NO306059B1 - Fremgangsmåte for racematspaltning av tramadol - Google Patents

Fremgangsmåte for racematspaltning av tramadol

Info

Publication number
NO306059B1
NO306059B1 NO970211A NO970211A NO306059B1 NO 306059 B1 NO306059 B1 NO 306059B1 NO 970211 A NO970211 A NO 970211A NO 970211 A NO970211 A NO 970211A NO 306059 B1 NO306059 B1 NO 306059B1
Authority
NO
Norway
Prior art keywords
tramadol
racemate cleavage
racemate
cleavage
Prior art date
Application number
NO970211A
Other languages
English (en)
Other versions
NO970211D0 (no
NO970211L (no
Inventor
Helmut Buschmann
Werner Winter
Ivars Graudums
Peter Jansen
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of NO970211D0 publication Critical patent/NO970211D0/no
Publication of NO970211L publication Critical patent/NO970211L/no
Publication of NO306059B1 publication Critical patent/NO306059B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO970211A 1996-01-19 1997-01-17 Fremgangsmåte for racematspaltning av tramadol NO306059B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (3)

Publication Number Publication Date
NO970211D0 NO970211D0 (no) 1997-01-17
NO970211L NO970211L (no) 1997-07-21
NO306059B1 true NO306059B1 (no) 1999-09-13

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970211A NO306059B1 (no) 1996-01-19 1997-01-17 Fremgangsmåte for racematspaltning av tramadol

Country Status (31)

Country Link
US (1) US5723668A (no)
EP (1) EP0787715B1 (no)
JP (1) JPH09216858A (no)
KR (1) KR100505527B1 (no)
CN (1) CN1131203C (no)
AR (1) AR005391A1 (no)
AT (1) ATE189205T1 (no)
AU (1) AU711750B2 (no)
BR (1) BR9700094A (no)
CA (1) CA2195370C (no)
CO (1) CO4520185A1 (no)
CZ (1) CZ291775B6 (no)
DE (2) DE19601745C1 (no)
DK (1) DK0787715T3 (no)
ES (1) ES2145373T3 (no)
GR (1) GR3032489T3 (no)
HU (1) HU223067B1 (no)
IL (1) IL120028A (no)
IN (1) IN182218B (no)
MY (1) MY116583A (no)
NO (1) NO306059B1 (no)
NZ (1) NZ299999A (no)
PE (1) PE29898A1 (no)
PL (1) PL187403B1 (no)
PT (1) PT787715E (no)
RU (1) RU2192407C2 (no)
SI (1) SI0787715T1 (no)
SK (1) SK281612B6 (no)
UA (1) UA45343C2 (no)
UY (1) UY24439A1 (no)
ZA (1) ZA97369B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
CA2295884A1 (en) 1997-07-15 1999-01-28 Russinsky Limited Tramadol, salts thereof and process for their preparation
DE19821039A1 (de) 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
BR0114395A (pt) * 2000-10-03 2005-08-16 Penwest Pharmaceuticals Compan Composição farmacêutica para administração por suprimento via oral
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
EP2489658B1 (en) 2005-01-26 2014-04-09 Allergan, Inc. 3-Heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimulant activity
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
KR20140054312A (ko) * 2007-02-12 2014-05-08 디엠아이 바이오사이언시스 인코포레이티드 조루 및 발기부전을 동시에 치료하는 방법
EP2486921A1 (en) * 2007-02-12 2012-08-15 DMI Biosciences, Inc. Reducing Side Effects of Tramadol
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
SK281612B6 (sk) 2001-05-10
PT787715E (pt) 2000-06-30
HUP9700141A2 (hu) 1998-01-28
IL120028A0 (en) 1997-04-15
KR970059155A (ko) 1997-08-12
DK0787715T3 (da) 2000-04-25
UY24439A1 (es) 1997-01-30
KR100505527B1 (ko) 2005-10-19
SI0787715T1 (en) 2000-04-30
HUP9700141A3 (en) 2000-03-28
CZ291775B6 (cs) 2003-05-14
CA2195370C (en) 2005-07-12
GR3032489T3 (en) 2000-05-31
RU2192407C2 (ru) 2002-11-10
CN1161957A (zh) 1997-10-15
JPH09216858A (ja) 1997-08-19
DE19601745C1 (de) 1997-10-09
NO970211D0 (no) 1997-01-17
SK6897A3 (en) 1997-08-06
HU9700141D0 (en) 1997-03-28
AR005391A1 (es) 1999-04-28
AU1223297A (en) 1997-07-24
ES2145373T3 (es) 2000-07-01
MX9700483A (es) 1997-07-31
HU223067B1 (hu) 2004-03-01
CO4520185A1 (es) 1997-10-15
PL318003A1 (en) 1997-07-21
MY116583A (en) 2004-02-28
ZA97369B (en) 1997-07-29
CZ15697A3 (cs) 1998-05-13
IL120028A (en) 1999-12-22
CA2195370A1 (en) 1997-07-20
UA45343C2 (uk) 2002-04-15
AU711750B2 (en) 1999-10-21
IN182218B (no) 1999-02-06
US5723668A (en) 1998-03-03
EP0787715A1 (de) 1997-08-06
EP0787715B1 (de) 2000-01-26
CN1131203C (zh) 2003-12-17
PL187403B1 (pl) 2004-07-30
ATE189205T1 (de) 2000-02-15
DE59604295D1 (de) 2000-03-02
BR9700094A (pt) 1998-09-22
NO970211L (no) 1997-07-21
NZ299999A (en) 1998-01-26
PE29898A1 (es) 1998-08-08

