GR861388B - Spiro-imidazolidines as aldose reductase inhibitors - Google Patents

Spiro-imidazolidines as aldose reductase inhibitors

Info

Publication number
GR861388B
GR861388B GR861388A GR860101388A GR861388B GR 861388 B GR861388 B GR 861388B GR 861388 A GR861388 A GR 861388A GR 860101388 A GR860101388 A GR 860101388A GR 861388 B GR861388 B GR 861388B
Authority
GR
Greece
Prior art keywords
imidazolidines
spiro
reductase inhibitors
aldose reductase
neuritic
Prior art date
Application number
GR861388A
Other languages
English (en)
Inventor
Lipinski Christopher Andrew
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of GR861388B publication Critical patent/GR861388B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GR861388A 1985-05-29 1986-05-28 Spiro-imidazolidines as aldose reductase inhibitors GR861388B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/738,924 US4575507A (en) 1985-05-29 1985-05-29 Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use

Publications (1)

Publication Number Publication Date
GR861388B true GR861388B (en) 1986-09-17

Family

ID=24970055

Family Applications (1)

Application Number Title Priority Date Filing Date
GR861388A GR861388B (en) 1985-05-29 1986-05-28 Spiro-imidazolidines as aldose reductase inhibitors

Country Status (21)

Country Link
US (1) US4575507A (el)
EP (1) EP0203791B1 (el)
JP (1) JPS61277671A (el)
KR (1) KR890001548B1 (el)
AT (1) ATE46332T1 (el)
AU (1) AU560429B2 (el)
DD (5) DD251972A5 (el)
DE (1) DE3665584D1 (el)
DK (1) DK248886A (el)
EG (1) EG17859A (el)
ES (2) ES8800228A1 (el)
FI (1) FI862251A (el)
GR (1) GR861388B (el)
HU (4) HU196060B (el)
IL (1) IL78954A (el)
NO (1) NO862123L (el)
NZ (1) NZ216334A (el)
PH (1) PH22213A (el)
PL (5) PL146020B1 (el)
PT (1) PT82650B (el)
ZA (1) ZA863934B (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198212B (en) * 1984-07-20 1989-08-28 Pfizer Process for production of spiro-imidasolones
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
CA1310269C (en) * 1987-03-20 1992-11-17 Billie M. York, Jr. Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US5202339A (en) * 1987-08-28 1993-04-13 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
WO1990002126A1 (en) * 1988-08-24 1990-03-08 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5068332A (en) * 1990-10-12 1991-11-26 American Home Products Corporation Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
US8326636B2 (en) * 2008-01-16 2012-12-04 Canyon Ip Holdings Llc Using a physical phenomenon detector to control operation of a speech recognition engine
KR20140128318A (ko) * 2012-02-09 2014-11-05 베링거 인겔하임 인터내셔날 게엠베하 1,4-보호된 9-하이드록시-5-옥소-1,4-디아자-스피로 [5.5] 운데칸의 입체선택적 합성 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
DE3367103D1 (en) * 1982-11-10 1986-11-27 Pfizer Sorbinil by optical resolution with aminopinane derivatives
SU1380610A3 (ru) * 1982-12-06 1988-03-07 Пфайзер Инк. (Фирма) Способ получени спирогетероазолидиндионов или их фармацевтически приемлемых солей
US4556670A (en) 1982-12-06 1985-12-03 Pfizer Inc. Spiro-3-hetero-azolones for treatment of diabetic complications
EP0159143B1 (en) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4762838A (en) 1985-08-30 1988-08-09 Pfizer Inc. Quinazolin-4(3H)-one derivatives as anticoccidial agents

Also Published As

Publication number Publication date
DD264215A5 (de) 1989-01-25
AU560429B2 (en) 1987-04-09
US4575507A (en) 1986-03-11
EP0203791A1 (en) 1986-12-03
HU196060B (en) 1988-09-28
AU5801286A (en) 1987-01-08
PL147398B1 (en) 1989-05-31
PH22213A (en) 1988-06-28
PL147400B1 (en) 1989-05-31
DD264214A5 (de) 1989-01-25
KR890001548B1 (en) 1989-05-08
DD264213A5 (de) 1989-01-25
PT82650A (en) 1986-06-01
PL147399B1 (en) 1989-05-31
ZA863934B (en) 1988-01-27
PL266364A1 (en) 1988-03-03
NZ216334A (en) 1988-08-30
FI862251A (fi) 1986-11-30
ES8801830A1 (es) 1988-02-16
HUT49882A (en) 1989-11-28
HUT49879A (en) 1989-11-28
DK248886A (da) 1986-11-30
DE3665584D1 (de) 1989-10-19
ES557391A0 (es) 1988-02-16
EP0203791B1 (en) 1989-09-13
PL266363A1 (en) 1988-03-03
FI862251A0 (fi) 1986-05-28
PL266366A1 (en) 1988-03-03
ATE46332T1 (de) 1989-09-15
IL78954A (en) 1989-09-28
IL78954A0 (en) 1986-09-30
HU199845B (en) 1990-03-28
HUT44767A (en) 1988-04-28
NO862123L (no) 1986-12-01
DK248886D0 (da) 1986-05-28
PL147397B1 (en) 1989-05-31
PL146020B1 (en) 1988-12-31
KR860008984A (ko) 1986-12-19
JPS61277671A (ja) 1986-12-08
HU893127D0 (en) 1990-01-28
PL266365A1 (en) 1988-03-03
DD251972A5 (de) 1987-12-02
DD273258A5 (de) 1989-11-08
PT82650B (pt) 1988-11-30
ES8800228A1 (es) 1987-11-01
EG17859A (en) 1991-11-30
ES555375A0 (es) 1987-11-01

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