DE10324447A1 - Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin - Google Patents
Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin Download PDFInfo
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- DE10324447A1 DE10324447A1 DE10324447A DE10324447A DE10324447A1 DE 10324447 A1 DE10324447 A1 DE 10324447A1 DE 10324447 A DE10324447 A DE 10324447A DE 10324447 A DE10324447 A DE 10324447A DE 10324447 A1 DE10324447 A1 DE 10324447A1
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| ES04735010T ES2361409T3 (es) | 2003-05-28 | 2004-05-27 | Generación de proteinas de unión sintéticas basadas en proteinas de ubiquitina. |
| AU2004242851A AU2004242851B2 (en) | 2003-05-28 | 2004-05-27 | Generation of artificial binding proteins based on ubiquitin proteins |
| PL04735010T PL1626985T3 (pl) | 2003-05-28 | 2004-05-27 | Generowanie sztucznych białek wiążących na bazie białek ubikwitynowych |
| EP04735010A EP1626985B1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| CN201310381691.XA CN103539851B (zh) | 2003-05-28 | 2004-05-27 | 基于泛素蛋白的人工结合蛋白的生产 |
| PT04735010T PT1626985E (pt) | 2003-05-28 | 2004-05-27 | Gera??o de prote?nas de liga??o artificiais ? base da prote?na ubiquitina |
| EP20100181802 EP2295446A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin-Proteinen |
| DE502004012225T DE502004012225D1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| DK04735010.3T DK1626985T3 (da) | 2003-05-28 | 2004-05-27 | Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner |
| EP09176574A EP2163559A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin-Proteinen |
| CNA2004800146101A CN1956996A (zh) | 2003-05-28 | 2004-05-27 | 基于泛素蛋白的人工结合蛋白的生产 |
| JP2006529936A JP4803817B2 (ja) | 2003-05-28 | 2004-05-27 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
| CA2524899A CA2524899C (en) | 2003-05-28 | 2004-05-27 | Generation of artificial binding proteins based on ubiquitin proteins |
| AT04735010T ATE499382T1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| PCT/EP2004/005730 WO2004106368A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| US11/283,332 US8790895B2 (en) | 2003-05-28 | 2005-11-18 | Generation of artificial binding proteins on the basis of ubiquitin proteins |
| US12/072,959 US8791238B2 (en) | 2003-05-28 | 2008-02-29 | Artificial binding proteins based on ubiquitin |
| JP2010226505A JP2011046722A (ja) | 2003-05-28 | 2010-10-06 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
| JP2011104112A JP5372992B2 (ja) | 2003-05-28 | 2011-05-09 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
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| DE10324447A DE10324447A1 (de) | 2003-05-28 | 2003-05-28 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
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| DE10324447A1 true DE10324447A1 (de) | 2004-12-30 |
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Cited By (1)
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| DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
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| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| PT2328616E (pt) | 2008-08-05 | 2015-08-26 | Novartis Ag | Composições e métodos para anticorpos dirigidos à proteína c5 do complemento |
| CA2746840A1 (en) | 2008-12-16 | 2010-06-24 | Novartis Ag | Yeast display systems |
| EP3275900A1 (en) | 2009-04-27 | 2018-01-31 | Novartis AG | Compositions and methods for increasing muscle growth |
| CA2759942A1 (en) | 2009-04-27 | 2010-10-07 | Novartis Ag | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betai subunit |
| WO2011018421A1 (en) | 2009-08-10 | 2011-02-17 | Morphosys Ag | Novel screening strategies for the identification of binders |
| WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
| US20120321697A1 (en) * | 2009-12-11 | 2012-12-20 | Gwangju Institute Of Science And Technology | Bpb-based cargo delivery system |
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| JP5667207B2 (ja) | 2009-12-14 | 2015-02-12 | シル プロテインズ ゲーエムベーハーＳｃｉｌ Ｐｒｏｔｅｉｎｓ ＧｍｂＨ | リガンドへの結合能を有するヘテロ多量体修飾ユビキチンタンパク質の同定方法 |
| JP5665110B2 (ja) * | 2009-12-18 | 2015-02-04 | 独立行政法人農業生物資源研究所 | 外来ＤＮＡ断片由来の逆方向反復配列を含むＤＮＡ断片の調製方法及びＤＮＡ型ＲＮＡｉライブラリの調製方法 |
| CA2798390A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| EP2566892B1 (en) | 2010-05-06 | 2017-12-20 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| EP3366697B1 (en) | 2010-08-10 | 2020-12-30 | Sachdev Sidhu | Specific active site inhibitors of enzymes or substrate binding partners and methods of producing same |
| MY162825A (en) | 2010-08-20 | 2017-07-31 | Novartis Ag | Antibodies for epidermal growth factor receptor 3 (her3) |
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| US8790895B2 (en) | 2014-07-29 |
| JP5372992B2 (ja) | 2013-12-18 |
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| US20080171851A1 (en) | 2008-07-17 |
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| CN103539851B (zh) | 2016-12-28 |
| CN103539851A (zh) | 2014-01-29 |
| CA2524899A1 (en) | 2004-12-09 |
| ES2361409T3 (es) | 2011-06-16 |
| DK1626985T3 (da) | 2011-06-14 |
| AU2004242851A1 (en) | 2004-12-09 |
| WO2004106368A1 (de) | 2004-12-09 |
| JP4803817B2 (ja) | 2011-10-26 |
| JP2008500953A (ja) | 2008-01-17 |
| PT1626985E (pt) | 2011-05-25 |
| CN1956996A (zh) | 2007-05-02 |
| CA2524899C (en) | 2012-02-07 |
| US20060099686A1 (en) | 2006-05-11 |
| ATE499382T1 (de) | 2011-03-15 |
| US8791238B2 (en) | 2014-07-29 |
| PL1626985T3 (pl) | 2011-07-29 |
| EP1626985B1 (de) | 2011-02-23 |
| EP1626985A1 (de) | 2006-02-22 |
| DE502004012225D1 (de) | 2011-04-07 |
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