DE1468937A1 - Verfahren zur Herstellung von Derivaten von Antibiotica - Google Patents

Verfahren zur Herstellung von Derivaten von Antibiotica

Info

Publication number
DE1468937A1
DE1468937A1 DE19651468937 DE1468937A DE1468937A1 DE 1468937 A1 DE1468937 A1 DE 1468937A1 DE 19651468937 DE19651468937 DE 19651468937 DE 1468937 A DE1468937 A DE 1468937A DE 1468937 A1 DE1468937 A1 DE 1468937A1
Authority
DE
Germany
Prior art keywords
formaldehyde
antibiotic
reaction
solution
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19651468937
Other languages
German (de)
English (en)
Inventor
Pierre Crooij
Hubert Vanderhaeghe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIT RECH IND THERAPEUT
Original Assignee
RIT RECH IND THERAPEUT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1279062A external-priority patent/GB1033394A/en
Application filed by RIT RECH IND THERAPEUT filed Critical RIT RECH IND THERAPEUT
Publication of DE1468937A1 publication Critical patent/DE1468937A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
DE19651468937 1962-04-03 1965-10-15 Verfahren zur Herstellung von Derivaten von Antibiotica Pending DE1468937A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1279062A GB1033394A (en) 1962-04-03 1962-04-03 New therapeutic agents
GB3895362 1962-10-15
GB4378564A GB1055616A (en) 1962-04-03 1964-10-27 N-methylated derivatives of basic antibiotics

Publications (1)

Publication Number Publication Date
DE1468937A1 true DE1468937A1 (de) 1969-07-31

Family

ID=27256888

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19651468937 Pending DE1468937A1 (de) 1962-04-03 1965-10-15 Verfahren zur Herstellung von Derivaten von Antibiotica

Country Status (6)

Country Link
BE (1) BE671195A (enExample)
CH (1) CH429025A (enExample)
DE (1) DE1468937A1 (enExample)
FR (1) FR90368E (enExample)
GB (1) GB1055616A (enExample)
NL (1) NL6513380A (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3457029B2 (ja) * 1992-09-11 2003-10-14 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド アミン類の製造方法

Also Published As

Publication number Publication date
BE671195A (enExample) 1966-04-21
NL6513380A (enExample) 1966-04-28
GB1055616A (en) 1967-01-18
CH429025A (fr) 1967-01-31
FR90368E (enExample) 1968-02-14

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