DD210265A5 - Verfahren zur herstellung eines pyrazolderivats - Google Patents

Verfahren zur herstellung eines pyrazolderivats Download PDF

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Publication number
DD210265A5
DD210265A5 DD83256094A DD25609483A DD210265A5 DD 210265 A5 DD210265 A5 DD 210265A5 DD 83256094 A DD83256094 A DD 83256094A DD 25609483 A DD25609483 A DD 25609483A DD 210265 A5 DD210265 A5 DD 210265A5
Authority
DD
German Democratic Republic
Prior art keywords
methyl
formula
acid
pyrazole
carboxylic acid
Prior art date
Application number
DD83256094A
Other languages
German (de)
English (en)
Inventor
James R Beck
Robert P Gajewski
Ronald F Hackler
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD210265A5 publication Critical patent/DD210265A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DD83256094A 1982-11-01 1983-10-28 Verfahren zur herstellung eines pyrazolderivats DD210265A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/437,994 US4495195A (en) 1982-11-01 1982-11-01 Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use

Publications (1)

Publication Number Publication Date
DD210265A5 true DD210265A5 (de) 1984-06-06

Family

ID=23738785

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83256094A DD210265A5 (de) 1982-11-01 1983-10-28 Verfahren zur herstellung eines pyrazolderivats

Country Status (13)

Country Link
US (1) US4495195A (en:Method)
EP (1) EP0112623A2 (en:Method)
JP (1) JPS5995272A (en:Method)
KR (1) KR840006629A (en:Method)
AU (1) AU2068583A (en:Method)
DD (1) DD210265A5 (en:Method)
DK (1) DK492783D0 (en:Method)
ES (1) ES526869A0 (en:Method)
FI (1) FI833931A7 (en:Method)
GB (1) GB2130205A (en:Method)
GR (1) GR79640B (en:Method)
IL (1) IL70075A0 (en:Method)
PT (1) PT77583B (en:Method)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001254A1 (en) * 1994-07-05 1996-01-18 Ciba-Geigy Ag Pyrazole derivatives as herbicides
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208555A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
JPS6425763A (en) 1987-04-24 1989-01-27 Mitsubishi Chem Ind Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient
US4861777A (en) * 1987-09-11 1989-08-29 Mitsubishi Kasei Corporation Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient
JP2751309B2 (ja) * 1988-02-16 1998-05-18 三菱化学株式会社 ピラゾール類およびこれを有効成分とする殺虫、殺ダニ、殺菌剤
JP2784925B2 (ja) * 1988-09-07 1998-08-13 日本農薬株式会社 ３又は５−フェニルピラゾール類又はその塩及び除草剤
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
US4956379A (en) * 1990-02-13 1990-09-11 Bristol-Myers Squibb Company Pyrazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
ATE247116T1 (de) * 1994-12-13 2003-08-15 Euro Celtique Sa Arylthioxanthine
EP0799040B1 (en) * 1994-12-13 2003-08-20 Euroceltique S.A. Trisubstituted thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
ID21775A (id) * 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
WO1999024038A1 (en) 1997-11-07 1999-05-20 Johns Hopkins University Methods for treatment of disorders of cardiac contractility
ATE440820T1 (de) * 2004-08-27 2009-09-15 Astellas Pharma Inc 2-phenylpyridinderivat
EP1783124A4 (en) * 2004-08-27 2009-07-08 Astellas Pharma Inc 2-PHENYLTHIOPHENDERIVAT
AU2006300422A1 (en) 2005-10-07 2007-04-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
EP1992361B1 (en) 2006-02-24 2012-05-02 Astellas Pharma Inc. Remedy or preventive for digestive ulcer
EP2754658A1 (en) 2009-02-27 2014-07-16 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
DK2610248T3 (en) 2010-08-27 2016-07-25 Teijin Pharma Ltd PROCESS FOR THE PREPARATION OF PHENYL-substituted heterocyclic derivative by means of the coupling method using a palladium compound
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative
EP2944635B1 (en) * 2014-05-15 2018-11-28 Council of Scientific & Industrial Research Pyrazole linked benzimidazole conjugates and a process for preparation thereof
CN106632245B (zh) * 2016-09-30 2019-11-15 华南理工大学 氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1261124B (de) * 1961-09-22 1968-02-15 Hoechst Ag Verfahren zur Herstellung von Pyrazolen
IT1053661B (it) * 1966-09-27 1981-10-10 Farmacosmici S P A Ammidi dell acido 3 5 metil 5 3 pirazol carbossilico
FR2104931B1 (en:Method) * 1970-09-08 1975-01-10 Ferlux
DE2508934A1 (de) * 1974-03-04 1975-09-11 Byk Gulden Lomberg Chem Fab Neue substituierte 5-amino-4- formyl-carbamoyl-pyrazole, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2410653A1 (de) * 1974-03-06 1975-10-30 Byk Gulden Lomberg Chem Fab Neue heterocyclisch substituierte 5amino-4-formylcarbamoyl-pyrazole, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
US3899508A (en) * 1974-04-12 1975-08-12 Lilly Co Eli 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof
US3903106A (en) * 1974-04-12 1975-09-02 Lilly Co Eli Pyrazole-3-carboxylic acids
US3895027A (en) * 1974-04-12 1975-07-15 Lilly Co Eli Process for preparing pyrazole-3-carboxylic acids
FR2320093A1 (fr) * 1975-08-05 1977-03-04 Sogeras Nouveaux acides diphenyl-pyrazole-5-acetiques
FR2353292A1 (fr) * 1975-08-05 1977-12-30 Sogeras Nouveaux derives du benzoyl-3 pyrazole
US4214090A (en) * 1976-01-14 1980-07-22 Commonwealth Scientific And Industrial Research Organization Fungicidal carboxamidopyrazoles
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
US4245106A (en) * 1979-07-05 1981-01-13 Monsanto Company Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001254A1 (en) * 1994-07-05 1996-01-18 Ciba-Geigy Ag Pyrazole derivatives as herbicides
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Also Published As

Publication number Publication date
PT77583A (en) 1983-11-01
FI833931L (fi) 1984-05-02
EP0112623A2 (en) 1984-07-04
IL70075A0 (en) 1984-01-31
ES8601900A1 (es) 1985-05-01
GB2130205A (en) 1984-05-31
GB8328755D0 (en) 1983-11-30
US4495195A (en) 1985-01-22
GR79640B (en:Method) 1984-10-31
FI833931A0 (fi) 1983-10-27
AU2068583A (en) 1984-05-10
ES526869A0 (es) 1985-05-01
PT77583B (en) 1986-05-27
KR840006629A (ko) 1984-12-01
DK492783D0 (da) 1983-10-27
FI833931A7 (fi) 1984-05-02
JPS5995272A (ja) 1984-06-01

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