JPS5995272A - ３−アリ−ル−５−ピラゾ−ル誘導体 - Google Patents

３−アリ−ル−５−ピラゾ−ル誘導体

Info

Publication number
JPS5995272A
JPS5995272A JP58203575A JP20357583A JPS5995272A JP S5995272 A JPS5995272 A JP S5995272A JP 58203575 A JP58203575 A JP 58203575A JP 20357583 A JP20357583 A JP 20357583A JP S5995272 A JPS5995272 A JP S5995272A
Authority
JP
Japan
Prior art keywords
methyl
general formula
carboxylic acid
acid
pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58203575A
Other languages
English (en)
Japanese (ja)
Inventor
ジエイムズ・ア−ル・ベツク
ロバ−ト・ピ−・ガジエウスキ
ロナルド・イ−・ハツクラ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS5995272A publication Critical patent/JPS5995272A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58203575A 1982-11-01 1983-10-28 ３−アリ−ル−５−ピラゾ−ル誘導体 Pending JPS5995272A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US437994 1982-11-01
US06/437,994 US4495195A (en) 1982-11-01 1982-11-01 Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use

Publications (1)

Publication Number Publication Date
JPS5995272A true JPS5995272A (ja) 1984-06-01

Family

ID=23738785

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58203575A Pending JPS5995272A (ja) 1982-11-01 1983-10-28 ３−アリ−ル−５−ピラゾ−ル誘導体

Country Status (13)

Country Link
US (1) US4495195A (en:Method)
EP (1) EP0112623A2 (en:Method)
JP (1) JPS5995272A (en:Method)
KR (1) KR840006629A (en:Method)
AU (1) AU2068583A (en:Method)
DD (1) DD210265A5 (en:Method)
DK (1) DK492783D0 (en:Method)
ES (1) ES8601900A1 (en:Method)
FI (1) FI833931L (en:Method)
GB (1) GB2130205A (en:Method)
GR (1) GR79640B (en:Method)
IL (1) IL70075A0 (en:Method)
PT (1) PT77583B (en:Method)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289879A1 (en) 1987-04-24 1988-11-09 Mitsubishi Kasei Corporation Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient
JPH02300173A (ja) * 1988-09-07 1990-12-12 Nippon Nohyaku Co Ltd ３又は５−フェニルピラゾール類又はその塩及び除草剤
WO1998018765A1 (en) * 1996-10-25 1998-05-07 Yoshitomi Pharmaceutical Industries, Ltd. 1-phenylpyrazole compounds and medicinal application thereof
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
US7612108B2 (en) 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
US7816558B2 (en) 2005-10-07 2010-10-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
KR20110120896A (ko) 2009-02-27 2011-11-04 데이진 화-마 가부시키가이샤 천이 금속 촉매를 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법
US8067446B2 (en) 2006-02-24 2011-11-29 Astellas Pharma Inc. Methods for treating an ulcer of the small intestine and stomach
WO2012026565A1 (ja) 2010-08-27 2012-03-01 帝人ファーマ株式会社 パラジウム化合物を用いたカップリング法によるフェニル置換複素環誘導体の製造法
WO2014157740A1 (ja) 2013-03-29 2014-10-02 帝人ファーマ株式会社 ピラゾール誘導体

