KR840005445A - 크산린 유도체의 제조방법 - Google Patents
크산린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840005445A KR840005445A KR1019830003383A KR830003383A KR840005445A KR 840005445 A KR840005445 A KR 840005445A KR 1019830003383 A KR1019830003383 A KR 1019830003383A KR 830003383 A KR830003383 A KR 830003383A KR 840005445 A KR840005445 A KR 840005445A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- compound
- carbon atoms
- formula
- alkyl
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- -1 halo compound Chemical class 0.000 claims 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000004990 dihydroxyalkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 229940075420 xanthine Drugs 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 다음 일반식(Ⅱ)의 할로 화합물을 다음 일반식(Ⅲ)의 아미노 화합물과 반응시켜 다음 일반식(I)의 크산틴 화합물을 얻고 필요하다면 그렇게 얻어진 일반식(I)의 화합물을 적당한 산으로 처리하여 상용하는 산 부가염을 얻음을 특징으로 하는 다음 일반식(I)의 크산틴 화합물 및 그것의 생리학적으로 내성을 갖는 산부가염의 제조방법.
-
- 상기식에서, R1은 수소원자 및 직쇄 및 측쇄를 포함하는 1내지 5탄소 원자를 갖는 알킬기로 구성된 그룹에서 선택하는 것이고, R2는 6탄소원자까지 포함하는 직쇄 및 측쇄 탄화수소기로서 이들 탄화수소기는 이중 결합을 가지며 페닐 및 벤질기를 포함하며, R3는 수소원자, 1내지 5탄소원자까지 함유하는 알킬, 히드록시알킬 및 디히드록시알킬로 구성된 그룹에서 선택된 것이고, R4는
-
- 일반식의 기로 구성된 그룹에서 선택한 것이고, 여기서 Y는 수소원자, 할로겐원자, 1내지 5탄소원자까지 각각 함유하는 알킬 및 알콕시기와 히드록시기로 구성된 그룹에서 선택한 치환기이며; Z는 메틸렌기, 2내지 5탄소원자를 갖는 직쇄 및 측쇄 탄화수소기로 구성된 그룹에서 선택한 것으로 이들 탄화수소기는 히드록시기로 치환된 것이며, A는로 구성된 그룹에서 선택한 아미노 잔기이며 여기서 p는 2 및 3에서 선택한 정수이고 q는 1 및 2에서 선택한 정수이고 X는 산소원자 및기로서 단일 결합을 구성하는 그룹에서 선택한 것이며 여기서 R5는 수소원자 및 1내지 5 탄소원자를 각각 갖는 알킬 및 알킬렌기로 구성된 그룹에서 선택한 것이며 m는 2내지 6까지 사이의 정수이고, R6는 1내지 5탄소원자까지 갖는 알킬로 구성된 그룹에서 선택한 것이고 은 염소 및 브롬으로 구성된 그룹에서 선택한 것이다.
- 다음 일반식(Ⅱ')의 화합물을 다음 일반식(Ⅲ')의 할로 화합물과 축합시켜 다음 구조식(I')의 화합물을 얻고 그렇게 얻어진 일반식(I')의 화합물을 적당한 산으로 처리하여 상용하는 산 부가염을 얻음을 특징으로 하는 다음 일반식(I')의 화합물과 그것의 생리학적으로 내성을 갖는 산 부가염의 제조방법.
