IL120028A - Method of separating the racemate of tramadol - Google Patents

Method of separating the racemate of tramadol

Info

Publication number
IL120028A
IL120028A IL12002897A IL12002897A IL120028A IL 120028 A IL120028 A IL 120028A IL 12002897 A IL12002897 A IL 12002897A IL 12002897 A IL12002897 A IL 12002897A IL 120028 A IL120028 A IL 120028A
Authority
IL
Israel
Prior art keywords
tramadol
racemate
separating
Prior art date
Application number
IL12002897A
Other languages
English (en)
Other versions
IL120028A0 (en
Inventor
Helmut Buschmann
Werner Winter
Ivars Graudums
Peter Jansen
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of IL120028A0 publication Critical patent/IL120028A0/xx
Publication of IL120028A publication Critical patent/IL120028A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL12002897A 1996-01-19 1997-01-17 Method of separating the racemate of tramadol IL120028A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (2)

Publication Number Publication Date
IL120028A0 IL120028A0 (en) 1997-04-15
IL120028A true IL120028A (en) 1999-12-22

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12002897A IL120028A (en) 1996-01-19 1997-01-17 Method of separating the racemate of tramadol

Country Status (31)

Country Link
US (1) US5723668A (xx)
EP (1) EP0787715B1 (xx)
JP (1) JPH09216858A (xx)
KR (1) KR100505527B1 (xx)
CN (1) CN1131203C (xx)
AR (1) AR005391A1 (xx)
AT (1) ATE189205T1 (xx)
AU (1) AU711750B2 (xx)
BR (1) BR9700094A (xx)
CA (1) CA2195370C (xx)
CO (1) CO4520185A1 (xx)
CZ (1) CZ291775B6 (xx)
DE (2) DE19601745C1 (xx)
DK (1) DK0787715T3 (xx)
ES (1) ES2145373T3 (xx)
GR (1) GR3032489T3 (xx)
HU (1) HU223067B1 (xx)
IL (1) IL120028A (xx)
IN (1) IN182218B (xx)
MY (1) MY116583A (xx)
NO (1) NO306059B1 (xx)
NZ (1) NZ299999A (xx)
PE (1) PE29898A1 (xx)
PL (1) PL187403B1 (xx)
PT (1) PT787715E (xx)
RU (1) RU2192407C2 (xx)
SI (1) SI0787715T1 (xx)
SK (1) SK281612B6 (xx)
UA (1) UA45343C2 (xx)
UY (1) UY24439A1 (xx)
ZA (1) ZA97369B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) * 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
DK0996613T3 (da) * 1997-07-15 2003-03-03 Russinsky Ltd Fremstilling af rent cis-tramadol-hydrochlorid
DE19821039A1 (de) 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
AU9497901A (en) * 2000-10-03 2002-04-15 Penwest Pharmaceuticals Compan Delivery system for multi-pharmaceutical active materials at various release rates
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
US6974839B2 (en) 2001-03-16 2005-12-13 Dmi Biosciences, Inc. Method of delaying ejaculation
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
US6780891B2 (en) 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
BRPI0607304A2 (pt) 2005-01-26 2009-08-25 Allergan Inc compostos tendo atividade analgésica e/ou imunoestimulante
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
CA2677690C (en) * 2007-02-12 2012-05-15 James V. Winkler Treatment of comorbid premature ejaculation and erectile dysfunction
WO2008100933A2 (en) 2007-02-12 2008-08-21 Dmi Biosciences, Inc. Reducing side effects of tramadol
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
UY24439A1 (es) 1997-01-30
IL120028A0 (en) 1997-04-15
MY116583A (en) 2004-02-28
BR9700094A (pt) 1998-09-22
SK281612B6 (sk) 2001-05-10
IN182218B (xx) 1999-02-06
CZ291775B6 (cs) 2003-05-14
CN1131203C (zh) 2003-12-17
KR100505527B1 (ko) 2005-10-19
NO970211D0 (no) 1997-01-17
EP0787715B1 (de) 2000-01-26
HU9700141D0 (en) 1997-03-28
HUP9700141A2 (hu) 1998-01-28
KR970059155A (ko) 1997-08-12
CA2195370C (en) 2005-07-12
UA45343C2 (uk) 2002-04-15
CN1161957A (zh) 1997-10-15
DE19601745C1 (de) 1997-10-09
SI0787715T1 (en) 2000-04-30
NO306059B1 (no) 1999-09-13
HUP9700141A3 (en) 2000-03-28
ZA97369B (en) 1997-07-29
HU223067B1 (hu) 2004-03-01
AR005391A1 (es) 1999-04-28
AU1223297A (en) 1997-07-24
ES2145373T3 (es) 2000-07-01
EP0787715A1 (de) 1997-08-06
JPH09216858A (ja) 1997-08-19
PL318003A1 (en) 1997-07-21
SK6897A3 (en) 1997-08-06
US5723668A (en) 1998-03-03
PL187403B1 (pl) 2004-07-30
DE59604295D1 (de) 2000-03-02
MX9700483A (es) 1997-07-31
PT787715E (pt) 2000-06-30
DK0787715T3 (da) 2000-04-25
AU711750B2 (en) 1999-10-21
GR3032489T3 (en) 2000-05-31
PE29898A1 (es) 1998-08-08
NO970211L (no) 1997-07-21
CO4520185A1 (es) 1997-10-15
CA2195370A1 (en) 1997-07-20
ATE189205T1 (de) 2000-02-15
NZ299999A (en) 1998-01-26
RU2192407C2 (ru) 2002-11-10
CZ15697A3 (cs) 1998-05-13

Similar Documents

Publication Publication Date Title
GB9600464D0 (en) Novel method
GB9521447D0 (en) Method
IL120028A0 (en) Method of separating the racemate of tramadol
AP9500717A0 (en) Novel method
GB2289946B (en) Method
IL119612A0 (en) Method for the production of khalas
GB9414624D0 (en) Novel method
GB9417135D0 (en) Method
GB9415073D0 (en) Novel method
HUP9901029A3 (en) Method for the production of rdspa alfa1
IL127970A (en) Process for the preparation of racemic phenethylamines
GB9507229D0 (en) Novel method
GB9609722D0 (en) Novel method
GB9621751D0 (en) Method of separation
GB9604465D0 (en) Novel method
GB9424723D0 (en) Method
GB9401566D0 (en) Method
GB9425041D0 (en) Enantiomer separation
GB9408267D0 (en) Separation method
GB9426019D0 (en) Novel method
GB9406789D0 (en) Novel method
GB9410214D0 (en) Novel method
GB9421473D0 (en) Novel method
GB9402624D0 (en) Novel method
GB9402623D0 (en) Novel method

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees