DE1121431T1 - Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren - Google Patents
Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptorenInfo
- Publication number
- DE1121431T1 DE1121431T1 DE1121431T DE99951991T DE1121431T1 DE 1121431 T1 DE1121431 T1 DE 1121431T1 DE 1121431 T DE1121431 T DE 1121431T DE 99951991 T DE99951991 T DE 99951991T DE 1121431 T1 DE1121431 T1 DE 1121431T1
- Authority
- DE
- Germany
- Prior art keywords
- endogenous
- amino acid
- gpcr
- region
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims abstract 56
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims abstract 56
- 125000000539 amino acid group Chemical group 0.000 claims abstract 29
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract 15
- 239000004472 Lysine Substances 0.000 claims abstract 15
- 150000007523 nucleic acids Chemical group 0.000 claims abstract 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract 13
- 150000001875 compounds Chemical class 0.000 claims abstract 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 11
- 102000005962 receptors Human genes 0.000 claims abstract 11
- 108020003175 receptors Proteins 0.000 claims abstract 11
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract 8
- 108020004705 Codon Proteins 0.000 claims abstract 7
- 230000003834 intracellular effect Effects 0.000 claims abstract 7
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 claims abstract 5
- 102000052301 human GNAZ Human genes 0.000 claims abstract 5
- 235000001014 amino acid Nutrition 0.000 claims 26
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 17
- 150000001413 amino acids Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 10
- 229940125425 inverse agonist Drugs 0.000 claims 7
- 108091008880 orphan GPCRs Proteins 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 5
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 5
- 239000000556 agonist Substances 0.000 claims 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 5
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 239000004031 partial agonist Substances 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 244000309464 bull Species 0.000 claims 1
- -1 lysine amino acid Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/170,496 US6555339B1 (en) | 1997-04-14 | 1998-10-13 | Non-endogenous, constitutively activated human protein-coupled receptors |
| PCT/US1999/023938 WO2000022129A1 (en) | 1998-10-13 | 1999-10-12 | Non-endogenous, constitutively activated human g protein-coupled receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1121431T1 true DE1121431T1 (de) | 2002-05-23 |
Family
ID=22620080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1121431T Pending DE1121431T1 (de) | 1998-10-13 | 1999-10-12 | Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren |
| DE69929993T Expired - Lifetime DE69929993T4 (de) | 1998-10-13 | 1999-10-12 | Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren |
| DE69929993A Expired - Lifetime DE69929993D1 (de) | 1998-10-13 | 1999-10-12 | Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69929993T Expired - Lifetime DE69929993T4 (de) | 1998-10-13 | 1999-10-12 | Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren |
| DE69929993A Expired - Lifetime DE69929993D1 (de) | 1998-10-13 | 1999-10-12 | Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6555339B1 (enExample) |
| EP (1) | EP1121431B9 (enExample) |
| JP (2) | JP4672866B2 (enExample) |
| KR (1) | KR100598752B1 (enExample) |
| CN (1) | CN1329511C (enExample) |
| AT (1) | ATE318311T1 (enExample) |
| AU (5) | AU769987B2 (enExample) |
| CA (1) | CA2342314A1 (enExample) |
| DE (3) | DE1121431T1 (enExample) |
| DK (1) | DK1121431T5 (enExample) |
| ES (1) | ES2163384T3 (enExample) |
| IL (2) | IL141965A0 (enExample) |
| NZ (1) | NZ510331A (enExample) |
| WO (2) | WO2000021987A2 (enExample) |
Families Citing this family (172)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888466B2 (en) | 1996-01-11 | 2011-02-15 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor HSATU68 |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US7816492B2 (en) * | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
| USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
| US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| PT1133559E (pt) * | 1998-11-20 | 2005-10-31 | Arena Pharm Inc | Receptor acoplato a proteina g orfao humano, rup3 |
| GB9903767D0 (en) * | 1999-02-18 | 1999-04-14 | Univ Glasgow | Receptor assay |
| AU6385200A (en) * | 1999-07-30 | 2001-02-19 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for prognostication, diagnosis, prevention, and treatment of bone-related disorders and other disorders |
| JP4768946B2 (ja) * | 1999-11-17 | 2011-09-07 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ヒトｇタンパク質共役型受容体の内因性および非内因性型 |
| EP1240199A2 (en) * | 1999-12-10 | 2002-09-18 | AstraZeneca AB | Method for screening of appetite control agents |
| JP2003517008A (ja) * | 1999-12-17 | 2003-05-20 | アストラゼネカ アクチボラグ | 新規化合物 |
| AU2001232132A1 (en) * | 2000-02-18 | 2001-08-27 | Glaxo Group Limited | Novel assay |
| GB0003902D0 (en) * | 2000-02-18 | 2000-04-05 | Glaxo Group Ltd | Assay |
| GB0003898D0 (en) * | 2000-02-18 | 2000-04-05 | Glaxo Group Ltd | Assay |
| WO2001064872A2 (en) * | 2000-02-29 | 2001-09-07 | Millennium Pharmaceuticals, Inc. | Gene 2465: methods and compositions for the diagnosis and treatment of cardiovascular, hepatic and bone disease |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| EP1278850B1 (en) * | 2000-04-26 | 2007-06-13 | Sanofi-Aventis Deutschland GmbH | Edg8 receptor, its preparation and use |
| EP1149907A1 (en) * | 2000-04-26 | 2001-10-31 | Aventis Pharma Deutschland GmbH | EDG8 receptor, its preparation and use |
| AU2001250536A1 (en) * | 2000-05-03 | 2001-11-12 | Astrazeneca Ab | Methods |
| AU2001274522A1 (en) * | 2000-06-15 | 2001-12-24 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
| EP1297130A2 (en) * | 2000-06-16 | 2003-04-02 | Incyte Genomics, Inc. | G-protein coupled receptors |
| WO2001098494A1 (fr) * | 2000-06-21 | 2001-12-27 | Takeda Chemical Industries, Ltd | Ligand de gpr8 et son adn |
| US20040086940A1 (en) * | 2000-07-04 | 2004-05-06 | Sachio Shibata | Novel g protein-coupled receptor protein and dna thereof |
| WO2002013845A2 (en) * | 2000-08-18 | 2002-02-21 | Novartis Ag | Inflammation related g-protein coupled receptor |
| AU2001286945A1 (en) * | 2000-08-30 | 2002-03-13 | John Hopkins University School Of Medicine | Identification of activated receptors and ion channels |
| AU2000276780A1 (en) * | 2000-10-02 | 2001-04-23 | Biofocus Discovery Limited | Cellular receptor mutations predicted by multiple-sequence-allignment |
| EP1344823A4 (en) * | 2000-11-30 | 2005-03-16 | Takeda Chemical Industries Ltd | NEW G-PROTEIN-COUPLED RECEPTOR PROTEINS AND THEIR DNAS |
| US7241579B2 (en) | 2000-12-22 | 2007-07-10 | Smithkline Beecham Corporation | Method of screening for GPR40 ligands |
| GB0031527D0 (en) * | 2000-12-22 | 2001-02-07 | Smithkline Beecham Plc | New use |
| CN1516706A (zh) * | 2001-02-26 | 2004-07-28 | 阿伦纳药品公司 | 人g蛋白偶联受体的内源性和非内源性形式 |
| US6809104B2 (en) | 2001-05-04 | 2004-10-26 | Tularik Inc. | Fused heterocyclic compounds |
| US6919176B2 (en) * | 2001-05-07 | 2005-07-19 | Amgen Inc. | Polypeptides and nucleic acids associated with cancer |
| EP1394543B1 (en) * | 2001-05-15 | 2007-08-29 | Takeda Pharmaceutical Company Limited | Screening method |
| US20020177190A1 (en) * | 2001-05-24 | 2002-11-28 | Yanbin Liang | Recombinant simian GPR3 receptor |
| CA2449553A1 (en) * | 2001-06-05 | 2002-12-19 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated versions of plant g protein-coupled receptor: gcr1 |
