DE19756261A1 - Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide - Google Patents

Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide

Info

Publication number
DE19756261A1
DE19756261A1 DE19756261A DE19756261A DE19756261A1 DE 19756261 A1 DE19756261 A1 DE 19756261A1 DE 19756261 A DE19756261 A DE 19756261A DE 19756261 A DE19756261 A DE 19756261A DE 19756261 A1 DE19756261 A1 DE 19756261A1
Authority
DE
Germany
Prior art keywords
phenyl
alkyl
hydroxy
aromatic
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19756261A
Other languages
German (de)
English (en)
Inventor
Elfi Biedermann
Max Dr Hasmann
Roland Dr Loeser
Benno Dr Rattel
Friedemann Dr Reiter
Barbara Schein
Klaus Prof Dr Seibel
Klaus Dr Vogt
Katja Dr Wosikowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Priority to DE19756261A priority Critical patent/DE19756261A1/de
Priority to ZA9811240A priority patent/ZA9811240B/xx
Priority to DE69830855T priority patent/DE69830855T2/de
Priority to PT98966352T priority patent/PT1042291E/pt
Priority to EP98966352A priority patent/EP1042291B1/en
Priority to AU22740/99A priority patent/AU2274099A/en
Priority to DK98966352T priority patent/DK1042291T3/da
Priority to AT98966352T priority patent/ATE299495T1/de
Priority to PCT/EP1998/008272 priority patent/WO1999031064A1/en
Priority to JP2000538991A priority patent/JP4838934B2/ja
Priority to ES98966352T priority patent/ES2246073T3/es
Publication of DE19756261A1 publication Critical patent/DE19756261A1/de
Priority to US09/596,086 priority patent/US7320993B1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE19756261A 1997-12-17 1997-12-17 Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide Ceased DE19756261A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE19756261A DE19756261A1 (de) 1997-12-17 1997-12-17 Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
ZA9811240A ZA9811240B (en) 1997-12-17 1998-12-08 New aryl-substituted pyridylalkane alkene and alkine carboxamides
AU22740/99A AU2274099A (en) 1997-12-17 1998-12-16 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic and immunosuppressive agents
PT98966352T PT1042291E (pt) 1997-12-17 1998-12-16 Piridilalcano, alceno e alcino carboxamidas substituidas com arilo, uteis como agentes citostaticos e imunossupressores
EP98966352A EP1042291B1 (en) 1997-12-17 1998-12-16 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic and immunosuppressive agents
DE69830855T DE69830855T2 (de) 1997-12-17 1998-12-16 Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel
DK98966352T DK1042291T3 (da) 1997-12-17 1998-12-16 Arylsubstituerede pyridylalkan-, alken- og alkyncarboxamidderivater, der er nyttige som cytostatiske og immunosuppressive midler
AT98966352T ATE299495T1 (de) 1997-12-17 1998-12-16 Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel
PCT/EP1998/008272 WO1999031064A1 (en) 1997-12-17 1998-12-16 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic and immunosuppressive agents
JP2000538991A JP4838934B2 (ja) 1997-12-17 1998-12-16 細胞増殖抑制剤及び免疫抑制剤として有用なアリール−置換ピリジルアルカン、アルケン及びアルキンカルボキサミド類
ES98966352T ES2246073T3 (es) 1997-12-17 1998-12-16 Piridilalcano-, alqueno- y alquino-carboxamidas sustituidas con arilo, utiles como agentes citostaticos e inmunosupresores.
US09/596,086 US7320993B1 (en) 1997-12-17 2000-06-16 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19756261A DE19756261A1 (de) 1997-12-17 1997-12-17 Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide

Publications (1)

Publication Number Publication Date
DE19756261A1 true DE19756261A1 (de) 1999-07-01

Family

ID=7852345

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19756261A Ceased DE19756261A1 (de) 1997-12-17 1997-12-17 Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
DE69830855T Expired - Lifetime DE69830855T2 (de) 1997-12-17 1998-12-16 Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69830855T Expired - Lifetime DE69830855T2 (de) 1997-12-17 1998-12-16 Aryl-substituierte pyridylalkan-, alken-, und alkin- carboxamidderivate, verwendbar als zytostatische und immunosuppressive mittel

Country Status (10)

Country Link
US (1) US7320993B1 (https=)
EP (1) EP1042291B1 (https=)
JP (1) JP4838934B2 (https=)
AT (1) ATE299495T1 (https=)
AU (1) AU2274099A (https=)
DE (2) DE19756261A1 (https=)
ES (1) ES2246073T3 (https=)
PT (1) PT1042291E (https=)
WO (1) WO1999031064A1 (https=)
ZA (1) ZA9811240B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348434A1 (en) * 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
EP2411364A1 (fr) * 2009-03-24 2012-02-01 Sanofi Composés anticancéreux, leur préparation et leur application en thérapeutique

