GB1055616A - N-methylated derivatives of basic antibiotics - Google Patents
N-methylated derivatives of basic antibioticsInfo
- Publication number
- GB1055616A GB1055616A GB4378564A GB4378564A GB1055616A GB 1055616 A GB1055616 A GB 1055616A GB 4378564 A GB4378564 A GB 4378564A GB 4378564 A GB4378564 A GB 4378564A GB 1055616 A GB1055616 A GB 1055616A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylated derivatives
- basic antibiotics
- antibiotic
- formaldehyde
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
N-Methylated derivatives of the neomycins, kanamycins and paromomycins are prepared by reacting said basic antibiotics with formaldehyde in an aqueous acidic medium without the addition of an external reducing agent. The antibiotic is preferably in the form of the acid addition salt and at least 1.5 moles of formaldehyde is used per amino group of the antibiotic. The compounds have hypocholesterolemic activity.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR90368D FR90368E (en) | 1962-04-03 | ||
GB4378564A GB1055616A (en) | 1962-04-03 | 1964-10-27 | N-methylated derivatives of basic antibiotics |
NO159978A NO117363B (en) | 1964-10-27 | 1965-10-06 | |
CH1386365A CH429025A (en) | 1962-04-03 | 1965-10-08 | Process for the preparation of N-methylated derivatives of basic antibiotics |
SE13141/65A SE324858B (en) | 1964-10-27 | 1965-10-11 | |
DE19651468937 DE1468937A1 (en) | 1962-04-03 | 1965-10-15 | Process for the preparation of derivatives of antibiotics |
NL6513380A NL6513380A (en) | 1962-04-03 | 1965-10-15 | |
BE671195A BE671195A (en) | 1962-04-03 | 1965-10-21 | |
AT959865A AT265516B (en) | 1964-10-27 | 1965-10-22 | Process for the preparation of new N-methyl derivatives of neomycins, kanamycins and paromomycins |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1279062A GB1033394A (en) | 1962-04-03 | 1962-04-03 | New therapeutic agents |
GB3895362 | 1962-10-15 | ||
GB4378564A GB1055616A (en) | 1962-04-03 | 1964-10-27 | N-methylated derivatives of basic antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1055616A true GB1055616A (en) | 1967-01-18 |
Family
ID=27256888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4378564A Expired GB1055616A (en) | 1962-04-03 | 1964-10-27 | N-methylated derivatives of basic antibiotics |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE671195A (en) |
CH (1) | CH429025A (en) |
DE (1) | DE1468937A1 (en) |
FR (1) | FR90368E (en) |
GB (1) | GB1055616A (en) |
NL (1) | NL6513380A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0587534A1 (en) * | 1992-09-11 | 1994-03-16 | Ciba-Geigy Ag | Process for the preparation of amines |
-
0
- FR FR90368D patent/FR90368E/fr not_active Expired
-
1964
- 1964-10-27 GB GB4378564A patent/GB1055616A/en not_active Expired
-
1965
- 1965-10-08 CH CH1386365A patent/CH429025A/en unknown
- 1965-10-15 NL NL6513380A patent/NL6513380A/xx unknown
- 1965-10-15 DE DE19651468937 patent/DE1468937A1/en active Pending
- 1965-10-21 BE BE671195A patent/BE671195A/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0587534A1 (en) * | 1992-09-11 | 1994-03-16 | Ciba-Geigy Ag | Process for the preparation of amines |
US5457233A (en) * | 1992-09-11 | 1995-10-10 | Ciba-Geigy Corporation | Process for the preparation of amines |
Also Published As
Publication number | Publication date |
---|---|
BE671195A (en) | 1966-04-21 |
CH429025A (en) | 1967-01-31 |
NL6513380A (en) | 1966-04-28 |
DE1468937A1 (en) | 1969-07-31 |
FR90368E (en) | 1968-02-14 |
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