DE1920037A1 - Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben - Google Patents

Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben

Info

Publication number
DE1920037A1
DE1920037A1 DE19691920037 DE1920037A DE1920037A1 DE 1920037 A1 DE1920037 A1 DE 1920037A1 DE 19691920037 DE19691920037 DE 19691920037 DE 1920037 A DE1920037 A DE 1920037A DE 1920037 A1 DE1920037 A1 DE 1920037A1
Authority
DE
Germany
Prior art keywords
pyridyl
oxadiazole
acid
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691920037
Other languages
German (de)
English (en)
Inventor
Korbonits Dipl-Ing Chem Dezsoe
Leszkovszky Dr Med Gyoergy
Reiter Dipl-Ing Chem Jozsef
Harsanyi Dipl-Ing Chem Kalman
Takacs Dipl-Ing Chem Kalman
Tardos Dr Med Laszlo
Csaba Vertesy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of DE1920037A1 publication Critical patent/DE1920037A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
DE19691920037 1968-04-26 1969-04-19 Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben Pending DE1920037A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000796 1968-04-26

Publications (1)

Publication Number Publication Date
DE1920037A1 true DE1920037A1 (de) 1970-11-12

Family

ID=10994349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691920037 Pending DE1920037A1 (de) 1968-04-26 1969-04-19 Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben

Country Status (15)

Country Link
US (1) US3647809A (enExample)
JP (1) JPS4824394B1 (enExample)
AT (2) AT292727B (enExample)
BE (1) BE732131A (enExample)
BR (1) BR6908381D0 (enExample)
CA (1) CA954858A (enExample)
CH (2) CH540925A (enExample)
DE (1) DE1920037A1 (enExample)
FR (1) FR2007529B1 (enExample)
GB (1) GB1271302A (enExample)
IL (1) IL31990A (enExample)
NL (1) NL6906401A (enExample)
NO (1) NO124253B (enExample)
PL (1) PL79435B1 (enExample)
SE (1) SE368576B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2625848A1 (de) * 1975-06-09 1976-12-16 Eszakmagyar Vegyimuevek Substituierte 1,2,4-oxadiazolidin-3- on-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel

Families Citing this family (38)

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US3853893A (en) * 1973-04-02 1974-12-10 Squibb & Sons Inc Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
ATE307129T1 (de) * 1999-08-19 2005-11-15 Nps Pharma Inc Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
AU2003264018A1 (en) 2002-08-09 2004-02-25 Astrazeneca Ab Compounds having an activity at metabotropic glutamate receptors
AU2004229392A1 (en) * 2003-04-09 2004-10-28 Exelixis, Inc. Tie-2 modulators and methods of use
CA2524867A1 (en) * 2003-05-15 2004-12-02 Merck & Co., Inc. 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
US20060189661A1 (en) * 2003-11-03 2006-08-24 Wagenen Bradford V Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
US8207147B2 (en) * 2003-12-24 2012-06-26 Prosidion Limited Heterocyclic derivatives as GPCR receptor agonists
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
CA2606087A1 (en) * 2005-04-26 2006-11-02 Neurosearch A/S Novel oxadiazole derivatives and their medical use
IL169855A (en) * 2005-07-25 2014-05-28 Elta Systems Ltd A system and method for locating a receiver location
WO2007013830A1 (en) 2005-07-26 2007-02-01 Portela & Ca. S.A. Nitrocatechol derivatives as comt inhibitors
EP1845097A1 (en) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
JP5253401B2 (ja) * 2006-09-07 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−４−イル誘導体
CL2007002594A1 (es) * 2006-09-08 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
DK2481410T3 (en) * 2007-01-31 2016-10-24 Bial - Portela & Ca S A Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen
DK2125797T3 (da) * 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
EP2195311B1 (en) * 2007-08-17 2011-03-23 Actelion Pharmaceuticals Ltd. Pyridine derivatives as s1p1/edg1 receptor modulators
EP2259777A2 (en) * 2008-02-28 2010-12-15 BIAL - Portela & Ca., S.A. Pharmaceutical composition for poorly soluble drugs
CN101965345B (zh) * 2008-03-06 2014-05-28 埃科特莱茵药品有限公司 吡啶化合物
JP5435745B2 (ja) * 2008-03-07 2014-03-05 アクテリオン ファーマシューティカルズ リミテッド 免疫調節剤としてのピリジン−２−イル誘導体
BRPI0908731A2 (pt) 2008-03-17 2017-05-16 Bial - Portela & C A S A formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol
PT2291080E (pt) * 2008-05-14 2015-10-30 Scripps Research Inst Novos modelamodeladores dos recetores da esfingosina fosfato
HUE025314T2 (en) 2009-02-10 2016-02-29 Monsanto Technology Llc Preparations and procedures for controlling nematodes
CN102448444B (zh) 2009-04-01 2016-05-25 巴尔-波特拉及康邦亚股份有限公司 包括硝基儿茶酚衍生物的药物制剂及其制备方法
PT2413913T (pt) * 2009-04-01 2022-06-09 Bial Portela & Ca Sa Formulações farmacêuticas que compreendem derivados de nitrocatecol e métodos para os preparar
TWI410421B (zh) 2009-07-16 2013-10-01 Actelion Pharmaceuticals Ltd 吡啶－４－基衍生物
CA2818470C (en) 2011-01-19 2019-03-05 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
US9126988B2 (en) 2011-12-13 2015-09-08 Bial—Portela & Ca, S.A. Intermediate for preparing a catechol-O-methyltransferase inhibitor
CN105143214B (zh) * 2013-02-15 2018-04-03 孟山都技术公司 用于控制线虫害虫的3,5‑二取代的‑4,5‑二氢‑1,2,4‑噁二唑
WO2016083863A1 (en) 2014-11-28 2016-06-02 Bial - Portela & Ca, S.A. Medicaments for slowing parkinson's disease
ES2770348T3 (es) 2015-05-20 2020-07-01 Idorsia Pharmaceuticals Ltd Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL120029C (enExample) * 1959-09-29
US3227725A (en) * 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2625848A1 (de) * 1975-06-09 1976-12-16 Eszakmagyar Vegyimuevek Substituierte 1,2,4-oxadiazolidin-3- on-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel

Also Published As

Publication number Publication date
JPS4824394B1 (enExample) 1973-07-20
CA954858A (en) 1974-09-17
PL79435B1 (en) 1975-06-30
IL31990A0 (en) 1969-06-25
SE368576B (enExample) 1974-07-08
FR2007529A1 (enExample) 1970-01-09
FR2007529B1 (enExample) 1973-03-16
US3647809A (en) 1972-03-07
BE732131A (enExample) 1969-10-01
GB1271302A (en) 1972-04-19
AT292728B (de) 1971-09-10
IL31990A (en) 1974-05-16
CH542232A (de) 1973-11-15
BR6908381D0 (pt) 1973-02-08
NL6906401A (enExample) 1969-10-28
NO124253B (enExample) 1972-03-27
AT292727B (de) 1971-09-10
CH540925A (de) 1973-08-31

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