Similar Documents

Publication Publication Date Title
NO306059B1 (no) Fremgangsmåte for racematspaltning av tramadol
DK0754756T3 (da) Fremgangsmåde til fremstilling af L-lysin
ID17271A (id) Proses untuk pengubahan etilbenzena
NO990756D0 (no) FremgangsmÕte for fremstilling av mellomprodukter for florfenikol
DE69800912D1 (de) Verfahren zur Herstellung von Ceramidverbindungen
ITMI951445A0 (it) Procedimento per la produzione di carbammati aromatici
NO306943B1 (no) Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol
DE69705333T2 (de) Verfahren zur Herstellung von Isophoron
BR9702501A (pt) Método para a produção de borrachas hidrogenadas
DK0874822T3 (da) Ny fremgangsmåde til fremstilling
PT880498E (pt) Processo para a preparacao de compostos dicetonicos
IT1289763B1 (it) Processo per la produziond di cefazolina
EE200000055A (et) Protsess tsüklopropüülatsetüleeni valmistamiseks
DK0690133T3 (da) Fremgangsmåde til enzymatisk spaltning af 2-amino-4-methylphosphinobutansyreamid-derivater
BR9408521A (pt) Método para sintetizar gama-pironas
AU3322097A (en) Process for the production of the isomers(R) and (S)-alpha-methyl-3(trifluoromethyl)benzeneethanamine
DE69518027T2 (de) Verfahren zur Herstellung von Acrylamid
NO20001896L (no) FremgangsmÕte for syntese av klorpurinmellomprodukter
ID22430A (id) Proses pembuatan senyawa-senyawa benzotiazolona
NO20003214D0 (no) FremgangsmÕte for fremstilling av elastomerer
BR9710391A (pt) Processo para prepara-Æo de fenetilaminas rac-micas
FI972694A (fi) Uusi menetelmä sameridiinin valmistamiseksi
IS5523A (is) Aðferð til að framleiða ísóprópýl-metýl-[2-(3-n-própoxýfenoxý)-etýl]amín
DK0852578T3 (da) Fremgangsmåde til fremstilling af visse acetonitriler
MD146B1 (ro) Procedeu pentru producerea alcoolului etilic

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees