GB1237008A - Novel indoline derivatives - Google Patents

Novel indoline derivatives

Info

Publication number
GB1237008A
GB1237008A GB60083/68A GB6008368A GB1237008A GB 1237008 A GB1237008 A GB 1237008A GB 60083/68 A GB60083/68 A GB 60083/68A GB 6008368 A GB6008368 A GB 6008368A GB 1237008 A GB1237008 A GB 1237008A
Authority
GB
United Kingdom
Prior art keywords
group
general formula
phenyl
atom
nitrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB60083/68A
Other languages
English (en)
Inventor
Antonio Canas-Rodriguez
Peter Rodway Leeming
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Pfizer Inc
Original Assignee
Pfizer Ltd Great Britain
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain, Pfizer Inc filed Critical Pfizer Ltd Great Britain
Priority to GB60083/68A priority Critical patent/GB1237008A/en
Priority to US885321A priority patent/US3644403A/en
Priority to BE743250D priority patent/BE743250A/xx
Priority to BR215242/69A priority patent/BR6915242D0/pt
Priority to ES374644A priority patent/ES374644A2/es
Priority to DE1963182A priority patent/DE1963182C2/de
Priority to CH1290273A priority patent/CH551411A/xx
Priority to FR6943961A priority patent/FR2026492B2/fr
Priority to SE17521/69A priority patent/SE360862B/xx
Priority to JP44101382A priority patent/JPS5011915B1/ja
Priority to CH1883569A priority patent/CH551412A/xx
Publication of GB1237008A publication Critical patent/GB1237008A/en
Priority to US00226291A priority patent/US3720771A/en
Priority to JP48133105A priority patent/JPS5218702B1/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB60083/68A 1968-12-18 1968-12-18 Novel indoline derivatives Expired GB1237008A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB60083/68A GB1237008A (en) 1968-12-18 1968-12-18 Novel indoline derivatives
US885321A US3644403A (en) 1968-12-18 1969-12-15 3-substituted-1-phenyl-indolines
BE743250D BE743250A (https=) 1968-12-18 1969-12-17
BR215242/69A BR6915242D0 (pt) 1968-12-18 1969-12-17 Agentes terapeuticos
ES374644A ES374644A2 (es) 1968-12-18 1969-12-17 Un procedimiento para preparar compuestos con agentes tera-peuticos que comprenden derivados de n-fenilindolina.
DE1963182A DE1963182C2 (de) 1968-12-18 1969-12-17 3-(3-Methylaminopropyl)-1-phenylindolin, Verfahren zu dessen Herstellung sowie dessen Verwendung bei der Bekämpfung depressiver Zustände
FR6943961A FR2026492B2 (https=) 1968-12-18 1969-12-18
CH1290273A CH551411A (de) 1968-12-18 1969-12-18 Verfahren zur herstellung neuer n-phenylindolin-derivate.
SE17521/69A SE360862B (https=) 1968-12-18 1969-12-18
JP44101382A JPS5011915B1 (https=) 1968-12-18 1969-12-18
CH1883569A CH551412A (de) 1968-12-18 1969-12-18 Verfahren zur herstellung neuer n-phenylindolin-derivate.
US00226291A US3720771A (en) 1968-12-18 1972-02-14 3-substituted-1-phenyl-indolines and indolinones in composition for alleviating mentol depression
JP48133105A JPS5218702B1 (https=) 1968-12-18 1973-11-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB60083/68A GB1237008A (en) 1968-12-18 1968-12-18 Novel indoline derivatives

Publications (1)

Publication Number Publication Date
GB1237008A true GB1237008A (en) 1971-06-30

Family

ID=10484978

Family Applications (1)

Application Number Title Priority Date Filing Date
GB60083/68A Expired GB1237008A (en) 1968-12-18 1968-12-18 Novel indoline derivatives

Country Status (10)

Country Link
US (2) US3644403A (https=)
JP (2) JPS5011915B1 (https=)
BE (1) BE743250A (https=)
BR (1) BR6915242D0 (https=)
CH (2) CH551412A (https=)
DE (1) DE1963182C2 (https=)
ES (1) ES374644A2 (https=)
FR (1) FR2026492B2 (https=)
GB (1) GB1237008A (https=)
SE (1) SE360862B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694017A (en) * 1983-05-19 1987-09-15 Otsuka Pharmaceutical Co., Ltd. 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity
WO1995016684A1 (en) * 1993-12-16 1995-06-22 H. Lundbeck A/S 3-substituted 1-arylindole compounds

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3882236A (en) * 1973-12-26 1975-05-06 Lilly Co Eli Pharmaceutical compositions containing substituted 2-oxo-indolines and the use thereof to treat anxiety and tension
US4080330A (en) * 1975-06-23 1978-03-21 Delmar Chemicals Limited Phenylindolines and process for their production
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
FR2420536A1 (fr) * 1978-03-22 1979-10-19 Roussel Uclaf Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments
JPS556986U (https=) * 1978-06-30 1980-01-17
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
US4314944A (en) * 1980-08-22 1982-02-09 Smithkline Corporation 4-Aminoalkyl-7-hydroxy-2(3H)-indolones
US4476307A (en) * 1982-09-20 1984-10-09 Pfizer Inc. Heteroylidene indolone compounds
US4977178A (en) * 1982-09-20 1990-12-11 Pfizer Inc. Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
JPH10503768A (ja) * 1994-08-02 1998-04-07 メルク シヤープ エンド ドーム リミテツド アゼチジン、ピロリジンおよびピペリジン誘導体
AU5877500A (en) * 1999-06-15 2001-01-02 Neurogen Corporation Piperidinyl and piperazinyl substituted benzofused lactams

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184466A (en) * 1965-05-18 Beta amino butyrylxnbqlines
US2759935A (en) * 1953-02-18 1956-08-21 Bristol Lab Inc Substituted 3-phenyloxindoles
GB1154976A (en) * 1967-02-21 1969-06-11 Pfizer Ltd N-Phenyl Indoline Derivatives
US3468907A (en) * 1967-04-10 1969-09-23 Schering Corp Glyceryl esters of alpha-(1-aroyl-3-indolyl)alkanoic acids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694017A (en) * 1983-05-19 1987-09-15 Otsuka Pharmaceutical Co., Ltd. 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity
WO1995016684A1 (en) * 1993-12-16 1995-06-22 H. Lundbeck A/S 3-substituted 1-arylindole compounds
AU682915B2 (en) * 1993-12-16 1997-10-23 H. Lundbeck A/S 3-substituted 1-arylindole compounds
CN1080261C (zh) * 1993-12-16 2002-03-06 H·隆德贝克有限公司 3－取代的1－芳基吲哚化合物

Also Published As

Publication number Publication date
CH551411A (de) 1974-07-15
BR6915242D0 (pt) 1973-02-13
SE360862B (https=) 1973-10-08
US3720771A (en) 1973-03-13
FR2026492B2 (https=) 1974-02-01
DE1963182C2 (de) 1983-05-19
JPS5011915B1 (https=) 1975-05-07
US3644403A (en) 1972-02-22
ES374644A2 (es) 1972-02-16
FR2026492A2 (https=) 1970-09-18
DE1963182A1 (de) 1970-10-15
BE743250A (https=) 1970-06-17
JPS5218702B1 (https=) 1977-05-24
CH551412A (de) 1974-07-15

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