ES2272344T3 - Preparacion laminar multicapas a base de polimeros hidrofilos para la liberacion rapida de principios activos. - Google Patents
Preparacion laminar multicapas a base de polimeros hidrofilos para la liberacion rapida de principios activos. Download PDFInfo
- Publication number
- ES2272344T3 ES2272344T3 ES00983105T ES00983105T ES2272344T3 ES 2272344 T3 ES2272344 T3 ES 2272344T3 ES 00983105 T ES00983105 T ES 00983105T ES 00983105 T ES00983105 T ES 00983105T ES 2272344 T3 ES2272344 T3 ES 2272344T3
- Authority
- ES
- Spain
- Prior art keywords
- layers
- layer
- substances
- polymers
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 239000000126 substance Substances 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 37
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 claims abstract description 31
- 239000002904 solvent Substances 0.000 claims abstract description 29
- 239000013543 active substance Substances 0.000 claims abstract description 16
- 238000001035 drying Methods 0.000 claims abstract description 14
- 239000011248 coating agent Substances 0.000 claims abstract description 9
- 238000000576 coating method Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 238000005507 spraying Methods 0.000 claims abstract description 4
- 238000001125 extrusion Methods 0.000 claims abstract description 3
- 239000010410 layer Substances 0.000 claims description 117
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 14
- 230000000144 pharmacologic effect Effects 0.000 claims description 10
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 9
- 229920003086 cellulose ether Polymers 0.000 claims description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 7
- -1 aromatics Substances 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 230000033458 reproduction Effects 0.000 claims description 5
- 210000001124 body fluid Anatomy 0.000 claims description 4
- 239000010839 body fluid Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 238000000354 decomposition reaction Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 235000003599 food sweetener Nutrition 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 239000003765 sweetening agent Substances 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
- 238000005266 casting Methods 0.000 abstract description 4
- 239000007921 spray Substances 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003125 aqueous solvent Substances 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000002356 single layer Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y10T428/31913—Monoolefin polymer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31855—Of addition polymer from unsaturated monomers
- Y10T428/31909—Next to second addition polymer from unsaturated monomers
- Y10T428/31928—Ester, halide or nitrile of addition polymer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954245A DE19954245A1 (de) | 1999-11-11 | 1999-11-11 | Mehrschichtige filmförmige Zubereitung aus hydrophilen Polymeren zur schnellen Freisetzung von Wirkstoffen |
| DE19954245 | 1999-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2272344T3 true ES2272344T3 (es) | 2007-05-01 |
Family
ID=7928670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00983105T Expired - Lifetime ES2272344T3 (es) | 1999-11-11 | 2000-11-03 | Preparacion laminar multicapas a base de polimeros hidrofilos para la liberacion rapida de principios activos. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7332230B1 (enExample) |
| EP (1) | EP1227801B1 (enExample) |
| JP (1) | JP4213383B2 (enExample) |
| KR (1) | KR100731263B1 (enExample) |
| CN (1) | CN1407886A (enExample) |
| AR (1) | AR026427A1 (enExample) |
| AT (1) | ATE339193T1 (enExample) |
| AU (1) | AU778619B2 (enExample) |
| CA (1) | CA2391406C (enExample) |