| JP2003018992A (ja) * | 2001-06-28 | 2003-01-21 | Inst Of Physical & Chemical Res | Ｐａｅｌ受容体、Ｐａｅｌ受容体発現細胞および動物、ならびにパーキンソン病治療薬のスクリーニング法 |
| US20050142548A1 (en) * | 2001-07-13 | 2005-06-30 | Thomson Anne M. | Allelic variants of grp50 |
| US20030109044A1 (en) * | 2001-10-16 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Methods of using 279, a human G protein-coupled protein receptor |
| US20030119742A1 (en) * | 2001-11-05 | 2003-06-26 | Millennium Pharmaceuticals, Inc. | Methods and compositions to treat cardiovascular disease using 139, 258, 1261, 1486, 2398, 2414, 7660, 8587,10183, 10550, 12680, 17921, 32248, 60489 or 93804 |
| US6902902B2 (en) | 2001-11-27 | 2005-06-07 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders |
| EP1463759B8 (en) | 2002-01-07 | 2013-07-10 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| EP1336655A1 (en) * | 2002-01-12 | 2003-08-20 | Aventis Pharma Deutschland GmbH | Method of identifying protein CAMS (constitutively active mutants) |
| US20030175889A1 (en) * | 2002-01-23 | 2003-09-18 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated versions of human G protein coupled receptor: FSHR |
| JP2005534282A (ja) * | 2002-02-06 | 2005-11-17 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | ニューロメジンｕ受容体に関連する疾患のための診断用および治療用物質 |
| US7214495B2 (en) | 2002-02-14 | 2007-05-08 | Takeda Pharmaceutical Company Limited | Screening method |
| AU2003218234A1 (en) * | 2002-03-15 | 2003-09-29 | Arena Pharmaceuticals, Inc. | Methods of expressing non-endogenous g protein coupled receptors in cells |
| AU2003241037A1 (en) * | 2002-06-08 | 2003-12-22 | Astrazeneca Ab | Methods for the detection of polymorphisms in human gpr50 |
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| WO2004015426A1 (en) * | 2002-08-06 | 2004-02-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human cxc chemokine receptor 5(cxcr5) |
| AU2003250165A1 (en) * | 2002-08-06 | 2004-02-25 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 19 (gpr19) |
| WO2004017994A1 (ja) * | 2002-08-22 | 2004-03-04 | Kyowa Hakko Kogyo Co., Ltd. | 喘息の予防および／または治療剤 |
| WO2004038407A2 (en) * | 2002-10-24 | 2004-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 12 (gpr12) |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| PL376659A1 (pl) | 2002-11-06 | 2006-01-09 | Tularik Inc. | Skondensowane związki heterocykliczne |
| US7960369B2 (en) | 2002-11-08 | 2011-06-14 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| US7189524B1 (en) | 2002-11-25 | 2007-03-13 | Amgen, Inc. | Receptor ligands and methods of modulating receptors |
| WO2004050853A2 (en) * | 2002-12-04 | 2004-06-17 | Synaptic Pharmaceutical Corporation | Uses of the snorf55 receptor |
| US20040157253A1 (en) * | 2003-02-07 | 2004-08-12 | Millennium Pharmaceuticals, Inc. | Methods and compositions for use of inflammatory proteins in the diagnosis and treatment of metabolic disorders |
| WO2004083388A2 (en) * | 2003-03-14 | 2004-09-30 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74 |
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| WO2001016159A1 (en) | 1999-08-27 | 2001-03-08 | Smithkline Beecham Corporation | Gpcr, theant |
| GB9923889D0 (en) | 1999-10-08 | 1999-12-08 | Pfizer Ltd | Novel polypeptide |
| GB9924951D0 (en) | 1999-10-21 | 1999-12-22 | Pfizer Ltd | Novel polypeptide |
| EP1230361A2 (en) | 1999-10-27 | 2002-08-14 | PHARMACIA & UPJOHN COMPANY | G protein-coupled receptors expressed in human brain |
| IL149569A0 (en) | 1999-11-17 | 2002-11-10 | Arena Pharm Inc | Endogenous and non-endogenous versions of human g protein-coupled receptors |
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1998
- 1998-10-13 US US09/170,496 patent/US6555339B1/en not_active Expired - Lifetime
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1999
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