DD216934A5 - Verfahren zur herstellung neuer derivate von xanthinen - Google Patents

Verfahren zur herstellung neuer derivate von xanthinen Download PDF

Info

Publication number
DD216934A5
DD216934A5 DD83253414A DD25341483A DD216934A5 DD 216934 A5 DD216934 A5 DD 216934A5 DD 83253414 A DD83253414 A DD 83253414A DD 25341483 A DD25341483 A DD 25341483A DD 216934 A5 DD216934 A5 DD 216934A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
carbon atoms
alkyl
general formula
xanthine
Prior art date
Application number
DD83253414A
Other languages
German (de)
English (en)
Inventor
Gilbert Regnier
Claude Guillonneau
Jacques Duhault
Michelle Boulanger
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of DD216934A5 publication Critical patent/DD216934A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD83253414A 1982-07-28 1983-07-27 Verfahren zur herstellung neuer derivate von xanthinen DD216934A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213155A FR2531085A1 (fr) 1982-07-28 1982-07-28 Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
DD216934A5 true DD216934A5 (de) 1985-01-02

Family

ID=9276395

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83253414A DD216934A5 (de) 1982-07-28 1983-07-27 Verfahren zur herstellung neuer derivate von xanthinen

Country Status (24)

Country Link
US (1) US4548820A (ko)
EP (1) EP0103497B1 (ko)
JP (1) JPS5942383A (ko)
KR (1) KR870001268B1 (ko)
AT (1) ATE17728T1 (ko)
AU (1) AU560809B2 (ko)
CA (1) CA1207766A (ko)
DD (1) DD216934A5 (ko)
DE (1) DE3362022D1 (ko)
DK (1) DK157550C (ko)
ES (1) ES524532A0 (ko)
FR (1) FR2531085A1 (ko)
GR (1) GR78891B (ko)
HU (1) HU188353B (ko)
IE (1) IE55773B1 (ko)
IL (1) IL69362A (ko)
MA (1) MA19860A1 (ko)
NO (1) NO159091C (ko)
NZ (1) NZ205035A (ko)
OA (1) OA07508A (ko)
PH (1) PH19275A (ko)
PT (1) PT77110B (ko)
SU (2) SU1240361A3 (ko)
ZA (1) ZA835496B (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648559A5 (de) * 1981-07-20 1985-03-29 Siegfried Ag Theophyllinderivate und verfahren zu deren herstellung.
FR2558162B1 (fr) * 1984-01-17 1986-04-25 Adir Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
HU197746B (en) * 1985-09-05 1989-05-29 Sandoz Ag Process for producing xantin derivatives and pharmaceutical compositions containing them
US4810706A (en) * 1985-12-20 1989-03-07 Recherche Syntex Piperazine derivatives of theophylline and theobromine
GB8716313D0 (en) * 1987-07-10 1987-08-19 Janssen Pharmaceutica Nv 2-(heterocyclylalkyl)imidazopyridines
US5298508A (en) * 1988-07-19 1994-03-29 The United States Of America As Represented By The Department Of Health And Human Services Irreversible inhibitors of adenosine receptors
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
FR2659656B1 (fr) * 1990-03-15 1994-09-09 Sanofi Sa Derives de pyrimidinedione-2,4 et medicaments les contenant.
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
DE19702785A1 (de) * 1997-01-27 1998-07-30 Bayer Ag Neue cyclische Harnstoffderivate
TR200201317T2 (tr) 1999-08-21 2002-11-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Sinerjistik kombinasyon.
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
AU2004233852A1 (en) 2003-04-25 2004-11-11 Novacardia, Inc. Method of improved diuresis in individuals with impaired renal function
CA2568436A1 (en) * 2004-04-16 2005-11-10 Novacardia, Inc. Combination therapy comprising an adenosine a1 receptor antagonist and an aldosterone inhibitor
RU2007118932A (ru) * 2004-10-22 2008-11-27 Смитклайн Бичам Корпорейшн (US) Производные ксантина с активностью нм74а
EP2024364A1 (en) * 2006-05-26 2009-02-18 Neuromed Pharmaceuticals, Ltd. Heterocyclic compounds as calcium channel blockers
JP2008025761A (ja) * 2006-07-24 2008-02-07 Kanaflex Corporation 排水管更生用樹脂管
RU2333212C3 (ru) * 2007-03-29 2019-08-26 Общество С Ограниченной Ответственностью "Фармвинг" ПРОИЗВОДНЫЕ 1-И 7-[ω-(БЕНЗГИДРИЛ-4-ПИПЕРАЗИНИЛ-1)АЛКИЛ]-3-АЛКИЛКСАНТИНОВ, ОБЛАДАЮЩИЕ ПРОТИВОГИСТАМИННОЙ И АНТИАЛЛЕРГИЧЕСКОЙ АКТИВНОСТЬЮ
HUE031039T2 (en) 2007-03-29 2017-06-28 Joint-Stock Company Obninsk Chemical Pharmaceutical Company An antihistamine and an anti-allergenic agent and a method for its preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH409974A (de) * 1959-03-25 1966-03-31 Merckle Kg Chem Pharm L Verfahren zur Herstellung neuer therapeutisch wirksamer Coffeino-(8)-alkylendiamine
GB1133989A (en) * 1964-12-08 1968-11-20 Chugai Pharmaceutical Co Ltd Theophylline derivatives, their salts and process for preparing the same
FR7828M (ko) * 1967-11-13 1970-05-25
JPS55118488A (en) * 1979-03-05 1980-09-11 Eisai Co Ltd Theobromine derivative and its preparation
JPS5618983A (en) * 1979-07-25 1981-02-23 Eisai Co Ltd Theophylline derivative and its preapration
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
DE3046927A1 (de) * 1980-12-11 1982-07-15 Josef Dipl.-Chem.Dr.rer.nat. 1000 Berlin Klosa 8-dialkylaminoalkylaether-coffein-platin-komplexe , verfahren zu ihrer herstellung und sie enthaltende arzneimittel
ES8303412A1 (es) * 1981-10-06 1983-02-01 Invest Tecnica Aplicada Procedimiento de obtencion de nuevas xantinas con actividad farmacologica

Also Published As

Publication number Publication date
ES8500275A1 (es) 1984-10-01
DK157550B (da) 1990-01-22
HU188353B (en) 1986-04-28
IL69362A (en) 1986-07-31
NO159091B (no) 1988-08-22
DE3362022D1 (en) 1986-03-13
IE55773B1 (en) 1991-01-16
NO159091C (no) 1988-11-30
NO832742L (no) 1984-01-30
ES524532A0 (es) 1984-10-01
SU1245261A3 (ru) 1986-07-15
AU1736183A (en) 1984-02-02
IE831762L (en) 1984-01-28
ATE17728T1 (de) 1986-02-15
EP0103497A1 (fr) 1984-03-21
GR78891B (ko) 1984-10-02
ZA835496B (en) 1984-03-28
DK342883D0 (da) 1983-07-27
OA07508A (fr) 1985-03-31
DK342883A (da) 1984-01-29
NZ205035A (en) 1986-04-11
FR2531085B1 (ko) 1984-11-23
DK157550C (da) 1990-06-11
MA19860A1 (fr) 1984-04-01
IL69362A0 (en) 1983-11-30
KR870001268B1 (ko) 1987-06-30
CA1207766A (fr) 1986-07-15
SU1240361A3 (ru) 1986-06-23
KR840005445A (ko) 1984-11-12
EP0103497B1 (fr) 1986-01-29
PT77110A (fr) 1983-08-01
FR2531085A1 (fr) 1984-02-03
AU560809B2 (en) 1987-04-16
JPS5942383A (ja) 1984-03-08
PH19275A (en) 1986-02-21
US4548820A (en) 1985-10-22
JPH0359903B2 (ko) 1991-09-12
PT77110B (fr) 1986-01-27

Similar Documents

Publication Publication Date Title
DD216934A5 (de) Verfahren zur herstellung neuer derivate von xanthinen
DE2614406C2 (ko)
DE69530989T2 (de) Neue pyrimidinderivate und verfahren zu ihrer herstellung
DE1795769C3 (de) 6,7,8,9-Tetrahydro-2H-pyrido [Ua] pyrimidinderivate, deren Salze mit Säuren und quaternäre Methosalze, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE3001328C2 (ko)
DE2345064C3 (de) 4-Amino-2-<l,2r3,4-tetrahydroisochinolin-2 yl)-chinazolinderivate und diese enthaltende Arzneimittel
DE1695556B2 (de) 3Alkyl-l,2,3,4,4a,9-hexahydropyrazino [1,2-f] morphanthridinderivate
DE2720085C2 (ko)
DD154364A5 (de) Verfahren zur herstellung von neuen derivaten des piperidylbenzimidazolinons
DE2305092A1 (de) Alpha-aminomethylbenzylalkoholderivate
DE69720021T2 (de) 1,4-disubstituierte piperazine
DE1620450A1 (de) Substituierte Benzimidazole
DD142048A5 (de) Verfahren zur herstellung von substituierten 2-phenylimino-imidazolidinen
DE2724434A1 (de) Neue, in 11-stellung substituierte 5,11-dihydro-6h-pyrido eckige klammer auf 2,3-b eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3326724A1 (de) In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DD282457A5 (de) Verfahren zur herstellung neuer heterocyclischer derivate
DE2040510A1 (de) Neue Azepin-Derivate
DE2225765A1 (de) 3- eckige Klammer auf 2-(4-Phenyl-lpiperazinyl)-äthyl eckige Klammer zu -indoline
EP0621037A1 (de) Pyrido-pyrimidindione, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE1720033A1 (de) Neue Indolderivate und Verfahren zu ihrer Herstellung
DE1076691B (de) Verfahren zur Herstellung von Phenthiazinderivaten
DE2340217C2 (de) 3-Benzoylthiophene, ihre Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP2159226B1 (de) Antihistamin- und antiallergienmittel sowie verfahren zu seiner herstellung
AT390062B (de) Verfahren zur herstellung von neuen trifluormethyl substituierten tetracyclischen chinazolinonen und ihrer saeureadditionssalze
DE2217420A1 (de) N-thienylmethyl-heterocyclen, deren saeureadditionssalze sowie verfahren zu deren herstellung

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee