DE1493887C3 - Alkanolaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel - Google Patents

Alkanolaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE1493887C3
DE1493887C3 DE1493887A DEJ0029095A DE1493887C3 DE 1493887 C3 DE1493887 C3 DE 1493887C3 DE 1493887 A DE1493887 A DE 1493887A DE J0029095 A DEJ0029095 A DE J0029095A DE 1493887 C3 DE1493887 C3 DE 1493887C3
Authority
DE
Germany
Prior art keywords
parts
mixture
propanol
acid
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1493887A
Other languages
German (de)
English (en)
Other versions
DE1493887A1 (de
DE1493887B2 (de
Inventor
Ralph Howe
Leslie Harold Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE1493887A1 publication Critical patent/DE1493887A1/de
Publication of DE1493887B2 publication Critical patent/DE1493887B2/de
Application granted granted Critical
Publication of DE1493887C3 publication Critical patent/DE1493887C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
DE1493887A 1964-09-30 1965-09-30 Alkanolaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel Expired DE1493887C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB39774/64A GB1078852A (en) 1964-09-30 1964-09-30 Alkanolamine derivatives

Publications (3)

Publication Number Publication Date
DE1493887A1 DE1493887A1 (de) 1972-06-15
DE1493887B2 DE1493887B2 (de) 1977-08-25
DE1493887C3 true DE1493887C3 (de) 1978-06-15

Family

ID=10411417

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1493887A Expired DE1493887C3 (de) 1964-09-30 1965-09-30 Alkanolaminderivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Country Status (13)

Country Link
US (1) US3408387A (enExample)
JP (2) JPS5031136B1 (enExample)
AT (2) AT261582B (enExample)
BE (1) BE670364A (enExample)
BR (1) BR6573584D0 (enExample)
CH (1) CH504407A (enExample)
DE (1) DE1493887C3 (enExample)
DK (2) DK113295B (enExample)
ES (2) ES318019A1 (enExample)
FR (1) FR5662M (enExample)
GB (1) GB1078852A (enExample)
NL (1) NL6512676A (enExample)
SE (1) SE313061B (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3857952A (en) * 1967-12-22 1974-12-31 May & Baker Ltd Certain benzene derivatives useful in treating cardiac disorders
ZA6808345B (en) * 1967-12-22 May & Baker Ltd Benzene derivatives
GB1269775A (en) * 1968-07-18 1972-04-06 Ici Ltd Alkanolamine derivatives
SE368197B (enExample) * 1968-11-18 1974-06-24 Pfizer
US3934032A (en) * 1969-02-21 1976-01-20 Imperial Chemical Industries Limited Alkanolamine derivatives for treating hypertension
US3873618A (en) * 1969-07-18 1975-03-25 Ici Ltd 1-{8 4-(4-Acetamidophenyl)phenoxy{9 -3-isopropyl-2-propanol
US4120978A (en) * 1970-01-08 1978-10-17 Ciba-Geigy Corporation Pharmaceutical composition for inhibiting and blocking cardioselective beta-receptors
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
US3864398A (en) * 1972-05-01 1975-02-04 Teikoku Hormone Mfg Co Ltd Process for the preparation of acylamino alkanol derivatives
JPS5323826B2 (enExample) * 1972-05-15 1978-07-17
FR2330383A1 (fr) * 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
US4064125A (en) * 1976-10-29 1977-12-20 E. R. Squibb And Sons, Inc. Substituted amides having antiinflammatory activity
US4177280A (en) * 1978-07-03 1979-12-04 Syntex (U.S.A.) Inc. Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents
DE2948056A1 (de) * 1979-11-29 1981-06-04 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4342783A (en) * 1980-06-30 1982-08-03 Synthelabo Anti-glaucoma agent
DE3640829A1 (de) * 1986-11-28 1988-06-09 Boehringer Ingelheim Kg Neue 1-aryloxy-3-amino-2-propanole, ihre herstellung und verwendung
GEP20074134B (en) 2002-08-19 2007-06-25 Pfizer Prod Inc Combination therapy for hyperproliferative diseases
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
DK3911648T3 (da) 2019-01-18 2025-01-13 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB922600A (en) * 1960-05-06 1963-04-03 Crookes Lab Ltd Ortho-tertiary-butyl phenolethers

Also Published As

Publication number Publication date
JPS5031136B1 (enExample) 1975-10-07
ES318019A1 (es) 1966-07-01
DE1493887A1 (de) 1972-06-15
DE1493887B2 (de) 1977-08-25
AT261586B (de) 1968-05-10
CH504407A (de) 1971-03-15
FR5662M (enExample) 1968-01-02
AT261582B (de) 1968-05-10
DK113295B (da) 1969-03-10
BE670364A (enExample) 1966-03-30
SE313061B (enExample) 1969-08-04
NL6512676A (enExample) 1966-03-31
US3408387A (en) 1968-10-29
ES358534A2 (es) 1970-07-01
DK122879B (da) 1972-04-24
BR6573584D0 (pt) 1973-08-02
JPS514978B1 (enExample) 1976-02-16
GB1078852A (en) 1967-08-09

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
EHJ Ceased/non-payment of the annual fee