BRPI0520677A2 - identificação e caracterização de anticorpos de função de bloqueio anti-ed-b-fibronectina - Google Patents
identificação e caracterização de anticorpos de função de bloqueio anti-ed-b-fibronectinaInfo
- Publication number
- BRPI0520677A2 BRPI0520677A2 BRPI0520677-4A BRPI0520677A BRPI0520677A2 BR PI0520677 A2 BRPI0520677 A2 BR PI0520677A2 BR PI0520677 A BRPI0520677 A BR PI0520677A BR PI0520677 A2 BRPI0520677 A2 BR PI0520677A2
- Authority
- BR
- Brazil
- Prior art keywords
- fibronectin
- characterization
- identification
- blocking function
- function antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
IDENTIFICAçãO E CARACTERIZAçãO DE ANTI-CORPOS DE FUNçãO DE BLOQUEIO ANTI-ED-B-FIBRONECTINA. A presente invenção refere-se aos polipeptídeos recombinantes, especialmente aos anticorpos ou fragmentos de anticorpos, que ligam a isoforma ED-B da fibronectina e podem bloquear sua função. Além disso, é publicada a aplicação diagnóstica e farmacêutica dos polipeptídeos de acordo com a invenção.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2005/012185 WO2007054120A1 (de) | 2005-11-09 | 2005-11-09 | Identifizierung und charakterisierung von funktionsblockierenden anti-ed-b-fibronektin antikörpern |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0520677A2 true BRPI0520677A2 (pt) | 2009-05-19 |
Family
ID=36170357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520677-4A BRPI0520677A2 (pt) | 2005-11-09 | 2005-11-09 | identificação e caracterização de anticorpos de função de bloqueio anti-ed-b-fibronectina |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1945767B1 (pt) |
JP (1) | JP2009514540A (pt) |
CN (1) | CN101356271A (pt) |
AT (1) | ATE463512T1 (pt) |
BR (1) | BRPI0520677A2 (pt) |
CA (1) | CA2628552A1 (pt) |
DE (1) | DE502005009389D1 (pt) |
WO (1) | WO2007054120A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
EP1925664A1 (en) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
WO2009102421A2 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind egfr |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
US20120301393A1 (en) | 2009-12-14 | 2012-11-29 | Scil Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain b of fibronectin |
US9562089B2 (en) | 2010-05-26 | 2017-02-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
WO2012172055A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
WO2012171541A1 (en) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Human fusion proteins comprising interferons and hetero-dimeric modified ubiquitin proteins |
EP2861616A1 (en) | 2012-06-13 | 2015-04-22 | Scil Proteins GmbH | Human fusion proteins comprising single chain tnfalpha and targeting domains |
WO2014094799A1 (en) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
WO2016124702A1 (en) | 2015-02-06 | 2016-08-11 | Scil Proteins Gmbh | Novel egfr binding proteins |
PL3322721T3 (pl) | 2015-07-16 | 2022-06-06 | Navigo Proteins Gmbh | Nowe białka wiążące immunoglobulinę i ich zastosowanie w oczyszczaniu na bazie powinowactwa |
WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
WO2017084017A1 (zh) * | 2015-11-16 | 2017-05-26 | 合肥立方制药股份有限公司 | Ed-b蛋白在诊断组织增生中的应用 |
EP3452097A1 (en) | 2016-05-04 | 2019-03-13 | Navigo Proteins GmbH | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
KR102578256B1 (ko) | 2016-08-11 | 2023-09-15 | 리플리겐 코포레이션 | 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질 |
EP3689903A4 (en) | 2017-09-30 | 2022-01-12 | Hefei Lifeon Pharmaceutical Co. Ltd. | FIBRONECTIN B DOMAIN BINDING PROTEIN |
CA3098444A1 (en) * | 2018-04-30 | 2019-11-07 | Viktor Veniaminovich Tets | Tetz-proteins and prion-like proteins and associated methods |
WO2020006357A1 (en) | 2018-06-29 | 2020-01-02 | Tets Viktor Veniaminovich | Methods for diagnosis and treatment of type 1 diabetes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997008320A1 (en) | 1995-08-18 | 1997-03-06 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
EP1990409A3 (en) | 1999-07-20 | 2011-05-18 | MorphoSys AG | Bacteriophage |
EP1267935A2 (en) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Novel treatment for eye disease |
EP1259548A1 (en) | 2000-02-24 | 2002-11-27 | Eidgenössische Technische Hochschule Zürich | Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis |
SK2882003A3 (en) | 2000-09-07 | 2003-08-05 | Schering Ag | Receptor in the EDb fibronectin domain |
-
2005
- 2005-11-09 WO PCT/EP2005/012185 patent/WO2007054120A1/de active Application Filing
- 2005-11-09 EP EP05811334A patent/EP1945767B1/de not_active Not-in-force
- 2005-11-09 DE DE502005009389T patent/DE502005009389D1/de active Active
- 2005-11-09 CN CNA2005800524909A patent/CN101356271A/zh active Pending
- 2005-11-09 AT AT05811334T patent/ATE463512T1/de not_active IP Right Cessation
- 2005-11-09 JP JP2008539258A patent/JP2009514540A/ja not_active Withdrawn
- 2005-11-09 BR BRPI0520677-4A patent/BRPI0520677A2/pt not_active IP Right Cessation
- 2005-11-09 CA CA002628552A patent/CA2628552A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1945767B1 (de) | 2010-04-07 |
CN101356271A (zh) | 2009-01-28 |
DE502005009389D1 (de) | 2010-05-20 |
CA2628552A1 (en) | 2007-05-18 |
WO2007054120A1 (de) | 2007-05-18 |
ATE463512T1 (de) | 2010-04-15 |
JP2009514540A (ja) | 2009-04-09 |
EP1945767A1 (de) | 2008-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: MORPHOSYS AG (DE) Free format text: TRANSFERIDO DE: BAYER SCHERING PHARMA AG |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 6A ANUIDADE. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: C07K 16/18 (2006.01), A61K 39/00 (2006.01), A61P 3 |