DD297838A5 - Verfahren zum einfuehren von genetischen einheiten in die zelle - Google Patents

Verfahren zum einfuehren von genetischen einheiten in die zelle Download PDF

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Publication number
DD297838A5
DD297838A5 DD90338709A DD33870990A DD297838A5 DD 297838 A5 DD297838 A5 DD 297838A5 DD 90338709 A DD90338709 A DD 90338709A DD 33870990 A DD33870990 A DD 33870990A DD 297838 A5 DD297838 A5 DD 297838A5
Authority
DD
German Democratic Republic
Prior art keywords
rna
ribozyme
genetic
genetic unit
trna
Prior art date
Application number
DD90338709A
Other languages
German (de)
English (en)
Inventor
Hartmut Beug
Max L Birnstiel
Matthew Cotten
Ernst Wagner
Harald Kandolf
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ��������@���������������@����������������������@���k�� filed Critical ��������@���������������@����������������������@���k��
Publication of DD297838A5 publication Critical patent/DD297838A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/111Antisense spanning the whole gene, or a large part of it
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121Hammerhead

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DD90338709A 1989-03-16 1990-03-14 Verfahren zum einfuehren von genetischen einheiten in die zelle DD297838A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT60989 1989-03-16

Publications (1)

Publication Number Publication Date
DD297838A5 true DD297838A5 (de) 1992-01-23

Family

ID=3495118

Family Applications (1)

Application Number Title Priority Date Filing Date
DD90338709A DD297838A5 (de) 1989-03-16 1990-03-14 Verfahren zum einfuehren von genetischen einheiten in die zelle

Country Status (20)

