ES2154310T3 - Procedimiento para la fabricacion de un dodecahidroisoquinolino-alfa,alfa'diamino-alcohol. - Google Patents

Procedimiento para la fabricacion de un dodecahidroisoquinolino-alfa,alfa'diamino-alcohol.

Info

Publication number
ES2154310T3
ES2154310T3 ES95114205T ES95114205T ES2154310T3 ES 2154310 T3 ES2154310 T3 ES 2154310T3 ES 95114205 T ES95114205 T ES 95114205T ES 95114205 T ES95114205 T ES 95114205T ES 2154310 T3 ES2154310 T3 ES 2154310T3
Authority
ES
Spain
Prior art keywords
alfa
diamino
alcohol
dodecahydroisoquinolino
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95114205T
Other languages
English (en)
Inventor
Hans Hilpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2154310T3 publication Critical patent/ES2154310T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

PROCESO PARA LA ELABORACION DE ALCOHOL AL , AL'' - DIAMINO DE LA FORMULA POR MEDIO DE ESTER L - FENILAMINA - ALQUILO INFERIOR N PROTEGIDO Y LAS CORRESPONDIENTES {AL} - AMINO - {AL''} HALOCETONAS N - PROTEGIDAS Y {AL} - AMINO - {AL''} HALOALCOHOL.
ES95114205T 1994-09-23 1995-09-11 Procedimiento para la fabricacion de un dodecahidroisoquinolino-alfa,alfa'diamino-alcohol. Expired - Lifetime ES2154310T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH290494 1994-09-23
CH373694 1994-12-09

Publications (1)

Publication Number Publication Date
ES2154310T3 true ES2154310T3 (es) 2001-04-01

Family

ID=25691689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95114205T Expired - Lifetime ES2154310T3 (es) 1994-09-23 1995-09-11 Procedimiento para la fabricacion de un dodecahidroisoquinolino-alfa,alfa'diamino-alcohol.

Country Status (9)

Country Link
US (5) US5591885A (es)
EP (1) EP0710651B1 (es)
JP (1) JP3819955B2 (es)
KR (1) KR100418237B1 (es)
CN (3) CN1116284C (es)
AT (1) ATE198740T1 (es)
DE (1) DE59508973D1 (es)
DK (1) DK0710651T3 (es)
ES (1) ES2154310T3 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
US5929284A (en) * 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
KR19980703369A (ko) * 1996-01-29 1998-10-15 후루따 다께시 카르보닐 화합물의 환원 방법
ES2194145T3 (es) 1996-12-11 2003-11-16 Hoffmann La Roche Procedimiento para la obtencion de anhidridos mixtos.
JP4482783B2 (ja) * 1999-01-28 2010-06-16 味の素株式会社 α−アミノケトン類の製造方法
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
US7038553B2 (en) * 2002-10-03 2006-05-02 International Business Machines Corporation Scalable computer system having surface-mounted capacitive couplers for intercommunication
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
PL2328883T3 (pl) * 2008-09-24 2015-01-30 Zach System Sposób wytwarzania nebivololu
CN102127061B (zh) * 2010-01-15 2016-02-17 浙江华海药业股份有限公司 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
JP2551901B2 (ja) * 1991-07-26 1996-11-06 エフ エム シー コーポレーション 接触アルキル化方法
JPH06184069A (ja) * 1991-11-19 1994-07-05 Lonza Ag α−ヒドロキシ−β−アミノカルボン酸の製造方法
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
DE59407243D1 (de) * 1993-07-15 1998-12-10 Hoffmann La Roche Verfahren zur Herstellung eines N-tert.Butylamids
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols

Also Published As

Publication number Publication date
US5977388A (en) 1999-11-02
CN1275563A (zh) 2000-12-06
CN1116284C (zh) 2003-07-30
CN1133620C (zh) 2004-01-07
US5684176A (en) 1997-11-04
EP0710651B1 (de) 2001-01-17
CN1275562A (zh) 2000-12-06
JP3819955B2 (ja) 2006-09-13
JPH0899959A (ja) 1996-04-16
ATE198740T1 (de) 2001-02-15
CN1127251A (zh) 1996-07-24
KR100418237B1 (ko) 2004-07-23
US5965733A (en) 1999-10-12
DE59508973D1 (de) 2001-02-22
DK0710651T3 (da) 2001-05-14
US5847144A (en) 1998-12-08
KR960010629A (ko) 1996-04-20
US5591885A (en) 1997-01-07
CN1111156C (zh) 2003-06-11
EP0710651A1 (de) 1996-05-08

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