层制剂 Pending CN1407886A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19954245A DE19954245A1 (de) 1999-11-11 1999-11-11 Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen
DE19954245.7 1999-11-11

Publications (1)

Publication Number Publication Date
CN1407886A true CN1407886A (zh) 2003-04-02

Family

ID=7928670

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00816734A Pending CN1407886A (zh) 1999-11-11 2000-11-03 用于迅速释放活性物质呈亲水性聚合物薄膜形式的多层制剂

Country Status (13)

Country Link
US (2) US7332230B1 (enExample)
EP (1) EP1227801B1 (enExample)
JP (1) JP4213383B2 (enExample)
KR (1) KR100731263B1 (enExample)
CN (1) CN1407886A (enExample)
AR (1) AR026427A1 (enExample)
AT (1) ATE339193T1 (enExample)
AU (1) AU778619B2 (enExample)
CA (1) CA2391406C (enExample)
DE (2) DE19954245A1 (enExample)
ES (1) ES2272344T3 (enExample)
IL (2) IL149573A0 (enExample)
WO (1) WO2001034121A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101005824B (zh) * 2004-06-17 2012-05-30 高露洁-棕榄公司 口腔护理薄膜
US8469036B2 (en) 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
CN106237338A (zh) * 2016-09-05 2016-12-21 四川大学 一种制备层状生物降解高分子药物控释材料的方法
CN111372568A (zh) * 2017-11-21 2020-07-03 Lts勒曼治疗系统股份公司 水溶性聚合物粘合层
CN111655242A (zh) * 2018-01-26 2020-09-11 Lts勒曼治疗系统股份公司 多层口服薄膜

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DE10107659B4 (de) 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
JP5089840B2 (ja) * 2001-09-25 2012-12-05 救急薬品工業株式会社 ニコチン含有フィルム製剤
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
KR20050000424A (ko) * 2002-05-16 2005-01-03 규큐 야쿠힝 고교 가부시키가이샤 속용성 필름형상 제제
US20040202698A1 (en) * 2003-04-02 2004-10-14 The Procter & Gamble Company Drug delivery systems comprising an encapsulated active ingredient
DE20307771U1 (de) * 2003-05-19 2004-09-23 Cofresco Frischhalteprodukte Gmbh & Co. Kg Beschichtung und Beutel
WO2005016321A1 (en) * 2003-08-15 2005-02-24 Qlt Usa, Inc. Adhesive bioerodible transmucosal drug delivery system
US20050079253A1 (en) * 2003-10-10 2005-04-14 Hiroshi Nakamura Bilayer edible sheet
US7727576B2 (en) 2004-04-16 2010-06-01 Hewlett-Packard Development Company, L.P. System and a method for producing layered oral dosage forms
DK1748762T3 (en) 2004-05-28 2014-03-17 Abbvie Deutschland Dosage form which can be obtained from a powder mixture comprising an inorganic pigment
CN101262786B (zh) * 2005-05-25 2015-04-08 美国无烟烟草有限责任公司 烟草组合物
FR2912915B1 (fr) * 2007-02-28 2012-11-16 Pf Medicament Film a desintegration rapide pour l'administration buccale de substances actives.
US20080260836A1 (en) * 2007-04-18 2008-10-23 Thomas James Boyd Films Comprising a Plurality of Polymers
US9044475B2 (en) 2009-06-12 2015-06-02 Cynapsus Therapeutics, Inc. Sublingual apomorphine
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
ES2426721T3 (es) 2010-08-06 2013-10-24 Electrolux Home Products Corporation N.V. Lavavajillas de sobremesa
EP2415382B1 (en) 2010-08-06 2012-08-29 Electrolux Home Products Corporation N.V. Table top dishwasher
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
ES2791715T3 (es) 2010-12-16 2020-11-05 Sunovion Pharmaceuticals Inc Películas sublinguales
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US20140271783A1 (en) * 2011-10-14 2014-09-18 Purdue Research Foundation Prefabricated pharmaceutical dosage forms from functional polymer films
WO2014018075A1 (en) 2012-07-23 2014-01-30 Crayola, Llc Dissolvable films and methods of using the same
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
MX383455B (es) 2013-12-31 2025-03-14 Johnson & Johnson Consumer Inc Proceso para formar un producto de película formado.
EP3089854B1 (en) 2013-12-31 2018-11-21 Johnson & Johnson Consumer Inc. Single-pass process for forming a multilayered shaped film product, product and apparatus
KR102240525B1 (ko) 2013-12-31 2021-04-16 존슨 앤드 존슨 컨수머 인코포레이티드 다층의 형상화된 필름을 형성하기 위한 방법
KR20240036586A (ko) * 2014-12-09 2024-03-20 어퀘스티브 테라퓨틱스, 인크. 선형 다당류-기반 필름 생성물
WO2016172095A1 (en) 2015-04-21 2016-10-27 Cynapsus Therapeutics, Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
CA3022840A1 (en) 2016-05-05 2017-11-09 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
EP3691610A1 (en) 2017-10-07 2020-08-12 Zim Laboratories Limited Process for the preparation of bi/multi-layer film, multi-layered film produced thereof and apparatus for producing such multi-layer films
DE102021100783A1 (de) 2021-01-15 2022-07-21 Lts Lohmann Therapie-Systeme Ag. Mehrschichtiger oraler dünnfilm
EP4422607A4 (en) 2021-10-25 2025-09-03 Aquestive Therapeutics Inc ORAL AND NASAL COMPOSITIONS AND METHODS OF TREATMENT