Country Link
EP (1) EP0387775B1 (pt)
JP (1) JP3330930B2 (pt)
KR (1) KR900014591A (pt)
AT (1) ATE140961T1 (pt)
AU (1) AU637354B2 (pt)
CA (1) CA2012312C (pt)
DD (1) DD297838A5 (pt)
DE (1) DE59010432D1 (pt)
DK (1) DK0387775T3 (pt)
ES (1) ES2090049T3 (pt)
FI (1) FI105103B (pt)
GR (1) GR3020935T3 (pt)
HU (2) HU215187B (pt)
IE (1) IE74850B1 (pt)
IL (1) IL93754A (pt)
NO (1) NO306623B1 (pt)
NZ (1) NZ232917A (pt)
PT (1) PT93440B (pt)
RU (1) RU2136751C1 (pt)
ZA (1) ZA901973B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471796A4 (en) * 1989-05-10 1993-05-05 Sloan Kettering Institute For Cancer Research Stably transformed eucaryotic cells comprising a foreign transcribable dna under the control of a pol iii promoter
DE4091533T (pt) * 1989-08-31 1992-01-30
JP2507895B2 (ja) * 1989-12-19 1996-06-19 工業技術院長 リボザイムの新規合成系
WO1991019789A1 (en) * 1990-06-19 1991-12-26 Commonwealth Scientific And Industrial Research Organisation Endonucleases
US6008343A (en) * 1990-06-19 1999-12-28 Gene Shears Pty. Ltd. Nucleotide based endonucleases
DE69123979T2 (de) * 1990-10-12 1997-04-30 Max Planck Gesellschaft Abgeänderte ribozyme
DE4104186A1 (de) * 1991-02-12 1992-08-13 Genentech Inc Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
FR2687411A1 (fr) * 1992-02-13 1993-08-20 Nice Sophia Antipolis Universi Vecteur comportant un gene viral transcrit par l'arn polymerase iii, et procede de production intracellulaire d'arn.
WO1993022433A2 (de) * 1992-04-28 1993-11-11 Frank Andreas Harald Meyer Medikament zur gentherapeutischen behandlung von menschen, tieren und pflanzen, insbesondere zur blockierung der virenvermehrung und der tumorgene sowie verfahren zur herstellung des medikaments
EP0641212A4 (en) * 1992-05-14 1997-05-21 Ribozyme Pharm Inc PROCESS AND REAGENT FOR PREVENTING THE DEVELOPMENT OF CANCER.
US5610052A (en) * 1992-08-26 1997-03-11 Ribozyme Pharmaceuticals Inc. Enzymatic RNA with activity to ras
US5989906A (en) * 1992-05-14 1999-11-23 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting P-glycoprotein (mdr-1-gene)
WO1993024133A1 (en) * 1992-05-27 1993-12-09 City Of Hope CHIMERIC tRNALYS-RIBOZYME MOLECULES
US5827935A (en) * 1992-05-27 1998-10-27 City Of Hope Chimeric tRNAlys -ribozyme molecules
DE69333937T2 (de) * 1992-06-29 2006-08-31 Gene Shears Pty. Ltd. Nukleinsäuren und sie verwendende verfahren zur bekämpfung viraler pathogene
WO1994013798A1 (en) * 1992-12-16 1994-06-23 Bergmann Johanna E Agents for the prevention and treatment of human alzheimer's disease
EP0647716B1 (fr) * 1993-07-06 2003-09-24 Universite De Nice-Sophia Antipolis Vecteur comportant un gène viral transcrit par l'ARN polymérase III
US5837503A (en) * 1993-07-07 1998-11-17 Universite De Nice-Sophia-Antipolis Vector containing viral gene transcribed by RNA polymerase III and methods for use
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
EP0707493A4 (en) * 1994-01-24 1999-03-31 Hope City COLOLIZATION OF TARGET MOLECULE AND ITS INHIBITOR
DE4424761C1 (de) * 1994-07-04 1995-06-08 Max Planck Gesellschaft Expressionskassette für die Antisense- und die Ribozym-Expression
JPH11506914A (ja) 1995-06-07 1999-06-22 コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション 最適化ミニザイムおよびミニリボザイムおよびその使用
FR2755976B1 (fr) 1996-11-15 1999-01-15 Idm Immuno Designed Molecules Nouveaux complexes d'acides nucleiques et de polymere substitue par des residus entrainant la destabilisation des membranes cellulaires
US6057156A (en) 1997-01-31 2000-05-02 Robozyme Pharmaceuticals, Inc. Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
AU1187099A (en) * 1997-10-21 1999-05-10 Ribozyme Pharmaceuticals, Inc. Peptide bond formation using nucleic acid catalysts
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CN101818145A (zh) 1998-03-20 2010-09-01 联邦科学和工业研究组织 控制基因表达
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
EP1147204A1 (en) 1999-01-28 2001-10-24 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1229134A3 (en) 2001-01-31 2004-01-28 Nucleonics, Inc Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods

Also Published As

Publication number Publication date
PT93440A (pt) 1990-11-07
IE74850B1 (en) 1997-08-13
CA2012312A1 (en) 1990-09-16
IL93754A0 (en) 1990-12-23
ZA901973B (en) 1991-11-27
NO901213D0 (no) 1990-03-15
EP0387775A1 (de) 1990-09-19
NZ232917A (en) 1997-07-27
IE900931L (en) 1990-09-16
AU5130190A (en) 1990-11-01
FI901296A0 (fi) 1990-03-15
HU215187B (hu) 1998-10-28
DE59010432D1 (de) 1996-09-05
EP0387775B1 (de) 1996-07-31
DK0387775T3 (da) 1996-11-04
HU901584D0 (en) 1990-06-28
HU211868A9 (en) 1995-12-28
AU637354B2 (en) 1993-05-27
ATE140961T1 (de) 1996-08-15
PT93440B (pt) 2001-07-31
RU2136751C1 (ru) 1999-09-10
KR900014591A (ko) 1990-10-24
NO306623B1 (no) 1999-11-29
JPH03130080A (ja) 1991-06-03
GR3020935T3 (en) 1996-12-31
FI105103B (fi) 2000-06-15
JP3330930B2 (ja) 2002-10-07
ES2090049T3 (es) 1996-10-16
HUT54206A (en) 1991-01-28
CA2012312C (en) 2001-08-14
NO901213L (no) 1990-09-17
IL93754A (en) 1995-12-31

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