ES2145373T3 - Procedimiento para el desdoblamiento de racemato de tramadol. - Google Patents

Procedimiento para el desdoblamiento de racemato de tramadol.

Info

Publication number
ES2145373T3
ES2145373T3 ES96120726T ES96120726T ES2145373T3 ES 2145373 T3 ES2145373 T3 ES 2145373T3 ES 96120726 T ES96120726 T ES 96120726T ES 96120726 T ES96120726 T ES 96120726T ES 2145373 T3 ES2145373 T3 ES 2145373T3
Authority
ES
Spain
Prior art keywords
procedure
development
tramadol racemate
tramadol
racemate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96120726T
Other languages
English (en)
Inventor
Helmut Dr Buschmann
Werner Prof Dr Winter
Ivars Dr Graudums
Peter Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Application granted granted Critical
Publication of ES2145373T3 publication Critical patent/ES2145373T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA DIVISION EN RACEMATOS DEL TRAMADOL.
ES96120726T 1996-01-19 1996-12-21 Procedimiento para el desdoblamiento de racemato de tramadol. Expired - Lifetime ES2145373T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (1)

Publication Number Publication Date
ES2145373T3 true ES2145373T3 (es) 2000-07-01

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96120726T Expired - Lifetime ES2145373T3 (es) 1996-01-19 1996-12-21 Procedimiento para el desdoblamiento de racemato de tramadol.

Country Status (31)

Country Link
US (1) US5723668A (es)
EP (1) EP0787715B1 (es)
JP (1) JPH09216858A (es)
KR (1) KR100505527B1 (es)
CN (1) CN1131203C (es)
AR (1) AR005391A1 (es)
AT (1) ATE189205T1 (es)
AU (1) AU711750B2 (es)
BR (1) BR9700094A (es)
CA (1) CA2195370C (es)
CO (1) CO4520185A1 (es)
CZ (1) CZ291775B6 (es)
DE (2) DE19601745C1 (es)
DK (1) DK0787715T3 (es)
ES (1) ES2145373T3 (es)
GR (1) GR3032489T3 (es)
HU (1) HU223067B1 (es)
IL (1) IL120028A (es)
IN (1) IN182218B (es)
MY (1) MY116583A (es)
NO (1) NO306059B1 (es)
NZ (1) NZ299999A (es)
PE (1) PE29898A1 (es)
PL (1) PL187403B1 (es)
PT (1) PT787715E (es)
RU (1) RU2192407C2 (es)
SI (1) SI0787715T1 (es)
SK (1) SK281612B6 (es)
UA (1) UA45343C2 (es)
UY (1) UY24439A1 (es)
ZA (1) ZA97369B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
WO1999003820A1 (en) * 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
CA2423558A1 (en) * 2000-10-03 2002-04-11 Penwest Pharmaceuticals Company Delivery system for multi-pharmaceutical active materials at various release rates
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
CN1289071C (zh) 2001-03-16 2006-12-13 Dmi生物科学公司 曲马朵物质在制备用于延缓男性射精的药物中的用途
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
US6780891B2 (en) 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
EP1841423B1 (en) 2005-01-26 2010-03-10 Allergan, Inc. Use of 1- benzyl-1- hydroxy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino propionic acid amides and related compounds as analgesics
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
KR20140054312A (ko) * 2007-02-12 2014-05-08 디엠아이 바이오사이언시스 인코포레이티드 조루 및 발기부전을 동시에 치료하는 방법
MX2009008511A (es) 2007-02-12 2010-01-20 Dmi Biosciences Inc Reduccion de efectos secundarios de tramadol.
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
EP0787715A1 (de) 1997-08-06
KR100505527B1 (ko) 2005-10-19
HUP9700141A2 (hu) 1998-01-28
SI0787715T1 (en) 2000-04-30
HUP9700141A3 (en) 2000-03-28
CA2195370C (en) 2005-07-12
GR3032489T3 (en) 2000-05-31
UY24439A1 (es) 1997-01-30
DE19601745C1 (de) 1997-10-09
ATE189205T1 (de) 2000-02-15
NO970211L (no) 1997-07-21
IN182218B (es) 1999-02-06
CZ15697A3 (cs) 1998-05-13
NZ299999A (en) 1998-01-26
US5723668A (en) 1998-03-03
CA2195370A1 (en) 1997-07-20
JPH09216858A (ja) 1997-08-19
SK281612B6 (sk) 2001-05-10
CN1161957A (zh) 1997-10-15
MY116583A (en) 2004-02-28
KR970059155A (ko) 1997-08-12
IL120028A0 (en) 1997-04-15
IL120028A (en) 1999-12-22
CN1131203C (zh) 2003-12-17
BR9700094A (pt) 1998-09-22
HU223067B1 (hu) 2004-03-01
CZ291775B6 (cs) 2003-05-14
DK0787715T3 (da) 2000-04-25
ZA97369B (en) 1997-07-29
PE29898A1 (es) 1998-08-08
DE59604295D1 (de) 2000-03-02
SK6897A3 (en) 1997-08-06
CO4520185A1 (es) 1997-10-15
UA45343C2 (uk) 2002-04-15
NO970211D0 (no) 1997-01-17
HU9700141D0 (en) 1997-03-28
AR005391A1 (es) 1999-04-28
AU711750B2 (en) 1999-10-21
RU2192407C2 (ru) 2002-11-10
PL318003A1 (en) 1997-07-21
MX9700483A (es) 1997-07-31
PT787715E (pt) 2000-06-30
AU1223297A (en) 1997-07-24
EP0787715B1 (de) 2000-01-26
PL187403B1 (pl) 2004-07-30
NO306059B1 (no) 1999-09-13

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