DE1963182C2 - 3-(3-Methylaminopropyl)-1-phenylindolin, Verfahren zu dessen Herstellung sowie dessen Verwendung bei der Bekämpfung depressiver Zustände - Google Patents

3-(3-Methylaminopropyl)-1-phenylindolin, Verfahren zu dessen Herstellung sowie dessen Verwendung bei der Bekämpfung depressiver Zustände

Info

Publication number
DE1963182C2
DE1963182C2 DE1963182A DE1963182A DE1963182C2 DE 1963182 C2 DE1963182 C2 DE 1963182C2 DE 1963182 A DE1963182 A DE 1963182A DE 1963182 A DE1963182 A DE 1963182A DE 1963182 C2 DE1963182 C2 DE 1963182C2
Authority
DE
Germany
Prior art keywords
methylaminopropyl
formula
compound
phenylindoline
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1963182A
Other languages
German (de)
English (en)
Other versions
DE1963182A1 (de
Inventor
Antonio Canas-Rodriques
Peter Rodway Canterbury Kent Leeming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of DE1963182A1 publication Critical patent/DE1963182A1/de
Application granted granted Critical
Publication of DE1963182C2 publication Critical patent/DE1963182C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1963182A 1968-12-18 1969-12-17 3-(3-Methylaminopropyl)-1-phenylindolin, Verfahren zu dessen Herstellung sowie dessen Verwendung bei der Bekämpfung depressiver Zustände Expired DE1963182C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB60083/68A GB1237008A (en) 1968-12-18 1968-12-18 Novel indoline derivatives

Publications (2)

Publication Number Publication Date
DE1963182A1 DE1963182A1 (de) 1970-10-15
DE1963182C2 true DE1963182C2 (de) 1983-05-19

Family

ID=10484978

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1963182A Expired DE1963182C2 (de) 1968-12-18 1969-12-17 3-(3-Methylaminopropyl)-1-phenylindolin, Verfahren zu dessen Herstellung sowie dessen Verwendung bei der Bekämpfung depressiver Zustände

Country Status (10)

Country Link
US (2) US3644403A (https=)
JP (2) JPS5011915B1 (https=)
BE (1) BE743250A (https=)
BR (1) BR6915242D0 (https=)
CH (2) CH551412A (https=)
DE (1) DE1963182C2 (https=)
ES (1) ES374644A2 (https=)
FR (1) FR2026492B2 (https=)
GB (1) GB1237008A (https=)
SE (1) SE360862B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882236A (en) * 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments
JPS556986U (https=) * 1978-06-30 1980-01-17
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4694017A (en) * 1983-05-19 1987-09-15 Otsuka Pharmaceutical Co., Ltd. 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
JPH10503768A (ja) * 1994-08-02 1998-04-07 メルク シヤープ エンド ドーム リミテツド アゼチジン、ピロリジンおよびピペリジン誘導体
AU5877500A (en) * 1999-06-15 2001-01-02 Neurogen Corporation Piperidinyl and piperazinyl substituted benzofused lactams

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184466A (en) * 1965-05-18 Beta amino butyrylxnbqlines
US2759935A (en) * 1953-02-18 1956-08-21 Bristol Lab Inc Substituted 3-phenyloxindoles
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3468907A (en) * 1967-04-10 1969-09-23 Schering Corp Glyceryl esters of alpha-(1-aroyl-3-indolyl)alkanoic acids

Also Published As

Publication number Publication date
CH551411A (de) 1974-07-15
BR6915242D0 (pt) 1973-02-13
SE360862B (https=) 1973-10-08
US3720771A (en) 1973-03-13
FR2026492B2 (https=) 1974-02-01
JPS5011915B1 (https=) 1975-05-07
US3644403A (en) 1972-02-22
ES374644A2 (es) 1972-02-16
FR2026492A2 (https=) 1970-09-18
DE1963182A1 (de) 1970-10-15
BE743250A (https=) 1970-06-17
JPS5218702B1 (https=) 1977-05-24
GB1237008A (en) 1971-06-30
CH551412A (de) 1974-07-15

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Legal Events

Date Code Title Description
OI Miscellaneous see part 1
8125 Change of the main classification

Ipc: C07D209/14

8180 Miscellaneous part 1

Free format text: DIE BEZEICHNUNG LAUTET RICHTIG: 3-(3-METHYLAMINOPROPYL)-1-PHENYLINDOLIN, VERFAHREN ZU DESSEN HERSTELLUNG SOWIE DESSEN VERWENDUNG BEI DER BEKAEMPFUNG DEPRESSIVER ZUSTAENDE

8181 Inventor (new situation)

Free format text: CANAS-RODRIQUES, ANTONIO LEEMING, PETER RODWAY, CANTERBURY, KENT, GB

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee