DE1920037A1 - Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben - Google Patents

Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben

Info

Publication number
DE1920037A1
DE1920037A1 DE19691920037 DE1920037A DE1920037A1 DE 1920037 A1 DE1920037 A1 DE 1920037A1 DE 19691920037 DE19691920037 DE 19691920037 DE 1920037 A DE1920037 A DE 1920037A DE 1920037 A1 DE1920037 A1 DE 1920037A1
Authority
DE
Germany
Prior art keywords
pyridyl
oxadiazole
acid
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19691920037
Other languages
German (de)
English (en)
Inventor
Korbonits Dipl-Ing Chem Dezsoe
Leszkovszky Dr Med Gyoergy
Reiter Dipl-Ing Chem Jozsef
Harsanyi Dipl-Ing Chem Kalman
Takacs Dipl-Ing Chem Kalman
Tardos Dr Med Laszlo
Csaba Vertesy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of DE1920037A1 publication Critical patent/DE1920037A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
DE19691920037 1968-04-26 1969-04-19 Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben Pending DE1920037A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUCI000796 1968-04-26

Publications (1)

Publication Number Publication Date
DE1920037A1 true DE1920037A1 (de) 1970-11-12

Family

ID=10994349

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19691920037 Pending DE1920037A1 (de) 1968-04-26 1969-04-19 Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben

Country Status (15)

Country Link
US (1) US3647809A (enExample)
JP (1) JPS4824394B1 (enExample)
AT (2) AT292728B (enExample)
BE (1) BE732131A (enExample)
BR (1) BR6908381D0 (enExample)
CA (1) CA954858A (enExample)
CH (2) CH542232A (enExample)
DE (1) DE1920037A1 (enExample)
FR (1) FR2007529B1 (enExample)
GB (1) GB1271302A (enExample)
IL (1) IL31990A (enExample)
NL (1) NL6906401A (enExample)
NO (1) NO124253B (enExample)
PL (1) PL79435B1 (enExample)
SE (1) SE368576B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2625848A1 (de) * 1975-06-09 1976-12-16 Eszakmagyar Vegyimuevek Substituierte 1,2,4-oxadiazolidin-3- on-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853893A (en) * 1973-04-02 1974-12-10 Squibb & Sons Inc Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles
JPS58150576A (ja) * 1982-03-03 1983-09-07 Sumitomo Chem Co Ltd 新規な１，２，４−オキサジアゾ−ル誘導体
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US6660753B2 (en) * 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
ATE307129T1 (de) * 1999-08-19 2005-11-15 Nps Pharma Inc Heteropolycyclische verbindungen und ihre verwendung als antagonisten von metabotropen glutamatrezeptoren
EP1582519A3 (en) * 1999-08-19 2005-12-21 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
PL369598A1 (en) * 2001-02-21 2005-05-02 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
US7074809B2 (en) 2002-08-09 2006-07-11 Astrazeneca Ab Compounds
CA2520255C (en) * 2003-04-09 2014-07-08 Exelixis, Inc. Tie-2 modulators and methods of use
WO2004103279A2 (en) * 2003-05-15 2004-12-02 Merck & Co., Inc. 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists
US20060189661A1 (en) * 2003-11-03 2006-08-24 Wagenen Bradford V Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
NZ547965A (en) * 2003-12-24 2009-12-24 Prosidion Ltd 1,2,4-Oxadiazole derivatives as GPCR receptor agonists
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
JP2008539195A (ja) * 2005-04-26 2008-11-13 ノイロサーチ アクティーゼルスカブ 新規のオキサジアゾール誘導体及びそれらの医学的使用
IL169855A (en) * 2005-07-25 2014-05-28 Elta Systems Ltd A system and method for locating a receiver location
SI1907382T1 (sl) 2005-07-26 2015-10-30 Bial-Portela & Ca S.A., Nitrokateholni derivati kot inhibitorji COMT
EP1845097A1 (en) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
MY149853A (en) * 2006-09-07 2013-10-31 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives as immunomodulating agents
AR062684A1 (es) * 2006-09-08 2008-11-26 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3- ilo, composicion farmaceutica que los contiene, y uso de los mismos en la preparacion de medicamentos
ES2597705T3 (es) * 2007-01-31 2017-01-20 Bial - Portela & Ca., S.A. Derivados de nitrocatecol como inhibidores de COMT administrados con un régimen de dosificación específico
DK2125797T3 (da) * 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
HRP20110449T1 (hr) * 2007-08-17 2011-07-31 Actelion Pharmaceuticals Ltd. Derivati piridina kao modulatori receptora s1p1/edg1
EP2259777A2 (en) * 2008-02-28 2010-12-15 BIAL - Portela & Ca., S.A. Pharmaceutical composition for poorly soluble drugs
CA2714665A1 (en) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Pyridine compounds
JP5435745B2 (ja) * 2008-03-07 2014-03-05 アクテリオン ファーマシューティカルズ リミテッド 免疫調節剤としてのピリジン−２−イル誘導体
EP2276758B1 (en) 2008-03-17 2016-01-06 Bial-Portela & CA, S.A. Crystal forms of 5- [3- (2, 5-dichloro-4, 6-dimethyl-1-oxy-pyridine-3-yl) [1,2,4] oxadiazol-5-yl]-3-nit robenzene-1, 2-diol
PL2291080T3 (pl) * 2008-05-14 2015-12-31 Scripps Research Inst Nowe modulatory receptorów sfingozyno-1-fosforanu
ES2754503T3 (es) 2009-02-10 2020-04-17 Monsanto Technology Llc Composiciones y procedimientos de lucha contra nematodos
AU2010231962B2 (en) * 2009-04-01 2015-05-21 Bial - Portela & Ca., S.A. Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same
KR102329271B1 (ko) * 2009-04-01 2021-11-22 바이알 - 포르텔라 앤드 씨에이 에스에이 니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법
KR101409131B1 (ko) 2009-07-16 2014-06-17 액테리온 파마슈티칼 리미티드 피리딘-4-일 유도체
WO2012098505A1 (en) 2011-01-19 2012-07-26 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
PL2791134T3 (pl) 2011-12-13 2020-03-31 BIAL - PORTELA & Cª S.A. Związek chemiczny użyteczny jako związek pośredni do wytwarzania inhibitora katechol-o-metylotransferazy
US9232800B2 (en) * 2013-02-15 2016-01-12 Monsanto Technology Llc 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles and compositions and methods for controlling nematode pests
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
EP3298008B1 (en) 2015-05-20 2019-11-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL256329A (enExample) * 1959-09-29
US3227725A (en) * 1962-04-17 1966-01-04 Union Carbide Corp Certain 3,5-disubstituted 1,2,4-oxadiazole compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2625848A1 (de) * 1975-06-09 1976-12-16 Eszakmagyar Vegyimuevek Substituierte 1,2,4-oxadiazolidin-3- on-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als pflanzenschutzmittel

