DD264213A5 - Verfahren zur herstellung eines spiroimidazolidins - Google Patents

Verfahren zur herstellung eines spiroimidazolidins Download PDF

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Publication number
DD264213A5
DD264213A5 DD86309078A DD30907886A DD264213A5 DD 264213 A5 DD264213 A5 DD 264213A5 DD 86309078 A DD86309078 A DD 86309078A DD 30907886 A DD30907886 A DD 30907886A DD 264213 A5 DD264213 A5 DD 264213A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
diabetes
aldose reductase
treatment
formula
Prior art date
Application number
DD86309078A
Other languages
German (de)
English (en)
Inventor
Christopher A Lipinski
Original Assignee
������@���Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Publication of DD264213A5 publication Critical patent/DD264213A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DD86309078A 1985-05-29 1986-05-27 Verfahren zur herstellung eines spiroimidazolidins DD264213A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/738,924 US4575507A (en) 1985-05-29 1985-05-29 Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use

Publications (1)

Publication Number Publication Date
DD264213A5 true DD264213A5 (de) 1989-01-25

Family

ID=24970055

Family Applications (5)

Application Number Title Priority Date Filing Date
DD86290626A DD251972A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen
DD86309080A DD264215A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen
DD86309079A DD264214A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen
DD86309078A DD264213A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung eines spiroimidazolidins
DD87309077A DD273258A5 (de) 1985-05-29 1987-11-16 Verfahren zur herstellung von spiroimidazolidinen

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DD86290626A DD251972A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen
DD86309080A DD264215A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen
DD86309079A DD264214A5 (de) 1985-05-29 1986-05-27 Verfahren zur herstellung von spiroimidazolidinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD87309077A DD273258A5 (de) 1985-05-29 1987-11-16 Verfahren zur herstellung von spiroimidazolidinen

Country Status (21)

Country Link
US (1) US4575507A (pl)
EP (1) EP0203791B1 (pl)
JP (1) JPS61277671A (pl)
KR (1) KR890001548B1 (pl)
AT (1) ATE46332T1 (pl)
AU (1) AU560429B2 (pl)
DD (5) DD251972A5 (pl)
DE (1) DE3665584D1 (pl)
DK (1) DK248886A (pl)
EG (1) EG17859A (pl)
ES (2) ES8800228A1 (pl)
FI (1) FI862251A (pl)
GR (1) GR861388B (pl)
HU (4) HU196060B (pl)
IL (1) IL78954A (pl)
NO (1) NO862123L (pl)
NZ (1) NZ216334A (pl)
PH (1) PH22213A (pl)
PL (5) PL146020B1 (pl)
PT (1) PT82650B (pl)
ZA (1) ZA863934B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198212B (en) * 1984-07-20 1989-08-28 Pfizer Process for production of spiro-imidasolones
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
CA1310269C (en) * 1987-03-20 1992-11-17 Billie M. York, Jr. Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US5202339A (en) * 1987-08-28 1993-04-13 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
WO1990002126A1 (en) * 1988-08-24 1990-03-08 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US8326636B2 (en) * 2008-01-16 2012-12-04 Canyon Ip Holdings Llc Using a physical phenomenon detector to control operation of a speech recognition engine
KR20140128318A (ko) * 2012-02-09 2014-11-05 베링거 인겔하임 인터내셔날 게엠베하 1,4-보호된 9-하이드록시-5-옥소-1,4-디아자-스피로 [5.5] 운데칸의 입체선택적 합성 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
DE3367103D1 (en) * 1982-11-10 1986-11-27 Pfizer Sorbinil by optical resolution with aminopinane derivatives
SU1380610A3 (ru) * 1982-12-06 1988-03-07 Пфайзер Инк. (Фирма) Способ получени спирогетероазолидиндионов или их фармацевтически приемлемых солей
US4556670A (en) 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
EP0159143B1 (en) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4762838A (en) 1985-08-30 1988-08-09 Pfizer Inc. Quinazolin-4(3H)-one derivatives as anticoccidial agents

Also Published As

Publication number Publication date
DD264215A5 (de) 1989-01-25
AU560429B2 (en) 1987-04-09
US4575507A (en) 1986-03-11
EP0203791A1 (en) 1986-12-03
HU196060B (en) 1988-09-28
AU5801286A (en) 1987-01-08
PL147398B1 (en) 1989-05-31
PH22213A (en) 1988-06-28
PL147400B1 (en) 1989-05-31
DD264214A5 (de) 1989-01-25
KR890001548B1 (en) 1989-05-08
PT82650A (en) 1986-06-01
PL147399B1 (en) 1989-05-31
ZA863934B (en) 1988-01-27
PL266364A1 (en) 1988-03-03
NZ216334A (en) 1988-08-30
FI862251A (fi) 1986-11-30
ES8801830A1 (es) 1988-02-16
HUT49882A (en) 1989-11-28
HUT49879A (en) 1989-11-28
DK248886A (da) 1986-11-30
DE3665584D1 (de) 1989-10-19
ES557391A0 (es) 1988-02-16
EP0203791B1 (en) 1989-09-13
GR861388B (en) 1986-09-17
PL266363A1 (en) 1988-03-03
FI862251A0 (fi) 1986-05-28
PL266366A1 (en) 1988-03-03
ATE46332T1 (de) 1989-09-15
IL78954A (en) 1989-09-28
IL78954A0 (en) 1986-09-30
HU199845B (en) 1990-03-28
HUT44767A (en) 1988-04-28
NO862123L (no) 1986-12-01
DK248886D0 (da) 1986-05-28
PL147397B1 (en) 1989-05-31
PL146020B1 (en) 1988-12-31
KR860008984A (ko) 1986-12-19
JPS61277671A (ja) 1986-12-08
HU893127D0 (en) 1990-01-28
PL266365A1 (en) 1988-03-03
DD251972A5 (de) 1987-12-02
DD273258A5 (de) 1989-11-08
PT82650B (pt) 1988-11-30
ES8800228A1 (es) 1987-11-01
EG17859A (en) 1991-11-30
ES555375A0 (es) 1987-11-01

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Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee
NPV Change in the person, the name or the address of the representative (addendum to changes before extension act)