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EP0781546A1 (en) * 1995-12-26 1997-07-02 Sanwa Kagaku Kenkyusho Co., Ltd. A multi-layered film preparation
WO1998017251A1 (en) * 1996-10-18 1998-04-30 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces

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CN1134163A (zh) * 1993-08-19 1996-10-23 辛勒斯治疗系统公司 水溶性压敏粘膜粘合剂和配备该粘合剂用于放置在有粘膜衬里的体腔内的器具
EP0781546A1 (en) * 1995-12-26 1997-07-02 Sanwa Kagaku Kenkyusho Co., Ltd. A multi-layered film preparation
WO1998017251A1 (en) * 1996-10-18 1998-04-30 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8469036B2 (en) 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8636011B2 (en) 2003-11-07 2014-01-28 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10765140B2 (en) 2003-11-07 2020-09-08 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
CN101005824B (zh) * 2004-06-17 2012-05-30 高露洁-棕榄公司 口腔护理薄膜
CN106237338A (zh) * 2016-09-05 2016-12-21 四川大学 一种制备层状生物降解高分子药物控释材料的方法
CN111372568A (zh) * 2017-11-21 2020-07-03 Lts勒曼治疗系统股份公司 水溶性聚合物粘合层
CN111372568B (zh) * 2017-11-21 2023-11-07 Lts勒曼治疗系统股份公司 水溶性聚合物粘合层
CN111655242A (zh) * 2018-01-26 2020-09-11 Lts勒曼治疗系统股份公司 多层口服薄膜

Also Published As

Publication number Publication date
CA2391406C (en) 2008-07-29
ATE339193T1 (de) 2006-10-15
US20080057087A1 (en) 2008-03-06
AU778619B2 (en) 2004-12-16
EP1227801A2 (de) 2002-08-07
AU1998101A (en) 2001-06-06
KR100731263B1 (ko) 2007-06-21
JP2003513906A (ja) 2003-04-15
EP1227801B1 (de) 2006-09-13
CA2391406A1 (en) 2001-05-17
WO2001034121A3 (de) 2002-04-11
IL149573A (en) 2007-09-20
DE50013472D1 (de) 2006-10-26
US7803430B2 (en) 2010-09-28
KR20020058006A (ko) 2002-07-12
DE19954245A1 (de) 2001-07-19
AR026427A1 (es) 2003-02-12
JP4213383B2 (ja) 2009-01-21
ES2272344T3 (es) 2007-05-01
US7332230B1 (en) 2008-02-19
WO2001034121A2 (de) 2001-05-17
IL149573A0 (en) 2002-11-10

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Application publication date: 20030402