DE1929107C3 - Antibiotika Axenomycin A und B, Verfahren zu deren Herstellung und ein die Antibiotika enthaltendes Arzneimittel - Google Patents
Antibiotika Axenomycin A und B, Verfahren zu deren Herstellung und ein die Antibiotika enthaltendes ArzneimittelInfo
- Publication number
- DE1929107C3 DE1929107C3 DE1929107A DE1929107A DE1929107C3 DE 1929107 C3 DE1929107 C3 DE 1929107C3 DE 1929107 A DE1929107 A DE 1929107A DE 1929107 A DE1929107 A DE 1929107A DE 1929107 C3 DE1929107 C3 DE 1929107C3
- Authority
- DE
- Germany
- Prior art keywords
- axenomycin
- antibiotics
- methanol
- salts
- following wavelengths
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 239000003242 anti bacterial agent Substances 0.000 title claims description 16
- 229940088710 antibiotic agent Drugs 0.000 title claims description 16
- 238000000034 method Methods 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title description 4
- 239000003814 drug Substances 0.000 title description 3
- 229940079593 drug Drugs 0.000 title description 2
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- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 239000001963 growth medium Substances 0.000 claims description 11
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- 239000000047 product Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- HAAYBYDROVFKPU-UHFFFAOYSA-N silver;azane;nitrate Chemical compound N.N.[Ag+].[O-][N+]([O-])=O HAAYBYDROVFKPU-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
- G21F7/00—Shielded cells or rooms
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1757068 | 1968-06-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1929107A1 DE1929107A1 (de) | 1970-02-19 |
| DE1929107B2 DE1929107B2 (de) | 1978-02-09 |
| DE1929107C3 true DE1929107C3 (de) | 1978-10-12 |
Family
ID=11150434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1929107A Expired DE1929107C3 (de) | 1968-06-11 | 1969-06-09 | Antibiotika Axenomycin A und B, Verfahren zu deren Herstellung und ein die Antibiotika enthaltendes Arzneimittel |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT285817B (enExample) |
| BE (1) | BE734341A (enExample) |
| BR (1) | BR6909580D0 (enExample) |
| CH (1) | CH506619A (enExample) |
| CS (1) | CS178807B2 (enExample) |
| DE (1) | DE1929107C3 (enExample) |
| DK (1) | DK120716B (enExample) |
| ES (1) | ES368198A1 (enExample) |
| FR (1) | FR2010640A1 (enExample) |
| GB (1) | GB1219709A (enExample) |
| IE (1) | IE32866B1 (enExample) |
| IL (1) | IL32358A (enExample) |
| NL (1) | NL153271B (enExample) |
| NO (1) | NO127927B (enExample) |
| SE (1) | SE354483B (enExample) |
| YU (1) | YU34212B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1044819B (it) * | 1970-05-04 | 1980-04-21 | Farmaceutici Italia | Composto antibiotico |
-
1969
- 1969-05-30 NL NL696908269A patent/NL153271B/xx unknown
- 1969-06-06 GB GB28849/69A patent/GB1219709A/en not_active Expired
- 1969-06-06 IL IL32358A patent/IL32358A/xx unknown
- 1969-06-06 CS CS6900004032A patent/CS178807B2/cs unknown
- 1969-06-06 FR FR6918667A patent/FR2010640A1/fr not_active Withdrawn
- 1969-06-06 IE IE769/69A patent/IE32866B1/xx unknown
- 1969-06-09 NO NO02366/69A patent/NO127927B/no unknown
- 1969-06-09 DK DK310069AA patent/DK120716B/da unknown
- 1969-06-09 BR BR209580/69A patent/BR6909580D0/pt unknown
- 1969-06-09 AT AT544069A patent/AT285817B/de not_active IP Right Cessation
- 1969-06-09 YU YU1444/69A patent/YU34212B/xx unknown
- 1969-06-09 SE SE08124/69A patent/SE354483B/xx unknown
- 1969-06-09 DE DE1929107A patent/DE1929107C3/de not_active Expired
- 1969-06-10 CH CH882169A patent/CH506619A/de not_active IP Right Cessation
- 1969-06-10 BE BE734341D patent/BE734341A/xx unknown
- 1969-06-10 ES ES368198A patent/ES368198A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| YU34212B (en) | 1979-02-28 |
| DE1929107A1 (de) | 1970-02-19 |
| BR6909580D0 (pt) | 1973-04-19 |
| NO127927B (enExample) | 1973-09-03 |
| FR2010640A1 (enExample) | 1970-02-20 |
| BE734341A (enExample) | 1969-12-10 |
| NL153271B (nl) | 1977-05-16 |
| NL6908269A (enExample) | 1969-12-15 |
| IE32866L (en) | 1969-12-11 |
| IL32358A (en) | 1972-11-28 |
| DK120716B (da) | 1971-07-05 |
| IE32866B1 (en) | 1973-12-28 |
| CH506619A (de) | 1971-04-30 |
| AT285817B (de) | 1970-11-10 |
| ES368198A1 (es) | 1971-05-01 |
| CS178807B2 (en) | 1977-10-31 |
| IL32358A0 (en) | 1969-08-27 |
| YU144469A (en) | 1978-06-30 |
| SE354483B (enExample) | 1973-03-12 |
| GB1219709A (en) | 1971-01-20 |
| DE1929107B2 (de) | 1978-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| EHJ | Ceased/non-payment of the annual fee |