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208555A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US4861777A (en) * 1987-09-11 1989-08-29 Mitsubishi Kasei Corporation Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient
JP2751309B2 (ja) * 1988-02-16 1998-05-18 三菱化学株式会社 ピラゾール類およびこれを有効成分とする殺虫、殺ダニ、殺菌剤
CA2036192A1 (en) 1990-02-13 1991-08-14 Nicholas Meanwell Heterocyclic carboxylic acids and esters
US4956379A (en) * 1990-02-13 1990-09-11 Bristol-Myers Squibb Company Pyrazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5294630A (en) * 1992-07-07 1994-03-15 Eli Lilly And Company Treatment of inflammatory bowel disease
US5436258A (en) * 1992-09-09 1995-07-25 Eli Lilly And Company Prevention of bone resorption
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
HRP950330A2 (en) * 1994-07-05 1997-10-31 Ciba Geigy Ag New herbicides
CA2206804C (en) * 1994-12-13 2002-03-19 Euro-Celtique, S.A. Trisubstituted thioxanthines
WO1996018399A1 (en) * 1994-12-13 1996-06-20 Euro-Celtique, S.A. Aryl thioxanthines
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
EP1044002A4 (en) 1997-11-07 2003-05-02 Univ Johns Hopkins METHODS FOR THE TREATMENT OF HEART CONTRACTILITY
EP2944635B1 (en) * 2014-05-15 2018-11-28 Council of Scientific & Industrial Research Pyrazole linked benzimidazole conjugates and a process for preparation thereof
CN106632245B (zh) * 2016-09-30 2019-11-15 华南理工大学 氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1261124B (de) * 1961-09-22 1968-02-15 Hoechst Ag Verfahren zur Herstellung von Pyrazolen
IT1053661B (it) * 1966-09-27 1981-10-10 Farmacosmici S P A Ammidi dell acido 3 5 metil 5 3 pirazol carbossilico
FR2104931B1 (en:Method) * 1970-09-08 1975-01-10 Ferlux
DE2508934A1 (de) * 1974-03-04 1975-09-11 Byk Gulden Lomberg Chem Fab Neue substituierte 5-amino-4- formyl-carbamoyl-pyrazole, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2410653A1 (de) * 1974-03-06 1975-10-30 Byk Gulden Lomberg Chem Fab Neue heterocyclisch substituierte 5amino-4-formylcarbamoyl-pyrazole, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
US3895027A (en) * 1974-04-12 1975-07-15 Lilly Co Eli Process for preparing pyrazole-3-carboxylic acids
US3903106A (en) * 1974-04-12 1975-09-02 Lilly Co Eli Pyrazole-3-carboxylic acids
US3899508A (en) * 1974-04-12 1975-08-12 Lilly Co Eli 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof
FR2353292A1 (fr) * 1975-08-05 1977-12-30 Sogeras Nouveaux derives du benzoyl-3 pyrazole
FR2320093A1 (fr) * 1975-08-05 1977-03-04 Sogeras Nouveaux acides diphenyl-pyrazole-5-acetiques
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
US4214090A (en) * 1976-01-14 1980-07-22 Commonwealth Scientific And Industrial Research Organization Fungicidal carboxamidopyrazoles
US4245106A (en) * 1979-07-05 1981-01-13 Monsanto Company Process for the preparation of 1-alkyl-3-aryl-4-pyrazolecarboxylates
US4346097A (en) * 1980-09-30 1982-08-24 Warner-Lambert Company Method for treating convulsions with pyrazole-4-carboxamide derivatives

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0289879A1 (en) 1987-04-24 1988-11-09 Mitsubishi Kasei Corporation Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient
JPH02300173A (ja) * 1988-09-07 1990-12-12 Nippon Nohyaku Co Ltd ３又は５−フェニルピラゾール類又はその塩及び除草剤
WO1998018765A1 (en) * 1996-10-25 1998-05-07 Yoshitomi Pharmaceutical Industries, Ltd. 1-phenylpyrazole compounds and medicinal application thereof
US7820700B2 (en) 2004-08-27 2010-10-26 Astellas Pharma Inc. 2-phenylpyridine derivative
US7612108B2 (en) 2004-08-27 2009-11-03 Astellas Pharma Inc. 2-phenylthiophene derivative
WO2006022374A1 (ja) * 2004-08-27 2006-03-02 Astellas Pharma Inc. ２－フェニルピリジン誘導体
JP4894517B2 (ja) * 2004-08-27 2012-03-14 アステラス製薬株式会社 ２−フェニルピリジン誘導体
US7816558B2 (en) 2005-10-07 2010-10-19 Astellas Pharma Inc. Triarylcarboxylic acid derivative
US8067446B2 (en) 2006-02-24 2011-11-29 Astellas Pharma Inc. Methods for treating an ulcer of the small intestine and stomach
US8426453B2 (en) 2006-02-24 2013-04-23 Astellas Pharma Inc. Treatment of a stomach or small intestine ulcer with 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid
KR20110120896A (ko) 2009-02-27 2011-11-04 데이진 화-마 가부시키가이샤 천이 금속 촉매를 사용한 커플링법에 의한 페닐 치환 복소 고리 유도체의 제조법
EP2754658A1 (en) 2009-02-27 2014-07-16 Teijin Pharma Limited Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
WO2012026565A1 (ja) 2010-08-27 2012-03-01 帝人ファーマ株式会社 パラジウム化合物を用いたカップリング法によるフェニル置換複素環誘導体の製造法
WO2014157740A1 (ja) 2013-03-29 2014-10-02 帝人ファーマ株式会社 ピラゾール誘導体
US9617240B2 (en) 2013-03-29 2017-04-11 Teijin Pharma Limited Pyrazole derivative

Also Published As

Publication number Publication date
FI833931A7 (fi) 1984-05-02
GB8328755D0 (en) 1983-11-30
FI833931A0 (fi) 1983-10-27
US4495195A (en) 1985-01-22
GR79640B (en:Method) 1984-10-31
EP0112623A2 (en) 1984-07-04
PT77583B (en) 1986-05-27
DD210265A5 (de) 1984-06-06
AU2068583A (en) 1984-05-10
ES526869A0 (es) 1985-05-01
KR840006629A (ko) 1984-12-01
ES8601900A1 (es) 1985-05-01
GB2130205A (en) 1984-05-31
IL70075A0 (en) 1984-01-31
PT77583A (en) 1983-11-01
FI833931L (fi) 1984-05-02
DK492783D0 (da) 1983-10-27

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