DD218371A5 - Verfahren zur herstellung von wff analoga - Google Patents
Verfahren zur herstellung von wff analoga Download PDFInfo
- Publication number
- DD218371A5 DD218371A5 DD84259373A DD25937384A DD218371A5 DD 218371 A5 DD218371 A5 DD 218371A5 DD 84259373 A DD84259373 A DD 84259373A DD 25937384 A DD25937384 A DD 25937384A DD 218371 A5 DD218371 A5 DD 218371A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- arg
- ala
- leu
- ser
- gln
- Prior art date
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- 210000002257 embryonic structure Anatomy 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 229940066493 expectorants Drugs 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
- 239000000960 hypophysis hormone Substances 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Chemical class 0.000 description 1
- 239000002184 metal Chemical class 0.000 description 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000011894 semi-preparative HPLC Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/457,862 US4529595A (en) | 1983-01-13 | 1983-01-13 | GRF Analogs |
| US06/488,748 US4595676A (en) | 1983-04-26 | 1983-04-26 | Rat hypothalamic GRF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD218371A5 true DD218371A5 (de) | 1985-02-06 |
Family
ID=27038761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD84259373A DD218371A5 (de) | 1983-01-13 | 1984-01-12 | Verfahren zur herstellung von wff analoga |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0117034B1 (fr) |
| JP (1) | JPH0689033B2 (fr) |
| KR (1) | KR900006713B1 (fr) |
| AR (1) | AR241452A1 (fr) |
| AU (1) | AU557046B2 (fr) |
| BG (1) | BG40815A3 (fr) |
| DD (1) | DD218371A5 (fr) |
| DE (1) | DE3473764D1 (fr) |
| DK (1) | DK161096C (fr) |
| EG (1) | EG16824A (fr) |
| ES (1) | ES8506263A1 (fr) |
| FI (1) | FI87080C (fr) |
| GR (1) | GR81733B (fr) |
| IE (1) | IE56568B1 (fr) |
| IL (1) | IL70530A (fr) |
| IN (1) | IN160129B (fr) |
| MX (1) | MX161186A (fr) |
| NO (1) | NO168362C (fr) |
| OA (1) | OA07631A (fr) |
| PL (1) | PL143842B1 (fr) |
| PT (1) | PT77934B (fr) |
| RO (1) | RO88702A (fr) |
| SG (1) | SG67591G (fr) |
| YU (1) | YU45587B (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL71150A (en) * | 1983-03-07 | 1987-02-27 | Sparamedica Ag | Growth hormone releasing factor analogs,their preparation and pharmaceutical compositions containing them |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
| US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| JPS61115098A (ja) * | 1984-11-09 | 1986-06-02 | Sumitomo Seiyaku Kk | ポリペプチド |
| CA1271600A (fr) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Peptides liberant l'hormone de croissance et methode de traitement chez les mammiferes |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| JPH06500311A (ja) * | 1990-06-29 | 1994-01-13 | エフ・ホフマン―ラ ロシュ アーゲー | ヒスチジン置換されたヒト成長ホルモン放出因子類縁体 |
| DE69108192T2 (de) * | 1990-12-10 | 1995-07-20 | Hoffmann La Roche | Verfahren zur enzymatischen Herstellung von GRF(1-44)NH2. |
| WO1992018531A1 (fr) * | 1991-04-09 | 1992-10-29 | F. Hoffmann-La Roche Ag | Analogues de somatocrinine |
| JPH0578344U (ja) * | 1992-04-03 | 1993-10-26 | 合同製鐵株式会社 | 多ストランド連続鋳造装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71150A (en) * | 1983-03-07 | 1987-02-27 | Sparamedica Ag | Growth hormone releasing factor analogs,their preparation and pharmaceutical compositions containing them |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
-
1983
- 1983-12-23 IL IL70530A patent/IL70530A/xx not_active IP Right Cessation
-
1984
- 1984-01-04 AR AR84295336A patent/AR241452A1/es active
- 1984-01-04 AU AU23075/84A patent/AU557046B2/en not_active Expired
- 1984-01-09 PT PT77934A patent/PT77934B/pt unknown
- 1984-01-10 EP EP84300150A patent/EP0117034B1/fr not_active Expired
- 1984-01-10 DE DE8484300150T patent/DE3473764D1/de not_active Expired
- 1984-01-11 GR GR73488A patent/GR81733B/el unknown
- 1984-01-11 NO NO840086A patent/NO168362C/no not_active IP Right Cessation
- 1984-01-12 PL PL1984245687A patent/PL143842B1/pl unknown
- 1984-01-12 MX MX200024A patent/MX161186A/es unknown
- 1984-01-12 JP JP59004235A patent/JPH0689033B2/ja not_active Expired - Lifetime
- 1984-01-12 DD DD84259373A patent/DD218371A5/de not_active IP Right Cessation
- 1984-01-12 ES ES528821A patent/ES8506263A1/es not_active Expired
- 1984-01-12 FI FI840111A patent/FI87080C/fi not_active IP Right Cessation
- 1984-01-12 IE IE62/84A patent/IE56568B1/en not_active IP Right Cessation
- 1984-01-12 DK DK012984A patent/DK161096C/da not_active IP Right Cessation
- 1984-01-12 KR KR1019840000097A patent/KR900006713B1/ko not_active IP Right Cessation
- 1984-01-12 IN IN17/MAS/84A patent/IN160129B/en unknown
- 1984-01-13 BG BG063874A patent/BG40815A3/xx unknown
- 1984-01-13 RO RO84113317A patent/RO88702A/fr unknown
- 1984-01-13 YU YU5284A patent/YU45587B/sh unknown
- 1984-01-14 EG EG27/84A patent/EG16824A/xx active
- 1984-02-12 OA OA58203A patent/OA07631A/xx unknown
-
1991
- 1991-08-19 SG SG675/91A patent/SG67591G/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |