DE3362022D1 - Xanthine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
Xanthine derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- DE3362022D1 DE3362022D1 DE8383401518T DE3362022T DE3362022D1 DE 3362022 D1 DE3362022 D1 DE 3362022D1 DE 8383401518 T DE8383401518 T DE 8383401518T DE 3362022 T DE3362022 T DE 3362022T DE 3362022 D1 DE3362022 D1 DE 3362022D1
- Authority
- DE
- Germany
- Prior art keywords
- image
- alkyl
- hydrogen
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8213155A FR2531085A1 (fr) | 1982-07-28 | 1982-07-28 | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3362022D1 true DE3362022D1 (en) | 1986-03-13 |
Family
ID=9276395
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383401518T Expired DE3362022D1 (en) | 1982-07-28 | 1983-07-25 | Xanthine derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (24)
Country | Link |
---|---|
US (1) | US4548820A (de) |
EP (1) | EP0103497B1 (de) |
JP (1) | JPS5942383A (de) |
KR (1) | KR870001268B1 (de) |
AT (1) | ATE17728T1 (de) |
AU (1) | AU560809B2 (de) |
CA (1) | CA1207766A (de) |
DD (1) | DD216934A5 (de) |
DE (1) | DE3362022D1 (de) |
DK (1) | DK157550C (de) |
ES (1) | ES524532A0 (de) |
FR (1) | FR2531085A1 (de) |
GR (1) | GR78891B (de) |
HU (1) | HU188353B (de) |
IE (1) | IE55773B1 (de) |
IL (1) | IL69362A (de) |
MA (1) | MA19860A1 (de) |
NO (1) | NO159091C (de) |
NZ (1) | NZ205035A (de) |
OA (1) | OA07508A (de) |
PH (1) | PH19275A (de) |
PT (1) | PT77110B (de) |
SU (2) | SU1240361A3 (de) |
ZA (1) | ZA835496B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH648559A5 (de) * | 1981-07-20 | 1985-03-29 | Siegfried Ag | Theophyllinderivate und verfahren zu deren herstellung. |
FR2558162B1 (fr) * | 1984-01-17 | 1986-04-25 | Adir | Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
HU197746B (en) * | 1985-09-05 | 1989-05-29 | Sandoz Ag | Process for producing xantin derivatives and pharmaceutical compositions containing them |
US4810706A (en) * | 1985-12-20 | 1989-03-07 | Recherche Syntex | Piperazine derivatives of theophylline and theobromine |
GB8716313D0 (en) * | 1987-07-10 | 1987-08-19 | Janssen Pharmaceutica Nv | 2-(heterocyclylalkyl)imidazopyridines |
US5298508A (en) * | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
FR2659656B1 (fr) * | 1990-03-15 | 1994-09-09 | Sanofi Sa | Derives de pyrimidinedione-2,4 et medicaments les contenant. |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
WO1994025462A1 (en) * | 1993-05-03 | 1994-11-10 | The United States Of America, Represented By The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
US5661153A (en) * | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
DE19702785A1 (de) * | 1997-01-27 | 1998-07-30 | Bayer Ag | Neue cyclische Harnstoffderivate |
JP5038568B2 (ja) | 1999-08-21 | 2012-10-03 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 協力剤の組合せ物 |
BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
NZ543109A (en) | 2003-04-25 | 2008-06-30 | Novacardia Inc | Method of improved diuresis in individuals with impaired renal function |
BRPI0509753A (pt) * | 2004-04-16 | 2007-10-16 | Novacardia Inc | composição farmacêutica e método de tratamento de doença cardiovascular |
EP1805180A1 (de) * | 2004-10-22 | 2007-07-11 | SmithKline Beecham Corporation | Xanthinderivate mit aktivität amhm74a-rezeptor |
EP2024364A1 (de) * | 2006-05-26 | 2009-02-18 | Neuromed Pharmaceuticals, Ltd. | Heterocyclische verbindungen als calciumkanalblocker |
JP2008025761A (ja) * | 2006-07-24 | 2008-02-07 | Kanaflex Corporation | 排水管更生用樹脂管 |
RU2333212C3 (ru) * | 2007-03-29 | 2019-08-26 | Общество С Ограниченной Ответственностью "Фармвинг" | ПРОИЗВОДНЫЕ 1-И 7-[ω-(БЕНЗГИДРИЛ-4-ПИПЕРАЗИНИЛ-1)АЛКИЛ]-3-АЛКИЛКСАНТИНОВ, ОБЛАДАЮЩИЕ ПРОТИВОГИСТАМИННОЙ И АНТИАЛЛЕРГИЧЕСКОЙ АКТИВНОСТЬЮ |
PT2159226T (pt) | 2007-03-29 | 2016-12-16 | Joint-Stock Company Obninsk Chemical Pharmaceutical Company | Agente anti-histamínico e antialérgico e um método para a produção do mesmo |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH409974A (de) * | 1959-03-25 | 1966-03-31 | Merckle Kg Chem Pharm L | Verfahren zur Herstellung neuer therapeutisch wirksamer Coffeino-(8)-alkylendiamine |
GB1133989A (en) * | 1964-12-08 | 1968-11-20 | Chugai Pharmaceutical Co Ltd | Theophylline derivatives, their salts and process for preparing the same |
FR7828M (de) * | 1967-11-13 | 1970-05-25 | ||
JPS55118488A (en) * | 1979-03-05 | 1980-09-11 | Eisai Co Ltd | Theobromine derivative and its preparation |
JPS5618983A (en) * | 1979-07-25 | 1981-02-23 | Eisai Co Ltd | Theophylline derivative and its preapration |
US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
DE3046927A1 (de) * | 1980-12-11 | 1982-07-15 | Josef Dipl.-Chem.Dr.rer.nat. 1000 Berlin Klosa | 8-dialkylaminoalkylaether-coffein-platin-komplexe , verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
ES8303412A1 (es) * | 1981-10-06 | 1983-02-01 | Invest Tecnica Aplicada | Procedimiento de obtencion de nuevas xantinas con actividad farmacologica |
-
1982
- 1982-07-28 FR FR8213155A patent/FR2531085A1/fr active Granted
-
1983
- 1983-07-22 KR KR1019830003383A patent/KR870001268B1/ko not_active IP Right Cessation
- 1983-07-25 US US06/516,946 patent/US4548820A/en not_active Expired - Fee Related
- 1983-07-25 AT AT83401518T patent/ATE17728T1/de not_active IP Right Cessation
- 1983-07-25 EP EP83401518A patent/EP0103497B1/de not_active Expired
- 1983-07-25 DE DE8383401518T patent/DE3362022D1/de not_active Expired
- 1983-07-26 SU SU833621202A patent/SU1240361A3/ru active
- 1983-07-26 GR GR72044A patent/GR78891B/el unknown
- 1983-07-27 DD DD83253414A patent/DD216934A5/de not_active IP Right Cessation
- 1983-07-27 CA CA000433287A patent/CA1207766A/fr not_active Expired
- 1983-07-27 NZ NZ205035A patent/NZ205035A/en unknown
- 1983-07-27 AU AU17361/83A patent/AU560809B2/en not_active Ceased
- 1983-07-27 PT PT77110A patent/PT77110B/pt active IP Right Revival
- 1983-07-27 IL IL69362A patent/IL69362A/xx not_active IP Right Cessation
- 1983-07-27 NO NO832742A patent/NO159091C/no unknown
- 1983-07-27 DK DK342883A patent/DK157550C/da not_active IP Right Cessation
- 1983-07-27 PH PH29308A patent/PH19275A/en unknown
- 1983-07-27 ZA ZA835496A patent/ZA835496B/xx unknown
- 1983-07-27 IE IE1762/83A patent/IE55773B1/en not_active IP Right Cessation
- 1983-07-27 HU HU832638A patent/HU188353B/hu not_active IP Right Cessation
- 1983-07-28 MA MA20081A patent/MA19860A1/fr unknown
- 1983-07-28 ES ES524532A patent/ES524532A0/es active Granted
- 1983-07-28 OA OA58075A patent/OA07508A/xx unknown
- 1983-07-28 JP JP58138664A patent/JPS5942383A/ja active Granted
-
1984
- 1984-06-13 SU SU843749947A patent/SU1245261A3/ru active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Free format text: TER MEER, N., DIPL.-CHEM. DR.RER.NAT. MUELLER, F., DIPL.-ING., 8000 MUENCHEN STEINMEISTER, H., DIPL.-ING., PAT.-ANW., 4800 BIELEFELD |
|
8339 | Ceased/non-payment of the annual fee |