DK1626985T3 - Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner - Google Patents

Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner

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Publication number
DK1626985T3
DK1626985T3 DK04735010.3T DK04735010T DK1626985T3 DK 1626985 T3 DK1626985 T3 DK 1626985T3 DK 04735010 T DK04735010 T DK 04735010T DK 1626985 T3 DK1626985 T3 DK 1626985T3
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DK
Denmark
Prior art keywords
protein
ubiquitin
proteins
generation
exposed region
Prior art date
Application number
DK04735010.3T
Other languages
English (en)
Inventor
Rainer Rudolph
Markus Dr Fiedler
Ulrike Fiedler
Original Assignee
Scil Proteins Gmbh
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Publication date
Application filed by Scil Proteins Gmbh filed Critical Scil Proteins Gmbh
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Publication of DK1626985T3 publication Critical patent/DK1626985T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
DK04735010.3T 2003-05-28 2004-05-27 Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner DK1626985T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10324447A DE10324447A1 (de) 2003-05-28 2003-05-28 Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
PCT/EP2004/005730 WO2004106368A1 (de) 2003-05-28 2004-05-27 Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen

Publications (1)

Publication Number Publication Date
DK1626985T3 true DK1626985T3 (da) 2011-06-14

Family

ID=33482283

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04735010.3T DK1626985T3 (da) 2003-05-28 2004-05-27 Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner

Country Status (13)

Country Link
US (2) US8790895B2 (da)
EP (3) EP2163559A1 (da)
JP (3) JP4803817B2 (da)
CN (2) CN103539851B (da)
AT (1) ATE499382T1 (da)
AU (1) AU2004242851B2 (da)
CA (1) CA2524899C (da)
DE (2) DE10324447A1 (da)
DK (1) DK1626985T3 (da)
ES (1) ES2361409T3 (da)
PL (1) PL1626985T3 (da)
PT (1) PT1626985E (da)
WO (1) WO2004106368A1 (da)

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US20060099686A1 (en) 2006-05-11
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PT1626985E (pt) 2011-05-25
CN103539851B (zh) 2016-12-28
JP4803817B2 (ja) 2011-10-26
AU2004242851A1 (en) 2004-12-09
CN103539851A (zh) 2014-01-29
JP2008500953A (ja) 2008-01-17
WO2004106368A1 (de) 2004-12-09
US20080171851A1 (en) 2008-07-17
DE502004012225D1 (de) 2011-04-07
EP2295446A1 (de) 2011-03-16
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CA2524899C (en) 2012-02-07
CA2524899A1 (en) 2004-12-09
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JP5372992B2 (ja) 2013-12-18
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