DE1493054C3 - Verfahren zur Herstellung von 19-Nordelta hoch 4,9,(10) -3-keto-steroiden der Androstanreihe - Google Patents

Verfahren zur Herstellung von 19-Nordelta hoch 4,9,(10) -3-keto-steroiden der Androstanreihe

Info

Publication number
DE1493054C3
DE1493054C3 DE1493054A DES0097278A DE1493054C3 DE 1493054 C3 DE1493054 C3 DE 1493054C3 DE 1493054 A DE1493054 A DE 1493054A DE S0097278 A DES0097278 A DE S0097278A DE 1493054 C3 DE1493054 C3 DE 1493054C3
Authority
DE
Germany
Prior art keywords
carboxy
keto
steroids
steroid
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1493054A
Other languages
German (de)
English (en)
Other versions
DE1493054A1 (de
Inventor
Francisco Dr. Palo Alto Calif. Alvarez (V.St.A.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of DE1493054A1 publication Critical patent/DE1493054A1/de
Application granted granted Critical
Publication of DE1493054C3 publication Critical patent/DE1493054C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1493054A 1964-06-01 1965-05-25 Verfahren zur Herstellung von 19-Nordelta hoch 4,9,(10) -3-keto-steroiden der Androstanreihe Expired DE1493054C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX7727364 1964-06-01

Publications (2)

Publication Number Publication Date
DE1493054A1 DE1493054A1 (de) 1969-06-12
DE1493054C3 true DE1493054C3 (de) 1973-01-04

Family

ID=19743026

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1493054A Expired DE1493054C3 (de) 1964-06-01 1965-05-25 Verfahren zur Herstellung von 19-Nordelta hoch 4,9,(10) -3-keto-steroiden der Androstanreihe

Country Status (6)

Country Link
US (1) US3277122A (cg-RX-API-DMAC10.html)
CH (1) CH468985A (cg-RX-API-DMAC10.html)
DE (1) DE1493054C3 (cg-RX-API-DMAC10.html)
FR (1) FR1435502A (cg-RX-API-DMAC10.html)
GB (1) GB1090242A (cg-RX-API-DMAC10.html)
NL (2) NL6506952A (cg-RX-API-DMAC10.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3370071A (en) * 1965-06-01 1968-02-20 Merck & Co Inc 3-keto-13beta-alkyl-17beta-acetyl-gona-4, 9-dienes and process
CH488682A (de) * 1965-07-30 1970-04-15 Ciba Geigy Verfahren zur Herstellung von 4,9,11-Trienen der 19-Nor-androstanreihe
US3761591A (en) * 1970-02-20 1973-09-25 Roussel Uclaf Novel pregnadiene
FR2077877B1 (cg-RX-API-DMAC10.html) * 1970-02-20 1974-02-01 Roussel Uclaf
US3919267A (en) * 1970-03-03 1975-11-11 Roussel Uclaf 13{62 -ethyl-17{60 -methyl-18,19-dinor-{66 {hu 4,9{b -pregnadiene-3,20-dione
NL7710462A (nl) * 1977-09-26 1979-03-28 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de pregnaanreeks.

Also Published As

Publication number Publication date
NL125068C (cg-RX-API-DMAC10.html)
NL6506952A (cg-RX-API-DMAC10.html) 1965-12-02
FR1435502A (fr) 1966-04-15
GB1090242A (en) 1967-11-08
CH468985A (de) 1969-02-28
DE1493054A1 (de) 1969-06-12
US3277122A (en) 1966-10-04

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Legal Events

Date Code Title Description
SH Request for examination between 03.10.1968 and 22.04.1971
C3 Grant after two publication steps (3rd publication)