JP2005534640A5 - - Google Patents
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- Publication number
- JP2005534640A5 JP2005534640A5 JP2004506791A JP2004506791A JP2005534640A5 JP 2005534640 A5 JP2005534640 A5 JP 2005534640A5 JP 2004506791 A JP2004506791 A JP 2004506791A JP 2004506791 A JP2004506791 A JP 2004506791A JP 2005534640 A5 JP2005534640 A5 JP 2005534640A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pentan
- dimethylamino
- methoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PZNRRUTVGXCKFC-UHFFFAOYSA-N 1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol Chemical compound CN(C)CC(C)C(O)(CC)C1=CC=CC(OC)=C1 PZNRRUTVGXCKFC-UHFFFAOYSA-N 0.000 claims description 19
- 239000013543 active substance Substances 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 208000002193 Pain Diseases 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000013268 sustained release Methods 0.000 claims description 8
- 239000012730 sustained-release form Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 5
- 208000000094 Chronic Pain Diseases 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 206010046543 Urinary incontinence Diseases 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 230000036407 pain Effects 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 229920002678 cellulose Polymers 0.000 claims 3
- 229920003086 cellulose ether Polymers 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 229920001600 hydrophobic polymer Polymers 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 208000009935 visceral pain Diseases 0.000 claims 2
- PZNRRUTVGXCKFC-IUODEOHRSA-N (2r,3r)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-ol Chemical compound CN(C)C[C@@H](C)[C@](O)(CC)C1=CC=CC(OC)=C1 PZNRRUTVGXCKFC-IUODEOHRSA-N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 claims 1
- 238000000576 coating method Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 description 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- FDPIMTJIUBPUKL-UHFFFAOYSA-N pentan-3-one Chemical compound CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224108A DE10224108A1 (de) | 2002-05-29 | 2002-05-29 | 1-Dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes Arzneimiitel mit verzögerter Wirkstofffreisetzung |
| DE10224108.2 | 2002-05-29 | ||
| PCT/EP2003/005488 WO2003099267A1 (de) | 2002-05-29 | 2003-05-26 | 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol enthaltendes arzneimittel mit verzögerter wirkstofffreisetzung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534640A JP2005534640A (ja) | 2005-11-17 |
| JP2005534640A5 true JP2005534640A5 (enExample) | 2013-12-05 |
| JP5459818B2 JP5459818B2 (ja) | 2014-04-02 |
Family
ID=29557413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506791A Expired - Fee Related JP5459818B2 (ja) | 2002-05-29 | 2003-05-26 | １−ジメチルアミノ−３−（３−メトキシ−フェニル）−２−メチル−ペンタン−３−オールを含有する、有効物質徐放性医薬 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1507519B1 (enExample) |
| JP (1) | JP5459818B2 (enExample) |
| AR (1) | AR039900A1 (enExample) |
| AT (1) | ATE326218T1 (enExample) |
| AU (1) | AU2003238397A1 (enExample) |
| CA (1) | CA2488220C (enExample) |
| DE (2) | DE10224108A1 (enExample) |
| DK (1) | DK1507519T3 (enExample) |
| ES (1) | ES2263976T3 (enExample) |
| MY (1) | MY134311A (enExample) |
| PE (1) | PE20040529A1 (enExample) |
| PL (1) | PL218397B1 (enExample) |
| PT (1) | PT1507519E (enExample) |
| WO (1) | WO2003099267A1 (enExample) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
| US5582837A (en) * | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| JPH06172161A (ja) * | 1992-12-10 | 1994-06-21 | Shin Etsu Chem Co Ltd | 徐放性錠剤 |
| DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| JPH1017497A (ja) * | 1996-07-02 | 1998-01-20 | Takeda Chem Ind Ltd | 徐放性製剤およびその製造方法 |
| DE10059412A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie der Harninkontinenz |
| DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
-
2002
- 2002-05-29 DE DE10224108A patent/DE10224108A1/de not_active Withdrawn
-
2003
- 2003-05-26 EP EP03732464A patent/EP1507519B1/de not_active Expired - Lifetime
- 2003-05-26 AU AU2003238397A patent/AU2003238397A1/en not_active Abandoned
- 2003-05-26 DE DE50303372T patent/DE50303372D1/de not_active Expired - Lifetime
- 2003-05-26 PL PL374186A patent/PL218397B1/pl unknown
- 2003-05-26 DK DK03732464T patent/DK1507519T3/da active
- 2003-05-26 JP JP2004506791A patent/JP5459818B2/ja not_active Expired - Fee Related
- 2003-05-26 AT AT03732464T patent/ATE326218T1/de not_active IP Right Cessation
- 2003-05-26 CA CA2488220A patent/CA2488220C/en not_active Expired - Fee Related
- 2003-05-26 PT PT03732464T patent/PT1507519E/pt unknown
- 2003-05-26 ES ES03732464T patent/ES2263976T3/es not_active Expired - Lifetime
- 2003-05-26 WO PCT/EP2003/005488 patent/WO2003099267A1/de not_active Ceased
- 2003-05-28 MY MYPI20031965A patent/MY134311A/en unknown
- 2003-05-29 PE PE2003000521A patent/PE20040529A1/es not_active Application Discontinuation
- 2003-05-29 AR ARP030101884A patent/AR039900A1/es unknown
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