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EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
WO2003004010A1 (en) * 2001-07-06 2003-01-16 Poseidon Pharmaceuticals A/S Carbonylamino derivatives useful for obtaining immune regulation
EP1641493A4 (en) 2003-06-30 2007-10-31 Merck & Co Inc RADIOACTIVELY MARKED CANNABINOID-1 RECEPTOR MODULATORS
US7291744B2 (en) 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
EP1797036A1 (en) * 2004-09-10 2007-06-20 UCB Pharma, S.A. Sigma receptor ligands
JP4521463B2 (ja) 2005-03-17 2010-08-11 ファイザー株式会社 疼痛の治療に有用なｎ−（ｎ−スルホニルアミノメチル）シクロプロパンカルボキサミド誘導体
CA2610354C (en) 2005-05-31 2011-03-29 Pfizer Inc. Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
EP2098231A1 (en) 2008-03-05 2009-09-09 Topotarget Switzerland SA Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury
WO2010066709A1 (en) * 2008-12-09 2010-06-17 Topotarget A/S Novel pyridinyl acrylamide derivatives
EP2440527A1 (en) * 2009-06-09 2012-04-18 Topo Target A/S Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase
JP6038792B2 (ja) 2010-09-03 2016-12-07 フォーマ ティーエム， エルエルシー． 癌などの疾患の治療のためのｎａｍｐｔ阻害剤としての４−｛［（ピリジン−３−イル−メチル）アミノカルボニル］アミノ｝ベンゼン−スルホン誘導体
CN106243023A (zh) 2010-09-03 2016-12-21 福马Tm有限责任公司 用于抑制nampt的胍化合物和组合物
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
EP2465498A1 (en) * 2010-11-23 2012-06-20 Faes Farma, S.A. Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions
RU2017112522A (ru) 2011-05-04 2019-01-24 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
WO2012154194A1 (en) 2011-05-09 2012-11-15 Forma Tm, Llc Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt)
WO2012177618A1 (en) 2011-06-20 2012-12-27 Emory University Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
US8741250B2 (en) 2011-08-05 2014-06-03 The Curators Of The University Of Missouri Hydroxylation of icosahedral boron compounds
US9382267B2 (en) * 2011-11-30 2016-07-05 The Curators Of The University Of Missouri Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
WO2013082150A1 (en) * 2011-11-30 2013-06-06 The Curators Of The University Of Missouri Small molecule inhibitors of nicotinamide phosphoribosyltransferase (nampt)
FR2996847B1 (fr) * 2012-10-16 2014-12-05 Centre Nat Rech Scient Composes 3,4-bis(catechol)pyrrole-n-substitues, leur preparation et utilisation dans le traitement du cancer
ITRM20120555A1 (it) * 2012-11-13 2014-05-14 Aboca Spa Societa Agricola Enteroclismi.
WO2015167825A1 (en) 2014-04-29 2015-11-05 Emory University Prostaglandin receptor ep2 antagonists, derivatives, compositions, and uses related thereto
US11584766B2 (en) 2018-02-05 2023-02-21 The Trustees Of Indiana University Nicotinamide phosphoribosyltransferase inhibitors and methods for use of the same
EP4628487A3 (en) 2019-03-20 2025-12-24 Emory University Prostaglandin receptor ep2 antagonists, derivatives, and uses related thereto

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EP0530444A1 (en) * 1991-08-01 1993-03-10 American Cyanamid Company Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor

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Patent Citations (2)

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US4283541A (en) * 1980-05-27 1981-08-11 Usv Pharmaceutical Corporation Pyridylacyl-hydroxamates
EP0530444A1 (en) * 1991-08-01 1993-03-10 American Cyanamid Company Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348434A1 (en) * 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
WO2003080054A1 (en) * 2002-03-27 2003-10-02 Fujisawa Deutschland Gmbh Use of pyridyl amides as inhibitors of angiogenesis
EP2411364A1 (fr) * 2009-03-24 2012-02-01 Sanofi Composés anticancéreux, leur préparation et leur application en thérapeutique

Also Published As

Publication number Publication date
DE69830855T2 (de) 2006-05-24
DE69830855D1 (de) 2005-08-18
ES2246073T3 (es) 2006-02-01
EP1042291A1 (en) 2000-10-11
JP2002508357A (ja) 2002-03-19
ZA9811240B (en) 1999-06-08
EP1042291B1 (en) 2005-07-13
ATE299495T1 (de) 2005-07-15
JP4838934B2 (ja) 2011-12-14
AU2274099A (en) 1999-07-05
PT1042291E (pt) 2005-11-30
US7320993B1 (en) 2008-01-22
WO1999031064A1 (en) 1999-06-24

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