DD269145A5 - Verfahren zur herstellung von alphahalogenierten dicarbonsaeure sowie deren verwendung - Google Patents

Verfahren zur herstellung von alphahalogenierten dicarbonsaeure sowie deren verwendung Download PDF

Info

Publication number
DD269145A5
DD269145A5 DD87307708A DD30770887A DD269145A5 DD 269145 A5 DD269145 A5 DD 269145A5 DD 87307708 A DD87307708 A DD 87307708A DD 30770887 A DD30770887 A DD 30770887A DD 269145 A5 DD269145 A5 DD 269145A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
alpha
diacid
esters
compounds
Prior art date
Application number
DD87307708A
Other languages
German (de)
English (en)
Inventor
Jacob Bar-Tana
Yoelit Migron
Jochanan Blum
Bruno Dreckmann
Johannes Pill
Original Assignee
��������@�K@�Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ��������@�K@�Kk�� filed Critical ��������@�K@�Kk��
Publication of DD269145A5 publication Critical patent/DD269145A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02Dicarboxylic acids
    • C07C55/21Dicarboxylic acids containing twelve carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/32Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD87307708A 1986-10-08 1987-10-06 Verfahren zur herstellung von alphahalogenierten dicarbonsaeure sowie deren verwendung DD269145A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863634356 DE3634356A1 (de) 1986-10-08 1986-10-08 Arzneimittel enthaltend alpha-halogenierte dicarbonsaeuren

Publications (1)

Publication Number Publication Date
DD269145A5 true DD269145A5 (de) 1989-06-21

Family

ID=6311352

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87307708A DD269145A5 (de) 1986-10-08 1987-10-06 Verfahren zur herstellung von alphahalogenierten dicarbonsaeure sowie deren verwendung

Country Status (18)

Country Link
US (1) US4908385A (da)
EP (1) EP0279978B1 (da)
JP (1) JP2583545B2 (da)
KR (1) KR960003807B1 (da)
AU (1) AU603613B2 (da)
CA (1) CA1311243C (da)
DD (1) DD269145A5 (da)
DE (2) DE3634356A1 (da)
DK (1) DK298588A (da)
ES (1) ES2037725T3 (da)
FI (1) FI90860C (da)
GR (1) GR3003697T3 (da)
HU (1) HU199385B (da)
IE (1) IE60236B1 (da)
IL (1) IL84107A (da)
PT (1) PT85882B (da)
WO (1) WO1988002746A1 (da)
ZA (1) ZA877444B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214198A (en) * 1991-12-20 1993-05-25 American Cyanamid Company Process for the manufacture of halomaleic and halofumaric esters
US5602164A (en) * 1992-04-28 1997-02-11 Senyorina Ltd. Anti-obesity drugs
DE4224670A1 (de) * 1992-07-25 1994-01-27 Boehringer Mannheim Gmbh Verwendung von â,w-Dicarbonsäuren als Fibrinogensenker
DE4439947A1 (de) * 1994-11-09 1996-05-15 Boehringer Mannheim Gmbh 2,2-Dichloralkancarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
IL119971A (en) * 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
JP3929775B2 (ja) 1999-09-13 2007-06-13 ニューゲン テクノロジーズ, インコーポレイテッド ポリヌクレオチド配列の線形等温増幅のための方法および組成物
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
EP1356094B1 (en) * 2000-06-26 2010-01-13 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
EP1427847B1 (en) 2000-12-13 2010-07-28 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
IL153504A0 (en) 2001-03-09 2003-07-06 Nugen Technologies Inc Methods and compositions for amplification of rna sequences
WO2002072773A2 (en) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
CA2521084A1 (en) * 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
WO2013084237A1 (en) 2011-12-08 2013-06-13 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2971915A (en) * 1957-02-11 1961-02-14 Shell Oil Co Lubricating oil compositions
US3678102A (en) * 1970-09-11 1972-07-18 Ugine Kuhlmann {60 ,{60 ,{60 {40 ,{60 {40 -tetrasubstituted carboxylic diacids and process for their preparation
GB1350611A (en) * 1971-07-15 1974-04-18 Bp Chem Int Ltd Production of tetramethyl suberic acid
IL64542A0 (en) * 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
GR3003697T3 (da) 1993-03-16
FI882669A0 (fi) 1988-06-06
JPH01501549A (ja) 1989-06-01
US4908385A (en) 1990-03-13
ES2037725T3 (es) 1993-07-01
AU8027787A (en) 1988-05-06
FI90860C (fi) 1994-04-11
WO1988002746A1 (en) 1988-04-21
JP2583545B2 (ja) 1997-02-19
PT85882B (pt) 1990-07-31
DK298588D0 (da) 1988-06-01
ZA877444B (en) 1989-01-25
IE872679L (en) 1988-04-08
HUT46645A (en) 1988-11-28
FI90860B (fi) 1993-12-31
KR880701700A (ko) 1988-11-04
EP0279978B1 (en) 1992-01-02
CA1311243C (en) 1992-12-08
FI882669A (fi) 1988-06-06
AU603613B2 (en) 1990-11-22
IE60236B1 (en) 1994-06-15
PT85882A (de) 1987-11-01
EP0279978A1 (en) 1988-08-31
DE3634356A1 (de) 1988-04-21
DK298588A (da) 1988-06-01
IL84107A0 (en) 1988-03-31
HU199385B (en) 1990-02-28
KR960003807B1 (ko) 1996-03-22
DE3775754D1 (de) 1992-02-13
IL84107A (en) 1992-09-06

Similar Documents

Publication Publication Date Title
DD269145A5 (de) Verfahren zur herstellung von alphahalogenierten dicarbonsaeure sowie deren verwendung
DE69300261T2 (de) Cyano-2-Hydroxy-3-Enamid-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte.
EP0185080A1 (da)
DE2637110A1 (de) Heteroarylbenzoxepin-essigsaeuren, ihre vorprodukte und derivate
DE2300107C2 (de) Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen
DE2909754A1 (de) Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
DE2846931A1 (de) Tetrazol-derivate
LV10618B (en) A novel derivatives of thienothiazine, method for preparing thereof and use
DE2502967A1 (de) Carbonsaeuren, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2500808B2 (de) 4-cyclopropylmethylenoxy-3-chlorphenylessigsaeure und ihre salze, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE1793264B2 (de) Substituierte phenylessigsaeuren
DE2811253C2 (de) 3β-Substituierte 18β-Olean-9-en-30-oylsäurederivate, Verfahren zur Herstellung derselben und solche enthaltende Arzneimittel
DE69025967T2 (de) Aryl- oder Heteroaryl-1-alkyl-pyrrol-2-carbonsäure-Derivate, zur Behandlung von durch Interleukin-1 hervorgerufenen Erkrankungen
DE2427272A1 (de) 1-(2-(beta-naphthyloxy)-aethyl)-3-methyl -pyrazolon-(5), verfahren sowie verwendung als antithrombotikum
CH649998A5 (de) Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
DE2626385A1 (de) Thenoylessigsaeurederivate
DE2442124A1 (de) Butyramid-derivate, verfahren zu deren herstellung und diese substanzen enthaltende arzneimittel
DE3246860A1 (de) Neue phenylessigsaeure-derivate, deren herstellung und die sie enthaltenden zusammensetzungen
DE2617592C3 (de) 2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE2628360A1 (de) Fusidinsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung
DE2263026A1 (de) Amidderivate von pyridincarbonsaeuren
EP0006218B1 (de) Substituierte Aminosäuren, ihre Verwendung und Herstellung und sie enthaltende Arzneimittel
DE2842495C2 (de) 4-Cyclohexyl-α-niederalkyl-1-naphthalinessigsäure, deren pharmakologisch verträgliche Salze und Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2624856A1 (de) 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung
DE69219588T2 (de) Oxaza substituierte phosphine

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee