DE1237125B - Verfahren zur Herstellung des antimikrobiell wirksamen 5-Acetylimino-3-(5-nitro-2-furyl)-delta 2-1, 2, 4-triazolins - Google Patents
Verfahren zur Herstellung des antimikrobiell wirksamen 5-Acetylimino-3-(5-nitro-2-furyl)-delta 2-1, 2, 4-triazolinsInfo
- Publication number
- DE1237125B DE1237125B DEN27590A DEN0027590A DE1237125B DE 1237125 B DE1237125 B DE 1237125B DE N27590 A DEN27590 A DE N27590A DE N0027590 A DEN0027590 A DE N0027590A DE 1237125 B DE1237125 B DE 1237125B
- Authority
- DE
- Germany
- Prior art keywords
- nitro
- furyl
- triazoline
- new
- acetylimino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 5-nitro-2-furyl Chemical group 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 3
- JRLFRFTXXMZSND-UHFFFAOYSA-N 1,2,4-triazoline Chemical compound C1NNC=N1 JRLFRFTXXMZSND-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 8
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical class NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 claims description 5
- 241000699670 Mus sp. Species 0.000 claims description 4
- 229960000583 acetic acid Drugs 0.000 claims description 4
- 239000012362 glacial acetic acid Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
- 241000607142 Salmonella Species 0.000 claims description 3
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims description 3
- 239000012965 benzophenone Substances 0.000 claims description 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims description 3
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 claims description 2
- 239000012346 acetyl chloride Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 230000003385 bacteriostatic effect Effects 0.000 claims 3
- 238000010790 dilution Methods 0.000 claims 3
- 239000012895 dilution Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 231100001274 therapeutic index Toxicity 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 2
- 238000002474 experimental method Methods 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000193985 Streptococcus agalactiae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- JIBRPWMCNASFRH-UHFFFAOYSA-N [O-][N+](C(O1)=CCC1=NN1C=NN=C1)=O Chemical compound [O-][N+](C(O1)=CCC1=NN1C=NN=C1)=O JIBRPWMCNASFRH-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 238000013207 serial dilution Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 230000002498 deadly effect Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- JMXRGHVWQMFKQW-UHFFFAOYSA-N 5-nitrofuran-2-carboxamide Chemical class NC(=O)C1=CC=C([N+]([O-])=O)O1 JMXRGHVWQMFKQW-UHFFFAOYSA-N 0.000 description 1
- 241000224483 Coccidia Species 0.000 description 1
- 241000223932 Eimeria tenella Species 0.000 description 1
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000002297 parasiticide Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/70—Nitro radicals
- C07D307/71—Nitro radicals attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/70—Nitro radicals
- C07D307/71—Nitro radicals attached in position 5
- C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
- C07D307/73—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by amino or imino, or substituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24751462A | 1962-12-27 | 1962-12-27 | |
| US294240A US3391155A (en) | 1962-12-27 | 1963-07-11 | 3-(5-nitro-2-furyl)-delta2-1, 2, 4-triazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1237125B true DE1237125B (de) | 1967-03-23 |
Family
ID=26938728
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEN27590A Pending DE1237125B (de) | 1962-12-27 | 1963-11-12 | Verfahren zur Herstellung des antimikrobiell wirksamen 5-Acetylimino-3-(5-nitro-2-furyl)-delta 2-1, 2, 4-triazolins |
| DEN27589A Pending DE1226592B (de) | 1962-12-27 | 1963-11-12 | Verfahren zur Herstellung von antimikrobiell wirksamen 3-(5-Nitro-2-furyl)-delta 2-1, 2, 4-triazolinen |
| DEN24002A Pending DE1213843B (de) | 1962-12-27 | 1963-11-12 | Verfahren zur Herstellung von antimikrobiell wirksamen 3-(5-Nitro-2-furyl)-delta 2-1, 2, 4-triazolinen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEN27589A Pending DE1226592B (de) | 1962-12-27 | 1963-11-12 | Verfahren zur Herstellung von antimikrobiell wirksamen 3-(5-Nitro-2-furyl)-delta 2-1, 2, 4-triazolinen |
| DEN24002A Pending DE1213843B (de) | 1962-12-27 | 1963-11-12 | Verfahren zur Herstellung von antimikrobiell wirksamen 3-(5-Nitro-2-furyl)-delta 2-1, 2, 4-triazolinen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3391155A (enExample) |
| BE (1) | BE641795A (enExample) |
| CH (1) | CH441348A (enExample) |
| DE (3) | DE1237125B (enExample) |
| DK (1) | DK107556C (enExample) |
| FI (1) | FI43315B (enExample) |
| FR (2) | FR1381647A (enExample) |
| GB (1) | GB1067992A (enExample) |
| NL (1) | NL302021A (enExample) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2385284A (en) * | 1942-01-24 | 1945-09-18 | Gen Chemical Corp | Insecticides and methods of using |
| US2987520A (en) * | 1956-07-11 | 1961-06-06 | Darrell V Sickman | Certain 4(nitroalkyl)-3, 5-dinitro-1, 2, 4-triazoles |
| US2863803A (en) * | 1957-05-13 | 1958-12-09 | Stauffer Chemical Co | Protecting materials against fungi by applying substituted dithiono and thiono-oxo-thiadiazolidines |
| NL262864A (enExample) * | 1960-05-06 |
-
0
- NL NL302021D patent/NL302021A/xx unknown
-
1963
- 1963-07-11 US US294240A patent/US3391155A/en not_active Expired - Lifetime
- 1963-11-12 DE DEN27590A patent/DE1237125B/de active Pending
- 1963-11-12 DE DEN27589A patent/DE1226592B/de active Pending
- 1963-11-12 DE DEN24002A patent/DE1213843B/de active Pending
- 1963-11-18 CH CH1412063A patent/CH441348A/de unknown
- 1963-12-16 GB GB49535/63A patent/GB1067992A/en not_active Expired
- 1963-12-20 DK DK596763AA patent/DK107556C/da active
- 1963-12-20 FR FR957953A patent/FR1381647A/fr not_active Expired
- 1963-12-20 FR FR957954A patent/FR3092M/fr active Active
- 1963-12-24 BE BE641795D patent/BE641795A/xx unknown
- 1963-12-27 FI FI2550/63A patent/FI43315B/fi active
Non-Patent Citations (1)
| Title |
|---|
| None * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1067992A (en) | 1967-05-10 |
| FR3092M (fr) | 1965-01-25 |
| DK107556C (da) | 1967-06-12 |
| DE1226592B (de) | 1966-10-13 |
| US3391155A (en) | 1968-07-02 |
| FI43315B (enExample) | 1970-11-30 |
| CH441348A (de) | 1967-08-15 |
| FR1381647A (fr) | 1964-12-14 |
| NL302021A (enExample) | |
| BE641795A (enExample) | 1964-04-16 |
| DE1213843B (de) | 1966-04-07 |
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