-
- 상기식에서, R2R4및 Z 및 A는 상기 1항에서 주어진 의미를 갖고, R'1는 1내지 5탄소원자까지 함유하는 직쇄 및 측쇄 알킬로 구성된 그룹에서 선택한 것이고, R'3는 1내지 5탄소원자까지 함유하는 알킬, 히드록시 알킬 및 디히드록시 알킬로 구성된 그룹에서 선택한 것이고 X는 염소 및 브롬으로 구성된 그룹에서 선택한 것이다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8213155A FR2531085A1 (fr) | 1982-07-28 | 1982-07-28 | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| FR82-13155 | 1982-07-28 | ||
| FR8213155 | 1982-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840005445A true KR840005445A (ko) | 1984-11-12 |
| KR870001268B1 KR870001268B1 (ko) | 1987-06-30 |
Family
ID=9276395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830003383A KR870001268B1 (ko) | 1982-07-28 | 1983-07-22 | 크산틴 유도체의 제조 방법 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4548820A (ko) |
| EP (1) | EP0103497B1 (ko) |
| JP (1) | JPS5942383A (ko) |
| KR (1) | KR870001268B1 (ko) |
| AT (1) | ATE17728T1 (ko) |
| AU (1) | AU560809B2 (ko) |
| CA (1) | CA1207766A (ko) |
| DD (1) | DD216934A5 (ko) |
| DE (1) | DE3362022D1 (ko) |
| DK (1) | DK157550C (ko) |
| ES (1) | ES524532A0 (ko) |
| FR (1) | FR2531085A1 (ko) |
| GR (1) | GR78891B (ko) |
| HU (1) | HU188353B (ko) |
| IE (1) | IE55773B1 (ko) |
| IL (1) | IL69362A (ko) |
| MA (1) | MA19860A1 (ko) |
| NO (1) | NO159091C (ko) |
| NZ (1) | NZ205035A (ko) |
| OA (1) | OA07508A (ko) |
| PH (1) | PH19275A (ko) |
| PT (1) | PT77110B (ko) |
| SU (2) | SU1240361A3 (ko) |
| ZA (1) | ZA835496B (ko) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH648559A5 (de) * | 1981-07-20 | 1985-03-29 | Siegfried Ag | Theophyllinderivate und verfahren zu deren herstellung. |
| FR2558162B1 (fr) * | 1984-01-17 | 1986-04-25 | Adir | Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant |
| HU197746B (en) * | 1985-09-05 | 1989-05-29 | Sandoz Ag | Process for producing xantin derivatives and pharmaceutical compositions containing them |
| US4810706A (en) * | 1985-12-20 | 1989-03-07 | Recherche Syntex | Piperazine derivatives of theophylline and theobromine |
| GB8716313D0 (en) * | 1987-07-10 | 1987-08-19 | Janssen Pharmaceutica Nv | 2-(heterocyclylalkyl)imidazopyridines |
| US5298508A (en) * | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
| US5290782A (en) * | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| FR2659656B1 (fr) * | 1990-03-15 | 1994-09-09 | Sanofi Sa | Derives de pyrimidinedione-2,4 et medicaments les contenant. |
| DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
| US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
| JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| WO1994025462A1 (en) * | 1993-05-03 | 1994-11-10 | The United States Of America, Represented By The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
| US5661153A (en) * | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
| DE19702785A1 (de) * | 1997-01-27 | 1998-07-30 | Bayer Ag | Neue cyclische Harnstoffderivate |
| JP5038568B2 (ja) | 1999-08-21 | 2012-10-03 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 協力剤の組合せ物 |
| BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
| NZ543109A (en) | 2003-04-25 | 2008-06-30 | Novacardia Inc | Method of improved diuresis in individuals with impaired renal function |
| BRPI0509753A (pt) * | 2004-04-16 | 2007-10-16 | Novacardia Inc | composição farmacêutica e método de tratamento de doença cardiovascular |
| EP1805180A1 (en) * | 2004-10-22 | 2007-07-11 | SmithKline Beecham Corporation | Xanthine derivatives with hm74a receptor activity |
| EP2024364A1 (en) * | 2006-05-26 | 2009-02-18 | Neuromed Pharmaceuticals, Ltd. | Heterocyclic compounds as calcium channel blockers |
| JP2008025761A (ja) * | 2006-07-24 | 2008-02-07 | Kanaflex Corporation | 排水管更生用樹脂管 |
| RU2333212C3 (ru) * | 2007-03-29 | 2019-08-26 | Общество С Ограниченной Ответственностью "Фармвинг" | ПРОИЗВОДНЫЕ 1-И 7-[ω-(БЕНЗГИДРИЛ-4-ПИПЕРАЗИНИЛ-1)АЛКИЛ]-3-АЛКИЛКСАНТИНОВ, ОБЛАДАЮЩИЕ ПРОТИВОГИСТАМИННОЙ И АНТИАЛЛЕРГИЧЕСКОЙ АКТИВНОСТЬЮ |
| PT2159226T (pt) | 2007-03-29 | 2016-12-16 | Joint-Stock Company Obninsk Chemical Pharmaceutical Company | Agente anti-histamínico e antialérgico e um método para a produção do mesmo |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH409974A (de) * | 1959-03-25 | 1966-03-31 | Merckle Kg Chem Pharm L | Verfahren zur Herstellung neuer therapeutisch wirksamer Coffeino-(8)-alkylendiamine |
| GB1133989A (en) * | 1964-12-08 | 1968-11-20 | Chugai Pharmaceutical Co Ltd | Theophylline derivatives, their salts and process for preparing the same |
| FR7828M (ko) * | 1967-11-13 | 1970-05-25 | ||
| JPS55118488A (en) * | 1979-03-05 | 1980-09-11 | Eisai Co Ltd | Theobromine derivative and its preparation |
| JPS5618983A (en) * | 1979-07-25 | 1981-02-23 | Eisai Co Ltd | Theophylline derivative and its preapration |
| US4426383A (en) * | 1980-09-04 | 1984-01-17 | Eisai Co., Ltd. | Theophylline and theobromine derivatives |
| DE3046927A1 (de) * | 1980-12-11 | 1982-07-15 | Josef Dipl.-Chem.Dr.rer.nat. 1000 Berlin Klosa | 8-dialkylaminoalkylaether-coffein-platin-komplexe , verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| ES8303412A1 (es) * | 1981-10-06 | 1983-02-01 | Invest Tecnica Aplicada | Procedimiento de obtencion de nuevas xantinas con actividad farmacologica |
-
1982
- 1982-07-28 FR FR8213155A patent/FR2531085A1/fr active Granted
-
1983
- 1983-07-22 KR KR1019830003383A patent/KR870001268B1/ko not_active IP Right Cessation
- 1983-07-25 US US06/516,946 patent/US4548820A/en not_active Expired - Fee Related
- 1983-07-25 AT AT83401518T patent/ATE17728T1/de not_active IP Right Cessation
- 1983-07-25 EP EP83401518A patent/EP0103497B1/fr not_active Expired
- 1983-07-25 DE DE8383401518T patent/DE3362022D1/de not_active Expired
- 1983-07-26 SU SU833621202A patent/SU1240361A3/ru active
- 1983-07-26 GR GR72044A patent/GR78891B/el unknown
- 1983-07-27 DD DD83253414A patent/DD216934A5/de not_active IP Right Cessation
- 1983-07-27 CA CA000433287A patent/CA1207766A/fr not_active Expired
- 1983-07-27 NZ NZ205035A patent/NZ205035A/en unknown
- 1983-07-27 AU AU17361/83A patent/AU560809B2/en not_active Ceased
- 1983-07-27 PT PT77110A patent/PT77110B/pt active IP Right Revival
- 1983-07-27 IL IL69362A patent/IL69362A/xx not_active IP Right Cessation
- 1983-07-27 NO NO832742A patent/NO159091C/no unknown
- 1983-07-27 DK DK342883A patent/DK157550C/da not_active IP Right Cessation
- 1983-07-27 PH PH29308A patent/PH19275A/en unknown
- 1983-07-27 ZA ZA835496A patent/ZA835496B/xx unknown
- 1983-07-27 IE IE1762/83A patent/IE55773B1/en not_active IP Right Cessation
- 1983-07-27 HU HU832638A patent/HU188353B/hu not_active IP Right Cessation
- 1983-07-28 MA MA20081A patent/MA19860A1/fr unknown
- 1983-07-28 ES ES524532A patent/ES524532A0/es active Granted
- 1983-07-28 OA OA58075A patent/OA07508A/xx unknown
- 1983-07-28 JP JP58138664A patent/JPS5942383A/ja active Granted
-
1984
- 1984-06-13 SU SU843749947A patent/SU1245261A3/ru active
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