Also Published As

Publication number Publication date
FR2007529A1 (enExample) 1970-01-09
PL79435B1 (en) 1975-06-30
CH542232A (de) 1973-11-15
US3647809A (en) 1972-03-07
SE368576B (enExample) 1974-07-08
BE732131A (enExample) 1969-10-01
IL31990A0 (en) 1969-06-25
BR6908381D0 (pt) 1973-02-08
NO124253B (enExample) 1972-03-27
CH540925A (de) 1973-08-31
GB1271302A (en) 1972-04-19
AT292728B (de) 1971-09-10
IL31990A (en) 1974-05-16
CA954858A (en) 1974-09-17
FR2007529B1 (enExample) 1973-03-16
JPS4824394B1 (enExample) 1973-07-20
AT292727B (de) 1971-09-10
NL6906401A (enExample) 1969-10-28

Similar Documents

Publication Publication Date Title
DE1920037A1 (de) Neue 1,2,4-Oxadiazol-Derivate und Verfahren zur Herstellung derselben
DE3788145T2 (de) Piperidinderivate, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung.
DE69600221T2 (de) Naphthalinderivate, ihre Herstellungsverfahren und Zwischenprodukte dafür, und diese enthaltende pharmazeutische Zusammensetzungen
DD201589A5 (de) Verfahren zur herstellung von aminothiadiazolen
DE3106460A1 (de) 2(1h)-pyridinon-derivate, ihre herstellung und sie enthaltende pharmazeutische zubereitungen
DD213920A5 (de) Verfahren zur herstellung von dihydropyridinen
KR930004843B1 (ko) 이미다졸 유도체 및 이의 제조방법
DE2726796A1 (de) Neue substituierte pyridine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
EP0772593A1 (de) Pyridylthioverbindungen zur bekämpfung von helicobacter-bakterien
DE1134080B (de) Verfahren zur Herstellung von 1, 3, 4-Thiadiazolen
DE3601143A1 (de) Cyclische imidderivate von 2-(4-butylpiperazin-1-yl)-pyridinen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
DD207377A5 (de) Verfahren zur herstellung von neuen theophyllin-derivaten
DE3686149T2 (de) Phenylnaphthyridine mit einer funktionellen gruppe in position 3, verfahren zu ihrer herstellung, diese enthaltende arzneimittel besonders als anti-ulcus.
DE2707268A1 (de) Indol-3-carbaldehyd-oxime und verfahren zu ihrer herstellung
US4412077A (en) Process for preparing 5-(lower-alkanoyl)-6-(lower-alkyl)-2(1H)-pyridinone
CH556847A (de) Verfahren zur herstellung neuer chinazolinon-derivate.
EP0089022A2 (en) Alkanoylpyridinones useful as cardiotonics and preparation thereof
US3530137A (en) Certain alkyl and aryl ethers and thioethers of tropine and derivatives thereof
DD209194A5 (de) Verfahren zur herstellung von als histamin h tief 2-rezeptor-antagonisten wirkenden pyrimidon-derivaten
DE2811477A1 (de) 1,2,4-triazin-5-on-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE1945896A1 (de) Pyridoindol-Derivate
EP0237908B1 (de) Pyridinderivate
AT391695B (de) Neue verbindungen, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
DD149218A5 (de) Verfahren zur herstellung von neuen pyrido eckige klammer auf 3,4-e eckige klammer zu-as-triazin-derivaten
AT338787B (de) Verfahren zur herstellung von neuen heterocyclischen verbindungen

Legal Events

Date Code Title Description
OHN Withdrawal