| DE (2) | DE19954245A1 (enExample) |
| ES (1) | ES2272344T3 (enExample) |
| IL (2) | IL149573A0 (enExample) |
| WO (1) | WO2001034121A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10107659B4 (de) | 2001-02-19 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
| JP5089840B2 (ja) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8603514B2 (en) * | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| KR20050000424A (ko) * | 2002-05-16 | 2005-01-03 | 규큐 야쿠힝 고교 가부시키가이샤 | 속용성 필름형상 제제 |
| US20040202698A1 (en) * | 2003-04-02 | 2004-10-14 | The Procter & Gamble Company | Drug delivery systems comprising an encapsulated active ingredient |
| DE20307771U1 (de) * | 2003-05-19 | 2004-09-23 | Cofresco Frischhalteprodukte Gmbh & Co. Kg | Beschichtung und Beutel |
| CA2535846A1 (en) * | 2003-08-15 | 2005-02-24 | Qlt Usa, Inc. | Adhesive bioerodible transmucosal drug delivery system |
| US20050079253A1 (en) * | 2003-10-10 | 2005-04-14 | Hiroshi Nakamura | Bilayer edible sheet |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| US8469036B2 (en) | 2003-11-07 | 2013-06-25 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| US7727576B2 (en) * | 2004-04-16 | 2010-06-01 | Hewlett-Packard Development Company, L.P. | System and a method for producing layered oral dosage forms |
| ES2452733T3 (es) | 2004-05-28 | 2014-04-02 | Abbvie Deutschland Gmbh & Co Kg | Forma de dosificación obtenible a partir de una mezcla pulverulenta que comprende un pigmento inorgánico |
| US20050281757A1 (en) * | 2004-06-17 | 2005-12-22 | Sayed Ibrahim | Oral care film |
| BRPI0611035A2 (pt) * | 2005-05-25 | 2010-08-10 | Us Smokeless Tobacco Co | composições de tabaco |
| FR2912915B1 (fr) * | 2007-02-28 | 2012-11-16 | Pf Medicament | Film a desintegration rapide pour l'administration buccale de substances actives. |
| US20080260836A1 (en) * | 2007-04-18 | 2008-10-23 | Thomas James Boyd | Films Comprising a Plurality of Polymers |
| DK2952191T3 (en) | 2009-06-12 | 2018-12-10 | Sunovion Pharmaceuticals Inc | Sublingual apomorphine |
| US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
| US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
| PL2415382T3 (pl) | 2010-08-06 | 2013-02-28 | Electrolux Home Products Corp Nv | Zmywarka nablatowa |
| EP2415383B1 (en) | 2010-08-06 | 2013-06-05 | Electrolux Home Products Corporation N.V. | Table top dishwasher |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| CA3115378A1 (en) | 2010-12-16 | 2012-06-21 | Sunovion Pharmaceuticals Inc. | Sublingual films comprising apomorphine and an organic base |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| WO2013056213A1 (en) * | 2011-10-14 | 2013-04-18 | Purdue Research Foundation | Ingestible multi-sheet unit having predetermined functions and combinations |
| US9822257B2 (en) | 2012-07-23 | 2017-11-21 | Crayola Llc | Dissolvable films and methods of using the same |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| JP6517216B2 (ja) | 2013-12-31 | 2019-05-22 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド | 多層賦形フィルム製品を形成するための単一パス方法 |
| JP6588020B2 (ja) | 2013-12-31 | 2019-10-09 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド | 多層賦形フィルムを形成するための方法 |
| KR102226590B1 (ko) | 2013-12-31 | 2021-03-12 | 존슨 앤드 존슨 컨수머 인코포레이티드 | 형상화된 필름 제품을 형성하기 위한 방법 |
| WO2016094567A1 (en) * | 2014-12-09 | 2016-06-16 | Monosol Rx, Llc | Linear polysaccharide based film products |
| JP7211706B2 (ja) | 2015-04-21 | 2023-01-24 | サノヴィオン ファーマシュティカルズ インコーポレーテッド | 口腔粘膜へのアポモルフィンの投与によるパーキンソン病の治療方法 |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| KR20190005199A (ko) | 2016-05-05 | 2019-01-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| CN106237338A (zh) * | 2016-09-05 | 2016-12-21 | 四川大学 | 一种制备层状生物降解高分子药物控释材料的方法 |
| EP3691610A1 (en) | 2017-10-07 | 2020-08-12 | Zim Laboratories Limited | Process for the preparation of bi/multi-layer film, multi-layered film produced thereof and apparatus for producing such multi-layer films |
| DE102017127452A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | Wasserlösliche Polymerklebschichten |
| DE102018101778A1 (de) * | 2018-01-26 | 2019-08-01 | Lts Lohmann Therapie-Systeme Ag | Mehrschichtiger Oraler Dünnfilm |
| DE102021100783A1 (de) | 2021-01-15 | 2022-07-21 | Lts Lohmann Therapie-Systeme Ag. | Mehrschichtiger oraler dünnfilm |
| US12465564B2 (en) | 2021-10-25 | 2025-11-11 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2700035A (en) * | 1950-08-26 | 1955-01-18 | Du Pont | Production of polyvinyl alcohol |
| US3511728A (en) * | 1964-03-16 | 1970-05-12 | Westinghouse Electric Corp | Methods for making flat electrical cables |
| JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
| US4439581A (en) * | 1981-09-03 | 1984-03-27 | Kanzaki Paper Manufacturing Co., Ltd. | Method for the production of microcapsules |
| JPS58134019A (ja) * | 1982-02-05 | 1983-08-10 | Ono Pharmaceut Co Ltd | プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法 |
| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| JPS63171565A (ja) * | 1987-01-07 | 1988-07-15 | 積水化学工業株式会社 | 口腔粘膜貼付用構成体およびその製造方法 |
| WO1995005416A2 (en) * | 1993-08-19 | 1995-02-23 | Cygnus Therapeutic Systems | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
| JPH07196992A (ja) * | 1993-12-28 | 1995-08-01 | Nippon Autom Kk | 制振シート |
| JP2791317B2 (ja) * | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | 多層フィルム製剤 |
| US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| US5760484A (en) * | 1997-02-11 | 1998-06-02 | Mosel Vitelic Inc. | Alignment mark pattern for semiconductor process |
-
1999
- 1999-11-11 DE DE19954245A patent/DE19954245A1/de not_active Withdrawn
-
2000
- 2000-11-03 CN CN00816734A patent/CN1407886A/zh active Pending
- 2000-11-03 IL IL14957300A patent/IL149573A0/xx active IP Right Grant
- 2000-11-03 DE DE50013472T patent/DE50013472D1/de not_active Expired - Lifetime
- 2000-11-03 CA CA002391406A patent/CA2391406C/en not_active Expired - Lifetime
- 2000-11-03 US US10/129,835 patent/US7332230B1/en not_active Expired - Lifetime
- 2000-11-03 EP EP00983105A patent/EP1227801B1/de not_active Expired - Lifetime
- 2000-11-03 WO PCT/EP2000/010856 patent/WO2001034121A2/de not_active Ceased
- 2000-11-03 AU AU19981/01A patent/AU778619B2/en not_active Expired
- 2000-11-03 KR KR1020027006077A patent/KR100731263B1/ko not_active Expired - Fee Related
- 2000-11-03 JP JP2001536121A patent/JP4213383B2/ja not_active Expired - Lifetime
- 2000-11-03 ES ES00983105T patent/ES2272344T3/es not_active Expired - Lifetime
- 2000-11-03 AT AT00983105T patent/ATE339193T1/de not_active IP Right Cessation
- 2000-11-10 AR ARP000105935A patent/AR026427A1/es unknown
-
2002
- 2002-05-09 IL IL149573A patent/IL149573A/en unknown
-
2007
- 2007-10-31 US US11/932,345 patent/US7803430B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1407886A (zh) | 2003-04-02 |
| AR026427A1 (es) | 2003-02-12 |
| EP1227801B1 (de) | 2006-09-13 |
| US7803430B2 (en) | 2010-09-28 |
| EP1227801A2 (de) | 2002-08-07 |
| JP2003513906A (ja) | 2003-04-15 |
| AU1998101A (en) | 2001-06-06 |
| DE19954245A1 (de) | 2001-07-19 |
| CA2391406C (en) | 2008-07-29 |
| ATE339193T1 (de) | 2006-10-15 |
| AU778619B2 (en) | 2004-12-16 |
| US7332230B1 (en) | 2008-02-19 |
| US20080057087A1 (en) | 2008-03-06 |
| KR100731263B1 (ko) | 2007-06-21 |
| IL149573A (en) | 2007-09-20 |
| WO2001034121A2 (de) | 2001-05-17 |
| CA2391406A1 (en) | 2001-05-17 |
| KR20020058006A (ko) | 2002-07-12 |
| IL149573A0 (en) | 2002-11-10 |
| DE50013472D1 (de) | 2006-10-26 |
| WO2001034121A3 (de) | 2002-04-11 |
| JP4213383B2 (ja) | 2009-01-21 |
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