UY24439A1 - Un procedimiento para el desdoblamiento de los racematos del tramadol - Google Patents

Un procedimiento para el desdoblamiento de los racematos del tramadol

Info

Publication number
UY24439A1
UY24439A1 UY24439A UY24439A UY24439A1 UY 24439 A1 UY24439 A1 UY 24439A1 UY 24439 A UY24439 A UY 24439A UY 24439 A UY24439 A UY 24439A UY 24439 A1 UY24439 A1 UY 24439A1
Authority
UY
Uruguay
Prior art keywords
tramadol
enantiomer
racemic
racemates
procedure
Prior art date
Application number
UY24439A
Other languages
English (en)
Inventor
Helmut Buschmann Dr
Dr Wolfgang Werner Alfred Strassburger Prof
Elmar Josef Friderichs Dr
Ivars Graudums Dr
Peter Jansen
De Werner Winter Prof
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of UY24439A1 publication Critical patent/UY24439A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento para el desdoblamiento de racematos del tramadol, caracterizado porque una sal racémica de tramadol se convierte una solución de base de tramadol racémico; se separa el enantiómero(-) de tramadol de la solución de base libre de tramadol racémico por precipitación selectiva con ácido L-(+) tartárico dejando aguas madres que contienen enantiómero (+) de tramadol; y de las aguas madres se separa la base libre de enantiòmero (+) de tramadol en una sal distinta de tartrato. La finalidad de la presente invención consiste entonces en desarrollar un procedimiento para el desdoblamiento de los racematos del tramadol mediante el cual puedan obtenerse los enantiómeros del tramadol evitando los inconvenientes conocidos relacionados con la utilización del ácido dibenzoil tartárico, con rendimientos elevados y constantes y altas purezas de enantiómeros. Ejemplo no limitante (figura 1): Clorhidraro de (-)-(1S,2S)-2-dimetilaminometil-1-(3-metoxifenil)-ciclohexanol (-1)
UY24439A 1996-01-19 1997-01-10 Un procedimiento para el desdoblamiento de los racematos del tramadol UY24439A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (1)

Publication Number Publication Date
UY24439A1 true UY24439A1 (es) 1997-01-30

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24439A UY24439A1 (es) 1996-01-19 1997-01-10 Un procedimiento para el desdoblamiento de los racematos del tramadol

Country Status (31)

Country Link
US (1) US5723668A (es)
EP (1) EP0787715B1 (es)
JP (1) JPH09216858A (es)
KR (1) KR100505527B1 (es)
CN (1) CN1131203C (es)
AR (1) AR005391A1 (es)
AT (1) ATE189205T1 (es)
AU (1) AU711750B2 (es)
BR (1) BR9700094A (es)
CA (1) CA2195370C (es)
CO (1) CO4520185A1 (es)
CZ (1) CZ291775B6 (es)
DE (2) DE19601745C1 (es)
DK (1) DK0787715T3 (es)
ES (1) ES2145373T3 (es)
GR (1) GR3032489T3 (es)
HU (1) HU223067B1 (es)
IL (1) IL120028A (es)
IN (1) IN182218B (es)
MY (1) MY116583A (es)
NO (1) NO306059B1 (es)
NZ (1) NZ299999A (es)
PE (1) PE29898A1 (es)
PL (1) PL187403B1 (es)
PT (1) PT787715E (es)
RU (1) RU2192407C2 (es)
SI (1) SI0787715T1 (es)
SK (1) SK281612B6 (es)
UA (1) UA45343C2 (es)
UY (1) UY24439A1 (es)
ZA (1) ZA97369B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) * 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
JP2001510180A (ja) 1997-07-15 2001-07-31 ラシンスキィ・リミテッド トラマドール、その塩酸塩、及びそれらの製造方法
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
EP1322303A1 (en) * 2000-10-03 2003-07-02 Penwest Pharmaceuticals Co. Delivery system for multi-pharmaceutical active materials at various release rates
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
HUE028654T2 (en) 2005-01-26 2016-12-28 Allergan Inc 3-aryl-3-hydroxy-2-aminopropionic amides, 3-heteroaryl-3-hydroxy-2-aminopropionic amides and related compounds having analgesic and / or immunostimulating activity
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
NZ579170A (en) 2007-02-12 2012-05-25 Dmi Biosciences Inc Reducing side effects of tramadol
EP2120570B1 (en) 2007-02-12 2012-05-16 DMI Biosciences, Inc. Treatment of comorbid premature ejaculation and erectile dysfunction
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
SK6897A3 (en) 1997-08-06
JPH09216858A (ja) 1997-08-19
NO970211D0 (no) 1997-01-17
PE29898A1 (es) 1998-08-08
NO970211L (no) 1997-07-21
CN1131203C (zh) 2003-12-17
CA2195370C (en) 2005-07-12
ZA97369B (en) 1997-07-29
HU9700141D0 (en) 1997-03-28
CN1161957A (zh) 1997-10-15
CZ15697A3 (cs) 1998-05-13
IN182218B (es) 1999-02-06
RU2192407C2 (ru) 2002-11-10
HU223067B1 (hu) 2004-03-01
SK281612B6 (sk) 2001-05-10
CZ291775B6 (cs) 2003-05-14
AU1223297A (en) 1997-07-24
KR100505527B1 (ko) 2005-10-19
DE59604295D1 (de) 2000-03-02
EP0787715B1 (de) 2000-01-26
CO4520185A1 (es) 1997-10-15
PL318003A1 (en) 1997-07-21
IL120028A (en) 1999-12-22
BR9700094A (pt) 1998-09-22
PT787715E (pt) 2000-06-30
ES2145373T3 (es) 2000-07-01
EP0787715A1 (de) 1997-08-06
MX9700483A (es) 1997-07-31
AU711750B2 (en) 1999-10-21
HUP9700141A2 (hu) 1998-01-28
CA2195370A1 (en) 1997-07-20
KR970059155A (ko) 1997-08-12
DK0787715T3 (da) 2000-04-25
IL120028A0 (en) 1997-04-15
HUP9700141A3 (en) 2000-03-28
DE19601745C1 (de) 1997-10-09
NZ299999A (en) 1998-01-26
PL187403B1 (pl) 2004-07-30
ATE189205T1 (de) 2000-02-15
MY116583A (en) 2004-02-28
SI0787715T1 (en) 2000-04-30
GR3032489T3 (en) 2000-05-31
NO306059B1 (no) 1999-09-13
AR005391A1 (es) 1999-04-28
US5723668A (en) 1998-03-03
UA45343C2 (uk) 2002-04-15

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Effective date: 20170110