DE19601745C1 - Verfahren zur Racematspaltung von Tramadol - Google Patents

Verfahren zur Racematspaltung von Tramadol

Info

Publication number
DE19601745C1
DE19601745C1 DE19601745A DE19601745A DE19601745C1 DE 19601745 C1 DE19601745 C1 DE 19601745C1 DE 19601745 A DE19601745 A DE 19601745A DE 19601745 A DE19601745 A DE 19601745A DE 19601745 C1 DE19601745 C1 DE 19601745C1
Authority
DE
Germany
Prior art keywords
tramadol
tartaric acid
base
hydrochloride
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19601745A
Other languages
German (de)
English (en)
Inventor
Helmut Heinrich Dipl Buschmann
Werner Prof Dipl Chem D Winter
Ivars Dr Graudums
Peter Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grünenthal GmbH
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Priority to DE19601745A priority Critical patent/DE19601745C1/de
Priority to MYPI96004865A priority patent/MY116583A/en
Priority to PE1996000930A priority patent/PE29898A1/es
Priority to AT96120726T priority patent/ATE189205T1/de
Priority to EP96120726A priority patent/EP0787715B1/de
Priority to DK96120726T priority patent/DK0787715T3/da
Priority to PT96120726T priority patent/PT787715E/pt
Priority to SI9630150T priority patent/SI0787715T1/xx
Priority to DE59604295T priority patent/DE59604295D1/de
Priority to ES96120726T priority patent/ES2145373T3/es
Priority to NZ299999A priority patent/NZ299999A/en
Priority to CO96068520A priority patent/CO4520185A1/es
Priority to US08/775,396 priority patent/US5723668A/en
Priority to ARP970100069A priority patent/AR005391A1/es
Priority to IN45CA1997 priority patent/IN182218B/en
Priority to UY24439A priority patent/UY24439A1/es
Priority to BR9700094A priority patent/BR9700094A/pt
Priority to HU9700141A priority patent/HU223067B1/hu
Priority to ZA9700369A priority patent/ZA97369B/xx
Priority to CA002195370A priority patent/CA2195370C/en
Priority to SK68-97A priority patent/SK281612B6/sk
Priority to PL97318003A priority patent/PL187403B1/pl
Priority to CZ1997156A priority patent/CZ291775B6/cs
Priority to JP9006903A priority patent/JPH09216858A/ja
Priority to CN97102069A priority patent/CN1131203C/zh
Priority to KR1019970001203A priority patent/KR100505527B1/ko
Priority to MXPA/A/1997/000483A priority patent/MXPA97000483A/xx
Priority to AU12232/97A priority patent/AU711750B2/en
Priority to NO970211A priority patent/NO306059B1/no
Priority to RU97100948/04A priority patent/RU2192407C2/ru
Priority to IL12002897A priority patent/IL120028A/xx
Priority to UA97010175A priority patent/UA45343C2/uk
Application granted granted Critical
Publication of DE19601745C1 publication Critical patent/DE19601745C1/de
Priority to GR20000400183T priority patent/GR3032489T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19601745A 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol Expired - Fee Related DE19601745C1 (de)

Priority Applications (33)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol
MYPI96004865A MY116583A (en) 1996-01-19 1996-11-22 A method of separating the racemate of tramadol
PE1996000930A PE29898A1 (es) 1996-01-19 1996-12-18 Procedimiento para el desdoblamiento de los racematos del tramadol
EP96120726A EP0787715B1 (de) 1996-01-19 1996-12-21 Verfahren zur Racematspaltung von Tramadol
DK96120726T DK0787715T3 (da) 1996-01-19 1996-12-21 Fremgangsmåde til racematspaltning af tramadol
PT96120726T PT787715E (pt) 1996-01-19 1996-12-21 Processo para a separacao das misturas racemicas de tramadolo
AT96120726T ATE189205T1 (de) 1996-01-19 1996-12-21 Verfahren zur racematspaltung von tramadol
SI9630150T SI0787715T1 (en) 1996-01-19 1996-12-21 Process for the optical resolution of tramadol
DE59604295T DE59604295D1 (de) 1996-01-19 1996-12-21 Verfahren zur Racematspaltung von Tramadol
ES96120726T ES2145373T3 (es) 1996-01-19 1996-12-21 Procedimiento para el desdoblamiento de racemato de tramadol.
NZ299999A NZ299999A (en) 1996-01-19 1996-12-23 Separation of tramadol racemate
CO96068520A CO4520185A1 (es) 1996-01-19 1996-12-30 Procedimiento para el desdoblamiento de los racematos del tramadol
US08/775,396 US5723668A (en) 1996-01-19 1996-12-31 Method of separating the racemate of tramadol
ARP970100069A AR005391A1 (es) 1996-01-19 1997-01-07 Procedimiento para la separación de racematos del tramadol.
IN45CA1997 IN182218B (enExample) 1996-01-19 1997-01-09
UY24439A UY24439A1 (es) 1996-01-19 1997-01-10 Un procedimiento para el desdoblamiento de los racematos del tramadol
BR9700094A BR9700094A (pt) 1996-01-19 1997-01-14 Método para separação racêmica de tramadol
ZA9700369A ZA97369B (en) 1996-01-19 1997-01-16 A method of separating the racemate of tramadol.
HU9700141A HU223067B1 (hu) 1996-01-19 1997-01-16 Eljárás tramadol racemáthasítására
NO970211A NO306059B1 (no) 1996-01-19 1997-01-17 Fremgangsmåte for racematspaltning av tramadol
PL97318003A PL187403B1 (pl) 1996-01-19 1997-01-17 Sposób rozszczepiania racematu 2-dimetyloaminometylo-1-(3-metoksyfenylo) cykloheksanolu
CZ1997156A CZ291775B6 (cs) 1996-01-19 1997-01-17 Způsob racemátového štěpení tramadolu
JP9006903A JPH09216858A (ja) 1996-01-19 1997-01-17 トラマドールのラセミ体分割方法
CN97102069A CN1131203C (zh) 1996-01-19 1997-01-17 一种分离曲马多外消旋体的方法
KR1019970001203A KR100505527B1 (ko) 1996-01-19 1997-01-17 트라마돌의라세미체를분리하는방법
MXPA/A/1997/000483A MXPA97000483A (en) 1996-01-19 1997-01-17 Procedure for the optic resolution of ramatic blend mixtures
CA002195370A CA2195370C (en) 1996-01-19 1997-01-17 A method of separating the racemate of tramadol
SK68-97A SK281612B6 (sk) 1996-01-19 1997-01-17 Spôsob racemátového štiepenia tramadolu
RU97100948/04A RU2192407C2 (ru) 1996-01-19 1997-01-17 Способ расщепления рацематов трамадола
IL12002897A IL120028A (en) 1996-01-19 1997-01-17 Method of separating the racemate of tramadol
UA97010175A UA45343C2 (uk) 1996-01-19 1997-01-17 Спосіб розділення рацемату трамадолу та спосіб розділення рацемічної солі трамадолу на (-) і (+)-енантіомери
AU12232/97A AU711750B2 (en) 1996-01-19 1997-01-17 A method of separating the racemate of tramadol
GR20000400183T GR3032489T3 (en) 1996-01-19 2000-01-27 Process for the optical resolution of tramadol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (1)

Publication Number Publication Date
DE19601745C1 true DE19601745C1 (de) 1997-10-09

Family

ID=7783112

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19601745A Expired - Fee Related DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol
DE59604295T Expired - Lifetime DE59604295D1 (de) 1996-01-19 1996-12-21 Verfahren zur Racematspaltung von Tramadol

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59604295T Expired - Lifetime DE59604295D1 (de) 1996-01-19 1996-12-21 Verfahren zur Racematspaltung von Tramadol

Country Status (31)

Country Link
US (1) US5723668A (enExample)
EP (1) EP0787715B1 (enExample)
JP (1) JPH09216858A (enExample)
KR (1) KR100505527B1 (enExample)
CN (1) CN1131203C (enExample)
AR (1) AR005391A1 (enExample)
AT (1) ATE189205T1 (enExample)
AU (1) AU711750B2 (enExample)
BR (1) BR9700094A (enExample)
CA (1) CA2195370C (enExample)
CO (1) CO4520185A1 (enExample)
CZ (1) CZ291775B6 (enExample)
DE (2) DE19601745C1 (enExample)
DK (1) DK0787715T3 (enExample)
ES (1) ES2145373T3 (enExample)
GR (1) GR3032489T3 (enExample)
HU (1) HU223067B1 (enExample)
IL (1) IL120028A (enExample)
IN (1) IN182218B (enExample)
MY (1) MY116583A (enExample)
NO (1) NO306059B1 (enExample)
NZ (1) NZ299999A (enExample)
PE (1) PE29898A1 (enExample)
PL (1) PL187403B1 (enExample)
PT (1) PT787715E (enExample)
RU (1) RU2192407C2 (enExample)
SI (1) SI0787715T1 (enExample)
SK (1) SK281612B6 (enExample)
UA (1) UA45343C2 (enExample)
UY (1) UY24439A1 (enExample)
ZA (1) ZA97369B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) * 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
DE69809055T2 (de) * 1997-07-15 2003-06-05 Russinsky Ltd., Cork Verfahren zur herstellung von reinem cis-tramadol
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
WO2002028383A1 (en) * 2000-10-03 2002-04-11 Penwest Pharmaceuticals Company Delivery system for multi-pharmaceutical active materials at various release rates
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
NZ528935A (en) 2001-03-16 2004-10-29 Dmi Biosciences Inc Method of delaying ejaculation
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
PL383715A1 (pl) 2005-01-26 2008-05-12 Allergan, Inc. Amidy kwasu 3-arylo-3-hydroksy-2-amino-propionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-amino-propionowego i ich związki pokrewne posiadające aktywność przeciwbólową i/lub pobudzającą odporność
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
US20080261991A1 (en) 2007-02-12 2008-10-23 Dmi Biosciences, Inc. Reducing Side Effects of Tramadol
JP2010518167A (ja) 2007-02-12 2010-05-27 ディーエムアイ バイオサイエンシズ インコーポレイテッド 併存する早漏及び勃起障害の治療
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
GB9017390D0 (en) * 1990-08-08 1990-09-19 Norgine Ltd Improvements in or relating to propylamine derivatives
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Arzneim.-Forschung/Drug Res. 28(I), 114 (1978) *

Also Published As

Publication number Publication date
MY116583A (en) 2004-02-28
NO970211L (no) 1997-07-21
UY24439A1 (es) 1997-01-30
ZA97369B (en) 1997-07-29
CZ291775B6 (cs) 2003-05-14
ATE189205T1 (de) 2000-02-15
NO306059B1 (no) 1999-09-13
PL187403B1 (pl) 2004-07-30
NO970211D0 (no) 1997-01-17
HUP9700141A2 (hu) 1998-01-28
JPH09216858A (ja) 1997-08-19
DE59604295D1 (de) 2000-03-02
HU9700141D0 (en) 1997-03-28
AR005391A1 (es) 1999-04-28
DK0787715T3 (da) 2000-04-25
MX9700483A (es) 1997-07-31
HU223067B1 (hu) 2004-03-01
US5723668A (en) 1998-03-03
SK281612B6 (sk) 2001-05-10
KR100505527B1 (ko) 2005-10-19
HUP9700141A3 (en) 2000-03-28
IL120028A0 (en) 1997-04-15
CA2195370A1 (en) 1997-07-20
IN182218B (enExample) 1999-02-06
KR970059155A (ko) 1997-08-12
GR3032489T3 (en) 2000-05-31
SK6897A3 (en) 1997-08-06
SI0787715T1 (en) 2000-04-30
EP0787715B1 (de) 2000-01-26
PE29898A1 (es) 1998-08-08
PT787715E (pt) 2000-06-30
CN1161957A (zh) 1997-10-15
PL318003A1 (en) 1997-07-21
RU2192407C2 (ru) 2002-11-10
EP0787715A1 (de) 1997-08-06
BR9700094A (pt) 1998-09-22
CZ15697A3 (cs) 1998-05-13
CO4520185A1 (es) 1997-10-15
NZ299999A (en) 1998-01-26
AU1223297A (en) 1997-07-24
IL120028A (en) 1999-12-22
ES2145373T3 (es) 2000-07-01
AU711750B2 (en) 1999-10-21
UA45343C2 (uk) 2002-04-15
CA2195370C (en) 2005-07-12
CN1131203C (zh) 2003-12-17

Similar Documents

Publication Publication Date Title
EP0787715B1 (de) Verfahren zur Racematspaltung von Tramadol
DE19601744C2 (de) Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol
EP0753506B1 (de) 6-Dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe
EP0983995B1 (de) Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe
DE69531356T2 (de) Kristallisierung von levobupivacaine und deren analogen
DE60109494T2 (de) Verfahren zur herstellung von salbutamolisomeren
EP1888506B1 (de) Trennung stereoisomerer n,n-dialkylamino-2-alkyl-3-phenyl-alkane
EP0157315B1 (de) Optisch aktives Di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat
EP0029175A1 (de) Verfahren zur Gewinnung der enantiomeren Formen von 4-Cyan-1-(N-methyl-N-(2'-((3",4"-dimethoxyphenyl))-ethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen Salzen
DE69607595T2 (de) Herstellung von optisch aktiven aliphetischen carbonsäuren
EP0224902B1 (de) Verbesserte Verfahren zur Herstellung von D-threo-1-(p-Methylsulfonylphenyl)-2-dichloracetamido-propandiol-1,3-(Thiamphenicol)sowie Verwendung geeigneter Zwischenprodukte
EP0461541B1 (de) Verfahren zur Racematspaltung von 2,2-Dimethylcyclopropancarbonsäure
DE10348674A1 (de) Racemisierung von optisch aktiven 2-substituierten Phenylglycinestern
DE60010927T2 (de) Verfahren zur herstellung von 3-amino-3-cyclopropylpropansäureestern
KR100472609B1 (ko) 레보부피바카인과그의유사체의결정화벙법
DE4133145A1 (de) Verfahren zur herstellung angereicherter diastereomeren von propranololanaloga mit zwei chiralen zentren
EP0474200A2 (de) Verfahren zur Racematspaltung von 2,2-Dimethylcyclopropancarbonsäure
MXPA97000483A (en) Procedure for the optic resolution of ramatic blend mixtures
DE1034186B (de) Verfahren zur Herstellung eines Esters der p-n-Butylamino-benzoesaeure
DE19624820A1 (de) Verfahren zur Herstellung von optisch aktiven 1-Phenyl-ethylaminen

Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee