DE3361100D1 - Disubstituted polymethylene imines, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Disubstituted polymethylene imines, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
DE3361100D1
DE3361100D1 DE8383400623T DE3361100T DE3361100D1 DE 3361100 D1 DE3361100 D1 DE 3361100D1 DE 8383400623 T DE8383400623 T DE 8383400623T DE 3361100 T DE3361100 T DE 3361100T DE 3361100 D1 DE3361100 D1 DE 3361100D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
chlorine
fluorine
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383400623T
Other languages
German (de)
Inventor
Alain Dhainaut
Michel Laubie
Jacques Duhault
Gilbert Regnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE3361100D1 publication Critical patent/DE3361100D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Polymethylene-imines of the formula: <IMAGE> in which: A is a hydrocarbon radical from C3 to C5 in a straight or branched chain possibly containing one or two double bonds and possibly substituted by one or more hydroxy radicals; X is CH or nitrogen; n is zero, one or two; Y is oxygen or N-R1 in which R1 is hydrogen, alkyl from C1 to C5, alkenyl from C2 to C5, cycloalkyl or cycloalkenyl from C3 to C7, or acetyl; R is hydrogen, alkyl from C1 to C5, cycloalkyl from C5 to C7 or phenyl optionally substituted by one or more fluorine or chlorine; and B is hydrogen, alkyl from C1 to C5, alkenyl from C2 to C5, or phenyl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, DELTA 3-chromanyl, thiochromenyl or chromanyl, each optionally substituted by fluorine, chlorine, alkyl or alkoxy from C1 to C5; or a radical of the formula: <IMAGE> in which: R2, R3 and R4 which may be the same or different, each represent hydrogen, or phenyl optionally substituted by fluorine or chlorine. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia.
DE8383400623T 1982-03-30 1983-03-25 Disubstituted polymethylene imines, processes for their preparation and pharmaceutical compositions containing them Expired DE3361100D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8205373A FR2524467A1 (en) 1982-03-30 1982-03-30 DISUBSTITUTED POLYMETHYLENE IMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

Publications (1)

Publication Number Publication Date
DE3361100D1 true DE3361100D1 (en) 1985-12-05

Family

ID=9272531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383400623T Expired DE3361100D1 (en) 1982-03-30 1983-03-25 Disubstituted polymethylene imines, processes for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US4514398A (en)
EP (1) EP0090733B1 (en)
JP (1) JPS58180482A (en)
AT (1) ATE16286T1 (en)
AU (1) AU559376B2 (en)
CA (1) CA1206150A (en)
DE (1) DE3361100D1 (en)
ES (1) ES8405273A1 (en)
FR (1) FR2524467A1 (en)
IE (1) IE55223B1 (en)
NZ (1) NZ203724A (en)
OA (1) OA07358A (en)
PT (1) PT76470B (en)
ZA (1) ZA832214B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58128002A (en) * 1982-01-25 1983-07-30 Sony Corp Recorder and reproducer
FR2544315B1 (en) * 1983-04-12 1985-07-05 Adir DISUBSTITUTED IMINES POLYMETHYLENE, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2567518B1 (en) * 1984-07-11 1987-11-13 Sanofi Sa NOVEL NITROGEN HETEROCYCLIC CORE COMPOUNDS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THE SAME
US5243047A (en) * 1988-02-15 1993-09-07 Imperial Chemical Industries Plc Triazole/thiazole amino-s-triazine bonding agents
JP2614921B2 (en) * 1989-07-05 1997-05-28 帝人株式会社 2,4,6-Trisubstituted-S-triazine derivative and method for producing the same
GB9024617D0 (en) * 1989-12-05 1991-01-02 Ici Plc Heterocyclic compounds
GB8929022D0 (en) * 1989-12-22 1990-02-28 Ici Plc Diazine derivatives
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
FR2664594B1 (en) * 1990-07-11 1992-09-18 Adir DISUBSTITUTED POLYMETHYLENE-IMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2667243B1 (en) * 1990-09-27 1994-11-04 Adir USE OF S DERIVATIVES OF TRIAZINE AND PYRIMIDINE FOR THE PRODUCTION OF DRUGS reversing the resistance to anti-cancer and anti-malarial agents.
FR2673627B1 (en) * 1991-03-07 1993-05-07 Adir TRIAZINES AND TRISUBSTITUTED PYRIMIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
EP0613477A1 (en) * 1991-11-12 1994-09-07 Pfizer Inc. Triazine derivatives for enhancing antitumor activity
KR100238346B1 (en) * 1993-04-07 2000-03-02 오쓰까 아끼히꼬 Peripheral vasodialating agent containing piperidine derivative as active ingredient
WO1997040010A1 (en) * 1996-04-24 1997-10-30 Emory University Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
US6943161B2 (en) * 1999-12-28 2005-09-13 Pharmacopela Drug Discovery, Inc. Pyrimidine and triazine kinase inhibitors
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
AU2011320024B2 (en) 2010-10-27 2014-10-30 The Walter And Eliza Hall Institute Of Medical Research Novel anti-cancer agents
CN105829304B (en) * 2013-12-20 2019-09-20 中国人民解放军军事医学科学院毒物药物研究所 N, N ' substituted piperidine aminated compounds, preparation method and the usage

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL277028A (en) * 1961-04-19
US3362221A (en) * 1964-06-30 1968-01-09 Hays Corp Magnetic flow transmitter system
US3270014A (en) * 1965-07-01 1966-08-30 Upjohn Co 1, 2-dihydro-1-hydroxy-1, 3, 5-triazines
US3576805A (en) * 1969-05-22 1971-04-27 American Cyanamid Co N**2,n**4,n**6-trisubstituted melamines

Also Published As

Publication number Publication date
ES521191A0 (en) 1984-06-01
AU1296783A (en) 1983-10-06
FR2524467A1 (en) 1983-10-07
JPS58180482A (en) 1983-10-21
NZ203724A (en) 1985-12-13
ZA832214B (en) 1983-12-28
US4514398A (en) 1985-04-30
PT76470B (en) 1986-03-11
ATE16286T1 (en) 1985-11-15
EP0090733A1 (en) 1983-10-05
EP0090733B1 (en) 1985-10-30
FR2524467B1 (en) 1984-05-11
OA07358A (en) 1984-08-31
PT76470A (en) 1983-04-01
ES8405273A1 (en) 1984-06-01
CA1206150A (en) 1986-06-17
IE55223B1 (en) 1990-07-04
IE830696L (en) 1983-09-30
AU559376B2 (en) 1987-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee