YU45587B - Postupak za dobijanje grf analoga - Google Patents
Postupak za dobijanje grf analogaInfo
- Publication number
- YU45587B YU45587B YU5284A YU5284A YU45587B YU 45587 B YU45587 B YU 45587B YU 5284 A YU5284 A YU 5284A YU 5284 A YU5284 A YU 5284A YU 45587 B YU45587 B YU 45587B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- arg
- ala
- leu
- gln
- ser
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 6
- -1 Met Chemical compound 0.000 abstract 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 2
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical group OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
POSTUPAK ZA DOBIJANJE GRF ANALOGA, opste formule (I) H-R1-Ala-Asp-Ala-Ile-Phe-Thr-R8-Ser-R10-Arg-R12-R13-Leu-R15-Gln-Leu-R18-Ala-Arg-Lys-Leu-R24-R25-Ile-R27-R28-Arg-Gln-Gl n-Gly- -Glu-R34-Asn-Gln-Glu-R38-R39-T40-Arg-R42-R43-R44-Y gde R1 je Tyr, Met, D-Tyr, Phe, D-Phe, Leu, D-His ili His; R8 je Ser ili Asn R10 je Tyr, Phe ili D-Tyr; R12 je Arg ili Lys; R13 je Ile ili Val; R15 je Gly ili D-Ala; R18 je Tyr ili Ser; R24 je His ili Gln; R25 je Glu ili Asp; R27 se bira iz grupe koju cine L-izomeri Ala, Nle, Ile, Leu i Val; R28 je Ser, Asn ili D-Ala; R34 je Arg ili Ser; R38 je Gln ili Arg; R39 je Arg ili Gly; R40 je Ser ili Ala; R42 je Phe ili Ala; R43 je Asn ili Arg; i R44 je prirodna amino kiselina ili des-R44; Y oznacava karboksilni deo amino kiselinskog ostatka na C-terminusu, - COOH ili -CONH2, ili njegove C-terminalno skracene verzije, naz nacen time, sto se gradi intermedijerni peptid koji ima formulu X1-R1 (X ili X2)-Ala-Aspe (X3)-Ala-ILe-Phe-Thr (X4)-R8 (X4 ili X5)-Ser (X4)-R10 (X2)-Arg (X6)-R12(X6 ili X7 7-R13-Leu-R15-Gln(X5)-Leu-R18(X2)-Ala-Arg(X6)-Lys(X7-Leu-Leu-R24(X ili X5)-R25 (X3)-Ile-R27-R28(X4 ili X5)-Arg(X6)-Gln(X5)-Gly-Glu(X3)-R34(X4 ili X6)- Asn(X5)-Gln(X5)-Glu(X3)-R38(X5 ili X6)-R39(X6)-R40(X4)-Arg(X6)-R42-R43 (X5 ili X6)-R44-X9 ili C-terminalno njegove skracene verzije, gde X1 je BOC, X5 je Tos, X2 je 2,6-dihlorobenzil, X3 je Bzl, X4 je Bzl, X5 je Xan, X6 je Tos, X7 je 2-hlorobenziloksikarbonil, i X9 je -O-CH2-nosac smole ili -NH-nosac smole posle kuplovanja u odnosima od oko 1-2 milimola zasticene amino kiseline na 1 gram smole u metilen hloridu ili eimetilformamidu ili u njihovoj smesi i odvajanje zasticenih grupa i dobivenog peptida se vrsi koriscenjem TFA u podesnom rastvaracu, takvom kao sto je metilen hlorid i zatim pomocu HF na temperaturi izmedju oko 0 C do -20 C i radi dobivanja cistog proizvoda formule (I), dobiveni peptid se rastvara u sircetnoj kiselini.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/457,862 US4529595A (en) | 1983-01-13 | 1983-01-13 | GRF Analogs |
| US06/488,748 US4595676A (en) | 1983-04-26 | 1983-04-26 | Rat hypothalamic GRF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU5284A YU5284A (en) | 1987-12-31 |
| YU45587B true YU45587B (sh) | 1992-07-20 |
Family
ID=27038761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU5284A YU45587B (sh) | 1983-01-13 | 1984-01-13 | Postupak za dobijanje grf analoga |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0117034B1 (sh) |
| JP (1) | JPH0689033B2 (sh) |
| KR (1) | KR900006713B1 (sh) |
| AR (1) | AR241452A1 (sh) |
| AU (1) | AU557046B2 (sh) |
| BG (1) | BG40815A3 (sh) |
| DD (1) | DD218371A5 (sh) |
| DE (1) | DE3473764D1 (sh) |
| DK (1) | DK161096C (sh) |
| EG (1) | EG16824A (sh) |
| ES (1) | ES8506263A1 (sh) |
| FI (1) | FI87080C (sh) |
| GR (1) | GR81733B (sh) |
| IE (1) | IE56568B1 (sh) |
| IL (1) | IL70530A (sh) |
| IN (1) | IN160129B (sh) |
| MX (1) | MX161186A (sh) |
| NO (1) | NO168362C (sh) |
| OA (1) | OA07631A (sh) |
| PL (1) | PL143842B1 (sh) |
| PT (1) | PT77934B (sh) |
| RO (1) | RO88702A (sh) |
| SG (1) | SG67591G (sh) |
| YU (1) | YU45587B (sh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| DE3482387D1 (en) * | 1983-03-07 | 1990-07-05 | Hoffmann La Roche | Polypeptide. |
| US4732972A (en) * | 1983-03-07 | 1988-03-22 | Hoffmann-La Roche Inc. | Polypeptides having growth hormone releasing activity |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
| US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| JPS61115098A (ja) * | 1984-11-09 | 1986-06-02 | Sumitomo Seiyaku Kk | ポリペプチド |
| CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
| FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| EP0544706A4 (en) * | 1990-06-29 | 1993-10-13 | Hoffmann-La Roche Inc. | Histidine substituted growth hormone releasing factor analogs |
| EP0490249B1 (en) * | 1990-12-10 | 1995-03-15 | F. Hoffmann-La Roche Ag | Process for the enzymatic preparation of GRF(1-44)NH2 |
| WO1992018531A1 (en) * | 1991-04-09 | 1992-10-29 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
| JPH0578344U (ja) * | 1992-04-03 | 1993-10-26 | 合同製鐵株式会社 | 多ストランド連続鋳造装置 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3482387D1 (en) * | 1983-03-07 | 1990-07-05 | Hoffmann La Roche | Polypeptide. |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| PT79094B (en) * | 1983-08-29 | 1986-08-14 | Salk Inst For Biological Studi | Grf analogs |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
-
1983
- 1983-12-23 IL IL70530A patent/IL70530A/xx not_active IP Right Cessation
-
1984
- 1984-01-04 AR AR84295336A patent/AR241452A1/es active
- 1984-01-04 AU AU23075/84A patent/AU557046B2/en not_active Expired
- 1984-01-09 PT PT77934A patent/PT77934B/pt unknown
- 1984-01-10 DE DE8484300150T patent/DE3473764D1/de not_active Expired
- 1984-01-10 EP EP84300150A patent/EP0117034B1/en not_active Expired
- 1984-01-11 GR GR73488A patent/GR81733B/el unknown
- 1984-01-11 NO NO840086A patent/NO168362C/no not_active IP Right Cessation
- 1984-01-12 IE IE62/84A patent/IE56568B1/en not_active IP Right Cessation
- 1984-01-12 IN IN17/MAS/84A patent/IN160129B/en unknown
- 1984-01-12 ES ES528821A patent/ES8506263A1/es not_active Expired
- 1984-01-12 FI FI840111A patent/FI87080C/fi not_active IP Right Cessation
- 1984-01-12 DD DD84259373A patent/DD218371A5/de not_active IP Right Cessation
- 1984-01-12 PL PL1984245687A patent/PL143842B1/pl unknown
- 1984-01-12 JP JP59004235A patent/JPH0689033B2/ja not_active Expired - Lifetime
- 1984-01-12 KR KR1019840000097A patent/KR900006713B1/ko not_active IP Right Cessation
- 1984-01-12 DK DK012984A patent/DK161096C/da not_active IP Right Cessation
- 1984-01-12 MX MX200024A patent/MX161186A/es unknown
- 1984-01-13 YU YU5284A patent/YU45587B/sh unknown
- 1984-01-13 BG BG8463874A patent/BG40815A3/xx unknown
- 1984-01-13 RO RO84113317A patent/RO88702A/ro unknown
- 1984-01-14 EG EG27/84A patent/EG16824A/xx active
- 1984-02-12 OA OA58203A patent/OA07631A/xx unknown
-
1991
- 1991-08-19 SG SG675/91A patent/SG67591G/en unknown
Also Published As
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