DD216163A5 - Verfahren zur herstellung eines oral verabfolgbaren cefaclor-praeparates mit verzoegerter wirkstoffabgabe - Google Patents
Verfahren zur herstellung eines oral verabfolgbaren cefaclor-praeparates mit verzoegerter wirkstoffabgabe Download PDFInfo
- Publication number
- DD216163A5 DD216163A5 DD84264197A DD26419784A DD216163A5 DD 216163 A5 DD216163 A5 DD 216163A5 DD 84264197 A DD84264197 A DD 84264197A DD 26419784 A DD26419784 A DD 26419784A DD 216163 A5 DD216163 A5 DD 216163A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- component
- granules
- ccl
- release
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 46
- 229960005361 cefaclor Drugs 0.000 title claims abstract description 23
- 230000003111 delayed effect Effects 0.000 title claims abstract description 18
- 239000013543 active substance Substances 0.000 title description 6
- WKJGTOYAEQDNIA-IOOZKYRYSA-N (6r,7r)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 WKJGTOYAEQDNIA-IOOZKYRYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 claims abstract description 35
- QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 claims abstract description 23
- 230000008569 process Effects 0.000 claims abstract description 12
- 239000008187 granular material Substances 0.000 claims description 87
- 239000000203 mixture Substances 0.000 claims description 48
- 239000003814 drug Substances 0.000 claims description 30
- 229940079593 drug Drugs 0.000 claims description 28
- 210000002966 serum Anatomy 0.000 claims description 23
- 239000002775 capsule Substances 0.000 claims description 21
- 238000012377 drug delivery Methods 0.000 claims description 20
- 239000011248 coating agent Substances 0.000 claims description 18
- 238000000576 coating method Methods 0.000 claims description 18
- 239000011324 bead Substances 0.000 claims description 16
- 239000000654 additive Substances 0.000 claims description 13
- 230000000996 additive effect Effects 0.000 claims description 7
- 239000002702 enteric coating Substances 0.000 claims description 7
- 238000009505 enteric coating Methods 0.000 claims description 7
- 239000003094 microcapsule Substances 0.000 claims description 6
- -1 alkyl methacrylate Chemical compound 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- 239000007931 coated granule Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000005923 long-lasting effect Effects 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 description 25
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 23
- 238000012360 testing method Methods 0.000 description 16
- 229920002261 Corn starch Polymers 0.000 description 15
- 239000008120 corn starch Substances 0.000 description 14
- 229940099112 cornstarch Drugs 0.000 description 14
- 244000005700 microbiome Species 0.000 description 13
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 11
- 238000013268 sustained release Methods 0.000 description 11
- 239000012730 sustained-release form Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 241000588724 Escherichia coli Species 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 8
- 235000010980 cellulose Nutrition 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- 241000191967 Staphylococcus aureus Species 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 235000010355 mannitol Nutrition 0.000 description 6
- 235000012054 meals Nutrition 0.000 description 6
- 229920000609 methyl cellulose Polymers 0.000 description 6
- 239000001923 methylcellulose Substances 0.000 description 6
- 235000010981 methylcellulose Nutrition 0.000 description 6
- 239000000902 placebo Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 229920001592 potato starch Polymers 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 235000021152 breakfast Nutrition 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920001800 Shellac Polymers 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000007012 clinical effect Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000004208 shellac Substances 0.000 description 3
- 229940113147 shellac Drugs 0.000 description 3
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 3
- 235000013874 shellac Nutrition 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000003405 delayed action preparation Substances 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 229940106052 methylcellulose (25 cps) Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 229940100445 wheat starch Drugs 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008202 granule composition Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229940090589 keflex Drugs 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58108289A JPS601128A (ja) | 1983-06-15 | 1983-06-15 | 作用持続型セフアクロル製剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
DD216163A5 true DD216163A5 (de) | 1984-12-05 |
Family
ID=14480890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD84264197A DD216163A5 (de) | 1983-06-15 | 1984-06-15 | Verfahren zur herstellung eines oral verabfolgbaren cefaclor-praeparates mit verzoegerter wirkstoffabgabe |
Country Status (23)
Country | Link |
---|---|
US (1) | US4713247A (ko) |
EP (1) | EP0129382B1 (ko) |
JP (1) | JPS601128A (ko) |
KR (1) | KR910004573B1 (ko) |
AT (1) | ATE56869T1 (ko) |
AU (1) | AU568654B2 (ko) |
BG (1) | BG60261B1 (ko) |
CA (1) | CA1213218A (ko) |
DD (1) | DD216163A5 (ko) |
DE (1) | DE3483282D1 (ko) |
DK (2) | DK291884A (ko) |
ES (1) | ES8602407A1 (ko) |
FI (1) | FI84556C (ko) |
GB (1) | GB2141342B (ko) |
GR (1) | GR81598B (ko) |
HU (1) | HU193434B (ko) |
IE (1) | IE58278B1 (ko) |
IL (1) | IL72083A (ko) |
NZ (1) | NZ208345A (ko) |
PH (1) | PH19902A (ko) |
PT (1) | PT78699B (ko) |
RO (1) | RO88924A (ko) |
ZA (1) | ZA844357B (ko) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229132A (en) * | 1985-02-22 | 1993-07-20 | Grimberg Georges Serge | Non-absorbable gastrointestinal medicament provided for treating the two levels of the digestive tract at the same time |
JPS61210025A (ja) * | 1985-03-14 | 1986-09-18 | Teisan Seiyaku Kk | 安定化された抗生物質複合顆粒製剤 |
AU591248B2 (en) * | 1986-03-27 | 1989-11-30 | Kinaform Technology, Inc. | Sustained-release pharaceutical preparation |
JPS62226926A (ja) * | 1986-03-27 | 1987-10-05 | Teisan Seiyaku Kk | 持続性複合顆粒剤 |
JPH0714863B2 (ja) * | 1986-06-02 | 1995-02-22 | 忠生 白石 | 時差溶解性の入浴剤 |
ZA881301B (en) * | 1987-02-27 | 1989-10-25 | Lilly Co Eli | Sustained release matrix formulations |
US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
BE1002079A4 (fr) * | 1988-07-01 | 1990-06-19 | S M B Lab | Composition pharmaceutique d'erythromycine a liberation prolongee, sa preparation et son utilisation. |
US5122384A (en) * | 1989-05-05 | 1992-06-16 | Kv Pharmaceutical Company | Oral once-per-day organic nitrate formulation which does not induce tolerance |
US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
WO1991019486A1 (en) * | 1990-06-14 | 1991-12-26 | Kalmo Enterprises, Inc. | Stable aqueous drug suspensions |
GB9318641D0 (en) * | 1993-09-08 | 1993-10-27 | Edko Trading Representation | Compositions |
ES2079327B1 (es) * | 1994-12-13 | 1996-08-01 | Lilly Sa | Formulaciones farmaceuticas de cefaclor. |
WO1997033569A1 (de) * | 1996-03-13 | 1997-09-18 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Arzneimittelzubereitung für ace-hemmer |
US5948440A (en) * | 1997-12-17 | 1999-09-07 | Ranbaxy Laboratories Limited | Modified release matrix formulation of cefaclor and cephalexin |
ZA98728B (en) * | 1998-01-29 | 1998-10-28 | Ranbaxy Lab Ltd | Modified release matrix formulations of cefactor and cephalexin |
KR100296413B1 (ko) * | 1998-04-01 | 2001-11-14 | 김선진 | 세파클러함유서방성정제 |
US20030170181A1 (en) * | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
JP2002541092A (ja) * | 1999-04-06 | 2002-12-03 | ファーマクエスト・リミテッド | メチルフェニデートのパルス性送達のための薬学的投薬形態 |
EP1180022A4 (en) * | 1999-05-14 | 2004-01-07 | Lilly Co Eli | PROCESS FOR THE MASS PRODUCTION OF PHARMACEUTICAL MATERIAL WITH UNIFORM SOLUBILITY |
US6596307B1 (en) | 1999-06-15 | 2003-07-22 | Eli Lilly And Company | Process for preparing pharmaceutical bulk material having uniform dissolution |
EP1257255A4 (en) * | 2000-02-24 | 2008-07-30 | Advancis Pharmaceutical Corp | THERAPEUTIC PRODUCT, ITS USE AND MANUFACTURE |
CA2400818C (en) * | 2000-02-24 | 2009-01-06 | Advancis Pharmaceutical Corporation | Antibiotic and antifungal compositions |
US7025989B2 (en) * | 2000-02-24 | 2006-04-11 | Advancis Pharmaceutical Corp. | Multiple-delayed released antibiotic product, use and formulation thereof |
JP2003531115A (ja) * | 2000-02-24 | 2003-10-21 | アドバンシス ファーマシューティカル コーポレイション | インヒビターを有する抗生物質組成物 |
US6991807B2 (en) * | 2000-02-24 | 2006-01-31 | Advancis Pharmaceutical, Corp. | Antibiotic composition |
CA2435305A1 (en) * | 2001-01-18 | 2002-07-25 | Natco Pharma Limited | Extended release pharmaceutical compositions containing beta-lactam antibiotics |
CA2478121A1 (en) * | 2002-03-07 | 2003-09-18 | Advancis Pharmaceutical Corporation | Antibiotic composition |
AU2003219184A1 (en) * | 2002-05-09 | 2003-11-11 | Diffucap-Chemobras Quimica E Farmaceutica, Ltda. | Novel method of preparing programmed-release compositions containing (s)-1-(n-(1-(ethoxycarbonyl)-3-phenylpropyl)-l-alanyl)-l-proline and the product thus obtained |
WO2005009364A2 (en) * | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
EP1648407A4 (en) * | 2003-07-21 | 2011-08-31 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION |
JP2006528189A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質産物、その使用法および製剤 |
JP2007502294A (ja) * | 2003-08-12 | 2007-02-08 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
EP1658034A4 (en) * | 2003-08-29 | 2011-06-22 | Middlebrook Pharmaceuticals Inc | ANTIBIOTIC PRODUCT, ITS USE AND FORMULATION |
CA2538064C (en) * | 2003-09-15 | 2013-12-17 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
AU2003290394A1 (en) * | 2003-09-30 | 2005-04-14 | Lupin Ltd. | Extended release formulation of beta-lactam antibiotics |
AU2006235483B2 (en) * | 2005-04-12 | 2010-11-25 | Elan Pharma International Limited | Controlled release compositions comprising a cephalosporin for the treatment of a bacterial infection |
JP2008545841A (ja) | 2005-06-02 | 2008-12-18 | ノボザイムス アクティーゼルスカブ | 不活性粒子及び活性粒子のブレンド |
US20060287212A1 (en) * | 2005-06-02 | 2006-12-21 | Novozymes A/S | Blends of inactive particles and active particles |
WO2010135396A2 (en) | 2009-05-19 | 2010-11-25 | Celgene Corporation | Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione |
CA2859203C (en) * | 2011-12-19 | 2020-08-25 | Salix Pharmaceuticals, Ltd. | Methods for treatment and prevention of opioid induced constipation using oral compositions of methylnaltrexone |
CA2936748C (en) | 2014-10-31 | 2017-08-08 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
CN104688701A (zh) * | 2015-03-20 | 2015-06-10 | 江苏亚邦强生药业有限公司 | 一种头孢克洛片剂及其制备方法 |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CN110408670A (zh) * | 2019-08-19 | 2019-11-05 | 苏州盛达药业有限公司 | 一种酶催化合成头孢克洛的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2738303A (en) * | 1952-07-18 | 1956-03-13 | Smith Kline French Lab | Sympathomimetic preparation |
US3906086A (en) * | 1971-07-19 | 1975-09-16 | Richard G Powers | Timed-release aspirin |
JPS52139713A (en) * | 1976-05-13 | 1977-11-21 | Shionogi & Co Ltd | Sustained release cefalexin preparations |
US4250166A (en) * | 1977-05-27 | 1981-02-10 | Shionogi & Co., Ltd. | Long acting preparation of cefalexin for effective treatments of bacterial infection sensitive to cefalexin |
GR74995B (ko) * | 1980-08-27 | 1984-07-12 | Ciba Geigy Ag | |
JPS5826816A (ja) * | 1981-08-11 | 1983-02-17 | Teisan Seiyaku Kk | 球形顆粒からなる持続性複合顆粒剤 |
-
1983
- 1983-06-15 JP JP58108289A patent/JPS601128A/ja active Granted
-
1984
- 1984-05-30 US US06/615,242 patent/US4713247A/en not_active Expired - Lifetime
- 1984-05-31 NZ NZ208345A patent/NZ208345A/en unknown
- 1984-06-04 GR GR74913A patent/GR81598B/el unknown
- 1984-06-06 PT PT78699A patent/PT78699B/pt unknown
- 1984-06-08 GB GB08414633A patent/GB2141342B/en not_active Expired
- 1984-06-08 IE IE144484A patent/IE58278B1/en not_active IP Right Cessation
- 1984-06-08 AT AT84303908T patent/ATE56869T1/de not_active IP Right Cessation
- 1984-06-08 ZA ZA844357A patent/ZA844357B/xx unknown
- 1984-06-08 EP EP84303908A patent/EP0129382B1/en not_active Expired - Lifetime
- 1984-06-08 DE DE8484303908T patent/DE3483282D1/de not_active Expired - Fee Related
- 1984-06-11 PH PH30800A patent/PH19902A/en unknown
- 1984-06-13 BG BG065844A patent/BG60261B1/bg unknown
- 1984-06-13 FI FI842406A patent/FI84556C/fi not_active IP Right Cessation
- 1984-06-13 IL IL72083A patent/IL72083A/xx unknown
- 1984-06-13 RO RO84114861A patent/RO88924A/ro unknown
- 1984-06-14 HU HU842312A patent/HU193434B/hu not_active IP Right Cessation
- 1984-06-14 DK DK291884D patent/DK291884A/da unknown
- 1984-06-14 DK DK291884A patent/DK170922B1/da not_active IP Right Cessation
- 1984-06-15 AU AU29418/84A patent/AU568654B2/en not_active Ceased
- 1984-06-15 DD DD84264197A patent/DD216163A5/de unknown
- 1984-06-15 CA CA000456659A patent/CA1213218A/en not_active Expired
- 1984-06-15 ES ES533901A patent/ES8602407A1/es not_active Expired
- 1984-06-15 KR KR1019840003359A patent/KR910004573B1/ko not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DD216163A5 (de) | Verfahren zur herstellung eines oral verabfolgbaren cefaclor-praeparates mit verzoegerter wirkstoffabgabe | |
DE2813480C2 (de) | Arzneimittel-Depotpräparat vom Mehrfacheinheitsdosen-Typ | |
DE2950977C2 (ko) | ||
DE69819481T2 (de) | Formulierungen von clarithromycin mit verlängerter wirkstoff-freisetzung | |
DE69530973T2 (de) | Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen | |
DE69721845T2 (de) | Orale morphinzubereitung in teilchenform | |
AT398166B (de) | Verfahren zur herstellung einer pharmazeutischen kapsel zur oralen verabreichung von nitrofurantoin (-salzen, -hydraten, -komplexen) | |
DE19541128C2 (de) | Stabilisierte schilddrüsenhormonhaltige Arzneimittel | |
DE2618129A1 (de) | Feste, subkutan implantierbare pille, enthaltend eine biologisch wirksame menge an 2 alpha-methylandrostan-17beta- 0l-3-on-17-propionat, verfahren zu deren herstellung und anwendung | |
CH678813A5 (ko) | ||
EP0250648B1 (de) | Pharmazeutisches Präparat zur verzögerten Freigabe von Ibuprofen | |
DD298205A5 (de) | Verfahren zum herstellen von langzeitwirkenden arzneimittelzubereitungen | |
DE3137125C2 (ko) | ||
DE2841668A1 (de) | Medikiertes tierfutter auf basis lebermehl | |
DE60308828T2 (de) | Orale pharmazeutische Zusammensetzung mit verzögerter Freisetzung | |
DE3040780A1 (de) | Pharmazeutische zusammensetzung zur behandlung von diabetes und verfahren zu deren herstellung | |
DE3638124C2 (de) | Neue pharmazeutische Verwendung von Ebselen | |
EP0116358B1 (de) | Komplexe von Prostaglandinen | |
DE3419131A1 (de) | Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung | |
DE3530780C2 (de) | Neue pharmazeutische Verwendung von 5-(3-n-Butyloxalylaminophenyl)-tetrazol | |
WO1998058639A1 (de) | Synergistisch wirkende zusammensetzungen zur selektiven bekämpfung von tumorgewebe | |
DE3040042A1 (de) | Pharmazeutische zubereitung des tiaramids oder seiner pharmazeutisch vertraeglichen salze | |
DE1925919A1 (de) | Arzneimittelzubereitung mit gleichmaessiger Arzneifreigabe | |
DE3315607A1 (de) | Verwendung von albendazol in oraler verabreichungsform bei der bekaempfung von echinokokkose des menschen und arzneimittel | |
DE3419129A1 (de) | Nifedipinpraeparate und verfahren zu ihrer herstellung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF04 | In force in the year 2004 |
Expiry date: 20040616 |